Casomorphins?

[Dr.Poop]

So there are naturally occuring substances very similar to morphine that have opioid activity in certain foods. These can be found in chocolate, cheese, and meat to name a few. Casomorphins are the ones found in cheese. My question: would it be possible to isolate these compounds and use them recreationally? If not, could they be converted to another more recreational opioid?

[jacky]

there is another food sourced opioid type compound that is a product of enzyme reaction in the stomach, the molecule is a gluten compound, that then gets broked down into a molecule called casien a.

these compounds are being researched, there are many analogs created of both. peptide research companies provide them.

so casien a and casomorphins are being used daily by many people all over the world.

the problem with trying to get high off compounds like these is that the body for the most part is able to break them down rapidly. some analogs may last longer. also some people it is theorized cannot sufficiently break down the products, and some hypothesis point to these compounds playing a role in autism and possibly adhd.

I was researching a body building product, that took these compounds, and actually put them through an enzyme process to render them 1 step further in the metabolism process so as to make the product more"bioavailable". but the product cost alot, and then they discontinued that certian line. the compounds are still available in gluten/whey products.....



anyone else familiar with these compounds.?

[antony]

I've noticed in whey based protien shakes, among other things that do give you a jolt of something. Don't want to say energy, but endorphins are DEFINATLEY released, more noticed when youre sober, and no pharms of any sort, but i did get good feelings on my surrondings, just for a short while.

[Mokelly]

I think what you are describing is what some observe to be a phenomenon called "being happy" this can occor randomly at times of being sober and has been reported world wide.....

[Dr.Poop]

Please elaborate. I've never heard this term......"happy"?
It is english, right?

[jacky]

opiates help give rise to learned behavior, novel experiences are marked by morphine release, then to reaccess that same information the brain releases another pulse of opiates. this takes place in the ventral tegmental region of the limbic system.
morphine can actually intensify reaction time and mathematical thought processes in humans in the right dose.

opiates/opioids endogenous occuring are very important neurotransmitters/hormonal messengers of the endocrine system.

I am convinced that opiates play a larger role in the psychedelic experience than people are aware of.......

morphine can be a scourge in some peoples life...
some people dont survive the experience.

I lost my way on heroin for awhile...or maybe I was just looking to get lost. but later, with a new sense of purpose, I put the morphine to work for me. and life was good.

[antony]

I think what you are describing is what some observe to be a phenomenon called "being happy" this can occor randomly at times of being sober and has been reported world wide.....

yea, your probably right. I get happy from drinking a protien shake. makes my day. fuck pharms, im going to GNC right now to get happy.

[jacky]

dairy creamer contains lots and lots of whey..............

[antony]

dairy creamer contains lots and lots of whey..............

mmmm....warm dairy creamer. wanna talk about nodding out?

[Egret Narcosa]

Since there is "external morphine" (Exorphins) naturally occuring in milk, I always wondered if that was what gets babies hooked on breast milk (instinct aside) to the point where you have to ween them off of it. I thought it might be a possibility.

In addition, I considered separating gluten, which is full of exorphins, from gluten flour (I found a procedure on a cooking site) and trying it out, but I could never figure out if a gluten molecule is small enough to cross the blood-brain barrier.

[Opiyum]

Peptides from Casomorphin & Gliadorphin

The information presented here is to be used under the supervision of a medical practitioner who is licensed to practice in your state. Accordingly, you and your medical practitioner must take the responsibility for the uses made of this material.

What is Gliadorphin?

Gliadorphin (or gluteomorphin) is a peptide derived from the wheat protein gluten. Other related grains such as rye, barley and oats also contain the sequence of amino acids found in gluten. Gliadorphin is very similar to casomorphin. Gliadorphin has been verified by mass spectrometry techniques to be present in urine samples of children with autism (http://www.greatplainslaboratory.com/autism.html). Both casomorphin and gliadorphin are composed of seven amino acids, which are abbreviated below. Both caseomorphin and gliadorphin start with the beginning N-terminal sequence tyr-pro (for tyrosine and proline) and the additional pro (proline) in positions 4 and 6 of both peptides, as indicated below.

Casomorphin tyr pro phe pro gly pro ile
Gliadorphin tyr pro gln pro gln pro phe
(http://www.greatplainslaboratory.com/gluten-casein.html#top)
What is Casomorphin?

Casomorphin (or casomorphin) is a peptide derived from the milk protein casein. Casein is one of the major proteins in the mild of all mammals including cows, goats and humans.
Dr. Reichelt in Norway, Dr. Cade at the University of Florida, and others found that urine samples from people with autism, PDD (http://www.greatplainslaboratory.com/autism.html), celiac disease and schizophrenia contained high amounts of the casomorphin peptide in the urine. We suspect that these peptides may also be elevated in other disorders such as chronic fatigue, fibromyalgia (http://www.greatplainslaboratory.com/fibromyalgia.html) and depression based on anecdotal reports of symptom remission after exclusion of wheat and dairy.

(http://www.greatplainslaboratory.com/gluten-casein.html#top)
Why are These Peptides Important?

The peptides from gluten and casein are important because the react with opiate receptors in the brain, thus mimicking the effects of opiate drugs like heroin and morphine. These compounds have been shown to react with areas of the brain such as the temporal lobes, which are involved in speech and auditory integration.
Children with autism (http://www.greatplainslaboratory.com/autism.html) frequently seem addicted to wheat and dairy products. Presumably, people with Autism and schizophrenia incompletely digest wheat and dairy products. These incompletely digested peptides are then absorbed into the body and bind ot opiate receptors, altering behavior and other physiological reactions.

(http://www.greatplainslaboratory.com/gluten-casein.html#top)
References
Dohan, F.C. "Schizophrenia: possible relationship to cereal grains and celiac disease. In: S. Sankar, ed, Schizophrenia: Current Concepts and Research. PJD Publications, Hicksville, NY, 1969 Page 539.
Dohan, F. C. "The possible pathogenic effect of cereal grains in schizophrenia--Celiac disease as a model." Acta Neurol. 31:195, 1976.
Dohan, F. C. et al. "Relapsed schizophrenics. More rapid improvement on a milk and cereal-free diet." Br. J. Psychiatry 115:595, 1969.
Kinivsberg, A. et al. "Dietary Intervention in Autistic Syndromes." Brain Dysfunction 3: 315-327, 1990.
Reichelt K. et al. "Gluten, mil proteins and autism: dietary intervention effects on behavior and peptide secretions." Journ of Applied Nutrition 42:1-11, 1990.
Reichelt K. et al. "Biologically active peptide-containing fractions in schizophrenia and childhood autism." Adv Biochem Psychopharmacol 28:627-47, 1981.good stuff