BA of intranasal H

[antifox]

wikipedia claims the bioavailablity of intranasal heroin is 44%-61%. I haven't been able to find anything anywhere to back this up. Anyone care to pipe in a little and end this?

[LovemRx]

Not that it matters, at all, but I am just bored to tears and in lots of withdrawal pain right now. Anyways, that seems about right - doing .1 shot IV would have me noddin but it would take about .15 - .20 up the nose to do the same, minus the rush. Oh well, can only remember that feeling. Closest I've come to that now is IV dilaudid, which was pretty damn close, but still not the same. Especially of that lovely east coast rock dope. Damn I needa get off this site!!!!!!!!!! my head's gonna explode soon I THINK

[Mallinckrodt]

. . .end what?

[antifox]

My frustration lol. Not my life

[LovemRx]

It seems as though I have caused frustration... Sorry. lol. Did not mean to have that effect - I am now drunk off my ass and almost ready for sleep, alcohol is a great thing when opiates and benzos are a pipe dream for ~12 more hours...

[JonnyMohawk]

that seems about right, it should have a cited source on the wikipedia page, if you spend the time looking for it :)

[antifox]

I did. I also searched wikipedia

"intranasal bioavalibity heroin"
"Intranasal bioavalibity diamorphine"
"snorted biovability herion"
"snorted bioavaibility diamorphine"

And one or two others. I couldn't find shit and wikipedia didn't reference it.

[roxi*stardust]

wikipedia claims the bioavailablity of intranasal heroin is 44%-61%. I haven't been able to find anything anywhere to back this up. Anyone care to pipe in a little and end this?


Normally Wiki makes the author provide a reference to back up this type of info, if the author doesn't provide it they (Wiki) will say the article contains information that isn't corroborated and that the citation is needed.

[antifox]

Swim is about to rail some really good white rock H he got sent from jersey and I want to get a general estimate so he can dose about 3/4 of what he would expect to need. BA is a huge player in that, so that's why I ask. thanks guys and girls

[InfectedMushroom]

You mean a friend you know that gets sent D from jersey?

[antifox]

exactly.

[Paregoric Kid]

morphine on its on has an intranasal bioavailability of 15-20%, when the morphine is mixed in a solution of chitosan it can have an intranasal bioavailability of over 60%. I've tried a morphine-chitosan mix before and it did improve the bioavailability in my opinion. I wouldn't doubt a heroin-chitosan mix would improve the bioavailability of heroin. 44-61% sounds like it could be correct, but maybe that info is regarding pure heroin and possibly using saline solution too, who knows.
I will check it out and see if I can find some better info.
some mod should edit my post Opiates and Opioids Bioavailability & Half-Life Thread (http://forum.opiophile.org/showthread.php?t=23643) to add the bioavailability for intranasal heroin.

[JonnyMohawk]

some mod should edit my post Opiates and Opioids Bioavailability & Half-Life Thread (http://forum.opiophile.org/showthread.php?t=23643) to add the bioavailability for intranasal heroin.


Done and done my friend.

Now I'm going to research this "chitosan" you speak of.

[Paregoric Kid]

oh btw up in my last post I meant "morphine on its own" not "morphine on its on"
April 2002
Intranasal Delivery of Morphine

L. Illum, P. Watts, A. N. Fisher, M. Hinchcliffe, H. Norbury, I. Jabbal-Gill, R. Nankervis and S. S. Davis
West Pharmaceutical Services, Drug Delivery and Clinical Research Centre Ltd., Albert Einstein Centre, Nottingham Science and Technology Park, Nottingham, United Kingdom
Morphine administered nasally to humans as a simple solution is only absorbed to a limited degree, with a bioavailability of the order of 10% compared with intravenous administration. This article describes the development of novel nasal morphine formulations based on chitosan, which, in the sheep model, provide a highly increased absorption with a 5- to 6-fold increase in bioavailability over simple morphine solutions. The chitosan-morphine nasal formulations have been tested in healthy volunteers in comparison with a slow i.v. infusion (over 30 min) of morphine. The results show that the nasal formulation was rapidly absorbed with a Tmax of 15 min or less and a bioavailability of nearly 60%. The shape of the plasma profile for nasal delivery of the chitosan-morphine formulation was similar to the one obtained for the slow i.v. administration of morphine. Furthermore, the metabolite profile obtained after the nasal administration of the chitosan-morphine nasal formulation was essentially identical to the one obtained for morphine administered by the intravenous route. The levels of both morphine-6-glucuronide and morphine-3-glucuronide were only about 25% of that found after oral administration of morphine. It is concluded that a properly designed nasal morphine formulation (such as one with chitosan) can result in a noninjectable opioid product capable of offering patients rapid and efficient pain relief.

[antifox]

I've read that about morphine, but I never took any time to read about it. Look like I am going to now :P. Does anyone know how much heroin crosses the BBB as heroin via intranasal and how much in converted to morphine via IR ingestion before metabolism occurs.

[skc74]

Not that its going to be of much use to you,but my place of work is trialling intranasal diamorphine for acute analgesia for kids and adults at the moment,and i suppose the article above explains why,in that diamorphine would cross the BBB more rapidly than morphine,i wander if i ask nicely they'd give me some and i could have a go at a rough guess as to the bioavailability:D!!!....or be fired and spend a night in a cell!!

[antifox]

You should replace the opiate with NSAID's and keep it for yourself! Then the little kids won't get pain meds and you get free highs dude. It's win win situation.


Or you could put in unsterile water and spread Hep C and other diseases like that fucktard nurse from the midwest who won't do any less than five years probably.

There are just something I'll never do for a fix, no matter how bad I was hurting. It would have to be certain life or death extremes.

[OverDriven]

oh btw up in my last post I meant "morphine on its own" not "morphine on its on"

I have the full text of that paper. You need a chitosan salt to properly use it to increase bioavailability. I believe they use chitosan glutamate if I remember correctly. You can also use the HCL salt. The chitosan you buy from vitamin suppliers is the base.

[antifox]

Pretty easy to convert it to a salt though.