Malli 60mg's

[antifox]

Anyway I can put these in my nose without gelling? Someone help me out. The high is meh when it's so extended like this.

[CrushNSniff]

I wish there was a better way to sniff these, the only way swim ever got off on these was to chew 'em, if you already IV I guess these will work if prepped right, crisped? or just find the right sticky for prep. Maybe plugging would be better? Is plugging morph better than sniffing?

[antifox]

The BA of oral and rectal morphine is around 33% and the sniffed BA is around 25%. Snorted morphine is way better than oral or rectal because he rush and nod from snorting beats the shit out of a little bit longer high. I don't really want to get back into needles.

I guess i'll just try to get it in liquid like I would for a shot and then spray it or drip it in my nose. I just wish there was an easier way or something that was not so time consuming.

[Ludakris]

The BA of oral and rectal morphine is around 33% and the sniffed BA is around 25%. Snorted morphine is way better than oral or rectal because he rush and nod from snorting beats the shit out of a little bit longer high. I don't really want to get back into needles.

I guess i'll just try to get it in liquid like I would for a shot and then spray it or drip it in my nose. I just wish there was an easier way or something that was not so time consuming.


I don't think your numbers are right on rectal ROA. you bypass first pass metabolism going in the back door, escalating the BA 2-3x oral. Aside form IV, plugging is the most efficient way of doing morphine.

[antifox]

I don't think your numbers are right on rectal ROA. you bypass first pass metabolism going in the back door, escalating the BA 2-3x oral. Aside form IV, plugging is the most efficient way of doing morphine.



Most studies indicate the mean BA of rectal morphine is 33% and some have shown as high as 41%. It's certaintly not 2x 3x higher than oral. Not even close.

This applies to hydromorphone as well.


Summary 21 healthy women undergoing gynaecological operations received rectal premedication with morphine 0.3 mg/kg body weight. Plasma concentrations of morphine were followed for 4 h by a GC/MS technique. In most patients the peak plasma concentration was reached after 30 min; the mean peak plasma level of morphine was 18 ng/ml (range 8.5–57 ng/ml). The bioavailability of rectal morphine was determined in 6 patients, who received an i.m. injection of morphine at a second operation. The mean bioavailability of rectal morphine was 31% (range 12%–61%). None of the patients showed any clinical sign of respiratory depression, and there was no increase in end-tidal carbon dioxide tension measured in 5 patients operated under spinal block.


If given in a colostomy the BA seems to be a tad bit higher around 43%.