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View Full Version : Real Info on Bupe ROAs and Bioavailability for Each



limitless_euphoria
06-02-2009, 04:21 PM
I don't mean to mislead with the title to this thread, I don't HAVE the information off-hand. The thing that bothers me is that I was going through posts on Bluelight and they had some really half-assed information on there. It seems like people just threw darts and a wall of numbers or guesstimated "Well, the oral bioavailability is like 10%, sublingual is 40%, plugging is 69% and IV is 100%."

So umm, where did these statistics come from again?

I'm just wondering if anyone knows the actual sublingual, intranasal, rectal, IM/IV bioavailability of bupe and has a citation to back it up. I've looked all over and I've found conflicting information. I thought I'd just put it out there and if you do answer please at least give us an idea of where or how you came by that percentage. Guesstimators needn't reply to this thread--if I wanted to go with guesses I would have stopped at reading the Bluelight thread.

dharma bum
06-02-2009, 04:32 PM
Well wikipedia says (so it must be true,right?) 31% sublingual and 50-60% sublingual high dose tablet?? What the hell?

I just noticed this. Does that mean if I take my prescribed 24 mg a day I get a higher % of bioavailability or just getting more bupe because I take more bupe?

Sorry LE..i tried to have somewhat of an answer but just created a new one question.

FWIW, I've always heard 30 % sublingual, 50-60 % insufflated, 75-80 % in the butthole. and of course you get all that good stuff in you if you just inject it. Yeah you know, you might lose a limb or die but at least you'll be more economical with your subs.

Oh and these numbers don't come from any source but what I've heard folks on here say, except the 31 % sublingual which came from wiki.

djbrutis
06-02-2009, 04:49 PM
i also have always had trouble trying to find legit B/A percentages. i'm especially interested on plugging B/A%, compared to snorting or sublingual. anyone have sourced info?

ryan
06-02-2009, 05:19 PM
i also have always had trouble trying to find legit B/A percentages. i'm especially interested on plugging B/A%, compared to snorting or sublingual. anyone have sourced info?

Yeah, for some reason bio-a's are all across the board for some opiates including bupe.
Some sources say this, others say that, and there's always a HUGE ass gap in between..

I honestly think that no matter what any study says it depends on the person..bupe is just plain weird.

limitless_euphoria
06-03-2009, 05:54 AM
Yeah, it's frustrating. I think what confuses me is I try all the different ROAs (minus IV/IM, got ridda all the rigs a while ago) and I get differing results. More recently I railed 4 mg worth (which is all my beat-to-shit nose/sinuses can handle) and it got me good. But yet if I were to plug say 8 mg worth I have to lay there for over 1/2 hour to 45 min but I can nod off of that.

The other comment I read by someone else who plugs bupe is that you don't have to redose as often which for me is true. I can plug 8-16 mg on a Monday morning and not even think about redosing until a Wednesday night. With the other ROAs, within a day and half I'm thinking of doing more.

I wonder if it absorbs slower in your ass vs. up your nose/under your tounge. That's why I'd like to see some legit data.There's a few "suspicious" posts on bluelight that say "just take the bupe as Rx-ed and you'll be best off," almost as if it's some kind of campaign to stop sub abuse.

Oh well, I guess variety is the spice of life. Plug some, snort some, do some sublingually... switching it up keeps things interesting. There's only so much plugging and snorting one can do, w/ bupe anyhow, before it starts to take it's toll and I find myself taking a break back to the traditional ROA.

lib.sOCialist
06-03-2009, 11:09 AM
Yeah, it's frustrating. I think what confuses me is I try all the different ROAs (minus IV/IM, got ridda all the rigs a while ago) and I get differing results. More recently I railed 4 mg worth (which is all my beat-to-shit nose/sinuses can handle) and it got me good. But yet if I were to plug say 8 mg worth I have to lay there for over 1/2 hour to 45 min but I can nod off of that.

The other comment I read by someone else who plugs bupe is that you don't have to redose as often which for me is true. I can plug 8-16 mg on a Monday morning and not even think about redosing until a Wednesday night. With the other ROAs, within a day and half I'm thinking of doing more.

I wonder if it absorbs slower in your ass vs. up your nose/under your tounge. That's why I'd like to see some legit data.There's a few "suspicious" posts on bluelight that say "just take the bupe as Rx-ed and you'll be best off," almost as if it's some kind of campaign to stop sub abuse.

Oh well, I guess variety is the spice of life. Plug some, snort some, do some sublingually... switching it up keeps things interesting. There's only so much plugging and snorting one can do, w/ bupe anyhow, before it starts to take it's toll and I find myself taking a break back to the traditional ROA.

Yep LE, the ONLY way i used to take my subs is insuffulation, or rectally, and the rush from plugging was always nice, came very close to nodding a couple times.

hydro chris
06-03-2009, 05:54 PM
Yep LE, the ONLY way i used to take my subs is insuffulation, or rectally, and the rush from plugging was always nice, came very close to nodding a couple times.rush from plugging for real? i know it wouldn't be no superduper rush but still im curious on this take..

djbrutis
06-03-2009, 09:53 PM
rush from plugging for real? i know it wouldn't be no superduper rush but still im curious on this take..

also very curious about this!! especially now you mention a "rush". even if it's the most subtle 'rush' there is, it's obviously still a rush, and would LOVE to nod on my bupe. ANYONE have multiple similar rectal admin b/a % sources ??? (second time i've asked, i know!)

Dan Steely
06-03-2009, 10:10 PM
Hmmm, curious about sticking things in your ass are ya? Lib's just tryin to sucker you guys into sticking pills in your butt.

djbrutis
06-04-2009, 10:33 AM
Well wikipedia says (so it must be true,right?) 31% sublingual and 50-60% sublingual high dose tablet?? What the hell?

I just noticed this. Does that mean if I take my prescribed 24 mg a day I get a higher % of bioavailability or just getting more bupe because I take more bupe?


I'm guessing wikipedia means 31% for the lower dose mixtures like Temgesic, and looks like 50-60% for the high dose formulations, like Subutex of Suboxone.

djbrutis
06-04-2009, 10:34 AM
Hmmm, curious about sticking things in your ass are ya? Lib's just tryin to sucker you guys into sticking pills in your butt.

hahahaha. never been this interested in that until ive realized i need my meds to last longer and take less than normal. i guess if it means ya gotta shove it up the browning, so be it.

limitless_euphoria
06-04-2009, 04:39 PM
Hmmm, curious about sticking things in your ass are ya? Lib's just tryin to sucker you guys into sticking pills in your butt.

Well Dan, in my book, if it's in the name of getting high--as long as it doesn't involve a penis--the butt is fair game. For any other purpose gay or otherwise I'd have no reason to "go there" ... :D

The Paregoric Man
06-04-2009, 06:27 PM
There is nothing sexual about plugging, unless you use this applicator.:D

http://www.dontspitswallow.com/dildo.jpg

Dan Steely
06-04-2009, 07:15 PM
Well Dan, in my book, if it's in the name of getting high--as long as it doesn't involve a penis--the butt is fair game. For any other purpose gay or otherwise I'd have no reason to "go there" ... :D

I was just bustin balls cause they said "curious" which used to be the headline to a gay chat line ad around here. In my circle curious became code for gay and we had a lot of fun with it.

roxi*stardust
06-05-2009, 09:14 PM
i also have always had trouble trying to find legit B/A percentages. i'm especially interested on plugging B/A%, compared to snorting or sublingual. anyone have sourced info?


It will be very hard to find legitimate information on the nasal or rectal bioavailablity of Suboxone or Subutex because it is a sublingual tablet. You can probably find information on the rectal and nasal bioavailablity of Buprennorphine itself but in what form is the question. Those tablets are formulated for sublingual administration so you probably get optimal results via that route.