Marinol/Medical Marijuana prescribed w/opiates

[roxi*stardust]

Does anyone get this RX'd by their PCP or PM doctor as an additive to other opiate pain relievers? In Medical Marijuana states does your PM doctor prescribe your Marijuana or do they support it's use? Just curious. I don't want to know if you yourself combine the two, I am interested in doctors prescribing practices when it comes to the two drugs together as a pain reliever.

[Dune]

I have a friend that was in a bad accident years ago. He is prescribed opies, benzos, and MARINOL. I believe it is prescribed to promote appetite. Don't have a lot of details, but that's a start.

[OxiContinKing]

Someone im my family was prescribed this, but it was for nausea, I'm pretty sure.

I used to get bottles of 30, and I would take like 10 and chew them up (they have liquid inside them, and the balls are like, hard gooey tastless candy, really not too bad) after dosing, and it definatley serves well as a potenator. Extremley well. Wish I could still get my hands on some.

I was smoking alot of good weed to at the time, so if you aren't (currently) a chronic smoker, you could probably get the same effect with less (maybe 5).

Or if you take the whole bottle and chew it up when your completley sober, you will get high.

:D

[roxi*stardust]

I am curious if doctors ar open to prescribing Marinol or Marijuana together with opiates for pain relef.

[devilsdrug]

well my friend who gets hundred and something oxy 15 ir is prescribed mm , the mm doc knows about the oxys and told him to keeptakin as prescribed

[Indy]

I am curious if doctors ar open to prescribing Marinol or Marijuana together with opiates for pain relef.

I've heard of it, but only if you don't enjoy either one of them! Can't have that, now can we? Of course, this was online, so the person might have just been lying or whatever.

I bet it works wonders for pain though. It tends to be the things that get you the highest also kill pain the best.

[halfalien_s4]

I've heard of it, but only if you don't enjoy either one of them! Can't have that, now can we? Of course, this was online, so the person might have just been lying or whatever.

I bet it works wonders for pain though. It tends to be the things that get you the highest also kill pain the best.




dude i can tell ya (me being a CP patient & all) from expiriencing, that Cannabis killes a lot of my pain....always has.....

[Indy]

dude i can tell ya (me being a CP patient & all) from expiriencing, that Cannabis killes a lot of my pain....always has.....

Can i ask you something? (Well i'm gonna be pretentious and just do it anyway) About either the marijuana or the opiates, whichever one or both you're prescribed.

Does the doctor understand that the meds cause euphoria and a "high"? I mean obviously he knows that it causes "euphoria" but does he really realize what that means?

Does he think you enjoy it? If so, how does he feel about it?

And you can add anything you think is related to your answers if you want to. Thanks in advance.

The reason i ask is because it really seems like some doctors HATE it when patients enjoy their medication, or get a "high" off it. I think it's because in our society you just aren't "supposed" to do it, and they don't like to see people undermining the 'system'.

[resorcinol]

I'm not sure how common this is, but it's probably a very effective adjuctive to opioid pain relief.

CB1 agonists alone are not nearly as strong analgesic as opioids (although they're often better than NSAID painkillers).

I think CB1 agonist drugs, including marijuana, are a great option for mild chronic pain that may not require opioid level pain relief. They'd probably greatly improve pain relief when added to opioid therapy for moderate to severe CP too. They're much less toxic than NSAIDs and thus a better option to add to opioid therapy IMO. However, the gov't treats cannabinoids with the same overzealous phobia as they do opioids in reality. Opiophobia is in itself ridiculous; cannabaphobia is even more senseless given the safety of cannabinoids from all angles (nonexistant overdose potential, no physical dependence, low psychic dependence). I'd be very happy to see them implemented as "first line" pain relievers for chronic pain instead of the NSAIDs. However, I wouldn't want their introduction to further the opiophobia either, since severe CP will still require opioids. Opioids are the only pain releivers the directly hinder action potential propagation along nociceptive (pain signal conducting) neurons.

Additionally, CB1 agonists would probably be great adjuctives to opioids because they indirectly modulate the opioidergic neurotransmitter system, and likely enhance the analgesic effect of mu agonists in addition to having their own mechanisms for releiving pain.

Interestingly, acetaminophen/APAP/paracetamol/tylenol possibly works by inhibiting the re-uptake of anandamide in the CNS (not enough to get one high on the anandamide, but enough to possibly activate cannabinoid mediated analgesia, albeit weakly). APAP is not an NSAID (although it does lower fever by inhibiting COX3 enzymes). It has been demonstrated that rimonabant (CB1 antagonist) blocks APAP's analgesic effects. It would make sense then that the much stronger enhancement of cannabinoid receptor signal transduction by CB1 agonist drugs, would provide much stronger analgesia than APAP does. In a way APAP is like SSRIs --- it's a centrally acting drug that is not overtly psychoactive, where other drugs that effect the same neurotransmitter system in a different more direct way are psychoactive.

Adding a CB1 agonist to opioids could 1)enhance pain relief of lower opioid doses, decreasing overall side effects, especially since CB1 agonists could mute some of the side effects like nausea that mu agonists cause while enhancing analgesia overall 2)reduce the speed of tolerance development to opioids by providing adjunctive CNS pain relief


Edit: Pain, in general, deserves more study. Specifically, the study should be free of bias against psychoactivity. Currently most pain research is hyperfocused on making opioids obsolete due to their psychoactivity ---- and so far the only drugs that they've discovered that provide comparable analgesia only work for very specific kinds of pain and are quite toxic. The thing is... mu agonists are the ONLY drugs that DIRECTLY inhibit action potential propagation on PAIN SIGNAL CARRYING NEURONS carrying signals to the pain-sensing parts of the CNS. That is why opioids are the BEST broad-spectrum pain killers.

There have been some intersting observations --- like that amphetamines have analgesic activity that is weaker than opioids but more potent than NSAIDs or any peripheral acting analgesic. The opioidergic and monoaminergic neurotransmitter systems are clearly intertwined. Also, perhaps physical and psychological pain have more than just a philosophical tie, perhaps they have a physiological tie in too. Proof and acknowledgement of that could not only help CP patients with their physiological pain, but also patients with mood, anxiety, and some other axis I disorders (psychological pain). Opioids relieve both types of pain extremely effectively. This should SCREAM OUT to scientists that our bodies are built such that the two overlap highly. Severe major depression has been shown to manifest physical aches and pain, and physical pain often manifests major depression. Hmm..... !

And cannabinoids, another neuromodulatory system in the brain, is analgesic when activated. Opioidergic system is neuromodualtory too. It appears that neuromodulatory systems are highly highly implicated in pain.

[Narkotikon]

I would think marijuana / THC / whatever other active chemicals are in pot would be a good adjunct to CP issues. Not sure if it's allowed to be prescribed for that though. I'd say it would probably be an "off label" use, unless you're in California or something. I know Marinol is prescribed for nausea and to increase appetite in end-stage cancer patients, and AIDS patients.

The few times I smoked it when I was in w/d a long time ago, I noticed it helped a lot with the RLS and leg aches. Not really that it killed the pain or whatever, but because it acted like a muscle relaxer I think. It just made my muscles like jelly. But, on the other hand, I get totally paranoid on pot, so I tend to not smoke it regularly / often. On one hand it's great for nausea, leg aches, etc. in w/d, but you also have the added anxiety / paranoia, at least for me. I'm already anxious / irritable in w/d. I don't need to be paranoid and looking out the windows when I'm in opiate w/d.