resorcinol
04-29-2009, 07:40 PM
that you feel would be novel for some reason and would also be an opioid you'd enjoy.
Edit to title: Wrong forum, wrong title. I had hydrocodone on the brain because my pick was derived from it. It can be a derivative of ANY opioid from ANY chemical class as long as it is a FULL MU AGONIST (you can predict this via SAR, you don't have to link to research that proves that it's a full agonist).
The chem forums don't get enough activity, so maybe a thread that more folks can fantasize in can liven the place up a little.
My pick is 14-methylseleno-hydrocodone.
Novel: It's novel because it has an unusual heteroatom in its structure; that heteroatom is selenium (a chalcogen like oxygen, so methylseleno [or just methseleno] groups are analogous in their behavior for bonding to methyloxy [methoxy] groups). So imagine oxycodone, but replace the 14-OH with a 14-O-Me group. Now get rid of the oxygen for 14-Se-Me. Me = methyl group.
Fun for me: SAR suggests that this opioid would be pretty potent (probably significantly more than oxycodone in potency). It would likely have high oral bioavailability just like oxycodone thanks to the 3-methoxy group which is good for a non-needle user like me (well, it would be good if I was still actively using opioids to get high -- but I know other opiophiles like me weigh oral bio-a heavily in describing an opioid's worth due to not using the needle, and this one would fit the bill) -- provided extrapolating from the SAR of phenanthrene opioids that contain oxygen as their chalcogen to those that contain selenium works, and it probably mostly does.
I also believe it would have the speedieness of oxycodone that I love.
What's your fantasy opioid that is
*Novel
*Would probably be fun for you
We've all got lots of fantasy must-try opioids, both currently on the market somewhere in the world or not, that would meet criterea 2. So criteria 1, novelty, is a must (not that I'll kill ya or anything if you post something less chemically novel :P ).
It doesn't have to be a different heteroatom like I chose for novelty -- just any odd feature in the chemical structure, or odd pharmacokinetics and pharmacodynamics (acting as a DNRI in addition to a mu agonist like lefetamine -- and yes you CAN say you THINK a compound you pick would act in both ways due to SAR, perhaps lefetamine analogs, this is just conjecture, no proof of dual activity needed), other oddness (non-alkaloids for example like herkinorin)... any odd feature.
Edit to title: Wrong forum, wrong title. I had hydrocodone on the brain because my pick was derived from it. It can be a derivative of ANY opioid from ANY chemical class as long as it is a FULL MU AGONIST (you can predict this via SAR, you don't have to link to research that proves that it's a full agonist).
The chem forums don't get enough activity, so maybe a thread that more folks can fantasize in can liven the place up a little.
My pick is 14-methylseleno-hydrocodone.
Novel: It's novel because it has an unusual heteroatom in its structure; that heteroatom is selenium (a chalcogen like oxygen, so methylseleno [or just methseleno] groups are analogous in their behavior for bonding to methyloxy [methoxy] groups). So imagine oxycodone, but replace the 14-OH with a 14-O-Me group. Now get rid of the oxygen for 14-Se-Me. Me = methyl group.
Fun for me: SAR suggests that this opioid would be pretty potent (probably significantly more than oxycodone in potency). It would likely have high oral bioavailability just like oxycodone thanks to the 3-methoxy group which is good for a non-needle user like me (well, it would be good if I was still actively using opioids to get high -- but I know other opiophiles like me weigh oral bio-a heavily in describing an opioid's worth due to not using the needle, and this one would fit the bill) -- provided extrapolating from the SAR of phenanthrene opioids that contain oxygen as their chalcogen to those that contain selenium works, and it probably mostly does.
I also believe it would have the speedieness of oxycodone that I love.
What's your fantasy opioid that is
*Novel
*Would probably be fun for you
We've all got lots of fantasy must-try opioids, both currently on the market somewhere in the world or not, that would meet criterea 2. So criteria 1, novelty, is a must (not that I'll kill ya or anything if you post something less chemically novel :P ).
It doesn't have to be a different heteroatom like I chose for novelty -- just any odd feature in the chemical structure, or odd pharmacokinetics and pharmacodynamics (acting as a DNRI in addition to a mu agonist like lefetamine -- and yes you CAN say you THINK a compound you pick would act in both ways due to SAR, perhaps lefetamine analogs, this is just conjecture, no proof of dual activity needed), other oddness (non-alkaloids for example like herkinorin)... any odd feature.