Nicomorphine? WTF>

[EleusisII]

Hey guys...

Just stumbled over an interesting painkiller we have in Europe: Nicomorphine...

It comes in 5mg pills, and does anybody know about nicomorphine or have tried it?

What's the connection with nicotine? What other opie is it comparable too, how enjoyable is it, or any other info would be greatly appreciated!

[Boxcar]

http://www.rxwiki.com/index.php?title=Nicomorphine

[resorcinol]

Oxidizing nicotine yields nicotinic acid (aka Niacin -- yes, the vitamin).

Nicomorphine is a heroin analog. Nicotinyl groups instead of acetyl groups are esterified onto morphine.

It's supposedly very fun and euphoric. 2.5x morphine in potency.

[Boxcar]

looks like itd be nice, rxwiki said 3 x morph. one question tho res.... if it has a high enuff amount of niacin, would it burn the skin the same as niacin does? i imagine it wouldnt be too high because of that tho.would be funny if you got the itchies along with the burnies from the niacin

[resorcinol]

looks like itd be nice, rxwiki said 3 x morph. one question tho res.... if it has a high enuff amount of niacin, would it burn the skin the same as niacin does? i imagine it wouldnt be too high because of that tho.would be funny if you got the itchies along with the burnies from the niacin

Since the drug is extensively hydrolyzed which produces Niacin as one of the metabolites, it's probably possible. You'd have to have a massive, really huge tolerance to need that much nicomorphine to get off though.

[Narkotikon]

The only thing I know about it is that it's supposedly used in Eastern Europe a lot, like in Russia, the Czech Republic, the Ukraine, etc., instead of diamorphine, which is used in Western Europe. At least that's what I read about it on Wiki a long time ago. Other than that, it's similar to heroin I think.

[resorcinol]

The only thing I know about it is that it's supposedly used in Eastern Europe a lot, like in Russia, the Czech Republic, the Ukraine, etc., instead of diamorphine, which is used in Western Europe. At least that's what I read about it on Wiki a long time ago. Other than that, it's similar to heroin I think.

Yes, I've heard it's similar to heroin too.

I doubt nicotinic anhydride is a watched chemical like AA is.

[Boxcar]

Since the drug is extensively hydrolyzed which produces Niacin as one of the metabolites, it's probably possible. You'd have to have a massive, really huge tolerance to need that much nicomorphine to get off though.

id hardley call my remembrence of niacin as gettin off........ i was thinkin of a few times i took handfuls of niacin, told it would flush system for UAs. burns the shit outta yer skin.. and i still failed UA. so for anyone that thinks niacin cleans or masks, WRONG!

[EleusisII]

Similar to heroin, eh?

Sounds like it might be an idea to whip up the good, ol' script pad!

That's a beautyful, very symmetric module... I gotta say there's something cool and ol' school about all those old, germanic morphine-analouges.

I'll try to get ahold of it in a couple of weeks, and write up a little report... Hell, maybe it might be worth to start a blog about it: www.olschoolteutonicmorph.com!

[red26]

Hey guys...

Just stumbled over an interesting painkiller we have in Europe: Nicomorphine...

It comes in 5mg pills, and does anybody know about nicomorphine or have tried it?

What's the connection with nicotine? What other opie is it comparable too, how enjoyable is it, or any other info would be greatly appreciated! Have you ever noticed that nicotine helps enhance or even re-up your high? Afew years ago Me and Jacky were talking about how ciggs help out the high. I've noticed that even if Im not getting a nicotine rush the smoke bounces my high back in.

[EleusisII]

Don't think it's because there is some sort of connection between the two. As I remember it, nicotine (and sugar as well) simply release endorphins on it's own.

So when you combine the two, even more endorphins are released, which further enhances the opiate high.

[jonny-5]

Have you ever noticed that nicotine helps enhance or even re-up your high? Afew years ago Me and Jacky were talking about how ciggs help out the high. I've noticed that even if Im not getting a nicotine rush the smoke bounces my high back in.


yea have you also noticed that when youre dopsick nicotine seems to make you sicker? theres definitely some connection there i donk know what it is.

[resorcinol]

Nicotine indirectly causes modest increases in dopamine release in the NAc. It's direct pharmacological effect is an agonist at nicotinic acetylcholine receptors.

[rolln7s]

id hardley call my remembrence of niacin as gettin off........ i was thinkin of a few times i took handfuls of niacin, told it would flush system for UAs. burns the shit outta yer skin.. and i still failed UA. so for anyone that thinks niacin cleans or masks, WRONG!

I too took a bunch of Niacin when i was younger because evryone kept saying how well it will clean your system......WRONG-O i thought i was gonna die or burst into flames. awful experience!! although my boyfriend at the time took the same amount and he was fine??? how does that work? hahah

[Hoss]

I too took a bunch of Niacin when i was younger because evryone kept saying how well it will clean your system......WRONG-O i thought i was gonna die or burst into flames. awful experience!! although my boyfriend at the time took the same amount and he was fine??? how does that work? hahah

What does it feel like to take a chunkload of Niacin? Obviously hot, but how long does it last/details/etc.? Hoss be curious mainly because I have never heard of it before.

[Boxcar]

What does it feel like to take a chunkload of Niacin? Obviously hot, but how long does it last/details/etc.? Hoss be curious mainly because I have never heard of it before.

it lasts quite a while, tho its been a good decade or so since i did that. fuckin-A it burns like a mutha tho. you get all hot and sticky and sweaty. it stings almost. instead of springin fer the shit that really masks fer the UA, i cheaped out on an urban legend with no credibility what-so-ever. thinkin that it would work.....
do you think i got the job? the job a friend got me, and vouched for me? well the answer is NO. the moral of the story.... dont cheap out. just buy the shit from the head shop that works, that comes with a money back guarantee. youll prolly pass the UA and get the job. NIACIN WILL NOT HELP YOU PASS A UA. it must clean you out somewhat tho, cuz you sure can feel it workin.

you should give it a shot hoss..... not really

[EleusisII]

Righty then...

I got my hands on some nicomorphine, 5mg pills, and fuck! That's some really good shit!
Does anybody know about it's bioavailability? I've looked online, and found a nice little study, that showed that nicomorphine had 80% bioavailability rectally, but what about IM and PO? Does it have as low bio-a as morphine orally?

I assume so, since it seems to be the case with most, if not all 'morphans'...

But damn, it's good stuff! Those German/austrians sure know their way around poppy-derivatives. Apparently there's a whole bunch of them, that were developed in Germany, and that you can still get there, but which aren't legal in the US, unfortunately.

[resorcinol]

Righty then...
I got my hands on some nicomorphine, 5mg pills, and fuck! That's some really good shit!
Does anybody know about it's bioavailability? I've looked online, and found a nice little study, that showed that nicomorphine had 80% bioavailability rectally, but what about IM and PO? Does it have as low bio-a as morphine orally?
I assume so, since it seems to be the case with most, if not all 'morphans'...
But damn, it's good stuff! Those German/austrians sure know their way around poppy-derivatives. Apparently there's a whole bunch of them, that were developed in Germany, and that you can still get there, but which aren't legal in the US, unfortunately.

PO (oral) bioavaliability is almost certainly low, like heroin an morphine. Heroin and nicomorphine are both esterified at position 3, but that doesn't help make oral bioavaliability high like having an ether there would (ala hydrocodone, oxycodone -- they have a methylether at position 3). Esters are quickly hydrolyzed in the gut, so you're basically absorbing mostly morphine if you take either heroin or nicomorphine orally. Ethers are more resistant to GI tract first pass metabolism and are absorbed intact, which gives hydrocodone and oxycodone their high oral bioavaliability.

IM bioavaliability will likely be 95% or more. The esters at pos 3 and 6 will begin to be attacked, but IM route is absorbed quickly enough that you still get lots of intact nicomorphine molecules in the bloodstream, and even the portion that is reverted to morphine in that short time has a pretty much complete bioavaliability also. Morphine like opioids and their esters are chewed up by the liver and gut orally, but any other ROA is typically much better. Insuffulated is marginally better; IV, IM, SC, and plugged are much better.

[PantyShot9]

it lasts quite a while, tho its been a good decade or so since i did that. fuckin-A it burns like a mutha tho. you get all hot and sticky and sweaty. it stings almost. instead of springin fer the shit that really masks fer the UA, i cheaped out on an urban legend with no credibility what-so-ever. thinkin that it would work.....
do you think i got the job? the job a friend got me, and vouched for me? well the answer is NO. the moral of the story.... dont cheap out. just buy the shit from the head shop that works, that comes with a money back guarantee. youll prolly pass the UA and get the job. NIACIN WILL NOT HELP YOU PASS A UA. it must clean you out somewhat tho, cuz you sure can feel it workin.

you should give it a shot hoss..... not really

Hold on guys I had a different experience on this subject. I have no idea about opiates but I know for a fact it cleans weed out of ur system. I don't smoke but my step-dad does and when he was on work release he took niacin(not high doses just normal ones)DAILY and also smoked daily and he passed all his UAs. I don't think it works as a quick fix just if u know u have a test at some point later down the road.

[robojunkie]

I gots to imagine throwing any dia-ester-lipophilic group on the 3,6 will be around heroin strength. Nico-etc is pyridine-3-carboxylate (whatever its attached to) ester, I imagine one could fair well with benzoic anhydride or fuck it, succinic anhydride, more common. Any aryl or alkly or arylalkly or hetaryl group that isn't to polar or an H-bond donor/acceptor would likely work. Hell there's shit like myrophine which if I recall the number correctly is just like diamorphine except that instead of two 2-Carbon acetyl groups there are two 12-Carbon myrisityl groups (just a long ass aliphatic, as in saturated, chain).

Here is some sillyness...how about something like 1,12-Dodecanedicarboxylic anhydride (a big fat ring with two anhydride centers) and making the 3,6-diester a ring with a big oily cycle?

OK I'm bored I'll shut the fuck up now...bet it would be fun just to make it and bang it and say one made it and banged it though, huh?

[Consumed.]

yea have you also noticed that when youre dopsick nicotine seems to make you sicker? theres definitely some connection there i donk know what it is.

Thats weird, I read that you are supposed to smoke cigs when you are in w/ds because its an anticholinergenic.
I was going to ask if anyone knew of this connection....

[robojunkie]

Thats weird, I read that you are supposed to smoke cigs when you are in w/ds because its an anticholinergenic.
I was going to ask if anyone knew of this connection....

I don't know the pharmacological relationship between nicotine and wds but I know I can't deal with wds as it is, no cancers and I wish I had cancer, well wish I was dead, sorta kinda. They've never made it worse though, they help some of the "anxiety".

[Consumed.]

I don't know the pharmacological relationship between nicotine and wds but I know I can't deal with wds as it is, no cancers and I wish I had cancer, well wish I was dead, sorta kinda. They've never made it worse though, they help some of the "anxiety".

Well I was about to ask the question and then OxyC said he cant smoke in W/Ds. It helps me in W/Ds. I mean I smoke like a fuckin chimney while I'm high but if there's no cigarettes while I'm in W/Ds I feel like the last of everything has now disapeared.

[Hoss]

I have an extremely hard time smoking while in WD as I begin gagging horribly/etc. - which sucks because I still crave nicotine even while sick, albeit at a much lower scale of intensity.

[stvip]

6-O position substitutions is what does the trick, not necessarily di-3,6 ones.
Want to see somethingneat (titilation gauranteed or money back)? Check out the effects of other acylations. They can't put all acyl anhydrides on chemical watch lists, can they? And even if they do, in analogy with the efficacy of GAA in acetylating at 6-O, as well as compounds which decompose into acetyl radicals (such as ASA or APAP), the list of possible acylators (and subsitutions needn't be limited to acyl groups either, as the example of nicomorphine demonstrates - check out halomophides, etc.) should be very large, varied and easily available. Have fun.

For example:
http://www.ncbi.nlm.nih.gov/pubmed/402470?dopt=AbstractPlus

And I now return to my silence.

[jonny-5]

i probably have one cig every 4-6 hours when im sick, i still kinda crave nicotine, i guess i wouldnt smoke if i didnt...but i smoke prolly every half hour normally. sometimes even more frequent.

[red26]

yea have you also noticed that when youre dopsick nicotine seems to make you sicker? theres definitely some connection there i donk know what it is. Thats gotta be in connection with blood pressure and vascular constriction or some such shit. If Im hungover smoking makes me wanna die.:(

By the way man. I fuckin LOVE yer avatar! I get a chuckle every once in a while when I look at that.

[jonny-5]

By the way man. I fuckin LOVE yer avatar! I get a chuckle every once in a while when I look at that.

thanks man.

"there are so many amendments

to the constitution

of the united states of america

i can only choose one...

fif! fiiiif!"

[bigNasty]

thanks man.

"there are so many amendments

to the constitution

of the united states of america

i can only choose one...

fif! fiiiif!"
not one, two, three, or foe BUT FIIFFFF!!!!!!