7-hydroxy mitragynine

[Canis aureus]

Hi all,

is anyone familiar with this isolate of kratom? There was article was it in PubMed that it's 20 X potent than one of the best known analgesic... I know that at least one company sells it...

[speciosa]

It's available on the market now, 99% pure (check my post on the vendor's forum). It's a very valuable material, and the PubMed article is accurate.

[Paregoric Kid]

one study suggests that it may have 20x the analgesic value of morphine. however, that does not necessarily mean they work the same or feel the same.

[jacky]

I am not convinced that this material is 20x more euphoric than morphine, nor 20x stronger of a pain reliever, kratoms effects are different from morphine...morphine is a compound that our body produces to some degree, and morphine in certian doses is known for its ability to INCREASE reaction time and mathematical problem solving, I think morphine and the other endogenous endorphins might increase such human abilitys compared with other compounds like merepidine or methadone which are known to inhibit reaction time to a degree.

I think that kratoms effects are slightly debilatating, causing some dizziness in me if the dose goes much over 10 grams of commercial leaf.

dont get me wrong, I really like kratom, and appreciate the current market very much, but I dont think kratom is in the same league with morphine or opium products. I have used kratom for extended periods of time and avoided the classic opiates and opium products, and was basically content with the material, but there was a flatness to the experience at times, whereas when I am maintaned on morphine or opium containing products the euphoria comes easier.

I havnt tried the purified 7 hydroxy mitragynine, but I have tried the mitragynine 90% and the 7 acetoxy analog, and the 41% alkaloidal resin, with the 41% being particularly a good deal in my opinion.
the mitragynine 90% seems to be more of the sedative side of kratom.
the 7 acetoxy seemed to cause some minor stomach discomfort and stimulation.....
my guess is that the 7-hydroxy is the stimulating, euphoric edge to kratom.

one intrepid explorer reported to me a year ago that they IVd an alkaloidal blend of kratom that they extracted via the standard ph manipulation extractions...the material was suspected around 50% alkaloidal that he ended up with....the portion that was IVd should have been enough to contain 1.5 milligrams of 7 hydroxy....anyway they reported no rush, with a strong effect coming on for a few hours, and a very dizzy side effect. the corresponding amount of leaf that the amount of alkaloidal extract was taken from would have been much more potent than the effect that they gleaned from the alkaloidal material alone. so perhaps there is a synergetic effect of all the kratom alkaloids, perhaps all of them dont make it through extraction, and perhaps the antagonist alkaloid in kratom could actually potentiate some of the effects of the mitragynine alkaloids?

[devilsdrug]

as usual thank u jacky for bringin this subject back to reality and not a shameless sales pitch, i for one havnt tried kratom yet but plan to soon like within the next several weeks

[Somniferous]

I havnt tried the purified 7 hydroxy mitragynine, but I have tried the mitragynine 90% and the 7 acetoxy analog, and the 41% alkaloidal resin, with the 41% being particularly a good deal in my opinion.
the mitragynine 90% seems to be more of the sedative side of kratom.
the 7 acetoxy seemed to cause some minor stomach discomfort and stimulation.....
my guess is that the 7-hydroxy is the stimulating, euphoric edge to kratom.

Jacky - What did you do with that 41% resin? Smoke? Eat? Dissolve into water and drink?

Also, regarding the various mitragynine analogues...

Mitragynine is apparently a selective D-opioid agonist, with some potential to cross over to the mu-opioid receptor (usually occurs in higher doses or when no other opiates are present).

I have no information about 7-AcetoxyMitragynine, BUT:

Wikipedia.com states that 7-HydroxyMitragynine is 30 times as strong as Mitragynine and (get this) 17 times as strong as morphine! Not only that, but it also states that 7-HydroxyMitragynine is a mu-opioid agonist, rather than a d-opioid agonist like regular Mitragynine.

I think perhaps a little more research needs to be done...

[robatussin]

I tried the stuff in question in a dose of about 10-15 mg. I would compare it to oxy strength wise, but there is a lack of euphoria. I am interested to try and mix it with other varieties though. 500 mg of this stuff is expensive. Anyone wanna split a half gram ;)

[jacky]

I just would grind the resin and eat it, put it in liquid etc....it really dissolves fast in the stomach.

[Hammilton]

I kinda want to try this stuff. Jacky, have you tried this at all?

[oxydose]

has anyone tried to bang this stuff yet? is it in a alchohol solution>

[mrklean]

I would like to recommend that everyone put a lot of thought in to anything that is said regarding the above poster's topic. How long potent isolates like the 7hydroxy are available legally could be affected by our discussions. I don't think that means we should avoid discussing it just try to post from a very thoughtful harm reduction oriented position. From what I have heard there is no reason to IV this stuff and there are some very big risks associated with attempting it.

[oxydose]

From what I have heard there is no reason to IV this stuff and there are some very big risks associated with attempting it.

any sources for these risks? I understand fully what this means and am actually very against these new extracts, even the 15x resins are bad for the sceduling. I'm in no way suggesting anyone here doing it but mearly wondering if anyones taken that step yet. But it is what it is, people are going to make money and thats where the gov comes in, they want there share too (fines etc).

Will kratom grow in the midwest US climate?

Its been banned in Thailand for years where its abuse is more previlant.