subutex to be taken off market? rumor or?

[BigLou]

ive heard from various people that they plan to discontinue subutex, does anyone know if there is any truth behind this or if it is just a rumor. thanks

[simfromstoke]

discontinue subutex....not very likely !!!

the french 10yr exclusive manufacturing licence ran out on it 3 wks ago and since then, england has been *FLOODED* with cheaper generics, but i chemist-shop and get the proper french ones cuz they are the best for what i need

but NO-WAY will they stop making bupe. if anything, now, there will be MORE of it




-sim

[duck]

discontinue subutex....not very likely !!!

the french 10yr exclusive manufacturing licence ran out on it 3 wks ago and since then, england has been *FLOODED* with cheaper generics, but i chemist-shop and get the proper french ones cuz they are the best for what i need

but NO-WAY will they stop making bupe. if anything, now, there will be MORE of it




-sim

I read it thinking quitting production of subutex, not bupe altogether. Maybe I'm wrong, just pointing it out.

[Saint]

In Holland they DID take subutex off the market. All you can get is subuxone now.. but this is Europe.

[simfromstoke]

In Holland they DID take subutex off the market. All you can get is subuxone now.. but this is Europe.

Holy SHIT Saint...

im scared now..
im only about 21 miles off the coast of mainland europe..
but i guess theres too many subutex heads here in england, and like i said.. the UK is flooded with generic bupe ATM..

thnx for the heads-up tho!!



-sim

[duck]

Holy SHIT Saint...

im scared now..
im only about 21 miles off the coast of mainland europe..
but i guess theres too many subutex heads here in england, and like i said.. the UK is flooded with generic bupe ATM..

thnx for the heads-up tho!!



-sim

Are you not fond of Suboxone, Sim?

[BigLou]

wow is the pat. up in the us? we dont have generic's yet. i cant wait till they make a generic suboxone, or even tex. i wonder if they would try to make them, ie. more naloxone or a special coding or some shit. different? hmm

[simfromstoke]

@ Duck
suboxone SCARES the shit outta me mate..
i like taking smack too often to have to worry about PWD's off naloxone..
im on subutex and have been for a year..
i love the subs but if i got forced into suboxone id go back on the smack full-time i think..lol
i dunno..
i suppose i could handle suboxone, id just have to suffer the waiting of getting the smack outta my system before geting back on by meds
it'd piss me off as i like how the subbies work for me and i can have smack whenever i want it ATM
so yeah i spoze i could handle suboxone..
i just wouldnt wanna do it by choice..lol




-sim

[duck]

@ Duck
suboxone SCARES the shit outta me mate..
i like taking smack too often to have to worry about PWD's off naloxone..
im on subutex and have been for a year..
i love the subs but if i got forced into suboxone id go back on the smack full-time i think..lol
i dunno..
i suppose i could handle suboxone, id just have to suffer the waiting of getting the smack outta my system before geting back on by meds
it'd piss me off as i like how the subbies work for me and i can have smack whenever i want it ATM
so yeah i spoze i could handle suboxone..
i just wouldnt wanna do it by choice..lol




-sim

Handling opiates and suboxone together has been a breeze for me...as a matter of fact, I do it everyday! I take a few mgs of suboxone each morning and then follow it with my opiates the rest of the day, usually util around midnight. Then, the next morning, around 8 or 9, back to subbies.

But, this is me, and a lot of people do get PWs.

[Narkotikon]

I'm not sure. The only reason I'd think they wouldn't take Subutex off the market would be for 1.) pregnant women who chose to go the bupe route rather than going with methadone, because the Narcan wouldn't be good for the fetus; and 2.) people who just are allergic to Narcan / naloxone, and therefore "need" the the Subutex / all-bupe formulation.

I do want them to hurry the fuck up and make a generic Suboxone or Subutex over here in the States though. I mean, god, buprenorphine has been around since the 80's and Narcan has been around even longer than that. Why in the hell should a pharm company get an exclusive license for years and years just because they decided to combine two previously existing drugs (Suboxone), or because they decided to put more of the drug into a pill (Subutex). It's fucking ridiculous to me. It's not like they invented the drug.

As for Precipiated w/d and bupe / Subutex / Suboxone. It really doesn't have anything to do with the Narcan / naloxone in it. It has to do with the bupe having a VERY high binding affinity for the receptors, and also being a partial agonist.

So, what happens is that if a person doesn't wait until they're in w/d before they take their first dose of Subutex or Suboxone, the bupe will displace whatever full-agonist (i.e., heroin, morphine, oxycodone) that is left in their system, and because the bupe is only a partial agonist, it will only bind to the receptors so much, and it may not be enough to get the person out of w/d.

Some Sub doctors over here do give Subutex on the first visit or two, then switch people over to Suboxone, but I"m not exactly sure why they do that. Maybe to make sure they're not allergic to the Narcan in the Suboxone formulation? I don't know. Not all doctors do that though. My ex-Sub doctor just started me out on Suboxone and told me to take the first dose when I got home and to make sure I was in w/d. It worked out fine. Nothing bad happened.

I mean, if you take the Suboxone sublingually as it's meant to be taken, none of the Narcan is supposed to get into your system, or at least not enough to cause any effect. Same thing for snorting. You can easily snort a Suboxone. Or, if you're actually stabilized on the Suboxone for a while, you're supposedly able to even shoot them, because, like I said, the binding affinity of Bupe is even higher than that of Narcan. So, in theory, the Narcan wouldn't be able to attach to the receptors because even it couldn't displace the bupe. I've never IV"d a Suboxone before, because I'm too afraid that it wouldn't work out that way, but people on here have said they've done it.

But, yeah, the precipitated w/d doesn't really have anything to do with the Narcan in it. It has to do with the bupe being a partial agonist and having a higher binding affinity for the opiate receptors. The Narcan is simply put in the Subxone as a deterrent for IV use. But, like I said, if you've been stabilized on the Subs / bupe for a while, it really doesn't work out that way. According to other people and Wikipedia that is. I've never done that, and doubt I ever would.

Edit: About the pharm company "inventing" the drug. Yes, the pharm company that produces Subutex / Suboxone "invented" / discovered bupe in the 80's, but that was a long time ago. I mean, you can get generic Temgesic / Buprenex (which were the original formulations of bupe I think), but you can't get generic Suboxone / Subutex yet? That's a crock of shit to me. I mean, with Subutex, all they did was increase the dose of bupe in a single pill. With Suboxone all they did was increase the dose AND add naloxone / Narcan. That's not a lot of work if you ask me. It certainly doesn't warrant a patent for years and years of mass profits. They NEED to come out with a generic form of Subs SOON. But, that's just my opinion. I mean, these types of drugs are supposed to help addicts. How in the hell can they help the addict if they can't afford them? Doesn't make much sense to me.

[Seedy]

@ Duck
suboxone SCARES the shit outta me mate..
i like taking smack too often to have to worry about PWD's off naloxone..
im on subutex and have been for a year..
i love the subs but if i got forced into suboxone id go back on the smack full-time i think..lol
i dunno..
i suppose i could handle suboxone, id just have to suffer the waiting of getting the smack outta my system before geting back on by meds
it'd piss me off as i like how the subbies work for me and i can have smack whenever i want it ATM
so yeah i spoze i could handle suboxone..
i just wouldnt wanna do it by choice..lol




-sim

Man since i been on subs i been chopping & changing without a problem - i'm prescribed 4mg a day (2mg gets me by just fine), thursday to saturday I'll drop to 1mg and take whatever real opiates I can get my hands on without a problem, sometimes skipping a day of subs even. The only time I've had the slightest problem was going on 1mg for 2 days, .5mg a day then skipping a day and dosing 3mg the next night. I started sweating profusely and was fully expecting to feel like shit but after about 45 minutes I was OK. After another 20 minutes I was getting high off the subs so I had some more :)

Don't worry about the naloxone in subs it makes fuck all difference IMO.

[oxy kid]

Handling opiates and suboxone together has been a breeze for me...as a matter of fact, I do it everyday! I take a few mgs of suboxone each morning and then follow it with my opiates the rest of the day, usually util around midnight. Then, the next morning, around 8 or 9, back to subbies.

But, this is me, and a lot of people do get PWs.

I think me and you are a lot alike.