Elaeocarpus grandis. delta opioid grandisine

[jacky]

http://forum.opiophile.org/images/attach/jpg.gif 00000004.jpg (http://forum.opiophile.org/attachment.php?attachmentid=3479&stc=1&d=1235933470) (54.1 KB)

Elaeocarpus grandis is an interesting species.

related to the rudraksha tree, elaeocarpus ganitrus, a sacred tree to most Hindu sects.

there are a number of related species.

there is a great report on the different alkaloid types, that are found in various related species.
the grandisine type compounds.

this report states that specifically grandisine F is the strongest of the range of the grandisine compounds as a delta opioid agonist.


heres a related bit of info...though the specific statements about grandisine F are not copy/paste able.

http://pubs.acs.org/appl/literatum/publisher/achs/journals/production/jnprdf/2006/jnprdf.2006.69.issue-9/np060179c/images/medium/np060179cn00001.gif
Five new indolizidine alkaloids, grandisines C, D, E, F, and G (4−8), and one known indolizidine alkaloid, (−)-isoelaeocarpiline (3), were isolated from the leaves of Elaeocarpus grandis and their structures determined by 1D and 2D NMR spectroscopy. Grandisine C (4) is isomeric with the known compound rudrakine (1). The absolute configuration of grandisine D (5) was deduced by its conversion to (−)-isoelaeocarpiline. Grandisine E (6) contains a novel tetracyclic ring system. Grandisine F (7) is the 14-amino analogue of grandisine C. Grandisine G (8) contains the novel combination of a piperidine attached to an indolizidine. Grandisines C, D, F, and G and (−)-isoelaeocarpiline showed receptor binding affinity for the human δ-opioid receptor with IC50 values of 14.6, 1.65, 1.55, 75.4, and 9.9 μM, respectively.





the above/below photo is of leaf and seed samples that I was sent from a kind person in Australia.


Elaeocarpus grandis
n : Australian tree having hard white timber and glossy green
leaves with white flowers followed by one-seeded glossy
blue fruit [syn: quandong (http://dictionary.die.net/quandong), quandong tree (http://dictionary.die.net/quandong%20tree), Brisbane (http://dictionary.die.net/brisbane%20quandong)
quandong (http://dictionary.die.net/brisbane%20quandong), silver quandong tree (http://dictionary.die.net/silver%20quandong%20tree), blue fig (http://dictionary.die.net/blue%20fig), Elaeocarpus
grandis]

[jacky]

I havnt done any research with the leaf material that I have.

its possible the pits/seeds of this plant might have some interesting attributes, as the rudraksha seed is used in ayurvedic preperations.

the fruit is called quandong, and is a somewhat common jam or jelly product in Australia.

but I have not heard much about any ethnobotanical use of the leaf of this plant.

if the leaf does turn out to be low toxicity, and have some bioactivity, even beneficial activity, it would be real interesting....because this is not a real rare plant down there. there are commercial growers of this fruit.

I found a person that has the tree growing on their property.

the seeds are hard as hell. jewelry quality, much as the rudraksha seed.
rudraksha seeds, and quandong seeds usually have 5 sections, fused together.
but there are seeds that have more or less sections.

each section is referred to as a "mukhi"...and the sections range from 1, to up in the 30's.
the more or less sections a seed has, that deviates from 5 sections, the more the seed is worth.
planting a rudraksha tree, after a few years, results in the possibility, that you might grow a seed worth thousands of dollars.
some seed mala's (rosaries/necklaces) are worth thousands. if not tens of thousands for the most elaborate and rare mukhi malas.

anyway, delta opioid activity is of interest to me. seems that some euphoria and pain relief might be possible...and that the delta opioid receptors might have some use for lowering tolerance, or managing other opiates/opioids.

[jacky]

grandisine B


http://www.york.ac.uk/res/rjkt/2006/images/resear3.gif

[jacky]

grandisine A is being researched by at least one group of researchers, for pain relief with possibly fewer side effects than standard opiates.

I think its possible that grandisine B might be used to produce grandisine F.

I cannot cut and paste the structure of grandisine F from the data source.

I was hoping to create some interest with a few chemists that supply ethnobotanical companies, into extracting and doing some alkaloid yeild on the leaf material that I can source. but so far no interest as of yet.

[Papa Verine]

Hey Jacky... Is this the same plant as Elaeocarpus fuscoides?

I found this article...

http://pubs.acs.org/doi/abs/10.1021/np060607e

It seems the article I found makes reference to different alkaloids in the plant then the ones you mentioned above.