Paregoric Kid
07-22-2009, 11:13 PM
here are two interesting papers I came across tonight that talk about Papaver rhoeas extracts and their effects on opiate tolerance and withdrawal.
Effects of Papaver rhoeas extract on the acquisition and expression of morphine-induced conditioned place preference in mice
Hedayat Sahraeia, Corresponding Author Contact Information, E-mail The Corresponding Author, Sayedeh Maedeh Fatemib, Shahrokh Pashaei-Radc, Zohreh Faghih-Monzavib, Seyed Hossein Salimid and Mohammad Kamalinegade
Received 7 May 2005;
revised 5 July 2005;
accepted 16 August 2005.
Available online 22 September 2005.
Abstract
In the present study, the effects of water–alcohol extract of Papaver rhoeas on the acquisition and expression of morphine-induced conditioned place preference (CPP) in mice were investigated. Subcutaneous (s.c.) administration of morphine (1, 10 and 20 mg/kg) produced place preference. On the other hand, intraperitoneal (i.p.) administration of the plant extract (25, 50 and 100 mg/kg) did not show any effect. Injection of extract (25, 50 and 100 mg/kg, i.p.) 30 min before the morphine administration decreased the acquisition of morphine CPP. Administration of the plant extract (25, 50 and 100 mg/kg, i.p.) 30 min before the test did not change the expression of morphine-induced CPP.
It could be concluded that Papaver rhoeas reduced the acquisition but not the expression of morphine-induced conditioned place preference.
Effects of Papaver rhoeas extract on the expression and development of morphine-dependence in mice
Ali Pourmotabbeda, Baharak Rostamiana, Gilla Manouchehria, Gilla Pirzadeh-Jahromib, Hedayat Sahraeib, Corresponding Author Contact Information, E-mail The Corresponding Author, Hassan Ghoshoonib, Homeira Zardoozc and Mohammad Kamalnegadd
Received 9 March 2004;
revised 23 August 2004;
accepted 23 August 2004.
Available online 18 October 2004.
Abstract
The problem of drug dependence still remains unresolved. In the present study, the effects of water–alcohol extract of Papaver rhoeas on the expression and acquisition of naloxone-induced jumping and diarrhea in morphine-dependent mice were investigated. Administration of three daily doses of morphine (12.5, 25 and 50 mg/kg) for three days in order to develop dependence to morphine caused a significant and dose-dependent increase in the number of jumping and diarrhea when the animals were challenged with naloxone (4 mg/kg). On the other hand, administration with the plant extract (25, 50 and 100 mg/kg) did not show any effect. Injection of extract (25, 50 and 100 mg/kg) 30 min before the naloxone administration in morphine-dependent mice decreased the number of jumping and diarrhea. Administration of extract (25, 50 and 100 mg/kg) 30 min before morphine injection increased the number of jumping but decreased the diarrhea. It could be concluded that the extract of Papaver rhoeas can ameliorate the withdrawal syndrome in morphine-dependent mice. Therefore, the extract might be useful to treatment of withdrawal signs in opioid addicts.
Effects of Papaver rhoeas extract on the acquisition and expression of morphine-induced conditioned place preference in mice
Hedayat Sahraeia, Corresponding Author Contact Information, E-mail The Corresponding Author, Sayedeh Maedeh Fatemib, Shahrokh Pashaei-Radc, Zohreh Faghih-Monzavib, Seyed Hossein Salimid and Mohammad Kamalinegade
Received 7 May 2005;
revised 5 July 2005;
accepted 16 August 2005.
Available online 22 September 2005.
Abstract
In the present study, the effects of water–alcohol extract of Papaver rhoeas on the acquisition and expression of morphine-induced conditioned place preference (CPP) in mice were investigated. Subcutaneous (s.c.) administration of morphine (1, 10 and 20 mg/kg) produced place preference. On the other hand, intraperitoneal (i.p.) administration of the plant extract (25, 50 and 100 mg/kg) did not show any effect. Injection of extract (25, 50 and 100 mg/kg, i.p.) 30 min before the morphine administration decreased the acquisition of morphine CPP. Administration of the plant extract (25, 50 and 100 mg/kg, i.p.) 30 min before the test did not change the expression of morphine-induced CPP.
It could be concluded that Papaver rhoeas reduced the acquisition but not the expression of morphine-induced conditioned place preference.
Effects of Papaver rhoeas extract on the expression and development of morphine-dependence in mice
Ali Pourmotabbeda, Baharak Rostamiana, Gilla Manouchehria, Gilla Pirzadeh-Jahromib, Hedayat Sahraeib, Corresponding Author Contact Information, E-mail The Corresponding Author, Hassan Ghoshoonib, Homeira Zardoozc and Mohammad Kamalnegadd
Received 9 March 2004;
revised 23 August 2004;
accepted 23 August 2004.
Available online 18 October 2004.
Abstract
The problem of drug dependence still remains unresolved. In the present study, the effects of water–alcohol extract of Papaver rhoeas on the expression and acquisition of naloxone-induced jumping and diarrhea in morphine-dependent mice were investigated. Administration of three daily doses of morphine (12.5, 25 and 50 mg/kg) for three days in order to develop dependence to morphine caused a significant and dose-dependent increase in the number of jumping and diarrhea when the animals were challenged with naloxone (4 mg/kg). On the other hand, administration with the plant extract (25, 50 and 100 mg/kg) did not show any effect. Injection of extract (25, 50 and 100 mg/kg) 30 min before the naloxone administration in morphine-dependent mice decreased the number of jumping and diarrhea. Administration of extract (25, 50 and 100 mg/kg) 30 min before morphine injection increased the number of jumping but decreased the diarrhea. It could be concluded that the extract of Papaver rhoeas can ameliorate the withdrawal syndrome in morphine-dependent mice. Therefore, the extract might be useful to treatment of withdrawal signs in opioid addicts.