a new method (kinda) to do pills

[inailedyourmom1]

It’s just an idea I came up with... I didn’t see anything like it in the search, but I would really know what to search for. I really don’t know any science to back any of it up. Any info and opinions would be nice.

What I want to do is crush up like ten 30mg ir and mix them with a bunch of water and dissolve it all like if I was going to IV it. Then using anything (needless syringe, diabetic needle, etc) filter it thru cotton or some sort of filter. Then I want to put all this into an empty nasal spray container I have that will spray the liquid out into a mist.

I like this idea if it works because it seems like it would be gentler on your sinus and nose. I have also heard that having the membranes in your noses slightly wet help it absorbs stuff better. It also seems like its better for your nose then snorting. Also because it’s more pure you only have to snort less. Also it would be very discreet in public

Think this will work? Think it would be better then just snorting line? any opinions?

[Opiyum]

There were some people on here who used to and possibly still do this. A lot of people do this with Subs....They use aspirators...I think thats what they are called...I may have that confused with the thing you use for vacuum funneling that or those are also called aspirators.
Brain hasn't been working well lately. Sorry.

[Stonnewolf]

theres a thread on this in suboxone forum.

[lib.sOCialist]

i did a thread on this topic as well, its been covered ;p

[Shadowsblaze]

I think I did a post as well. Swim just crushed 2 in 1ml. water. Swim thinks its the tits with 6 drops of Real lime juice cause he can feel it when his nose is numb.

[Papa Verine]

Definately not a new idea. I was doing this with cocaine years ago. I'd be out bar-hopping and just do a spray up each nostril whenever I felt like it. Then half the bar would come up to me and be like "Hey dude, can I get a spray of that?"

[SeVeN]

Isnt this thread verbatum from what someone posted not to long ago??

[Papa Verine]

Isnt this thread verbatum from what someone posted not to long ago??

Pretty much... I remember it, or them.

[JonnyMohawk]

Isnt this thread verbatum from what someone posted not to long ago??

Yep.


and also it should be noted insufflation (snorting) is not the most effective route for many drugs.

Take Oxycontin (Oxycodone HCL) for example, the bioavailability when swallowed is around 87% while insufflation is around 45%.

and for all you pluggers out there rectal is an estimated 61.6%.


anyhow its just something to take into consideration :]

[mikey5string]

Yep.



Take Oxycontin (Oxycodone HCL) for example, the bioavailability when swallowed is around 87% while insufflation is around 45%.




:]


really? that seems a more drastic figure than im used to seeing.

[inailedyourmom1]

Yeah sorry if it was a repost... I don’t read many of the other boards so I didn’t realize it had bee post some where else. I didn’t see anything like it in the oxycodone board. I did try to search and nothing had came up with the terms I had tried.

Also the only other one I found was on the suboxone board. And suboxone and oxycodone are 2 different drugs with different bioavailbilties. Also mines goes into purifying the pill a bit more to get a more “concentrated” form, and the fact that it might be healthier with out all the filler (also you snort less because it has more oxycodone in each “sniff”). Also thought maybe the fact that there is no filler and it’s like a liquid maybe it would be absorbed better and have a higher bioavailability or faster onset.

I don’t know, with that being said, I still think its a valid question to be asked and if it has been covered some where else, maybe some links or search terms I should try and I wont bother to asked again if its been covered. Like I said I tried searching and didn’t find the answers on here.

[drew1503]

Yep.


and also it should be noted insufflation (snorting) is not the most effective route for many drugs.

Take Oxycontin (Oxycodone HCL) for example, the bioavailability when swallowed is around 87% while insufflation is around 45%.

and for all you pluggers out there rectal is an estimated 61.6%.


anyhow its just something to take into consideration :]

If the plugging portion is true then why is there a warning for Oxy CR in the package insert? I think that figure is for immediate release or Roxi.

OxyContin® is NOT INDICATED FOR RECTAL ADMINISTRATION. Data from a
study involving 21 normal volunteers show that OxyContin Tablets administered per rectum
resulted in an AUC 39% greater and a Cmax 9% higher than tablets administered by mouth.
Therefore, there is an increased risk of adverse events with rectal administration.

I would like some insight if anyone can shed some.

[JonnyMohawk]

If the plugging portion is true then why is there a warning for Oxy CR in the package insert? I think that figure is for immediate release or Roxi.

OxyContin® is NOT INDICATED FOR RECTAL ADMINISTRATION. Data from a
study involving 21 normal volunteers show that OxyContin Tablets administered per rectum
resulted in an AUC 39% greater and a Cmax 9% higher than tablets administered by mouth.
Therefore, there is an increased risk of adverse events with rectal administration.

I would like some insight if anyone can shed some.

Hmm thats interesting. My facts could be a bit off but they were from a reputable source.


Wikipedia says the following

Oxycodone can be administered orally, intranasally, via intravenous/intramuscular/subcutaneous injection or rectally. The bioavailability of oral administration averages 60–87%, with rectal administration yielding the same results; intranasal varies between 55-70%.
Oxycodone is approximately 1.5–2 times as potent as morphine when administered orally.However, 10–15 mg of oxycodone produces an analgesic effect similar to 10 mg of morphine when administered intramuscularly.[64] Therefore, as a parenteral dose, morphine is approximately up to 50% more potent than oxycodone.




That conflicts with the study you cited, so I'm not really sure.

[drew1503]

I have always wondered, I have searched and it looks like it only is the controlled release that has that warning, here in the package insert directly from Purdue: www.purduepharma.com/PI/Prescription/Oxycontin.pdf
I have also seen the same % you stated from other sites and it has been bothering me. Someone here has to know.

[JonnyMohawk]

Yeah I see what you are talking about, perhaps someone else can shed more light.


What I didn't know was this:

"Food Effects
Food has no significant effect on the extent of
absorption of oxycodone from OxyContin.
However, the peak plasma concentration of
oxycodone increased by 25% when a OxyContin
160 mg Tablet was administered with a high-fat meal."


25 Percent? Wow.



Also I kind of feel like we hijacked this thread, even if there was a duplicate recently... so to OP I am sorry.

[taj]

Yeah I see what you are talking about, perhaps someone else can shed more light.


What I didn't know was this:

"Food Effects
Food has no significant effect on the extent of
absorption of oxycodone from OxyContin.
However, the peak plasma concentration of
oxycodone increased by 25% when a OxyContin
160 mg Tablet was administered with a high-fat meal."


25 Percent? Wow.



Also I kind of feel like we hijacked this thread, even if there was a duplicate recently... so to OP I am sorry.

wow, I thought the high fat meal thing was more like a placebo effect, but 25%?!, that's pretty significant..

[inailedyourmom1]

and apparently every one ignored my last post and the facts that i mentioned about the "duplicate post"

[Opiyum]

Yeah I see what you are talking about, perhaps someone else can shed more light.


What I didn't know was this:

"Food Effects
Food has no significant effect on the extent of
absorption of oxycodone from OxyContin.
However, the peak plasma concentration of
oxycodone increased by 25% when a OxyContin
160 mg Tablet was administered with a high-fat meal."


25 Percent? Wow.



Also I kind of feel like we hijacked this thread, even if there was a duplicate recently... so to OP I am sorry.

Wow...25% and a greasy cheeseburger....I think this calls for a relapse and I think when I tell my therapist about this great news she will agree.

[Lu_cid]

it seems like this may be a good way to conceal the fact that u have anything illicit. i dont see any cop asking what is in your nasal spray bottle. then again im sure there is some asshole out there that may.

[bodytec]

ooooooooooooooooommmmmmmmmmmmmmmgggggggggggggg!!!! !!!!!!!!!!!!!!!!

JUST GET YOUR O.C.'S AND BBBBBBBAAAAAAAAAAAANNNNNNNNNNGGGGGGGG

THEM!!!WOOOOOOOOO WOOOOOOOOOO!!!!!!

[BlueMajick]

The nasal spray bottle is definitely a good method of transporting the solution, or suspension, or whatever it is technically, but I've done the same thing in another method, and it works fantastically.

I've crushed up OCs many times and instead of just doing the line up the nose pipe, I'll scrape the powder into a water bottle cap, add some water (very small amounts work better for me) and then swirl it around a bit until it's not clumped anymore; clumping seems like more of an issue with large amounts of water. Then I'll just tip it back into my nose-tril like taking a shot. I get the benefits of some of it absorbing immediately, but it is more long term going down your throat...oral bioavailability is greater for oxycodone as we all know.

This is my fav way to do it if I have time, and don't feel like i'm going to dump the bottle cap all over, which i have done, or pour it missing my nose and all over my face... I can't imagine dealing with that scenario all the time like needle users must have to... ugh.

If I don't have the time to prepare it this way, and i just snort it... I'll try to follow it with some water poured down my nose the same way sans OC mixed in, within 1-3 minutes of snorting, to wash the rest down for oral absorption.

[doctor diesel]

Couldn't be arsed to read through the whole thread, so apologies if I'm about to ask something that's already been dealt with.... but.... is it possible to use this method with the tan powder H we get in Britain?
I mean, will the powder dissolve with water, or does it need heating first, or citric or summink blah blah blah.....

Eh?

Doc

[nick]

Couldn't be arsed to read through the whole thread, so apologies if I'm about to ask something that's already been dealt with.... but.... is it possible to use this method with the tan powder H we get in Britain?
I mean, will the powder dissolve with water, or does it need heating first, or citric or summink blah blah blah.....

Eh?

Doc

Needs heat and citric,doc.I wouldn't bother,I'd stick to smoking ,if I were you.

[doctor diesel]

Okay Nick, ta. That's what I needed - expert advice.

[OverDriven]

I've done this. It isn't anything new. I've been recommending that people take dilaudid this way for a long time on another forum. The problem with using oxy for this is that you have to dissolve a huge amount. Most nasal sprayers dispense about .1 ml with every pump. So if you want 20mg per pump, you have to dissolve 200mg per ml. If you have any tolerance, you will still need several pumps even at this level. For a 10ml bottle (and most are larger than this), you will have to dissolve two grams of oxy to fill it and still get 20mg per pump.

Dillies are nice for this because it takes so much less to get you high. Also, dilaudid has the highest bioavailability this way (short of shooting it of course). It's around 65%, which is higher than snorting powder, plugging, oral, etc.

PS - if you do this, PLEASE measure the amount your bottle pumps before mixing anything. The numbers I posted are from the bottles I've seen. That doesn't mean every bottle uses this amount. You can easily OD if you don't measure and get your math right.

[inailedyourmom1]

yeah idk about all that.. i know for iving that its basicly like 90mg per cc wich is equal to 1ml. so is it even possible to disolve that much in that little of water? and also whats the problem with taking more then one pump. take like 2 at a time 3 times and hour and it will keep you going all day. idk. ill by trying this after my next script and ill let people know how it goes.

[lib.sOCialist]

I've done this. It isn't anything new. I've been recommending that people take dilaudid this way for a long time on another forum. The problem with using oxy for this is that you have to dissolve a huge amount. Most nasal sprayers dispense about .1 ml with every pump. So if you want 20mg per pump, you have to dissolve 200mg per ml. If you have any tolerance, you will still need several pumps even at this level. For a 10ml bottle (and most are larger than this), you will have to dissolve two grams of oxy to fill it and still get 20mg per pump.

Dillies are nice for this because it takes so much less to get you high. Also, dilaudid has the highest bioavailability this way (short of shooting it of course). It's around 65%, which is higher than snorting powder, plugging, oral, etc.

PS - if you do this, PLEASE measure the amount your bottle pumps before mixing anything. The numbers I posted are from the bottles I've seen. That doesn't mean every bottle uses this amount. You can easily OD if you don't measure and get your math right.

impossible lol... the absolute most you can fit into a ml of water is around 150mg's

"Oxycodone hydrochloride dissolves in water (1000 mg's in 6 to 7 mL) and is considered slightly soluble in alcohol (octanol water partition coefficient is 0.7)."

http://www.rxlist.com/roxicodone-drug.htm