Physical Dependence?

[ShamanicHaze]

How fast does physical dependence take to form? I've used 4 days in a row. Friday- 80mg Oxycodone, Saturday- 12.5mg Oxymorphone, Sunday- 15mg Oxymorphone, Monday- 17.5mg Oxymorphone. I havn't not used any opioids today nor have I had any cravings. Right now I'm getting some stomach cramps. I'm pretty sure this is just from being way to fucking high, not eating much today, and not shitting enough due to being high. I am, however worried about my friend. On Friday he used 50mg Oxycodone and 10mg Oxymorphone, Saturday- 15mg Oxymorphone, Sunday- 15mg Oxymorphone, Monday- 15mg Oxymorphone, Tuesday- 20mg Oxymorphone. He also keeps on ragging on "junkies". I am worried he might be doing this to cover up his own love for the drug.

[Opiyum]

Are these four days the first four days of use ever? IF not how long since last time you used before these four days and how long have you been using opiates all together? Even if you answered these questions it's still gonna be hard to say man.
There is no formula for how long it takes and it's not as if one day your not dependent then the next you are. It just doesn't work that way.

[chinaski]

Everybody reacts to drugs or the lack of them differently. That's just genetics.

That said, 4 days isn't very long. You might have a bit of a hangover but I don't think you'll have any real w/ds.

Basically the only way you'll know if you're physically dependent something is to stop taking it for at least 3-4 days.

[jo-jo]

I don't know about how quickly the physical dependence will take hold for you, but I can tell you SWIM's experience.

SWIM was sniffing both the Opana ERs and IRs for about 3 months. Towards the end it was in what I consider to be large amounts. She went through a 60 count 30mg ER script in about 9 days and a 100 count 10mg IR script in 5 days. So that's about 200mg a day.

She quit CT and the w/d's were from hell. Please be careful with oxymorphone. It'll really sneak up on you and it's a powerful drug!

ETA: SWIM was also eating between 100-600 5mg oxycodone a month during that time period too...

[ShamanicHaze]

Are these four days the first four days of use ever? IF not how long since last time you used before these four days and how long have you been using opiates all together? Even if you answered these questions it's still gonna be hard to say man.
There is no formula for how long it takes and it's not as if one day your not dependent then the next you are. It just doesn't work that way.


Nah, I've used them plenty of times. Last time before Friday was probably 2 weeks before that. I'm pretty sure that I'm fine as I've read that oxymorphone w/ds usually come on in 6 hours. Just a little worried about my bro. He just blew 5mgs more and said, "Oops, I accidentally did the whole thing."

[JonnyMohawk]

I think you'll be alright man, I doubt you will experience withdrawals from that at all.

and the unlikely chance you do, they will be a piece of cake.

Best wishes!

[OpiXPO]

I wouldnt worry about it, I dont think thats long enough for a benzo dependency to form, so most likely not an opiate dependency. I am NOT a health professional though. Or even Health Amature :P

[jo-jo]

Nah, I've used them plenty of times. Last time before Friday was probably 2 weeks before that. I'm pretty sure that I'm fine as I've read that oxymorphone w/ds usually come on in 6 hours. Just a little worried about my bro. He just blew 5mgs more and said, "Oops, I accidentally did the whole thing."

SWIM wasn't able to sleep in during her Opana run as she'd wake up starting to feel shitty and need that morning snort. The day she quit CT, w/d's were pretty much full-blown by about noonish

[Morfiend]

There is no difference other than duration and severity between a minor opiate hangover and opiate withdrawal. In a sense, you are dependent from a single use. If you want to know how dependent you are, just quit taking them and find out. There is no other way.

[upstate_007]

Will you develop a dependence? Only one way to find out for sure. Stop........wait....see how you feel.

[LongKissGoodNite]

Yes -- just stop and see how you feel.

This is where you encounter the 'problematique'. You will most likely abstain for a day or two max - and say to yourself, "Well, I've waited this long and nothing has happened to me, I feel pretty OK, so I am probably fine to do some more tonight". And so you continue your use for another bender, going as long, or perhaps longer than the last time.

So this will repeat itself until you make so many compromises and justifcations in your mind that your "window" of time between runs or dosing will erode slowly into nothing. The chipper becomes strung out.

Not saying this is how it will happen with you - or that it will happen at all. But if it were to happen, it might happen this way ... probably. I've seen it happen this way.

[ShamanicHaze]

I could definitely see that happen. The good thing is, I used up/god rid of all of my opanas.

[Dan Steely]

Keep it to the wknds or you will regret it.

[Duckfeet]

Separating the physical from the mental is nonsensical, to me, tho most do it: I don't as I think they're both physical manifestations of the same thing. And I might *feel* opiates really good, if I haven't done any in a while, but as soon as I dose, all my my brain and body go into overdrive and tolerance and dependence quickly kick in. I get strung out after three days, much as I hate to admit and hate to face it. Even 30 percodans over a 3 day period, and on day four I'm sick...recognizably sick, too, not just "wondering."

You'll find out, anyway...asking us won't change anything: you'll still do the opiates, but to answer your original question, in this case, probably not: give it a few more tries, tho, do'em a week next time, and you'll get real clear about withdrawals...you can't go backwards with tolerance, tho many on here have claimed to...once I got it...I got it.

There are other better indicators than cramps in the stomach, tho...practice will make them very obvious.

[Chipper]

<snip> There are other better indicators than cramps in the stomach, tho...practice will make them very obvious.

It's the constant yawning that always lets me know that I'm heading for malaise. I often wonder if it's a bit different for everyone (probably is). Yep, def. the yawns for me.

[Duckfeet]

Me too. The first indicator, even after a bad heroin run, is I'll start yawning and get *really* sleepy...but until I take that first nap, it seems bearable, and "not that bad..." But once I sleep, I get really knocked out for about an hour, and wake up in full blown withdrawals, with yawning, sweating, freezing, aches and misery all over...ooohhh, gives me the blues just thinking about it...:(

It's the constant yawning that always lets me know that I'm heading for malaise. I often wonder if it's a bit different for everyone (probably is). Yep, def. the yawns for me.

[djbrutis]

for me, oxymorph has been nothing but the devil for my tolerance. absolutely insane how fast opana will shoot your tolerance up so high. if you have the mental strength, more power to you. but, if you're like me, opana is like no other pharmaceutical and it's pretty hard to resist. oh how i miss thee.

[LongKissGoodNite]

for me, oxymorph has been nothing but the devil for my tolerance. absolutely insane how fast opana will shoot your tolerance up so high. if you have the mental strength, more power to you. but, if you're like me, opana is like no other pharmaceutical and it's pretty hard to resist. oh how i miss thee.

I completely agree. I was at a stage in my habit where an 80mg Oxycontin would get me feeling nice. For about 2 weeks all my connect could offer were the 40mg Opana ER. I've never been so high in my life. Of course when that was all over I was still buying the same number of 80s, but I was ripping through them 2 to 3 at a time. My habit was never the same after that.

I still think about those opanas from time to time - I think about them randomly - Its not a good memory, Its more like something you think about from your past and feel really angry/shitty about, wished you hadn't done it .. i think they call that 'regret'.

[RxQueen]

It's the constant yawning that always lets me know that I'm heading for malaise. I often wonder if it's a bit different for everyone (probably is). Yep, def. the yawns for me.

my first warning sign of impending doom always seems to be sneezes. not normal ones either... i'm talking about those real sudden, hard, violent sneezes. the kind that make me wanna check the tops of my shoes for expelled brain matter. ugh. those always start before the yawning for me.

to the OP... if you've never been seriously strung out and gone through the dope-sickness, you'll have a lot more leeway to play around with before getting physically dependent. i think that once you've crossed that line, the actual dependence part comes back to you quicker. at least it did for me... before i ever went through the sickness, i could use for a lot more days in a row than i can these days, without getting dependent.

[chopstix]

How fast does physical dependence take to form?

Depends on how long it takes me to cook the shot and find a vein.

There is no difference other than duration and severity between a minor opiate hangover and opiate withdrawal.

Bullshit.

Go drink drink MD everyday for 6mos; and then try a week long break on a cement floor, and then come back and spout that shit.

Pure ignorance speaking.. :rolleyes:

[The Paregoric Man]

Depends on how long it takes me to cook the shot and find a vein.



Bullshit.

Go drink drink MD everyday for 6mos; and then try a week long break on a cement floor, and then come back and spout that shit.

Pure ignorance speaking.. :rolleyes:

I think you misunderstood him, what he was saying was that there is no hard line between "not dependant" and "dependant". Withdrawal is not all or nothing, but in degrees. Even with a single use of opiates you experience WD even though it is to such a small degree you may not notice. The so called opiate hangover is just a small degree of withdrawal. This makes sense scientifically assuming our current understanding of how the brain attempts to maintain homeostasis is correct. Even a single dose of opiates will cause the brain to adjust its endorphin production and change receptor regulation.

[Chipper]

I think you misunderstood him, what he was saying was that there is no hard line between "not dependant" and "dependant". Withdrawal is not all or nothing, but in degrees. Even with a single use of opiates you experience WD even though it is to such a small degree you may not notice. The so called opiate hangover is just a small degree of withdrawal. This makes sense scientifically assuming our current understanding of how the brain attempts to maintain homeostasis is correct. Even a single dose of opiates will cause the brain to adjust its endorphin production and change receptor regulation.

To me, an opiate hangover means that I took too much of it and I feel nauseous the next day. Not to detract from what you are saying, TPM.

[bigNasty]

my first warning sign of impending doom always seems to be sneezes. not normal ones either... i'm talking about those real sudden, hard, violent sneezes. the kind that make me wanna check the tops of my shoes for expelled brain matter. ugh. those always start before the yawning for me.
.
+1. You ever noticed the mist cloud that comes out with the WD sneezes? I'll have my TV, cell phone, dog, body, and floor covered in sneeze mist. Sneezing is how I know if I'm actually in physical WD's instead of just craving

[Paregoric Kid]

4 days of use in an opiate naive person isn't long enough to cause physical dependence. if that was the case doctors would taper down people that get pain killers for short term problems. for example, when I broke my ankle years ago I got prescribed percocet for 1 1/2-2 months and afterward that was the end of it, no tapers. there are some changes in the endorphin system from short term use but not nearly enough changes to cause physical dependence. in my own experience it took quite a while to actually become physically dependent.
now if you were previously physically dependent and started using again that is a different story.