My Theory On Weed

[Narkotikon]

Okay, so I did get weed tonight. I did not get anymore Xanax though. Couldn't get an opportunity. But this isn't about that. And yes, I know a trip report is clique and a waste of server space, but I think my perspective might be unique because I've not smoked up since 2005, and because I'm prone to paranoia (more on that to come).

Okay, so this guy that my sister sees got a quarter of an ounce. The weight looked right to me, from what I remember, but I suppose that could be wrong. He got half, and I got half. My half is still enough to make about 3 joints. Same for his. Then, we had two earlier, so that would be a total of 8 joints out of this bag. We shared the two joints (I took one roach), and then divided the rest.

Now, normally, I can (and usually do) get really fucking paranoid on pot. And I've always assumed that it's because I'm just really sensitive to it, and have an abnormally low tolerance. BUT, this time I'm not paranoid. Then, I got to thinking that maybe it's just because all the other pot I've had has been kick-ass weed, and this stuff is just mediocre, and that's the difference. I had never thought of that before because I just always assumed it was decent weed, and not great stuff. Or, it could have been that this guy rolled itsy bitsy thing vegetarian joints, and I"m used to big phat hamburger joints. So, maybe it's not that the pot is bad, but that I just always smoked way too much before, and was just too stoned.

So, I'm not sure of the reason.

Cigarette Break..............

Okay, so, the point is that my theory now is that I don't get naturally paranoid on ALL pot, but that it's either a different strain that doesn't produce as much paranoia, or it's because it's mediocre pot and just not strong enough to produce paranoia in me, or that it's because the joints I smoked were smaller, and not enough to produce a sense of paranoia.

And I swear this was supposed to end with one major point, and not three, but god, I'm stoned, so who in the hell knows what that grand epiphany was.

But, I'm listening to Orbital, and it sounds SO FUCKING GOOD. I love music on pot.

OH, I remember. I was going to be paranoid, because at first this guy was like "let's clean yoru sister's house." And, I was nice at first, all giggly, and said ok, because I wanted to say thank you to my sister, because she's the one who funded this, and probably the only reason I ended up with half, and not less, or none at all. But, anyway, that was making me paranoid. Then, my sister, because it was later and she wanted to go to bed, said no, it's too late to clean. Then I got on here and started listening to music.

So, the theory is that I'm not paranoid because I think it's that I have to be in the right setting doing what I want to do, like listen to music and be on here, as opposed to doing something someone else wants me to do, or playing into their notions of how I should be. In short, I feel like the paranoia is coming from me trying to please others / be something I don't want to be. Now that the cleaner is off my back, I can relax. I guess all the other times before I was smoking with the wrong crowd / or just uncomfortable with myself. Maybe it's because I don't really repsect him and I don't care what he thinks of me. I don't know. I just thought this was interesting.

And I highly suggest Orbital's Moebius if you're stoned. GOOD SHIT!

[SHELLEY]

i don't like orbital and i am constantly stoned (now too)
i like to listen to three six mafia while smoking
the lyrics are so... banal and simplistic that its good stoner music

"slob on my knob like corn on the cob, come in with me and do your job
lay on the bed and give me head, don't have to ask, don't have to beg"

hah! :rolleyes::D

[squareone]

I didnt read most of your post...maybe cause I'm drunk. I notice pot can make people insecure or feel funny. I can get paranoid if I am stoned its usually in front of girls I think I act funny stoned or something?

[Badly Drawn Girl]

Am I alone in my hate for weed? I cannot stand it. One time when I was ridiculously messed up on crack someone loaded my pipe with weed in order to make me come down (without my knowledge until I inhaled) Oh lord, was I angry. Weed just stops me dead in my tracks. I cannot think, I cannot speak, I can barely breathe. It's a nightmare. I did use it regularly at one point in my life as a cure for insomnia. I would take a toke and fall out for the night. A small nugget of weed would last me a month. I've never bought it, never craved it, and seriously doubt I will ever smoke it again. I just don't understand how people can smoke all day and function. I'm actually envious!

PS Hey Shelley, aren't you still on 'done? Don't you get UA'd at your clinic? Just wondering how you get around the weed.

[SHELLEY]

PS Hey Shelley, aren't you still on 'done? Don't you get UA'd at your clinic? Just wondering how you get around the weed.

i just failed every single piss test for pot, that's all :D

[Badly Drawn Girl]

i just failed every single piss test for pot, that's all :D

LOL, well there ya go. I've failed every piss test for Oxy... well I think I passed my last one but my counselor hasn't bothered talking to me in months. And I'm due for another one either this week or next. I've been clean 8 days so I should pass that one too. I'm crossing my fingers because I need two clean UA's to move up a step and earn another take home.

[SHELLEY]

LOL, well there ya go. I've failed every piss test for Oxy... well I think I passed my last one but my counselor hasn't bothered talking to me in months. And I'm due for another one either this week or next. I've been clean 8 days so I should pass that one too. I'm crossing my fingers because I need two clean UA's to move up a step and earn another take home.

they wont give me take homes tho
but i'm down to 10mg now, might just say fuck it from here on out

[alowishus]

Didn't read one thing not even the first post, Nark my friend - you have so time on your hands. ;)

[Raz]

Hey Narki bro , wazz up....So ya hadda toke wiv dat coke head dude , who's leechin off ya sis....

Heres my 2 bobs worth amigo on why ya didnt get para tokin dis time.....Its basically coz ya didnt give a shit about wat dis hombre finks of you.....When stoned,if you over analyse tings, then dat just feeds on itself.And then you can start questioning every fuckin fing....

When peeps ask me why weed does dis n dat, de advice i give is dont toke when ya is depressed or in surroundings that make you feel uncomfortable....Coz if ya dont feel good in da 1st place, weed is just gonna intensify whatever your feelin, good, bad or indifferent.....

Basically if ya tokin some real head stonin weed, den ya just gotta go wiv it and laff at yaself and definately dont start no analysin shit, either self analysis or otherwise.....Coz it will just lead to stoned, confusin introspection......Leave all dat self analysis shit alone and just try and enjoy.....And all i smoke is cannabis, day in day out, never a cig on its own, always a joint.....

And i just like da meelow feelin it gives me...Without it i would be "uptight",snappy...........

[pinn3d]

I never heard Orbital.... I like weed though..... Paranoia seems only to come if I'm in a situation that I don't wanna be in, or I can't change it....I prefer smoking alone......



I think the better quality weeds will give less paranoia.... maybe cuz its a cleaner high, and you don;t need to smoke as much to get the same effect.... I used to get completely spun out smoking with others in college..... I would just get quivered and sit there, unable to speak.... just stuck in my head....... I can usually handle myself now, but I tend to just smoke alone---- makes it easier ---- just have to deal with myself...;)

[limitless_euphoria]

Welcome back fellow stoner. Even if some devine being came down and said, "You can only use one substance ever again and you have to give up all others," I would choose weed.

Despite all the propaganda my life pot has never, ever brought me to a dark place and my love for it has never made me exercise bad judgment.

[ItsLupus]

BDG you are not the only one!I have tried it several times and experience horrid side effects.I have not tried in quite a few years due to the last episode.I swore never again!Thanks be that I am not the only one! ;)

[sweet pea]

I never heard Orbital.... I like weed though..... Paranoia seems only to come if I'm in a situation that I don't wanna be in, or I can't change it....I prefer smoking alone......

I think the better quality weeds will give less paranoia.... maybe cuz its a cleaner high, and you don;t need to smoke as much to get the same effect.... I used to get completely spun out smoking with others in college..... I would just get quivered and sit there, unable to speak.... just stuck in my head....... I can usually handle myself now, but I tend to just smoke alone---- makes it easier ---- just have to deal with myself...;)

i actually think the opposite and tend to agree w/ nark. i'm not prone to anxiety or paranoia, but when i get *really* high, usually b/c of the type of weed i smoke & of course, too much of it, i tend to start getting too into my own head & over-analyzing shit, as raz says. shitty weed just doesn't really even make me high. it just gives me a headache.

but, i think that theory is pretty good & i tend to agree w/ that. i smoke every night, but i can't get too high if i have a lot on my mind, or else i'll just sit there and think about it non-stop and then i start to get panicky. i'll still smoke, just not as much, and it keeps the paranoia/anxiety away, which goes along w/ what you've said.

[Narkotikon]

Yeah, it was really pleasant. I basically just listened to music and chatted on here a bit. But, yes, I do think it's the situation you're in. I've heard that pot is basically a "mood enhancer." It takes whatever mood you're in and just intensifies it. I do think I didn't get paranoid because I don't really care what that guy thinks of me. If I had been around people I was trying to impress, or people who I cared about, then I think it might have made me paranoid. As per the quality of the stuff. Hell, I'm not sure. It stinks, and it got me stoned, so that's all I really care about.

Pot definitely isn't my drug of choice, but it's nice when you're bored and trying to stay off other things I guess. I do like listening to music on it. I just hate that paranoid feeling, which is why I was so surprised I didn't get any paranoia. I usually do. Although, I will say, re-reading what I wrote, it doesn't seem like such an epiphany now. Last night it was like this great revelation, like I was handed special knowledge from god or something. Now it's like, eh, that's not so impressive of a thought process. But, yes, I still agree with it. Just isn't as impressive anymore I guess. Pot has a tendency to make me get epiphanies.

[StinkyPickle]

SNIP: Although, I will say, re-reading what I wrote, it doesn't seem like such an epiphany now. Last night it was like this great revelation, like I was handed special knowledge from god or something. Now it's like, eh, that's not so impressive of a thought process. But, yes, I still agree with it. Just isn't as impressive anymore I guess. Pot has a tendency to make me get epiphanies.

One time when I was stoned I had this awesome idea. It was a little box that you put bread in and it toasts it. My friends had fun with that one for years.

The effects weed has definitely varies greatly between people. Some people get creative, some fall asleep. Some people get paranoid and don't talk to anyone, some people spout things off like they just kissed the Blarney Stone (DON'T DO THAT, by the way, locals get drunk and piss on it) I knew a chick that would have crazy hallucinations when she smoked. She was a very down to earth person, too. She wasn't the type to exaggerate things to get attention. I will agree to some point about the mood enhancer. Sometimes before I smoke I just want to be left alone. After I smoke I become this incredible hermit. Sometimes I'm in a happy playful mood, and I turn into a 6 year old after I smoke and just want to hang out with my kids and make goofy noises and shoot Nerf darts at my wife.

[Narkotikon]

Eh, I change my mind. Weed is STILL not for me. I just toked up again before I went home (I know, stupid, because I kind of wanted to go home, and now I can't drive b/c there's no way in hell I"m getting behind the wheel stoned and freaking out driving). I'm getting paranoid now. This guy my sister dates is kind of creeping me out now. Damnit! Happy thoughts, happy thoughts, good music. Get sober. Go home. Weed, ugg. I'll stick with opiates.

[SeVeN]

You were so high when you typed this post. Try weed by yourself when you have no place to go or nothing to do. I smoke at night if at all. And still get somewhat paranoid. With tolerance I don't think it gos away, you just get jaded to it.

But the thought process of being really high is great, especially compared to just being stoned all the time.

[StinkyPickle]

You were so high when you typed this post. Try weed by yourself when you have no place to go or nothing to do. I smoke at night if at all. And still get somewhat paranoid. With tolerance I don't think it gos away, you just get jaded to it.

But the thought process of being really high is great, especially compared to just being stoned all the time.


Say you only smoke once a year. You get super baked and you hear a noise. Well, you're stoned, OF COURSE it's the cops, because someone had to have smelled it. So you freak out.

Now say you smoke every night (like me) You get super baked and you hear a noise. You've heard this noise a thousand times while baked so you can rationalize it more. You realize that no one can smell what you've been smoking, and even if they did, it's most likely not enough to cause alarm. You also can tell yourself that there's not going to be cops banging at your door because someone smelled a little weed. Shit, you get a bigger fine for parking in a handicapped spot than if a cop caught you with a roach. Well, unless you're in Nevada.

[SeVeN]

Yeh. Here you might end up in jail, probation and big fine. Of course some Cops do respect privacy. AKA your in your own home.

[Narkotikon]

Thank god, he's leaving. I don't know how in the hell people can drive on weed, but he apparently smokes a lot more. I don't, so maybe it doesn't affect his driving as much. I don't care. I'm glad he's leaving. Fucker is fucking freaking me out. Just the little sarcastic comments that piss me off that I guess he thinks I'd find funny, like bitching about my sister. Fucker. Apparently pot makes me a bitch too. Hmmmm. Listen to more music, get sober, go home. Try to not second-guess my bad opinion of him.

Edit: And I just now realized that I"m journaling my daily events like someone else. Sorry for that. I'll stop now. God, weed makes me dumb. I don't feel as though opiates do that.

[SeVeN]

On of my favorite thing in the world use to be driving around stoned. Guesse different strokes for different folks.

[barbiegal]

Yeah,I'll go with the paranoid group. I won't even condsider driving if I'm high (which is rarely) especially in the dark because I just know every car coming up behind is a cop. Just not worth it,like opiates SO much better!

[resorcinol]

If I smoke too much weed I get CRAZY fucking paranoid. It's a steep dose response curve too.... it's almost like crossing a dosage line for me, right up to the line I'm ok, but if I cross it, two hour long panic attack and major paranoia. Worse paranoia than taking too much adderall causes by FAR for me.

This is why I rarely ever smoke any. If I do I make SURE I'm well below "the line".

[nick]

Nark bro,weed is a sensitiser.So,don't get wasted with folks or situations you're not comfortable with.As Seven wisely points out,get stoned on your own.

Now go and eat some ice cream.

[Kristy85]

Love ma weed! Got a J on now (as I do every nite) as it helps me to Zzzzzzzzzzzz :D Great for when I'm rattlin too!

[chopstix]

I love to drive stoned, even if I am a little 'noided it totally puts me in the zone and I feel focused and less prone to distraction. I love to burn a little on the 4 hour trip it takes to come down out of the Sierra, there's just something about driving around those mountains blazed - it's fun to burn on the ski hill too (later in the day, not first thing). For me it just provides a kind of shift in perspective and for some reason I especially enjoy it in really beautiful outdoor settings.. I also find it great for passing time during road trips; gimme a lil herb, a grip of redbulls and some good music, and I'll drive 18 hours...

I also think it can be a great tool for introspection, I've experienced some pretty profound insight while high, ideas that remained interesting long after the herb wore off..

This won't make much difference to most folks, simpy cos most people don't have the luxury of choosing, but if ya wanna puff and have a problem with paranoia, if you can stick to Indica (as opposed to Sativa) dominant strains, they really tend to be a lot "heavier" - much more of a relaxed, glued-to-the-couch kind of high, where Sativa tends to be more stimulating and more likely to make ya tweaky. Indica dominant herb and hash help me a lot with my insomnia.

I really didn't put much weight into the Indica vs. Sativa effect claims, until I became a medical smoker, but now that I can be so selective, I'm convinced of it. There's also some things that can happen after harvest and during the curing process that can have a pretty big imact on the effects of a certain crop.

Both certainly can bring it on but if you take the pepsi challenge with both, I'd bet most people could tell the difference between two good strains as far as being a little speedier vs. heavier and a bit more relaxing.

I totally understand why people hate the shit though. I smoked for years, then quit for years (because I started getting paranoid), and have recently started again, and I smoke everyday now but I doubt I'll keep that up for very long.

I'm glad I picked it up again, it's not good to smoke a lot everyday but for me it is something that I (again) can really enjoy while hiking or skiing or camping somewhere beautiful..

[Narkotikon]

I'm home now, thank god. It's all about introspection I think. I'm already a naturally introspective / analytical / sensitive person. Weed just brings that side of me out even more. I totally clam up. Plus, it's just such a fucking gamble: will I get paranoid this time? I still have one roach and one rolled joint and enough loose weed to make two more joints out of what I brought home, and I just don't want to touch it right now. It's just not for me. Weed is very hit or miss, whereas opiates ALWAYS treat me right, if that makes any sense.

Plus, I swear the fucker was intentionally trying to "make" me paranoid. He was saying really personal shit about him and my sister that I really DID NOT want to know. I mean, what brother wants to know about his sister's sex life. OMG, I wanted to hit him so hard. What ended up happening was he left to go wherever, my sister was asleep upstairs because she works tonight (3rd shift social worker), and I just stayed downstairs listening to Orbital and being on here. That helped some, but I was still paranoid. Yes, when I do smoke the rest of this pot, it's going to be when I'm alone and can not worry about other people. I hate that paranoid feeling. I just get a creepy vibe from this guy. He seems shady as fuck. I have absolutely NO idea what she sees in him. I feel sorry for her and am pissed at her at the same time: yes, he shouldn't treat her badly because she's basically paying for his ass; but at the same time she's willing to put up with it and never follows through. I wish I could kick his ass out and be done with it. I'm sure I could take him, and I"m not the most aggressive / physically intimidating person.

But, all in all, I had a decent time. I had only planned on staying until Sunday afternoon, but she was off until tonight, so she asked if I wanted to stay. So, I did. It was nice to get out of the house, and she and I had a good time when we ran errands and talked and stuff, but he was really sketchy. One minute, he's be pleasant and easy-going, then the next minute he'd be making sarcastic comments about her, or my family, or even about my dead dad. I mean, what the fuck? I do NOT like him.

Damnit, I'm journaling again.

[Mayo]

Damnit, I'm journaling again.

ha.. Well this is THE place to do it now. You must have been a huge influence on some of our new crop while they were lurkers Nark.
Your conclusion about different types of weed causing anxiety/paranoia etc is true (i think i saw that somewhere in your post).

Chop just mentioned that too about the different strains, even the curing process's effects,
and ratios of active compounds in weed.

There was a post about this a while back, with a video, about the paranoia-inducing compounds
and the lol/happy/relaxing/ ones.

http://forum.opiophile.org/showthread.php?t=18158

ahhh..remembering the 'phile last summer..good stuff

[nycjrt]

I used to get incredibly paranoid when I smoked in HS/college, hence always preferred drinking and 'hard' drugs to weed. Over the past few years I've smoked a handful of times and actually enjoyed it- I think it has to do with the weed being of much better quality and I am careful to not do too much- a few tokes of high quality shit though and music does sound incredible.
p.s. Nark your sister's BF sounds like a real dick. I haven't listened to Orbital in ages, I'm going to dig out some cds tonight- The Orb would be pretty good to listen to stoned on weed too- nice and relaxing...

[Narkotikon]

The Orb would be pretty good to listen to stoned on weed too- nice and relaxing...

Yeah, The Orb is amazing if you want to chill out. I'd HIGHLY recommend the album The Orb's Adventures Beyond The Ultraworld.

Some Orbital songs I like are:

Halcyon + on + on (both regular and live versions)
Belfast
Petrol
The Moebius
The Lush series (Lush 3-1, 3-2, and 3-3, and I think there may be a 3-4 too, but I don't have it on my computer)
The Box (Part One and Part Two)

Sasha's Xpander and The Silence were good too, as well as Underworld's Born Slippy (the end song to Trainspotting).

[Chipdorq]

i used to love it in high school, but only once or twice a week. i'd get super paranoid, tho. i couldn't understand how people would blaze b4 class. in college, in the beginning, i used to get bad depression when i was coming off the high. not like with coke, but still a funk, overall sadness.

now i smoke everyday and i love it. its like anything, do it enough and your body will accommodate. i still get self-conscious, but i love to blaze before chores. it makes them fun.

also, i like the combined effects of weed w other drugs i like. i wont do adderall, dex, or ritalin (i actually hate ritalin), without a huge supply of weed on hand. its speedbally and floaty, whereas speed is just SPEEDY.

I LOVE hydro and oxy, but need weed (and a drink or two) to kick that shit in nicely. there's an addiction term for this (needing a combination of drugs to get off right), not co-dependent, but something similar.

all my people are out, so i'm out, and i'm meeting a friend who can break me off adderal and maybe Vics, and I'm stressin about the weed! my 2cents

and halcyon + on + on is a DOPE song!

[nycjrt]

i love underworld too - second toughest in the infants and [I]beacoup fish[/I are great to listen too high- they are actual albums, compiled more like old rock lps or something... Underworld are an incredible live group too- i saw them back in the mid-90s, and again last summer in central park- i've been to hundreds of shows, and literally thousands of nights out at some of the world's best clubs and i put those two Underworld concerts in my top 5 concert/club experience - up there with the first lollapaloozaw/ jane's. To keep things topical someone passed me a joint at the central park show (a stranger- i hadn't had that happen in a while- in high school i was so broke i would wander around the arena waiting/hoping people would pass something my way- back then it worked 99% of the time- i don't see much of that anymore, sad) i didn't get paranoid off that pot either:)i had also munched a ton of shrooms so the herb just enhanced everything

[Narkotikon]

I LOVE hydro and oxy, but need weed (and a drink or two) to kick that shit in nicely. there's an addiction term for this (needing a combination of drugs to get off right), not co-dependent, but something similar.



Poly-drug user OR synergism come to mind. Perhaps one of those? Poly-drug abuse just basically applies to people who will do more than one thing, or have more than one DOC, or who just want to get high and don't care about what it is.

Synergism implies that you're mixing the drugs to get a different effect than you would from either one alone. The classic example is cocaethylene. Doing coke AND drinking alcohol will create a metabolite called cocaethylene that is more potent than regular cocaine, and also has a longer half-life, thereby prolonging the coke high. Lot's of coke addicts drink when they do coke and don't know why. That's why.

[Mayo]

... Lot's of coke addicts drink when they do coke and don't know why. That's why.

perhaps a small percentage, I wouldn't say lots. Pretty sure most of them drink for the same reasons many people drink.
they just like doing coke too. IOW, they just like to drink when they party, and like to do coke also.
not because it makes the speedy buzz more potent or anything like that.

[Narkotikon]

perhaps a small percentage, I wouldn't say lots. Pretty sure most of them drink for the same reasons many people drink.
they just like doing coke too. IOW, they just like to drink when they party, and like to do coke also.
not because it makes the speedy buzz more potent or anything like that.

Well, yeah, I mean, I do think they probably drink for social reasons, or because they're alcoholics too, not necessarily because of that. But that's what ultimately happens. I don't think a lot of coke addicts know that. I always did it for the prolongation of the coke high, but then again I get off on learning this kind of thing, so I always tried to get more bang for my buck.

Edit: I do think though that when they drink and do coke, they'd probably notice something "better" or "different." But, I doubt all would make the connection that it's because of the alcohol. So, yeah, most probably don't know why they do it.

[SeVeN]

Nah I agree lots of people drink when on coke or do coke when they drink to kinda "balance out" ^^

[chopstix]

Fuck I drink on coke just to keep myself sane.

Poly-drug user OR synergism

I was thinking poly-dependent or poly-(ab)user.. Poly-sumthing..

[resorcinol]

I'd really love to try a synthetic CB1 agonist that is an alkaloid like win55 212,2.

These isolated (single drug) CB1 agonists are almost definitely a cleaner buzz than weed, for a few reasons: less metabolic competition between active and inactive cannabinoids, less interference of other cannabinoids besides THC in the psychoactive effect, and synthetic alkaloid CB1 agonists are very water solube in salt form and don't dissolve in the body's fatty tissue like THC does.

The fact that the alkaloids clear the system quicker than THC ever could (because THC lingers in fat tissue and is continously present in minute concentrations for an extended perioid), for the poor people that DO have a horrible panic ridded wigged out experience, reduce the post-experience dysphoria (and IME, this phenomenon is real... it only happens to me if I go over the line smoking too much and wig out, but if I do get major paranoia and anxiety, the three days after I'm INCREDIBLY dysphoric). Think alkaloid CB1 agonists may be less likely to cause this after-effect. It would also reduce "burnout" type feelings.

The people on bluelight that have tried win 55 compound say it produces a more sativa like high, but with much less anxiety and paranoia than a sativa high from MJ. This is interesting, since isolate THC produces paranoia more easily like a sativa strain of MJ than indica strains where CBD seems to reduce paranoia. It's interesting because it seems strange that win 55 wouldn't be similar to THC and be very likely to induce paranoia without CBD's presence (and admittedly BL trip reports arent's scientific, but it's all we've got to go on atm).

Maybe it has something to do with the fact that THC is a CB1 PARTIAL agonist while win 55 is a FULL agonist at the CB1 receptor. Perhaps weed really is the bupe of cannabinoids despite being the prototypical cannabinoid drug. The reviews for win 55 are glowing across the board pretty much.

Furthermore, we all know bupe has its "oddities" beyond having a ceiling effect.... due to its partial agonism of mu. Partial agonism introduces more than just a ceiling effect I think -- I just can't pinpoint exactly why... but bupe users have even introduced the cliche phrase that "bupe is a weird drug" (it's been repeated a fuck ton of times here and on other drug boards)... things that can't be ascribed to a ceiling effect only. Maybe THC is more anxiety provoking than selective full CB1 agonists are (they're all synthetic since THC is the only CB1 agonist (it's a PARTIAL though) one known to be produced naturally. some are SEMI-synthetic though, since they resemble the structure of THC. others, and win 55 is one of them, are fully synthetic. they can be described just like the opioid class is (plant based/natural, semi-synthetic, and fully synthetic)).

[nick]

perhaps a small percentage, I wouldn't say lots. Pretty sure most of them drink for the same reasons many people drink.
they just like doing coke too. IOW, they just like to drink when they party, and like to do coke also.
not because it makes the speedy buzz more potent or anything like that.

Ummm,I'm not sure about that,man.If someone using C and booze knows it or not that combination has one hell of a synergy.In fact it creates a whole new drug Coca ethyl.Hell,it used to be sold in this form in coca wines and tonics-used to be Winston Churchill's fav.

I used to have a client who's doc was coke and cheap perfume(with one hell of an alcohol content) -honestly.

[Mayo]

Ummm,I'm not sure about that,man.If someone using C and booze knows it or not that combination has one hell of a synergy.In fact it creates a whole new drug Coca ethyl.Hell,it used to be sold in this form in coca wines and tonics-used to be Winston Churchill's fav.
I used to have a client who's doc was coke and cheap perfume(with one hell of an alcohol content) -honestly.

Well I can't speak as to why 'coke addicts' drink. Many tho probably to take the edge off the speedy effect, not increase it.

From personal experience, I used coke because of the physical sensations, not mental.
Like the numbness and the taste. I didn't like the speedy effect much, and never used it regularly.
I only used it while partying, and everyone was always drinking too, just because well, it was a party, you know?
But alcohol is almost always present at parties, so the drinking and coke using is no surprise to me,
independent of producing a more potent compound.

Methylphenidate and booze also produces ethylphenidate which is much more potent, and toxic,
than the parent compound, similar to the coke thing. Which is why I specifically never drank when taking ritalin.

[Mayo]

Partial agonism introduces more than just a ceiling effect I think -- I just can't pinpoint exactly why... but bupe users have even introduced the cliche phrase that "bupe is a weird drug" (it's been repeated a fuck ton of times here and on other drug boards)... things that can't be ascribed to a ceiling effect only.


Yes people say its a weird drug. Did they say in what sense?
So high affinity, weak intensity (intrinsic activity), resulting in its blocking effect, lack of euphoria, and ceiling effect.

From what I remember the 'weirdness' was its lack of continuing efficacy? Is that right?
This happens with many people, tho not some, and with some psychoactive drugs, but not many.
The 'poopout' effect resulting from continual use.
Possibly caused by receptor deregulation, and/or less number of receptors.

On the other hand, some drugs simply become ineffective when used on an on-again off-again basis.
Is this likely due to a change in conformation, and does it occur more with drugs having high affinity?
The strong binding could cause a permanent alteration in conformation I suppose.
I really haven't looked into this at all in quite a while.

I think I read that those who use bupe on-again off-again are the ones lamenting its weirdness,
rather than those who use it on a continual basis.
Description of the weirdness and regularity of bupe use - a starting point for investigating causality.


This is not unrealted to weed. I never experienced the bad anxiety when using weed daily.
It only began after I ended years of continual use, abstained for a few years, and then started smoking again.
Now, every time I smoke I get the anxiety/paranoia. I didn't push through to see if it would go away with daily use,
nor did I seek out different strains to see if that was the cause. I just assumed it was a change in circumstances,
both environmental and neurological.

[SHELLEY]

Welcome back fellow stoner. Even if some devine being came down and said, "You can only use one substance ever again and you have to give up all others," I would choose weed.

me too! absolutely! :)
i went through different stages in my life
where i had different docs: crack, coke, heroin, meth, etc
and of course i've experimented with (and absolutely HATED) hallucinogens and ketamine
but before all the other drugs began,
throughout my addiction to the other drugs,
and after i quit all the other drugs,
i've always, and i mean ALWAYS, smoked weed
i suppose that means that mj is my REAL drug of choice, right? :D

[resorcinol]

I just had some thoughts and far flung theories about weed anxiety (and probably am way off on this in reality), and made a connection between partial agonists and how they differ in their interaction with their receptors -- and made a connection between buperenorphine.

The thought I had was that maybe -- like bupe can cause huge tolerance increases if the dose is high enough despite no euphoria and even inadequate control of cravings -- simply because its allosteric interaction with mu is so strong affinity wise -- that maybe people who smoke weed constantly eventually see increasing anxiety and paranoia develop due to d9-THC having a "self limiting" ability to intoxicate without unpleasant side effects once tolerance to the drug reaches the ceiling imposed by partial agonism. The side effects of THC begin to overwhelm the positive effects of the cannabinoid high when this ceiling is approached.

That still doesn't account for one off uses of WIN 55 212,2 seeming to cause less paranoia than one off uses of THC in NON TOLERANT people... BUT perhaps it DOES account for it if a non tolerant person smokes TOO MUCH and reaches THC blood concentrations that start to express exaggerate the negative side effects which has a detrimental effect on the high (the side effects that are negative... possibly overpowering the positive feelings because d9-THC starts to loose efficacy at producing greater positive effects of CB1 activation once one runs into the doses / concentrations where it becomes apparent that THC is really only a partial agonist.

One thing that it being a partial agonist DOES account for quite possibly is the inability of heavy daily long term MJ users to achieve much of a high at all from the plant. Perhaps a full agonist like the WIN 55 compound could bring back the high for these folks. Of course, if those folks turned to WIN 55 weed would become even MORE useless, since a full agonist like WIN 55 can be dosage increased indefinitely to compensate for tolerance being a full agonist of CB1 (just like opioid full agonists can be increased indefinitely to account for tolerance). Weed, if somebody already heavily tolerant to it switched to a full CB1 agonist like WIN 55 or one of the several other synthetic and semi-synthtic full CB1 agonists on the RC market to recapture the high, would raise tolerance higher than they could raise it with MJ... and MJ would become just like bupe to them. No high, just not quite sober either.

I'm sure there are other factors as to why MJ / d9-THC causes more paranoia issues than WIN 55 -- some I mentioned before were:
*longer elimination half life for d9THC than for WIN 55 (I think this is true, but somebody might have to check up on that one because I don't remember for sure)... paranoia and burnout may be less likely to set in
*storage of THC in fatty tissue for LONG periods of time in chronic heavy MJ users... which may manifest paranoia eventually due to CONSTANT exposure to the drug even when not smoking due to this storage bank built up in the body fat. Where WIN 55 or other synthetic CB1 agonist alkaloidal drugs are not stored in fat and clear in a more typical manner... more akin to the way most opioids clear the system

^
This would be a HUGE thing for passing piss tests for people that want a cannabinoid high. THC as we all know because of the fatty tissue storage keeps a constant low level of the drug and its metabolites in the bloodstream for extended periods... making weed one of the most annoying drugs when it comes to piss tests. WIN 55 would clear totally within 2 or 3 days more like cocaine and short acting opioids. ATM they don't test for this obscure compound at the time that currently isn't illegal and wouldn't fall under the analog act due to being so obscure -- I'm speaking more hypothetically... like in the event WIN 55 or an alkaloid CB1 agonist like it took off and became a street drug alternative to weed (and would then be added to tests).

I don't really see that happening though. Most MJ users I think like the smoking ritual as much as the high. These synthetic alkaloid cannabinoids are "powder drugs" that, while they're as benign as weed in reality, would turn a lot of potheads off just becuase it's a powder and white powders are associated with hard drugs. Even IV WIN 55 citrate wouldn't be a "hard drug" IMO since it still has the low potential for psychic addiction, nonexistant potential for physical addiction, and benign effects on the body / extremely low OD risk just like weed. But the white powder thing wouldn't appeal to a lot of "pot only" drug users I think, because many of them (not all, but it's a fair assumption that a large portion feel this way) are all about weed being natural, and WIN 55 is a synthetic single compound that "looks" like an ensnaring white powder drug.

[hovadagod]

I believe the paranoia is dependent on the strain...although some people don't get paranoid from any strain. Sour diesel feels like opiates. No paranoia.

[Narkotikon]

I've just realized how useless weed is for me. 1.) I can't smoke it without 100% knowing for sure I won't get paranoid. 2.) I can't smoke it because of the smell, with me living at home and all. I'm pretty sure my mom doesn't know what weed smells like. I mean, I was never a huge pot smoker, so I've never really smoked it when I was around her, so she never caught on to what the smell was. But, I don't want to risk it.

I thought of smoking part of one of those joints in the garage last night after she went to bed, but decided against it. I would have used Febreeze or an air freshener, but I was still thinking it would be noticeable. Plus, I didn't want to risk getting paranoid again.

I was thinking about baking a batch of brownies, and setting a small portion of the batter aside and putting some weed in there and just baking that "weed batter" in a separate, smaller dish. That wouldn't be so odd, because I do cook and bake here sometimes.

My questions are:

1. Is putting the weed in brownies less likely to cause paranoia? I've never done it. I've always heard though that when you ingest the weed orally it's more of a body high than a head high, and less anxiety / paranoia prone. Is that true?

2. How do you make brownies? How much pot should I put into that smaller pan of batter? I was thinking half a joint. I have three joints left, and one roach. Maybe only a third of a joint would be enough. Also, do you just put the weed directly into the batter, or do you have to do that "weed butter" thing where you let the weed cook in melted butter, then add the butter to the batter? I have no idea what I'm doing.

This sounds like such a luxury problem. I should be thankful that I have a little bit of pot, but damn, it's so fucking useless for my purposes. It's not like a bump or a pill or a line or whatever. There's no smell with that. And, I know how pills will react with me. Weed is such a gamble as to how I'll react to it.

[jack-a-roe]

Okay, so I did get weed tonight. I did not get anymore Xanax though. Couldn't get an opportunity. But this isn't about that. And yes, I know a trip report is clique and a waste of server space, but I think my perspective might be unique because I've not smoked up since 2005, and because I'm prone to paranoia (more on that to come).

Okay, so this guy that my sister sees got a quarter of an ounce. The weight looked right to me, from what I remember, but I suppose that could be wrong. He got half, and I got half. My half is still enough to make about 3 joints. Same for his. Then, we had two earlier, so that would be a total of 8 joints out of this bag. We shared the two joints (I took one roach), and then divided the rest.

Now, normally, I can (and usually do) get really fucking paranoid on pot. And I've always assumed that it's because I'm just really sensitive to it, and have an abnormally low tolerance. BUT, this time I'm not paranoid. Then, I got to thinking that maybe it's just because all the other pot I've had has been kick-ass weed, and this stuff is just mediocre, and that's the difference. I had never thought of that before because I just always assumed it was decent weed, and not great stuff. Or, it could have been that this guy rolled itsy bitsy thing vegetarian joints, and I"m used to big phat hamburger joints. So, maybe it's not that the pot is bad, but that I just always smoked way too much before, and was just too stoned.

So, I'm not sure of the reason.

Cigarette Break..............

Okay, so, the point is that my theory now is that I don't get naturally paranoid on ALL pot, but that it's either a different strain that doesn't produce as much paranoia, or it's because it's mediocre pot and just not strong enough to produce paranoia in me, or that it's because the joints I smoked were smaller, and not enough to produce a sense of paranoia.

And I swear this was supposed to end with one major point, and not three, but god, I'm stoned, so who in the hell knows what that grand epiphany was.

But, I'm listening to Orbital, and it sounds SO FUCKING GOOD. I love music on pot.

OH, I remember. I was going to be paranoid, because at first this guy was like "let's clean yoru sister's house." And, I was nice at first, all giggly, and said ok, because I wanted to say thank you to my sister, because she's the one who funded this, and probably the only reason I ended up with half, and not less, or none at all. But, anyway, that was making me paranoid. Then, my sister, because it was later and she wanted to go to bed, said no, it's too late to clean. Then I got on here and started listening to music.

So, the theory is that I'm not paranoid because I think it's that I have to be in the right setting doing what I want to do, like listen to music and be on here, as opposed to doing something someone else wants me to do, or playing into their notions of how I should be. In short, I feel like the paranoia is coming from me trying to please others / be something I don't want to be. Now that the cleaner is off my back, I can relax. I guess all the other times before I was smoking with the wrong crowd / or just uncomfortable with myself. Maybe it's because I don't really repsect him and I don't care what he thinks of me. I don't know. I just thought this was interesting.

And I highly suggest Orbital's Moebius if you're stoned. GOOD SHIT!

Narko, I have a similar but different (oxymoron i know) story about herb. I live in Northern Cali where the bud is always dank, sticky and smelly. For years I was an all day-every day stoner. I mean hardcore wake-n-bake and then smoke all day. This was chronic shit too, organic indoor/outdoor from friends in Mendocino and Humbolt County, some of the best pot in the world. I started to sell it and before long I was flipping 2-4 lbs. a week! Thats moving some decent weight. I'm married and have kids. One of my main customers went down. Cops said they had him under surveilence for 2 months so they must have seen me. Everytime I smoked after that I got super paranoid, that was almost five years ago and I still cant enjoy weed, and I'm surrounded by it:mad: So I just use other things...;)

[LeChuck]

Different strains of weed have very different highs to them due to the variance in ratio between the cannabinoids present. The main strains are sativas and indicas, sativas tending to have a high THC:CBD ratio, indicas having a lower THC:CBD ratio. Most strains are hybrid sativa/indicas, but if you've ever smoked well-grown pure sativa/indicas it's easy to tell them apart. Sativas tend to have a more energetic, psychedelic, and possibly even hallucinogenic high, whereas indicas are a more body high, couch-lock "stoned" feeling.

Personally, I vastly prefer indicas, as I tend to get extremely anxious smoking sativas.

My guess is you either had some shitty weed or an indica.

Anyone who gets anxious/paranoid smoking, just take some xanax before you smoke next time. Works for me anyway.

I've just realized how useless weed is for me. 1.) I can't smoke it without 100% knowing for sure I won't get paranoid. 2.) I can't smoke it because of the smell, with me living at home and all. I'm pretty sure my mom doesn't know what weed smells like. I mean, I was never a huge pot smoker, so I've never really smoked it when I was around her, so she never caught on to what the smell was. But, I don't want to risk it.
You should get a vaporizer. They produce virtually no smell and are more efficient and safer anyway.

I was thinking about baking a batch of brownies, and setting a small portion of the batter aside and putting some weed in there and just baking that "weed batter" in a separate, smaller dish. That wouldn't be so odd, because I do cook and bake here sometimes.

My questions are:

1. Is putting the weed in brownies less likely to cause paranoia? I've never done it. I've always heard though that when you ingest the weed orally it's more of a body high than a head high, and less anxiety / paranoia prone. Is that true?
Not really...in my experience the high from brownies can potentially be much more euphoric, but it can also be much worse as it lasts way, way longer, and it's virtually impossible to dose correctly. Several times I've eaten brownies I ended up tripping balls (and yes, you absolutely can trip on weed if it is good) and being high all day and much of the next day. It takes so long for the high to set in that it's really tempting to eat more brownies and you decide the weed is weak so you eat some more and then suddenly you're a lot higher than you wanted to be. If you can get the dose right I think it's better than smoking, and you might be less anxious, but again, it's tricky.

. How do you make brownies? How much pot should I put into that smaller pan of batter? I was thinking half a joint. I have three joints left, and one roach. Maybe only a third of a joint would be enough. Also, do you just put the weed directly into the batter, or do you have to do that "weed butter" thing where you let the weed cook in melted butter, then add the butter to the batter? I have no idea what I'm doing.
Best way would be to make cannabutter, but unless you cook with weed a lot it doesn't really matter. Easiest way is just to mix the weed directly with the batter. Use eggs and make sure you use lots of butter since the cannabinoids are fat-soluble. How much you should use depends how good the weed is and how many brownies you want to eat. If it's a decent sized batch use 1/4 oz. If it's a smaller batch or it's very potent weed use 1/8 oz. Dose is probably 1 - 3 brownies, depending. It's hard to get it right.

If you don't have a lot of pot and just want to try eating it there are other ways to cook it. You can scramble it with eggs and it works pretty well, though it tastes weird. Maybe add some butter with the eggs. If you can stomach poppy tea you shouldn't have any trouble eating weed though.

[Cherry's Jubilee]

Am I alone in my hate for weed? I cannot stand it. One time when I was ridiculously messed up on crack someone loaded my pipe with weed in order to make me come down (without my knowledge until I inhaled) Oh lord, was I angry. Weed just stops me dead in my tracks. I cannot think, I cannot speak, I can barely breathe. It's a nightmare. I did use it regularly at one point in my life as a cure for insomnia. I would take a toke and fall out for the night. A small nugget of weed would last me a month. I've never bought it, never craved it, and seriously doubt I will ever smoke it again. I just don't understand how people can smoke all day and function. I'm actually envious!


my thoughts exactly! i could've written this word for word if anyone had ever hijacked my crack pipe. i am practically catatonic on that shit. one little hit of pot fucks me up a hundred times more than any other drug or combination of drugs i've ever done...and there are lots and lots of those...

i completely and utterly lose my entire grasp on the world. everything is confusing, i can't talk, i can't think, i'm terrified, i can't get away, and it lasts FOREVER. i swear i am still fucked up 24 hours after one hit of a joint! sad, i know.

it was like that from the very first time i tried it, which sucks because my stupid ass did it anyway because my friends did and i thought i just wasn't cool enough to understand what was fun about it and when i got cooler i would think it was fun. so of course i decided to suffer through the misery of continuing to smoke it, waiting for it to get fun, never considering that maybe, just maybe, it affected me differently than it did them and no amount of coolness would alter that even though most nights someone ended up talking me down out of a tree that i had been wordlessly clinging to for hours or doing the "Search for CJ" when they were ready to leave, splitting up to check closets and under beds til they found where i was huddled sobbing and patiently explain that no, they weren't kidnapping me and yes, it really was them in their bodies, not bad guys... :rolleyes:

yes, i am so stupid that i deliberately and single-handedly traumatized MYSELF and made high school even more terrifying than it would have been anyway because i was waiting to get cool so i would like weed. i know. i KNOW.

fortunately after about a year of that my friends had enough and i was never, ever allowed to smoke pot ever again. but like BDG, i am VERY envious of those that enjoy it and can smoke it and function. i wish i loved it. i could taper off opiates and switch to pot and still be able to have the relief of getting high and feeling good whenever i wanted without becoming physically dependent or having to hide my socially unacceptable, looked-down-upon, taboo drug use. and it's cheap and accessible and doesn't typically destroy relationships or jobs...

wow thanks to whoever reads that whole post. apparently i have some pretty significant, deep-seated, emotionally-charged feelings related my inability to smoke pot.

3311

[LeChuck]

I too am jealous of people who can smoke weed every day. I can't function high, at all. I can barely move if I have more than a couple hits. I can't think, at all, even with one hit. I think it's just impossible to be a pothead in my chosen profession and actually do anything.

I used to smoke every day anyway, and somehow I kept making A's in all my classes. I guess they were still easy at that point. Now weed makes me edgy in small amounts and terrified / paralyzed in larger amounts, unless I take a large amount of Xanax, which just fucks me up even more. It's a nice feeling but all I can do is lie there on the couch watching TV until I pass out a couple hours later. :rolleyes:

[resorcinol]

I believe the paranoia is dependent on the strain...although some people don't get paranoid from any strain. Sour diesel feels like opiates. No paranoia.

Addendum a the TOP of this post: the last paragraph is interesting. If you don't want to read the long post (understandable) but are waffling on whether to read this, read the last paragraph. It's about how a yet to be identified compound in tobacco smoke is an irreversible inhibitor of MAO-B although it's not too potent (but potent enough to matter... it's within the range of MAO-B inhibition caused by Rx MAOIs) and is a very weak reversible inhibitor of MAO-A. More info down there

You really think weed feels like opioids?

I'll admit they have some things in common: changes in thought pattern, introspection enhancement, desire to relax

But they've a different feel.

Opioids are FAR, FAR more euphoric. Only stimulants compete with opioids for euphoric intensity for me. I guess for me euphoria is hedonistic enjoyment though.

Maybe for some people euphoria is the very unique and often amusing pot makes your mind wander to. Kinda like indirect euphoria. Pot DOES have a touch of intrinsic euphoria though by increasing dopamine release in the mesolimbic pathway (by the same mechanism of action that opioids do it too, just in a much weaker fashion since CB1 receptors are found low concentration in the VTA -- the area of the brain where GABA-B receptor activation inhibits downstream dopamine release in the NAc). Opioids bind mu, which is on presynaptic neurons in the VTA that releases GABA -- normally this GABA is released in sufficient quantities that sufficient GABA(B) receptors on the post-synaptic dopamine neuron are activated strongly enough to keep dopamine release in check... ie keep you sober. Opioids dramatically reduce the release of GABA from these neurons in the VTA, which results in much less stimulation of the inhibitory GABA(B) receptor on the post-synaptic dopamine neuron leading to the VTA. That dopamine neuron then fires action potentials MUCH more quickly than normally, reducing a highly increased level of dopamine into the NAc. It's a biochemical cascade. I only brought it up because weed / agonism of CB1 receptors also does this to a degree. The reason the euphoria doesn't approach that of opioids is simply because there are less CB1 receptors BY FAR in the VTA... there are some CB1 receptors there which could account and probably does account for the mood lift, but there are enormous amounts of mu receptors there -- no competition.

So actually I guess I can see the point in you comment. They're both subtle-ish highs (minus injected IV strong opioids during the rush).... a very background feeling that would be unlikely to make day to day tasks / decisions impaired too much. Drugs that act on neuromodulatory neurotransmitter systems are likely to also be less neurotoxic than blunt force instruments like amphetamines that go straight to the NAc and force dopamine into the synapse. Both the endocannabinoid system and the endogenous opioid system are neuromodulatory neurotransmitter systems.

Knowledge is more limited, sadly, on the neuromodulatory neurotransmitter and their receptors (the system is the transmitter(s), the receptor(s), and the pathways in the brain involved). Most of the psych research for the past century has focused extremely intensely on just three damn neurotransmitters.... serotonin, norephinephrine, and dopamine. Especially serotonin.... it's all serotonin now. Acetylcholine got a lil research after it was found that nicotine in cigs was a nicotinic acetylcholine receptor agonist (it was named NICOTINIC after that fact actually). Central agonism of N-acetylcholine receptors seems to somehow cause downstream dopamine release. Keep in mind that anticholinergics like diphenhydramine and atropine don't block nicotine's effect... most "anticholinergics" are antagonists of MUSCARINIC, M-acetylcholine receptors... which have a different function than N-acetylcholine receptors.

Nicotine also doesn't seem to be the only agent that makes tobacco hard to quit. It's been proven conclusively that SOMETHING in tobacco smoke is a fairly potent (not as potent as selegiline... maybe a day of smoking going through a pack packs the MAO-B inhibitor punch of about 1/5 the potency of selegiline. The yet to be identified compound appears to be an irreversible inhibitor of MAO-B, too... not reversible. Luckily loosing a good portion of functional MAO-B is not the super big deal that loosing most functional MAO-A is when it comes too food, else ciggy smokers would be in trouble... or tobacco would have never took off. MAO-A is also inhibited, but much more weakly (I think I read the yet unidentified agent in tobacco smoke doing this inhibits MAO-A at around 1/15 the potency with which it inhibits MAO-B. The weak MAO-A inhibition from this mystery compound in tobacco is also reversible... which is a VERY good thing.


*Man, I'm sorry guys. My stim dose got bumped up a little, and I was actually Rx'd another stim (phentermine) to counteract weight gain from an antidepressant. Since I'm just starting the higher dose I'm a little talkative.

[LeChuck]

I don't know resorcinol, I have had some incredibly euphoric experiences on weed, and I don't just mean psychologically euphoric, experience-enhancing, enlightening thoughts, or anything like that (although each of these can be euphoric as well), but just pure physical euphoria. When I started smoking I never ever got paranoid, no matter how much I smoked / vaporized / ate, and I'd frequently consume so much pot that my entire body would feel like it was vibrating in this warm and benevolent way, and I just felt perfectly content and full of bliss and nothing could go wrong. And this feeling would last for hours until I finally drifted off into sleep. I can't get that feeling anymore on weed, not even close, and some people never can. I can't really compare it to any other drug.

My point is I don't think you can really quantify euphoria and say "opiates are the most euphoric drug." For many people this is true, but some people absolutely hate opiates who greatly enjoy other drugs. I do think opiates are more consistently euphoric than weed (by far), and I tend to think the euphoria experienced on weed is far more subjective, dependent on all the circumstances of its intake rather than a purely chemical rush, but you can't discount weed as a euphoria-inducing agent. It has very different effects on different people. I feel very little euphoria with weed these days, unless I take a lot of xanax with it, but still my best drug experiences were all with weed.

[hovadagod]

The bottom line is some strains feel different than others depending on alkaloid ratio. Eating weed makes you more paranoid if you need to make a rule but I am sure there are plenty of exceptions.

Interesting about tobacco addiction. I find that if anything leads to paranoia it would be indica rather than sativa but I don't know. I bet that weed that is well flushed before harvest leads to less paranoia. Basically, weed distracts you from the emotional pain in your life and allows one to put themselves in a trance while watching TV or reading or whatever. With weed I think you need the TV or book to get the euphoria while with opi's you don't need shit.

[pain-pateint]

Mates ---

Cannabinoids fascinate me, and it gets even more insteresting when you remember our bodies makes endocannaibnoids -- called anandamide, if I recall. My friend/colleague Ethan Russo has a good book reviewing cannabinoid pharmacology....some clinicians doing medical mj work say it's the "Bible" of cannabis pharmacology.....http://www.amazon.com/Cannabis-Cannabinoids-Pharmacology-Toxicology-Therapeutic/dp/0789015072/ref=sr_1_9?ie=UTF8&s=books&qid=1232644080&sr=1-9.

Best,

M