View Full Version : Favorite BENZO to use as a potentiator
resorcinol
11-06-2008, 04:18 PM
What's your favorite benzo to use as an opioid potentiator when you choose to use one in addition to your opioid dose?
I'm excluding all enzyme inhibitors, stomach antacids / absorbtion aids, and antihistamines.
I'll allow barbiturates and other GABAergic agonists as a choice, but you MUST have tried the drug you pick with an opioid in order to pick it in the poll. It's silly to say you prefer something that you haven't even tried; I know it's just a poll, but I really want honest opinions here. I'm sure barbs like Nembutal and Seconal are better opioid potentiators than any benzo, but if you haven't tried the combo, please don't pick it. Same goes for GHB, etc.
I personally like oxazepam best as an opioid potentiator. Carisoprodol is such a close second. Lorazepam is a more distant second place.
If I just want a benzo high standalone I really like bromazepam, clonazepam, and then diazepam and alprazolam in third place in that order.
To enhance opioids though, oxazepam really does the trick for me. I've mentioned before that I think benzos are pretty damn good potentiators, but in LOW doses. I don't want my opioid high and its euphoria to be overpowered by the sloppy, ethanol like intoxication that high dose benzos can produce. I just want a subtle addition to the subjective "buzzed" feeling -- I'm not really looking for a boost in euphoria when I potentiate with benzos, they really don't potentiate the euphoria all that much IME.
When I want to potentiate the euphoria of opioids, I take dexmethylphendiate (Focalin IR) 5 to 10 mg or amphetamines (Adderall IR) 5 to 10 mg. This is a surefire way to get a more intense pleasure kick from your opioids, but you won't like this combo if you're someone who really loves the nod. Dexmethylphenidate, amphetamine, and other euphoric DNRI / DN releaser stimulants (others are methamphetamine, dexamphetamine, phendimetrazine, diethylpropion, propylhexedrine, phentermine, etc), while they significantly boost euphoria, will kill the nod by keeping you alert.
But back to benzos; oxazepam is a good potentiator benzo for me BECAUSE it's not too potent. 30 mg oxazepam = 10 mg diazepam in potency; oxazepam has a much shorter half life though so it can be buzzier. It's easier to titrate your oxazepam to your desired level of potentiation too because you're dealing with a weaker benzo that's measured in larger mg doses. 30 mg oxazepam is usually my potentiation dose, but I sometimes go up to 45 mg or occasionally 60 mg if I'm in the mood for a noddier high.
The super potent benzos like clonazepam, alprazolam, and bromazepam add TOO MUCH benzo feeling to the high, and I don't want that when I want the unique effects of opioids.
You could end up overdoing it with oxazepam and getting benzoed out more than you wanted too, but you'd have to take a much larger amount to overpower the opioid high -- say, 150 mg or more.
After oxazepam, my second favorite is lorazepam for potentiation. Even though it's quite potent, it has a metabolic profile very similar to that of oxazepam in that it's metabolized by glucuronidation at its hydroxide group; ie, lorazepam and oxazepam both don't require hepatic oxidation to be eliminated like most benzos. This gives them a short half life and duration of action -- more in line with the duration and half life of most common recreational opioids. Taking a benzo that lasts way longer than the opioid you're also taking can leave you feeling a bit hung over.
I'm sure GHB would be extremely lovely, but I haven't tried it with opioids, or even alone. It's on my to-do list :P
The poll is multiple choice if you have more than one favorite GABA agonist opioid potentiator.
bigNasty
11-06-2008, 04:30 PM
Taking a benzo that lasts way longer than the opioid you're also taking can leave you feeling a bit hung over.
I usually only take a benzo with my opi dose at night so my answer is diazepam. Usually just 10 mg's to add a sleepiness/calmness to my high and make it easy for me to fall asleep if/when my opi wears off. It keeps me from taking more opi's and wasting them.
If i was to take a benzo with my opi's to socialize with people and planned to stay awake for awhile, it would probably be .5 mg's of xanax
And of course my answer is booze now that i see it's a choice. I think you could give the most shy person you've ever met a small opi dose and a few beers and they'd start talking and socializing alot. Booze and opi's go together like lamb and tuna fish.
SeVeN
11-06-2008, 04:33 PM
Xanax for me. Usually mixed with alcohol. Let me mention this has caused me to fall out hard before which is really very scary because when this has happened in the past I never had a responsible friend around.
resorcinol
11-06-2008, 04:40 PM
I agree that booze is surprisingly decent as a potentiator. Like benzos though, I like the dose of the GABA agonist to be kept mild for the purpose of potentiating opioids.
Don't wanna overpower that high and just feel high on benzos or alcohol instead.
GABA agonists are, IMO, situationally euphoric drugs. They can be very euphoric when you're chillin with your friends and being silly and "drunk", but set and setting comes into play otherwise. I don't find GABA agonists very intrinsically euphoric; GABA agonists used alone aren't very fun.
Opioids on the other hand, like euphoric uppers, are always euphoric.
This is of course all IMO.
EDIT: I shoulda make the title "Favorite GABA agonist to use as a potentiator" since we've gone way beyond benzos. Perhaps the benzo title will attract more thread views though.
Tbird921
11-06-2008, 04:48 PM
Xanax or K-pins with some jager bombs and a little bud. A dank combo.
Saint
11-06-2008, 04:54 PM
Booze (a few beers) and as a close second oxazepam.. I only need a s little as 20 mgs to get a nice nod on (if mixed with done). But I don't like the 'fall-sleep nod', just a little buzz after a week of hard work.
A friend of mine takes 350 mgs oxazepam a day on top of 120 mgs of done. I just couldn't believe it at first but the other day he got a seizure again because he'd run out of oxazepam.
Crazy.. and the reason I'm really, really careful with benzo's..
resorcinol
11-06-2008, 05:09 PM
Booze (a few beers) and as a close second oxazepam.. I only need a s little as 20 mgs to get a nice nod on (if mixed with done). But I don't like the 'fall-sleep nod', just a little buzz after a week of hard work.
A friend of mine takes 350 mgs oxazepam a day on top of 120 mgs of done. I just couldn't believe it at first but the other day he got a seizure again because he'd run out of oxazepam.
Crazy.. and the reason I'm really, really careful with benzo's..
350 mg oxazepam every day is one hell of a habit for sure. Getting in that deep with benzos is worse than even a high dose opioid addiction imo.
Since oxazepam is short acting, the w/d are one of the worst too as benzo withdrawals go.
rockbottom
11-06-2008, 05:18 PM
in the old days it was barbs--all the ones you listed reds-yellowjackets- rainbows--but i dont see them any more --now days for me no1 is halcion then xanax--im drooling just thinking about it:rolleyes:
Boxcar
11-06-2008, 05:36 PM
i chose two, the top two.
reason one: i feel when on a good opiate roll, the right amount of klonopin, for me, would be like 4 mg, just gives it a strong boost of legs, i loved chewin on like a third of a 100mcg mylan with usually 1, if it were the middle of the night and i didnt hafta talk or see anyone than id take 2 kpins. but it was like this warm, mushy floating effect, that then got picked up by a pair of power lifter legs. making it last for a couple to a few hours
reason two: somthin about a good strong hydro roll, like when that smell you referred to starts in, id take the xanax about 30 minutes later. they hydro highs never last long for me, so once i smell it, as that smell tends to fade away id take a zannie bar. which let me drift off lazily into a night of sleep where i wake up 6 hours later in the same postion. which is nice because i havnt had descent sleeping habits, since i got sick 6 years ago.
i dont get alotta benzos, im not scripted them, so i have to buy em, and peronally 5 bucks a xanax pisses me off so i dont typically get those. i had a friend that gave me kpins and somas all the time. i generally saved the kpins for WDs.
reason three: i didnt vote on but i love, a quarter piece of 100 mcg mylan with 2 somas. i like it but its dangerous. i dont necessarily mean health wise i dont know about that. but i do know that i would walk around, well more like stumble around, like a drunkard, slurring my speech and unable to really do anything. i can remeber once riding my bike and the chain came off, i flipped the bike around to put the chain on, stumbling around, worried that the neighbors were gonna think i was drunk and retarded... next thing i know i was like 50 feet from my bike walkin up to what i thot was my place, luckily i came to before i was up the porch and at the door because it wasnt my place it was the neighbors place 4 doors down.
so as much as i like the feeling, i dont like not being in control, especially when i know that i can do things and not really know im doin it.
totally off topic. as a teen a bunch of us ate the seeds of whats called jimsonweed. the gnarliest night of my life. serious hallucinations, i mean real ones, not like shrooms and acid. i mean. i sat talkin to people all night long that were not there. anyway i did some crazy shit. i pissed in the hamper because the toilet was fulla water, i kept wakin my mom up to tell her my friends were stayin the night, she kept tellin me they werent here and to go to sleep, ao i brought all my friends in her room.... i swear we all sat there fer like a half hour talkin to my mom. but later my mom said i was just holdin 4 different conversations and movin my head like i was really talkin to people. it was then i decided i didnt like not having control. scary because i cook alot, i went to culinary school, i think if i woulda decided to make some food i coulda cut a finger off or somthing. i dont like scary shit like that no more. thats pretty much why i hate alchohol so much. people lose control and dont know what they are doin. good thing thats the legal drug eh!
Saint
11-06-2008, 05:38 PM
350 mg oxazepam every day is one hell of a habit for sure. Getting in that deep with benzos is worse than even a high dose opioid addiction imo.
Since oxazepam is short acting, the w/d are one of the worst too as benzo withdrawals go.
Yeah, he uses booze and 'done for withdrawals but those are of no use with a habit like his.
And I'm really starting to notice some awfully devastating effects on the guy: apart from the occasional seizure (that nearly cost him his life) he's having trouble with his memory. And I'm talking BIG trouble here, not just forgetting a few names or not being too clearheaded.
He also started stuttering out of nowhere, sometimes he's hardly able to speak at all. And he's is unable to deal with just about any practical issue in life; paying the bills, writing a letter to the phone company, getting a new passport, making a call to his bank etc. He needs my help with everything and practically sits on the couch all day.
And the guy is still wondering 'how I manage to keep my benzo habit so low'... well, it's because I have a frightening example.. Really, it's pretty sad to watch him fall apart like that and no detox has worked so far..
ndoftaworld
11-06-2008, 06:23 PM
1 or 2mg kpins do great 4 me. Of course I could pop more, or add a halcion .25mg or two... but then my nod turns into a 4 hr. passout :(
Tho when out of opies (as I have been recently, thank Jebus I got that fixed ;) ) I do enjoy the nice benzo buzz... 15-20mg of kpins and 2 or 3mg (8-12 pills) halcions, totally zombified :D Just sux that I don't remember anything I did or said l8er on...
Nd
resorcinol
11-07-2008, 07:12 AM
1 or 2mg kpins do great 4 me. Of course I could pop more, or add a halcion .25mg or two... but then my nod turns into a 4 hr. passout :(
Tho when out of opies (as I have been recently, thank Jebus I got that fixed ;) ) I do enjoy the nice benzo buzz... 15-20mg of kpins and 2 or 3mg (8-12 pills) halcions, totally zombified :D Just sux that I don't remember anything I did or said l8er on...
Nd
I find it extremely hard to enjoy benzos as a high when I'm in w/d from opioids.
I actually do enjoy a benzo buzz alone (in other words, when I've got just enough opies on board that I'm not sick), but if I'm sick, benzos only serve as a helper to make w/d a little less painful.
I wouldn't be able to enjoy a benzo buzz (or alcohol either) during w/d no matter what the dose was. I think I'd just feel even more lethargic with marginal help for the anxiety.
The only drugs that would make me feel high and good again in opioid w/d, other than opioids, would be amphetamines in a high enough dose to cause euphoria, but I don't do that because when the crash comes I just wanna die. Crash + w/d = satan's prolapsed anus
Boxcar
11-07-2008, 11:10 AM
I find it extremely hard to enjoy benzos as a high when I'm in w/d from opioids.
I actually do enjoy a benzo buzz alone (in other words, when I've got just enough opies on board that I'm not sick), but if I'm sick, benzos only serve as a helper to make w/d a little less painful.
I wouldn't be able to enjoy a benzo buzz (or alcohol either) during w/d no matter what the dose was. I think I'd just feel even more lethargic with marginal help for the anxiety.
The only drugs that would make me feel high and good again in opioid w/d, other than opioids, would be amphetamines in a high enough dose to cause euphoria, but I don't do that because when the crash comes I just wanna die. Crash + w/d = satan's prolapsed anus
benzos in WDS, its not a high i enjoy, its being able to lay somewhat comfortably, with out the ansiness and, restlessness, and restless legs. its the being able to sleep for a few hours as oppossed to 10 minutes, that i enjoy.
the tweakin can definitley COVER the WD, but you have to stay goin untill you get some opiates, cuz if you dont, man o man, like you said prolapsed anus is NO FN GOOD
Narkotikon
11-10-2008, 08:22 PM
I chose the barbiturate choice, because I really LOVED the way Fioricet (butalbital) potentiated my poppy pod tea a long time ago. I'm not sure if that would be a short, intermediate, or long acting barbiturate, but I loved it. If I had to guess, I'd say it's probably an intermediate barb, or possibly a long. I only say that because I know it's a lot weaker than something like pentobarbitol (Nembutol).
For a second choice, I'd pick the short-acting benzos (Xanax, Ativan). I just really really love Ativan, even moreso than Xanax. I know a lot of people don't like it, but I do for some reason. I'd say it's my favorite, then Xanax, then Klonopin, then Valium. I've never tried bromazepam, or triazolam, or oxazepam, but I've heard they're great too, especially triazolam (Halcion--the holy grail of benzos). I just like the anxiolytics better than the hypnotics. When I take a benzo, I don't want to fall asleep, you know? I just figure what's the point of getting high if I'm going to sleep through it?
Good poll. Again, I'd say my first choice would be the barbs, then the short-acting benzos, although I will say I've had much more experience with the benzos. Barbs are just too uncommon in the US now. They're effective, but also a lot more dangerous than benzos, and I think that's probably why they're rarely scripted anymore--benzos took their place; they're just as effective in most cases, but a lot safer.
I will say that I prefer barbs over benzos alone. I don't find benzos that euphoric. They're kind of like alcohol in a pill form to me. Barbs, on the other hand, are a lot more euphoric (although not like opiates) in my opinion. They just hit that GABA G-spot.
RxQueen
11-11-2008, 07:41 AM
Crash + w/d = satan's prolapsed anus
hahahahahahaha! that's the best line i've heard in a minute. i'm definitely gonna try to remember that so i can use it sometime!
i voted for soma... i really like to use a bit with my opiates. it's not much on its own, unless i just really need some sleep and take enough to hit that good "soma coma." and i don't like to use enough of it (or any other type of benzo in excess) while enjoying an opiate high... i'm pretty sure i've said it before, but i prefer not having my opiates clouded over by benzos.
i forgot that we could pick multiple answers, or i might have picked a second choice of long-acting benzos (valium types). xanax is alright, but i've always preferred the longer-acting ones... can't say why, but there it is.
ndoftaworld
11-11-2008, 03:33 PM
Hehe, wish I could get Soma's... but kinda afraid to ask... well I guess, since I've been cut from my patches from one doc, asking for a NON-narcotic ain't so bad ;)
And as Nark put it... I'm rx'ed the 'Holy Grail' of benzo's... but after awhile, they do lose their potency :( And only 'certain' people have heard of em, so no bragging rights there...
Still, a few mg's of kpins with MAYBE one or two .25 halcies... and well no matter WHAT opie's I'm on.. I'm definitely nodding :D
WGFJ is still my FAVORITE potentiator... cheap, legal, and proven to work.
Nd
resorcinol
11-11-2008, 05:00 PM
Hehe, wish I could get Soma's... but kinda afraid to ask... well I guess, since I've been cut from my patches from one doc, asking for a NON-narcotic ain't so bad ;)
And as Nark put it... I'm rx'ed the 'Holy Grail' of benzo's... but after awhile, they do lose their potency :( And only 'certain' people have heard of em, so no bragging rights there...
Still, a few mg's of kpins with MAYBE one or two .25 halcies... and well no matter WHAT opie's I'm on.. I'm definitely nodding :D
WGFJ is still my FAVORITE potentiator... cheap, legal, and proven to work.
Nd
Yep, you've got the holy grail of 'em potency wise. Triazolam has the highest GABAa-BZD receptor affinity and highest potency by weight of all of the benzodiazepines on the pharmaceutical market right now.
I'm a strong believer though, that to a pretty strong degree, a drug being weaker can simply be compensated for by taking a proportionally larger dose. This almost always works as long as there is no ceiling effect and no side effects appear at high doses.
Temazepam is a good example. It's a weak benzo, but most benzo heads say it's euphoric as fuck and one of their favorites. It just needs to be taken in 100 mg + doses when a tolerance is present.
You've got a huge benzo tolerance though, ndoft. If you need 10 mg kpin to get off, you'd need to take like 400 mg temazepam to get off according to the benzo dose charts!
With opiates, hydrocodone is my favorite example of a weak drug that can get tolerant people buzzed up in high doses. I use Duragesic 25 mcg per hour patches and when i'm not using one (like now), 100 mg hydrocodone gives me a good buzz. Of course if your tolerance is REALLY big, hydrocodone will become useless at some point because you'll get to a dose where side effects are simply too great.... however, at that tolerance, oxycodone is probably rapidly becoming useless as well.
resorcinol
11-11-2008, 05:07 PM
I chose the barbiturate choice, because I really LOVED the way Fioricet (butalbital) potentiated my poppy pod tea a long time ago. I'm not sure if that would be a short, intermediate, or long acting barbiturate, but I loved it. If I had to guess, I'd say it's probably an intermediate barb, or possibly a long. I only say that because I know it's a lot weaker than something like pentobarbitol (Nembutol).
Butalbital is intermediate acting, you're right.
Butalbital actually ain't all that bad. It's a much better barbiturate than the shitty ass one that everyone knows about: phenobarbital (Luminal). Phenobarbital is very long acting, crosses the BBB slowly, and has a hangover = yuck.
Butalbital (Fioricet) isn't as good as pentobarbital (Nembutal) or secobarbital (Seconal), but it's pretty decent. I mean, I haven't actually tried it, but I'm guessing that it's decent based on its pharmacokinetics / dynamics and people's reports.
ndoftaworld
11-11-2008, 05:09 PM
Hehe... me, a benzo tolerance? No :rolleyes:
Kinda how I feel about the perc's I'm scripted (the ONLY opies I get right now :( ) I take a Promethazine to stop the nausea, then have to take 15-20 perc's to feel good (I know... bad apap and all) When I get my refills (another 60 perc's) I'm gonna CWE... now that I know I'm doing it right from WC's "friend's" video ;)
Can't wait till I see my PM doc first of December... he started off w/ 120 perc's... and when he reads my records showing OC's, patches, 'done, etc... I'm sure he'll be even nicer. hehe.
EDIT: My mom used to talk about Seconal's and Qaaludes too... makes me wish I was 10 or so years older...
Nd
resorcinol
11-11-2008, 05:19 PM
EDIT: My mom used to talk about Seconal's and Qaaludes too... makes me wish I was 10 or so years older...
Nd
My dad says he did quaaludes when he was a teenager, and that they were his favorite drug besides weed. He described the effects as "all of the great things about booze, but with none of the nasty side effects and hangovers". He said he also used Seconal (secobarbital) but that he found quaaludes more fun.
Chemically they're methaqualone. I'd love to give 'em a try some day along with a barb like secobarbital or amobarbital.
Oh, this reminds me. On the research chem market, a Quaalude / methaqualone analog has appeared. It's methylmethaqualone. Effects appear to be the same as regular methaqualone. Unfortunately only a few people over at BL have tasted it, and none of them that I saw had also tasted regular methaqualone way back when to compare.
ndoftaworld
11-11-2008, 05:25 PM
I found a *foreign* website that has TONS of 'reseach' chemicals available.... from ephedrine to ketamine, and I think some of the barbitals are available too. Some have a purchase limit, but like for the K, it's only 1g (and sold in 1g increments for $15 I think)
Definitely considering ordering, just afraid customs will fuck w/ me cause I'm gonna order lotsa goodies if I take the time and trouble ;)
Nd
jonny-5
11-11-2008, 05:27 PM
kpins are my favorite opi potentiator, they get me nodding like a MOTHERFUCKER. they can make a little bit of dope go a long way...
909kick
11-11-2008, 05:50 PM
nothing like some good ol valium!
resorcinol
11-11-2008, 05:54 PM
kpins are my favorite opi potentiator, they get me nodding like a MOTHERFUCKER. they can make a little bit of dope go a long way...
Agree totally about klonopin bringing on HEAVY nods. I stick with 2 mg max of klonopin for potentiation.
Serax (oxazepam) brings on a lighter nod, but mostly just makes the buzzing feeling inside my head and all over my body stronger.
Of course, opioids and benzos are best when they're BOTH combined with a third drug -- one from the stimulant category, like me right now :D
100 mg hydrocodone, 10 mg dexmethylphenidate, 1 mg clonazepam, 30 mg oxazepam all coursing through my system right now. Mmmmmm I feel warm and fuzzy :o
jonny-5
11-11-2008, 06:02 PM
Agree totally about klonopin bringing on HEAVY nods. I stick with 2 mg max of klonopin for potentiation.
Serax (oxazepam) brings on a lighter nod, but mostly just makes the buzzing feeling inside my head and all over my body stronger.
Of course, opioids and benzos are best when they're BOTH combined with a third drug -- one from the stimulant category, like me right now :D
100 mg hydrocodone, 10 mg dexmethylphenidate, 1 mg clonazepam, 30 mg oxazepam all coursing through my system right now. Mmmmmm I feel warm and fuzzy :o
yeah i made the mistake of doing two shots and then taking 6mg of kpin before class one time. i was nodding so hard all day...it was bad.
ndoftaworld
11-11-2008, 06:19 PM
yeah i made the mistake of doing two shots and then taking 6mg of kpin before class one time. i was nodding so hard all day...it was bad.
God... I remember when I couldn't stop smiling all the way to the pharm when I first got scripted 90 kpins and 30 halcies a month w/ 3 refills... no ??'s asked :D Prolly could go thru those in a week if I was trying for a benzo buzz :D
Only thing is the morning residuals... w/ kpins I CAN'T wake up before 8 and sometimes a lot longer than that... just a general BLAH! and sleepiness. Halcies PUT me to sleep (sometimes) but they don't leave me feeling like crap all the next day.
Still gonna try for Soma's... it's a muscle relaxant right? So, I gotta ask a PCP and NOT my shrink bout em... pretty sure he'll go for it, since, like I said, they are NON-narcotic (no fucking contract applies :mad: )
Nd
resorcinol
11-11-2008, 06:41 PM
God... I remember when I couldn't stop smiling all the way to the pharm when I first got scripted 90 kpins and 30 halcies a month w/ 3 refills... no ??'s asked :D Prolly could go thru those in a week if I was trying for a benzo buzz :D
Only thing is the morning residuals... w/ kpins I CAN'T wake up before 8 and sometimes a lot longer than that... just a general BLAH! and sleepiness. Halcies PUT me to sleep (sometimes) but they don't leave me feeling like crap all the next day.
Still gonna try for Soma's... it's a muscle relaxant right? So, I gotta ask a PCP and NOT my shrink bout em... pretty sure he'll go for it, since, like I said, they are NON-narcotic (no fucking contract applies :mad: )
Nd
Yeah man clonazepam has a long half life and will give hangovers. I think triazolam is better for high doses with the intent of getting fucking plastered.
I like benzos, but I never get excited about them the same way I do about opioids. Even that 160 pills of 10/325 mg hydrocodone script got me way more hyped than my kpin and serax scripts ever could.
I mainly love benzos for how they add to and extend the opioid high, and allow me to drift into opiated sleep, since opiates with no other downers actually keep me awake.
You'll most likely have no prob getting Soma, and it's heavenly to mix with opioids. Carisoprodol is its chemical name; it's a GABA-A agonist, but it binds at a different allosteric site than benzos do. It's thought that carisoprodol (Soma) and meprobamate (Miltown) bind to the same allosteric site on GABA-A as barbiturates and act as agonists. Carisoprodol and meprobamate are together known as the carbamate group of sedatives, and they have abuse potential since they act on GABA in a similar way as barbs and benzos.
ndoftaworld
11-11-2008, 06:52 PM
Yeah man clonazepam has a long half life and will give hangovers. I think triazolam is better for high doses with the intent of getting fucking plastered.
I like benzos, but I never get excited about them the same way I do about opioids. Even that 160 pills of 10/325 mg hydrocodone script got me way more hyped than my kpin and serax scripts ever could.
I mainly love benzos for how they add to and extend the opioid high, and allow me to drift into opiated sleep, since opiates with no other downers actually keep me awake.
You'll most likely have no prob getting Soma, and it's heavenly to mix with opioids. Carisoprodol is its chemical name; it's a GABA-A agonist, but it binds at a different allosteric site than benzos do. It's thought that carisoprodol (Soma) and meprobamate (Miltown) bind to the same allosteric site on GABA-A as barbiturates and act as agonists. Carisoprodol and meprobamate are together known as the carbamate group of sedatives, and they have abuse potential since they act on GABA in a similar way as barbs and benzos.
My (old, but current for now ;) ) PCP knows I'm on kpins and halcies... and I'm gonna use the 'dumb' tactic for soma's... 'Uh, I've been reading about a medication that helps with muscle spams, which COULD be some of the cause of my CP... it's called carisoprodol...?" And let him be the 'Genius' that thinks it up and scripts it, hehe :D
Nd
resorcinol
11-11-2008, 07:46 PM
My (old, but current for now ;) ) PCP knows I'm on kpins and halcies... and I'm gonna use the 'dumb' tactic for soma's... 'Uh, I've been reading about a medication that helps with muscle spams, which COULD be some of the cause of my CP... it's called carisoprodol...?" And let him be the 'Genius' that thinks it up and scripts it, hehe :D
Nd
Hell yeah, work it right out of him!
Just don't play too dumb. You sound like you've got that done. Doc may think a junkie wouldn't know the chemical name, but a person doing net research may have seen the generic chemical name and not the brand name and thus be calling it that.
If you get a nazi doc... you'll be labeled junkie if you suggest any CNS active medication that is either a GABA agonist, mu opioid agonist, NMDA antagonist, DNRI, DN releaser, etc etc. No matter what tactic you use.
But you don't have a doc like that, right?
ndoftaworld
11-11-2008, 08:09 PM
Hell yeah, work it right out of him!
Just don't play too dumb. You sound like you've got that done. Doc may think a junkie wouldn't know the chemical name, but a person doing net research may have seen the generic chemical name and not the brand name and thus be calling it that.
If you get a nazi doc... you'll be labeled junkie if you suggest any CNS active medication that is either a GABA agonist, mu opioid agonist, NMDA antagonist, DNRI, DN releaser, etc etc. No matter what tactic you use.
But you don't have a doc like that, right?
Hehe, from him... I'm already labelled a junky. Broke the pain contract, um 3 times. Failed a piss test (which they didn't care about pot... only that I didn't say I was using), re-scheduled the appt. a week later, and prolly failed this last test too (oops! :o ) Though he didn't cut me from all opies... just the patches :( So, I'm back where I started (for now neway): 120 perc's a month :|
His nurse even asked if I wanted to discuss addiction programs... I was like 'I am NOT A SEEKER! Yes, I visited the ER... because fucking Percocet 5/325's don't do SHIT, especially when I've been on fent for the last 4 months... and other shit MUCH stronger than 5mg oxy b4 THAT! err! :mad: But, like I said, he didn't cut me from all narcotics... just gave me enough to catch a buzz for a week or two, then suffer and feel like death the rest of the month... ain't dr.'s great? :rolleyes:
Soon, tho... I'll be in PM again... getting REAL CP meds. Can't wait, ahh...
Nd
resorcinol
11-11-2008, 08:18 PM
Hehe, from him... I'm already labelled a junky. Broke the pain contract, um 3 times. Failed a piss test (which they didn't care about pot... only that I didn't say I was using), re-scheduled the appt. a week later, and prolly failed this last test too (oops! :o ) Though he didn't cut me from all opies... just the patches :( So, I'm back where I started (for now neway): 120 perc's a month :|
His nurse even asked if I wanted to discuss addiction programs... I was like 'I am NOT A SEEKER! Yes, I visited the ER... because fucking Percocet 5/325's don't do SHIT, especially when I've been on fent for the last 4 months... and other shit MUCH stronger than 5mg oxy b4 THAT! err! :mad: But, like I said, he didn't cut me from all narcotics... just gave me enough to catch a buzz for a week or two, then suffer and feel like death the rest of the month... ain't dr.'s great? :rolleyes:
Soon, tho... I'll be in PM again... getting REAL CP meds. Can't wait, ahh...
Nd
Totally Ndoftaworld, go for PM.
But this time, please be careful man. Be wary of pee tests. There are ways to pass them. Synthetic urine, a friends urine... hell, some clinics don't test most patients if they have no reason to suspect you.
Be careful when you get the goodies next time!
ndoftaworld
11-11-2008, 08:38 PM
Totally Ndoftaworld, go for PM.
But this time, please be careful man. Be wary of pee tests. There are ways to pass them. Synthetic urine, a friends urine... hell, some clinics don't test most patients if they have no reason to suspect you.
Be careful when you get the goodies next time!
My PM doc (saw him back in like Feb.) didn't whiz quiz, no contract, just a 3 hour visit, ending up w/ 'Hmm, I think it might be nerve damage... in which case, no trigger point injections, or anything we usually try will work... HERE! here's 120 perc's!' Refilled it w/o me seeing him again too, but by that time I was in TX, and they wouldn't accept a NE CII script, hence me finding the Dr. of ALL Dr. down there and getting the OC's, patches, etc.
But of course... that was uh, 9 months ago, and it WAS a new practice when I got in. Many things could have changed since then, tho I know the Dr. is the same... he can't say 'no.' makes his nurses do it for him ;) Feel kinda sorry for him when I walk into the pharm... DEA is gonna be watching his back BIG TIME w/ the scripts I'm hoping for ;) hehe
And @ my current PCP, kinda pissed me off. I took in records of being on patches, tho they didn't last 3 days, so... he kept me on same dose/#, but added perc's for bt (BS I know), then said he wanted blood and urine tests for a CBC, protein count, etc. NO IDEA IT WAS A DRUG SCREEN! until they called me 3 or 4 days later wanting me to come in for another THEN. Hence, why I rescheduled... so @ refill time, another doc wrote for same amt. of perc's (40) but no patches. @ my last appt. w/ MY doc, got nothing but 56 perc 5's (refills in 2 weeks). Didn't even give me an exact 60/2 weeks?? WTF?? 112 percocet 5's for a CP patient that was previously on fentanyl around-the-clock... thanks doc :rolleyes:
Nd
God_Albino
11-14-2008, 05:01 PM
clonazepam and xanax are tied; shit like ativan and halcion feel great for maybe 15-20 minutes as a potentiator, followed by 8 hours of sleep and a wasted buzz.
id even take ambien over the harder-hitting benzos, in terms of being able to stay awake and enjoy myself.
PantyShot9
11-14-2008, 05:12 PM
I picked the carbamates I am a huge fan of carisoprodol in all uses potentiater, recreational, and therapeutic.
Paregoric Kid
11-14-2008, 07:17 PM
I occasionally like benzos, barbiturates, and ethanol. never got to try paraldehyde. lyrica is good. I tried a couple milligrams of ambien with oxycodone and it seemed to have a benzo-like effect in such a low dose. never was really big on these kinds of drugs though, getting an alcohol or benzo or barb habit is way worse than opiate addiction.
resorcinol
11-14-2008, 11:27 PM
I occasionally like benzos, barbiturates, and ethanol. never got to try paraldehyde. lyrica is good. I tried a couple milligrams of ambien with oxycodone and it seemed to have a benzo-like effect in such a low dose. never was really big on these kinds of drugs though, getting an alcohol or benzo or barb habit is way worse than opiate addiction.
I agree that getting a GABA agonist habit is far worse than an opioid habit, since physical dependence on those agents causes a more severe w/d syndrome, but also because the intoxication from strong GABA agonist drugs is much harder to hide than opioid mu agonist intoxication, especially in the doses used by benzo and barb heads. Blackouts are also a concern that don't happen with opioids no matter the dose because of their fundamentally different pharmacology.
GABAa-BZD agonists like benzodiazepines and z-drugs (I HATE the label "nonbenzodiazepines" since that leads people to think their MOA is different in the brain. They should be called "atypical benzodiazepines" instead) cause a severe physical dependence, but I'd imagine barbiturates or similar drugs (like methaqualone and meprobamate) cause an even worse physical dependence.
I think this because of their pharmacology. Benzos and atypical z-drug benzos are more GABA "modulators". GABAa-BZD agonism only changes the inonophoric GABAa receptor's conformation when GABA is also present, hence them being less addictive / fun / etc than barbs and barb like drugs. Barbiturates bind at a totally different allosteric site on GABAa and are really true full GABA agonists in that they can open the ion channel themselves without GABA's presence. That's why they're more fun and also more addictive, including physically. I'd imagine barb w/d is one of the worst feelings a human being could possibly ever experience.
Ethanol I think produces a physical dependence as bad as that of barbs, but its saving grace is that it takes more exposures and much much heavier use to form serious physical dependence. Drinking all day every day for a few years is needed to produce dependence on the barbiturate like severity level.
I'm not sure about GABAb agonists like GHB / sodium oxybate. Anecdotal info seems to suggest that they're actually more euphoric than the GABAa agonists are, and most GABAergic downers out there, including ethanol, barbs and barb like drugs, and benzos and atypical zdrug benzos all act on GABAa receptors. GABAb receptors are GPCRs like mu opioid receptors are, not ionotropic receptors like GABAa. I'm not sure how physical dependence on GABAb agonists ranks and manifests. If anyone knows either from reading about it or personal experience, post about it.
I've never tried sodium oxybate (I like that name better than GHB for this drug) but I'd really like to. I'm more interested in it than I am barbs like secobarbital, actually. It sounds like GABAb agonists have a greater euphoria to sedation ratio.
Now that sodium oxybate is scheduled and the precursor / prodrug GBL and the prodrug 1,4-butanediol are extremely hard to get in the USA, I'd like to see an alternative potent GABAb agonist developed. It's certainly possible, and the molecule may be a simple one -- GHB is simple. Although I'd imagine other simple molecule GABAb agonists wouldn't be all that potent just like sodium oxybate -- sodium oxybate is dosed in grams... not potent at all. I bet a more complex molecule could agonize GABAb in small mg doses and could be put in pills. I
It's kinda like with ethanol for GABAa. For GABAa: ethanol is to barbiturates as For GABAb: sodium oxybate is to the more complex molecules I'm suggesting.
I think the pharma companies should also look into potent GABAb agonists as a new avenue to treat anxiety and insomnia. So far they've focused almost entirely on GABAa agonism for this purpose.
D-Stabilized
11-15-2008, 10:37 PM
Not a benzo but Vistaril (hydroxyzine) is a great opioid potentiator for me. Definitely increases the effects of the opis without significant sedation, again for me at least. It also has the side benefit of being an antihistamine thus reducing/eliminating the "itchies" and other histamine related annoyances which I still get to this day if the opi dose is high enough despite over a quarter century of chronic use. There were plenty of times when I never would have been able to make my scripts last the month with the aid of vistaril. It was one of my old pain doctors who suggested/scripted it. His words were, "It'll just all-around make the pain medications work better". true dat.
For me, "potentiate" is far too thick of brush to stroke the benzo effect on an opiate high. Yes, it certainly increases sedation, but I strongly deny that it increases euphoria. With most benzos I've used, it does reduce anxiety through making me feel highly disconnected, but I would certainly not call that euphoria.
Thus, for me, I think benzos actually water down the opiate high...similar to weed. They seem to cover up the purity of the physical feelings and also of the mental euphoria.
All IMHO, of course-- I could see how those who really like nodding out ( I hate it for the most part) would consider it truly potentiation.
SuperJunky
02-09-2009, 09:23 AM
My favorite gaba potentiator would be lorazepam, though temazepam is a close second. I love triazolam for WD but it's too strong to mix w/ opiates unless I balance it out w/ some meth. I also voted for GBL because that would be my third choice, though after you build some tolerance I get really nasty rebound anxiety and insomnia. While these are my favorites I usualy only have acess to diazepam and gbl so I make do.
Any one else take GABA pills along w/ there benzos, barbs, and G? I find it helps add to their effect.
I've takrn a vetrinary mixture of sodium thiopental and pentobarbital called combuthal, it's a pure powder meant to be dissolved and injected but I always just snorted small bumps of the nasty smelling crap. I found it to be a bit to powerful, I really didn't realize how fucked up I was either. I have most of the bottle left some where but thats the thing, I stashed it some where while doing it and havn't been able to find it for a few months now.
Narkotikon
02-09-2009, 01:12 PM
I'd like to change my vote. I think way back when I voted for short to intermediate acting barbs. I've never done a "short" barb, like Seconal, Nembutal, Tuinal, etc., but I voted that because I did like butalbital, and that's an intermediate acting barb.
I'd like to change it to short acting benzos, particularly Ativan. I noticed last night when I did the seeds, the 2mg of Ativan I did made it even better. However, when I did one of the 2mg Xanax pills, it just overpowered it. I wish I hadn't have done that now. It lessened the euphoria and turned it from an "opiate" high to a "benzo" high. Today I just feel groggy. Coffee is helping with that though.
I know that benzos potentiate opiates, but I think it works in degrees. Now, I wouldn't say seeds are as good as pods, or pharms or heroin or anything like that, UNLESS you can do a lot to compensate. I did 2.5lbs, and they were good, but as soon as I took the Xanax, it just turned it into more of a benzo high than an opiate high. And, given the choice between an opiate high or a benzo high, I'll always choose the opiate high. I should have just stuck with the Ativan.
ndoftaworld
02-09-2009, 02:46 PM
I'm having a benzo 'confusion' so to speak...
As most know, I'm prescribed enough benzo's for a small third-world country: 90kpins and 30 halcies a month. Trouble is... the halcies don't do SHIT, even after taking 2mg+, and where I USED to take 20-30mg of kpins, 5 now leaves me completely amnesiac to the day before... even the time BEFORE taking the benzo's...?
My tolerance should be (and IS) thru the roof for them, how come the side effects of one are becoming prominent, and the other useless? Shit. And outta opies till 2morrow :(
Nd
austinslacker
02-25-2009, 02:34 PM
I enjoy 2-4 suboxone sucking down 2 mg xanax at the same time.... Gets me a great nod.
OCintheOC
02-25-2009, 03:15 PM
i would have to say for anxiety and good level high to combine with methadone kloni. but to when i need to get obliterated def xanny bars are my poison
The benzo of choice in my country is oxazepam in 50mgs pills called Serenal 50, its a great dose and its very popular here, certainly its the benzo of choice among opiate users and its very hard to get without a prescription and not many docs write a prescription of it except for junkies.. Because most junkies around here, the old timers, not the newones that mostly smoke.. most of the oldtimers used to shoot have hepatitis C and because oxazepam is one of the least harmful benzos for the liver doctors at rehab and methadone clinics prescribe oxazpepam to junkies in treatment or in MMT if the user claims it has anxiety from coke abuse or whatever anxiety source..
In here its the famous benzo, like xanax is on the US, serenal 50 is in here... I used to love it too, its gradual onset of around 2 to 3 hours was ok for chilling, in my benzo years i used to take around a box a day, its was 30x50mgs a day plus some other benzos.. but thats another story..
Oxazepam altought is not my favourite benzo, it is my favourite for mixing with opiates because it doesnt overpower that much opiates like some "stronger" and faster hiting benzos most times do..
Saint
05-22-2009, 01:36 AM
In Amsterdam it's the number 1 benzo too. Almost every 'junky' uses oxazepam. Xanax and klonopin are non-existent here.
But 30 times 50 mgs a day?? I wouldn't lve to tell with that amount..
hovadagod
05-23-2009, 08:21 AM
350 mg oxazepam every day is one hell of a habit for sure. Getting in that deep with benzos is worse than even a high dose opioid addiction imo.
Since oxazepam is short acting, the w/d are one of the worst too as benzo withdrawals go.
This is not IYO (IMO). This is factual shit.
Ragdoll
05-31-2009, 02:55 PM
^^^ IMO ITA.
In other words, in my opinion, I totally agree :)
I've found an excellent potentiator is kombucha tea. Also have spoken with some friends about this and they've discovered the same.
bodytec
06-27-2009, 02:13 PM
i haven't voted yet,but what about seroquel? i'm not sure what family it is in.
i know it says it is an anti-psychotic.it really works good with oxy's if you ask me.
plus it isn't too long-acting(at least not on me) so one could use it really late at night,for sleep,
without having to worry abt not getting up in the morning or being hung-ass-over,like tyl.p.m.
my doc wrote me the seroquel50mg for sleep,cause he said they work good with subs.
i ended up taking them waaay too quick. i really do like them,for everyday use too.
i hope i'm not psychotic.i used to think,back when i was coming up thru grade school,
that if you abused a medication for a long period of time,if you stopped,you would HAVE the
psycological problem that it was supposed to be treating!!
--sorry i got off subject!
Narkotikon
08-19-2009, 05:23 PM
I don't think Seroquel would qualify for this poll. You're right, it's an anti-psychotic, and like other anti-psychotics, it probably lowers dopamine / serotonin levels. This poll is more about benzos and barbs. I think, if I remember correctly, I voted for short to intermediate acting barbs (butalbital, as in Fiorinal / Fioricet). I've never done Nembutal, Tuinal, or Seconal, and given the way things are today concerning doctors and scripts, I don't think I'll ever get the chance. Strong barbs like that have pretty much been replaced by benzos, and even benzos are harder to get know / are being replaced by "non-addictive" drugs.
I've never taken Seroquel. The only thing I know about it is that it's an anti-psychotic, and that it's used for that and also for sleep because it's so sedating.
Personally, I would never take it, just because I have been given Risperdal, Geodon, and Abilify. Granted, they're newer anti-psychotics, and aren't as bad as Haldol or something older like that, but they still made me feel like shit, very dysphoric, and like a zombie. I just have never liked those drugs. Plus, anti-psychotics can have lots of negative side effects like tardive dyskinesia when taken over the long term. On psych wards they give a "cocktail" shot of Haldol, Ativan, and Cogentin (the Cogentin is given to help with the side effects of the Haldol, especially concerning movement) to the uncontrollable patients to calm them down. It's kind of like a chemical restraint jacket. I just don't like anti-psychotics at all. And now, whenever some quack doctor wants to give me a script for one for sleep, or anger issues, or something like that, I say "no thanks." I personally don't think that class of drugs should be used for things aside from schizophrenia unless it's really really warranted. For instance, I think there are better options for sleep other than Seroquel. If I were a doctor, I'd be very wary of prescribing that for sleep, and would rather give Trazodone or Elavil or something like that for a non-addictive choice.
harmonik
08-19-2009, 10:16 PM
Temazepam. Long HL hypnotic, I'm guessing..
xannyman
10-24-2009, 01:31 PM
Obviosly by my screen name it is XANAX. I love that shit and my Dr. scripts me 90 2mg bars per month. I think it is alot but this DR. knows my family and has known me for my entire life and gives me the most rediculous amount of schedule 2 and 3 drugs!!
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