resorcinol
11-13-2008, 05:37 AM
We've prolly had one before, but it's been a good long while since us 'philes have talked about the 'ol smokey stuff.
How many of y'all like it / dislike it?
I like it, but I have to take care to not overdo it, because overdoing it for me is an INSTANT panic attack, absolutely for sure. I don't just zone out and get glued to the spot I'm in if I overdo it, i fucking flip out if I overdo it.
But in doses below this threshold, I enjoy the high. I prefer sativa strains, as they're more heady, more euphoic, cause more of the interesting thought changes, and don't immobilize by body as much. The sativa strains, I believe, have a higher THC:CBD ratio (IE, more THC compared to a constant amount of CBD).
Taking a more chemical standpoint, what surprised me was that d-9-THC is only a partial agonist at CB1 receptors. CB1 receptors are the target that causes the psychoactive effects of marijuana and synthetic cannabinoids.
A synthetic full CB1 agonist, WIN 55-212-2, received glowing reviews in a thread over at bluelight.
There are other similar threads about other synthetic cannabinoids, and more are popping up everyday.
Just a note for those of you who plan on looking to the RC market for synthetic cannabinoids; you want the compounds that have a higher affinity for CB1 than CB2. CB2 receptors are barely even found in the brain... their conc there is extremely low... most CB2 receptors are found on immune system cells, and their function is pretty unknown.
So you want compounds that have a higher binding affinity for CB1 than CB2.
It really shocked me that d-9-THC, the primary active in weed, is only a PARTIAL agonist of CB1. Weed is the bupe of cannabinoids!
Anecdotal evidence from people trying these synthetic cannabinoids that are FULL CB1 agonists rather than partial CB1 agonists seems to suggest that they're:
1)more euphoric than marijuana / d-9-THC
2)more like SATIVA strains of weed than indica strains
3)cause less anxiety for the same amount of high
The WIN 55 compound, in particular, sounds like it has more EUPHORIA than weed does as a cannabinoid.
There's also some evidence on BL that these synthetic full CB1 agonists are better at getting people with very high weed tolerances high than weed is. This makes sense because full agonists activate the receptor more fully (obviously) so there's less of a wall / ceiling effect.
The synthetics that are water soluble, like WIN 55, also seem to cause less "burnout", probably because they're "in and out", they're more easily metabolized and excreted than compounds like THC which are stored in fatty tissue.
Out of all the synthetics, WIN 55 is the one I'm most interested in getting my hands on. Someday, someone who certainly is NOT me may indeed do just that :P
Edit: I forgot to mention: there's some evidence that the fact that THC is only a partial agonist is part of the reason that it's so hard to overdose on. The relative lack of CB1 receptors in the brainstem is part of the reason, but it can't be all of the reason.
It is likely that these synthetics that are FULL agonists of CB1, while almost certainly more fun than weed, are also more able to cause an overdose via respiratory depression. It would take a higher dose than with opioids still, but there's evidence that it's possible to OD of FULL CB1 agonists. So be careful if you try these drugs.
How many of y'all like it / dislike it?
I like it, but I have to take care to not overdo it, because overdoing it for me is an INSTANT panic attack, absolutely for sure. I don't just zone out and get glued to the spot I'm in if I overdo it, i fucking flip out if I overdo it.
But in doses below this threshold, I enjoy the high. I prefer sativa strains, as they're more heady, more euphoic, cause more of the interesting thought changes, and don't immobilize by body as much. The sativa strains, I believe, have a higher THC:CBD ratio (IE, more THC compared to a constant amount of CBD).
Taking a more chemical standpoint, what surprised me was that d-9-THC is only a partial agonist at CB1 receptors. CB1 receptors are the target that causes the psychoactive effects of marijuana and synthetic cannabinoids.
A synthetic full CB1 agonist, WIN 55-212-2, received glowing reviews in a thread over at bluelight.
There are other similar threads about other synthetic cannabinoids, and more are popping up everyday.
Just a note for those of you who plan on looking to the RC market for synthetic cannabinoids; you want the compounds that have a higher affinity for CB1 than CB2. CB2 receptors are barely even found in the brain... their conc there is extremely low... most CB2 receptors are found on immune system cells, and their function is pretty unknown.
So you want compounds that have a higher binding affinity for CB1 than CB2.
It really shocked me that d-9-THC, the primary active in weed, is only a PARTIAL agonist of CB1. Weed is the bupe of cannabinoids!
Anecdotal evidence from people trying these synthetic cannabinoids that are FULL CB1 agonists rather than partial CB1 agonists seems to suggest that they're:
1)more euphoric than marijuana / d-9-THC
2)more like SATIVA strains of weed than indica strains
3)cause less anxiety for the same amount of high
The WIN 55 compound, in particular, sounds like it has more EUPHORIA than weed does as a cannabinoid.
There's also some evidence on BL that these synthetic full CB1 agonists are better at getting people with very high weed tolerances high than weed is. This makes sense because full agonists activate the receptor more fully (obviously) so there's less of a wall / ceiling effect.
The synthetics that are water soluble, like WIN 55, also seem to cause less "burnout", probably because they're "in and out", they're more easily metabolized and excreted than compounds like THC which are stored in fatty tissue.
Out of all the synthetics, WIN 55 is the one I'm most interested in getting my hands on. Someday, someone who certainly is NOT me may indeed do just that :P
Edit: I forgot to mention: there's some evidence that the fact that THC is only a partial agonist is part of the reason that it's so hard to overdose on. The relative lack of CB1 receptors in the brainstem is part of the reason, but it can't be all of the reason.
It is likely that these synthetics that are FULL agonists of CB1, while almost certainly more fun than weed, are also more able to cause an overdose via respiratory depression. It would take a higher dose than with opioids still, but there's evidence that it's possible to OD of FULL CB1 agonists. So be careful if you try these drugs.