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PantyShot9
10-15-2008, 04:30 PM
Since grapefruit juice helps slows down the metabolism of morphine when drank with codeine would this also work with tramadol and M1? Any experiences of this or trams and cimetidine?
Nu Jerzey Devil
10-15-2008, 05:13 PM
Grapefruit juice will inhibit certain Cytochrome P450 enzymes as we all know. Tramadol is metabolized into M1 (more potent) through the CYP450 system (Specifically CYP 2D6). Grapefruit juice most strongly effects CYP 3A4 which metabolizes some opioids, but I am not sure about tramadol. I am not positive but my guess is that Grapefruit juice might slow down the metabolism of Tramadol, but that would create less of an effect just as codeine displays most of its effects from being metabolized into morphine.
PantyShot9
10-16-2008, 02:00 AM
Well in my thread Ok strange info Woody Bear said that grapefruit juice when drank with taking codeine slows the metabolism of it to morphine making it stronger. Could the same be true of tramadol and M1 considering trams are just synthetic codeine?
Indy
10-16-2008, 02:24 AM
Codeine actually isn't made weaker by grapefruit juice, as the pathway that converts codeine to morphine is NOT inhibited by GFJ, what IS inhibited is the pathway from codeine to norcodeine, so actually more codeine is left over to be converted into morphine, potentiating it. Now this is in THEORY, so everyone's different.

ANYWAYS, on topic, I really don't know, but in my experience, grapefruit juice never really made much difference for me. Try it and see.
PantyShot9
10-16-2008, 10:41 PM
I'm only wondering because this is the best I can get from my doctor painwise right now and it really isn't cutting it. I'm picking up my tramadol tomorrow and I'm gonna try GFJ with it so I'll let u guys know what happens.
Paregoric Kid
10-17-2008, 02:52 AM
why would you want to do that? you would want to metabolize as much of tramadol or codeine as possible because they are prodrugs. metabolizing tramadol produces M1 or O-desmethyltramadol which is much stronger than tramadol itself as an opiate agonist.
Nu Jerzey Devil
10-17-2008, 07:17 PM
why would you want to do that? you would want to metabolize as much of tramadol or codeine as possible because they are prodrugs. metabolizing tramadol produces M1 or O-desmethyltramadol which is much stronger than tramadol itself as an opiate agonist.

That's exactly what I was thinking....