DXM to alleviate WD's

[Phluck]

I've heard a few references to the use of small doses of DXM to reduce withdrawal symptoms. I've got a few DXM containing products around the house, but they all seem to contain pseudoephedrine which I can't imagine making me feel good at all. One guy said it worked "suprisingly well".

Anyone got any experience with this?

[chemboy7]

DXM (dextromethorphan) isn't truely an opaite, just opaite-like... and that is still a generalization. I am unsure if it would be of any help with withdrawls, although I doubt it. If I remember correctly DXM is active on the Kappa receptors in the brain whereas opoid agonist are active mainly in the Mu receptor. If your freind is looking for an OTC concoction to ease his withdrawls I would suggest Loperamide (Immodium) as this is an opaite, albeit not recreational in the least, with a long half life in the body and a great reputation for putting gange gorman in his place.

[malefiacrum]

I read a post on here last week, and it mentioned to try a spoonfull of DM syrop and a glass of grapefruit juice before a nice cuppa tea, and tried it; it worked well, I've heard a lot of people talk about this, just never tried it myself, however, because I skipped my moring dose to try this new method, I noticed when I took the DM that some of my wds did seem to subside. Now whether this was in and antipation of my tea, or if it had something to do with the DM not too sure...just thought I'd mention it related to what is posted above....

[malefiacrum]

sorry, on another note, I found some of these DM breath strips, like when you look on the package the medicinal ingredients is DM, and they were like 5 bucks for 12, 15mg in each....just thought that was funny

[Opiyum]

DXM (dextromethorphan) isn't truely an opaite, just opaite-like... and that is still a generalization. I am unsure if it would be of any help with withdrawls, although I doubt it. If I remember correctly DXM is active on the Kappa receptors in the brain whereas opoid agonist are active mainly in the Mu receptor. If your freind is looking for an OTC concoction to ease his withdrawls I would suggest Loperamide (Immodium) as this is an opaite, albeit not recreational in the least, with a long half life in the body and a great reputation for putting gange gorman in his place.

Hey d'are Chemboy...I got the Loper we told me about before but I got both the brand name and the Giant Eagle version. Same active ingredients 48 2 mg Loperimide pills.
Anybody have experience with Brand name being significantly better?
Haven't needed either yet but my bank account is gonna get the best of me soon enough.

[chemboy7]

Hey d'are Chemboy...I got the Loper we told me about before but I got both the brand name and the Giant Eagle version. Same active ingredients 48 2 mg Loperimide pills.
Anybody have experience with Brand name being significantly better?
Haven't needed either yet but my bank account is gonna get the best of me soon enough.


Naw, brand name/generic... same difference, different price. But you should have got the liquid form of the drug and not the pills if you are using it for WD (which I know you are) because not only does it absorb into your system alot faster it is a bad idea to have a stomach full of pills (gonna need something like 8-10 of those 2mg atleast) when you are sick. If you must use the pills I suggest that you crush the little bastards up, throw the powder in a zig zag or tiny piece of toliet paper, and down it (Parachuting) so you can absorb it better with less chance of just throwing it up before it can be of much help.

[Phluck]

DXM (dextromethorphan) isn't truely an opaite, just opaite-like... and that is still a generalization. I am unsure if it would be of any help with withdrawls, although I doubt it. If I remember correctly DXM is active on the Kappa receptors in the brain whereas opoid agonist are active mainly in the Mu receptor. If your freind is looking for an OTC concoction to ease his withdrawls I would suggest Loperamide (Immodium) as this is an opaite, albeit not recreational in the least, with a long half life in the body and a great reputation for putting gange gorman in his place.

Yeah, I know it's not an opiate, but I'm going by several accounts on the internet. I've heard someone say it worked "suprisingly well" to make him feel better, in small doses, and a mention somewhere else. I was just curious if anyone had actually tried it.

Does Immodium actually work? I've heard people claim it does, but others have said that this is all placebo effect.

[Opiyum]

Yeah, I know it's not an opiate, but I'm going by several accounts on the internet. I've heard someone say it worked "suprisingly well" to make him feel better, in small doses, and a mention somewhere else. I was just curious if anyone had actually tried it.

Does Immodium actually work? I've heard people claim it does, but others have said that this is all placebo effect.

I will be trying it in no less than a week and all I can say is alot of people hear endorsed it and I believe them. If it is a placebo effect and you just ruined it for me I'll be pissed. I was so confident until I heared this....maybe if I do a forty and a joint that will relieve the doubt... ... ...

[chemboy7]

Yeah, I know it's not an opiate, but I'm going by several accounts on the internet. I've heard someone say it worked "suprisingly well" to make him feel better, in small doses, and a mention somewhere else. I was just curious if anyone had actually tried it.

Does Immodium actually work? I've heard people claim it does, but others have said that this is all placebo effect.

No sir, it is definately not a placebo effect. When it comes to taming withdrawls with OTC medications Loperamide is the only way to go. Go with the liquid form (it kinda taste like liquerish) because your body will absorb the drug faster and you wouldn't want to swallow all those pills on gange gut... the consistency of the liquid Immodium may actually soothe your sour stomach. Loperamide is itself an opaite, this is why it has the ability to aileviate diahhera (sp) because as we all know opaites constipate you. It also has a rather long half life in the body so you may even be able to get away with dosing only once a day depending on the size of your habit.

[katomic]

Trust me DXM does help it binds to NMDA receptors like K, PCP and ibogain. NMDA is somthing to do with addiction tho I cant quite remember how?
K would do a lot better job if you can get it

[edited for grammer]

[chemboy7]

Trust me DXM does help it binds to NMDA receptors like K, PCP and ibogain. NMDA is somthing to do with addiction tho I cant quite remember how?
K would do a lot better job if you can get it

[edited for grammer]

Alright, I suppose that I could see that... it makes sense. I have heard of Ibogaine being used with sucess and just didn't put two and two (NMDA activity) together. I can admitt when I am wrong, or better yet, likely to be wrong.

[Phluck]

Hrmm... maybe I'll give the Immodium a try at some point... I was looking at something just after reading this thread earlier that mentioned people using Immodium long term got some opiate like withdrawals... so that's interesting.

[jacky]

dxm is an nmda antagonist, similiar to pcp, ketamine, memantine. all of these can have interaction with opiate tolerance.
actually dxm is approved for opiate tolerance maintenance by the FDA, but only in people suffering from chronic pain/terminal illness. this is relatively new. alot of people dont know that dxm can positively influence habituated opiate addicts.
some kappa opioid agonists have been reputed to help opiate tolerance as well....

when I took it for this reason i would notice the next day that opiates effected me stronger, and I would have near normal bowel movements. I noticed more of a potentiation effect hours after taking the dxm, less of a potentiation when taking with the opiates.

the pharmaceutical product "morphidex" is an equal mix of dxm to morphine. I am not sure if this medication is still being used though.

some people may not notice much from dxm, the chemical seems to affect people in strikingly different ways....

[Phluck]

That's interesting... I just read something else about DXM potentiating opiates. Was the Morphinex meant to be a cough suppressant?

[psilocybin]

^^yes it does very well so I most say:D

DXM is very useful to stop WD.