Myrrh Terpenes

[imalgen]

Furanoeudesma-1,3-diene and curzarene
Furanoeudesma-1,3-diene, A sesqiterpene from MYRRH, is a specific agonist of opiod delta receptors
P. Dolara, C. Luceri, M. Lodovici, C. Ghelardini, S. Aiolli and M.N. Romanelli
Pharmacological Research
Volume 31, Supplement 1, 1995, Page 34

Myrrh, described in Greek medicine, Plinius and the Gospel, was
used as a perfume and as a general remedy. It is a resinous
compound from Commphorae myrrha, scrubs typical of the
Middle East. It was given to Jesus by the Magi Kings and proposed
as a drink (vinum myrratum) before crueifictinn, a potion that he
refused. We eharacterlzed ehemieaUy the components of the
hexane extract of myrrh by flash chromatography with hexane on
silica. The hexane extract had four main sesquiterpenoid
components (furanodiene, lindestrene, furanoeudesma-l,3-diene
and eurzarene, MWs ranging from 214 to 216). The mixture of
these four compounds at a dose of 50 mg/kg, increased leak
latency time in the mouse hot plate test (from 15_+0.8 s to 22_+2
s, P<0.05) and decreased the number of stretehings in the mouse
writhing test from 43+4 to 26_+2, I,_+ SE, P<0,05. These responses
were blocked by 1 mg/kg of naloxone and by the 8 specific
antagonist naltrindole (1 mg/Kg), which did not block the effect of
5 mg/kg morphine p.o. We studied the structure of curzarene and
furanoeudesma with computer molecular modelling, comparing
hem with the ~ opiod specific agonist D-Pen2D-Pen 5 (DPDPE)
and we found a good overlapping of the three steric structures. We
also characterized the binding of the sesquiterpenes of myrrh to
CNS opiod receptors with 3H-diprenorphine. Furanoeudesma was
able to displace the specific binding of diprenorphine to opioid
receptors. Myrrh contains agonists of/t oplod receptors, effective
orally, which explain its popularity in the folk medicine in the past.

There are myrrh terpene isolates available that are showing extremely strong potential. Anyone here have any experience with them?

SWIM has tried (so far) up to 75mg oral, 50mg smoked and 50mg sublingual; All provided very strong effects. Think "pleasurable sighs" and a nice "warm hug". :o

[30_Units]

Are those doses of the same myrrh hexane extract as stated in the quote-or of isolated chemical?

Interesting in any event.

How would you characterize the differences in effect of a pure delta agonist versus mostly mu agonists?

[Papa Verine]

Oooohhh... It's a good day at Opiophile. I have to go shopping now.

[bronyraur]

Very interesting.

I think I'm gonna do some "research".

[imalgen]

Are those doses of the same myrrh hexane extract as stated in the quote-or of isolated chemical?

Interesting in any event.

How would you characterize the differences in effect of a pure delta agonist versus mostly mu agonists?

No, im not sure how this specific isolate product (furanoeudesma-1,3-diene and curzarene) is processed.

Its a much different effect than mu, dont get that "love" feeling from the delta it seems. But more research must take place before any statement can be made, still trying to understand the effects.

[jacky]

about 7 years ago I started experimenting with myrrh powder, and extracts.

what I get from the plant resin, is stimulating, and euphoric.
I would go as far to call the plant an entheogen...
though some have disputed this with me.
early on, some people even disputed psychoactivity.
and some still do, even though some scientific research shows some potential.

at one point, a couple of freinds brought a light powdered substance to me that they were sold as a type of organic opioid, they were smoking in a glass bulb.
ended up the material was most likely a 5x myrrh extract.

I have used oral, nasal, and vaporization/smoking routes.
the raw, well powdered resin is strong enough, and tolerated by my sinus's....so I used to insuffilate the myrrh powder for the more potent effect.

too much myrrh taken orally can work as a purgative.

I think alot of the magic with myrrh, is when its combined with other substances.
on the tail end of a 2ct-2 or mescaline trip myrrh vaporized or snorted can do wonders.
the magic returns, and the stimulant edge keeps me experiencing when normally I would just pass out.
I have ended up hiking in the foothills/mountians close to my house, at 7 am, after tripping all night, because the myrrh I had just ingested gave me a strong enough stimulant push to make the trip.

I havnt tried any of the isolates, mainly because myrrh seems potent enough in its natural form...but it would be interesting to test the isolates against the raw, full spectrum material.

I think this plant is an exciting species as a target for compounds for augmentation.
as a precursor source, myrrh would be amazing, as there is no way that the government would be able to illegalize this substance...its just too popularly used in too many religions.
so if some interesting semi synthetics could be made from this plant, I would be all for testing some out.

the other thing about myrrh is, that most if not all skin/dermal types that it seems to come in contact with, seem to benefit.
I can snuff the powder, and suffer no nasal problems. if anything, sometimes it seems to make my sinus's actually clear up.
maybe that is the action of the stimulation.
I brush my teeth with myrrh toothpaste.

myrrh is good stuff.....but many people cant get beyond it being an incense. I admit I was suprised myself when I first learned that myrrh was a common product used alongside herbs .

[imalgen]

The 15x commonly available is DAMNED potent insufflated. A small "key bump" size sniffed provided for a very warm half hour long experience. Without a doubt having some type of opiate activity this route. The terpene fraction has yet to be insufflated by my research subject. Maybe later today.