resorcinol
03-14-2009, 08:40 PM
This is an interesting group of opioids that I haven't fantasized about taking too much yet. I've heard etonitazene mentioned once or twice here before (by robojunkie I think), but other than that, it's pretty obscure and unnoticed (this class of opioids).
Frankly they sound lovely, and their structures are fresh and different from other classes: this probably means that they'd have another new "personality": the high would be very much like other mu agonists, but each class seems to have a motif effect that is more prominent than in other classes: for example, -codone's and speediness (ie oxycodone). Or open chain opioids and heavy sedation (ie methadone). Piperadine opioids and rushy highs but short half lives (ie fentanyl).
Nitazene itself is 2x more potent than morphine. The phenyl ring is then para-substituted to create many analogs with WIDELY varying potency. This is what I find most fascinating about this class: the para-substituent GREATLY effects affinity for mu all by itself, one change. "R" will be what the para-sub is, and then I'll give the potency, and the name:
R=
hydrogen -- nitazene -- 2x morphine
chlorine -- 3x morphine -- clonitazene
ethylthio -- 30x morphine -- ethylthionitazene
methylthio -- 50x morphine -- methylthionitazene
isopropoxy -- 500x morphine -- isopropoxynitazene
ethoxy -- 1000x morphine -- etonitazene
WOW! Look at how much changing that sub can boost potency. Etonitazene is a powerhouse. I believe it was mentioned on the board before because some chemist working for a US chem company was synth-ing etonitazene and worked himself up to like 100 mg / day of it!!! (it's 1000x morphine, as potent as etorphine, and he was using 100 mg a day). When he got busted, MMT couldn't hold him even at 500 mg or something crazy so he committed suicide. IMO they should have SLOWLY tapered him with fentanyl then started MMT when his tolerance was no longer fucking stratospheric: obviously MMT isn't gonna be useful with a tolerance as extreme as THAT.
This is an interesting class though. If the dude liked it enough to jack his tolerance to such extreme levels, it's probably a euphoric class of opioids. I think I'd PERSONALLY like to stick with nitazene or clonitazene: I don't see the need for the crazy potent ones.
Frankly they sound lovely, and their structures are fresh and different from other classes: this probably means that they'd have another new "personality": the high would be very much like other mu agonists, but each class seems to have a motif effect that is more prominent than in other classes: for example, -codone's and speediness (ie oxycodone). Or open chain opioids and heavy sedation (ie methadone). Piperadine opioids and rushy highs but short half lives (ie fentanyl).
Nitazene itself is 2x more potent than morphine. The phenyl ring is then para-substituted to create many analogs with WIDELY varying potency. This is what I find most fascinating about this class: the para-substituent GREATLY effects affinity for mu all by itself, one change. "R" will be what the para-sub is, and then I'll give the potency, and the name:
R=
hydrogen -- nitazene -- 2x morphine
chlorine -- 3x morphine -- clonitazene
ethylthio -- 30x morphine -- ethylthionitazene
methylthio -- 50x morphine -- methylthionitazene
isopropoxy -- 500x morphine -- isopropoxynitazene
ethoxy -- 1000x morphine -- etonitazene
WOW! Look at how much changing that sub can boost potency. Etonitazene is a powerhouse. I believe it was mentioned on the board before because some chemist working for a US chem company was synth-ing etonitazene and worked himself up to like 100 mg / day of it!!! (it's 1000x morphine, as potent as etorphine, and he was using 100 mg a day). When he got busted, MMT couldn't hold him even at 500 mg or something crazy so he committed suicide. IMO they should have SLOWLY tapered him with fentanyl then started MMT when his tolerance was no longer fucking stratospheric: obviously MMT isn't gonna be useful with a tolerance as extreme as THAT.
This is an interesting class though. If the dude liked it enough to jack his tolerance to such extreme levels, it's probably a euphoric class of opioids. I think I'd PERSONALLY like to stick with nitazene or clonitazene: I don't see the need for the crazy potent ones.