resorcinol
12-13-2008, 04:08 AM
These are a class of fully synthetic opioids that sound very promising in the euphoria department. The few sources where I've seen them mentioned all claim that the class has a "high abuse potential" and some say that's part of the reason why they never became pharmaceutical products for pain relief in humans.
I know at least one is used as a painkiller for pets in Japan under the brand name Othon (chemical name dimethylthiambutene). I'm sure there are occasional incidences of othon abuse in Japan, probably by veterinarians, but since opioids in general aren't so popular there, and drug laws are so strict there, it's not surprising that we don't see many reports of somebody claiming to have tried the drug. Japanese hard drug users overwhelmingly prefer amphetamine, methamphetamine, and other prescription stimulants / speed over other drugs, and benzodiazepines come in second place (nimetazepam, flutoprazepam, and temazepam especially). I'd imagine the japanese hard drug users that do use opioids mostly just use heroin or perhaps occasionally prescribed opioid painkillers meant for use in humans, and probably not so much a somewhat rare veterinary opioid.
However, this assertion that the class is very euphoric has to have originated from a study on abuse liability at some point, I just haven't found it.
None of these opioids in this class are super potent or anything (that's not necessarily a bad thing, in the scheme of things, one of the most popular opioids in the world -- heroin -- isn't really that potent... when you compare it to stuff like fentanyl analogs. as long as it's potent ENOUGH and isn't a prodrug and is a full agonist, meaning no ceiling effect, potency doesn't matter very much. lower potency just means you take more on a mg basis per dose). They're all around the same potency as morphine. I believe ethylmethylthiambutene is the most potent derivative from this class discovered so far, and it's 1.2x morphine's potency as an agonist of mu receptors.
Here's ethylmethylthiambutene's structure:
http://upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Ethylmethylthiambutene_structure.svg/140px-Ethylmethylthiambutene_structure.svg.png
I find them interesting simply because they're so obscure, but unlike some other obscure opioids, it's POSSIBLE that a determined person could acquire and try some (particularly dimethylthiambutene / Othon) since it's marketed commercially in Japan. It wouldn't be easy by any means, especially with the strictness of Japan's drug laws -- overall not worth it with the abundance of already incredibly fun opioids we already have. It's just a fantasy I guess.
And I'm not sure I've seen this class mentioned here before. They've got a novel structure; thiophene rings serve as the aromatic rings, which is unique for opioids. You can kinda see the resemblance to open chain opioids, although sources suggest these drugs would be really fun unlike methadone, the most pervasive open chain structured opioid, and they of course have a much shorter half life than methadone. Their euphoria may possibly resemble dipipanone's, but that's really just speculation.
I know at least one is used as a painkiller for pets in Japan under the brand name Othon (chemical name dimethylthiambutene). I'm sure there are occasional incidences of othon abuse in Japan, probably by veterinarians, but since opioids in general aren't so popular there, and drug laws are so strict there, it's not surprising that we don't see many reports of somebody claiming to have tried the drug. Japanese hard drug users overwhelmingly prefer amphetamine, methamphetamine, and other prescription stimulants / speed over other drugs, and benzodiazepines come in second place (nimetazepam, flutoprazepam, and temazepam especially). I'd imagine the japanese hard drug users that do use opioids mostly just use heroin or perhaps occasionally prescribed opioid painkillers meant for use in humans, and probably not so much a somewhat rare veterinary opioid.
However, this assertion that the class is very euphoric has to have originated from a study on abuse liability at some point, I just haven't found it.
None of these opioids in this class are super potent or anything (that's not necessarily a bad thing, in the scheme of things, one of the most popular opioids in the world -- heroin -- isn't really that potent... when you compare it to stuff like fentanyl analogs. as long as it's potent ENOUGH and isn't a prodrug and is a full agonist, meaning no ceiling effect, potency doesn't matter very much. lower potency just means you take more on a mg basis per dose). They're all around the same potency as morphine. I believe ethylmethylthiambutene is the most potent derivative from this class discovered so far, and it's 1.2x morphine's potency as an agonist of mu receptors.
Here's ethylmethylthiambutene's structure:
http://upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Ethylmethylthiambutene_structure.svg/140px-Ethylmethylthiambutene_structure.svg.png
I find them interesting simply because they're so obscure, but unlike some other obscure opioids, it's POSSIBLE that a determined person could acquire and try some (particularly dimethylthiambutene / Othon) since it's marketed commercially in Japan. It wouldn't be easy by any means, especially with the strictness of Japan's drug laws -- overall not worth it with the abundance of already incredibly fun opioids we already have. It's just a fantasy I guess.
And I'm not sure I've seen this class mentioned here before. They've got a novel structure; thiophene rings serve as the aromatic rings, which is unique for opioids. You can kinda see the resemblance to open chain opioids, although sources suggest these drugs would be really fun unlike methadone, the most pervasive open chain structured opioid, and they of course have a much shorter half life than methadone. Their euphoria may possibly resemble dipipanone's, but that's really just speculation.