OMG Opana

[chopstix]

I think Dilaudid just lost it's crown. I had the pleasure (fucking understatement) of booting a 10mg Opana IR this am. Very, very much like the old Knoll k4s (like 2-3 of them) but this shit has some nice legs too..

Been awhile since I've had a real hit of *morphone and there's no question when you have the real deal, it did feel a lot like D but a tiny but less edgy on the rush (to me, D is a very "sharp" rush, this was slightly diff but it could have been a number of things) and it does seem to have much longer legs - this stuff is fucking awesome! My only "complaint" is, like D, you need a good vein to do it justice and that's getting to be tough for me..

Seems like there's quite a bit of binder, not surprising since I also had a 20mg ER that was smaller. I peeled that one and railed it. I'm not that familiar with oxy so I haven't experienced the infamous jelling effect till today - it didn't seem that bad though, it just took a long time to drain and what did drain didn't taste bitter or anything but it was kinda jelly like, the pill was about the size of a 40mg OC, so two fairly thick lines. It seemed to be working, then I blasted the 10mg IR and started speaking in tongues...

And oh, yeah, I read that the liquid preps are a little acidic (something like 2.5 - 4.5) - so you might wanna try a pinch of citric if you come across any. Score for you if ya do..

[jdub]

Dude. I need to get my hands on some of these. Do you think (to the board in general) that Dr's are starting to switch to these to avoid the negative attention / connotations of OC, the "synthetic heroin."??

[Thanat0s]

first time with opana IR blew my fucking mind as well... gave my roommate at the time a shot and she couldnt speak except to mumble "a ton of bricks...'

my fav pharm by far, ive only injected it but i cant see a reason to take it any other way.

[underide]

You lucky bastards!
I keep reading about the scene across the pond you have and keep thinking " i'd like to have at least a fraction of that!". And by 'that', i mean diversity (of opiates)
I have never tried hydromorphone or oxymorphone. Not many of us did over here.
All we have here is our heroin base, endless methadone and plenty of worthless codeine. You just hardly ever find any 'interesting' opiate pharms to have fun with. It seems like the docs over here are not as likely to write scripts for any GOOD opites as they would be over in North America. I know for a fact that Hydromorphone is actually prescribed over here too, but it must be quite rare, since we just don't see it on the streets.
The only pharm that i got a chance to experiment with over here that's even worth mentioning is Palfium, and now it's off the market.

[Saint]

You lucky bastards!
I keep reading about the scene across the pond you have and keep thinking " i'd like to have at least a fraction of that!". And by 'that', i mean diversity (of opiates)
I have never tried hydromorphone or oxymorphone. Not many of us did over here.
All we have here is our heroin base, endless methadone and plenty of worthless codeine. You just hardly ever find any 'interesting' opiate pharms to have fun with. It seems like the docs over here are not as likely to write scripts for any GOOD opites as they would be over in North America. I know for a fact that Hydromorphone is actually prescribed over here too, but it must be quite rare, since we just don't see it on the streets.
The only pharm that i got a chance to experiment with over here that's even worth mentioning is Palfium, and now it's off the market.

Same goes for the Netherlands (and most of Europe I guess). It's 'just' methadone and heroin. Even subs are hard to come by.
Way back in my early stages of junkhood I could still get morfine-amps or palfium - & opium was all over the place - but I haven't seen anyone selling or using those in ages.

[nick]

Yeah,there isn't the pill/pharm culture on this side of the pond.There a few other opiates available,but they're rarely rxed.

I miss palfium too.

[Seedy]

^^ You think you have it hard in Europe, try living in NZ. NO H AT ALL, $120 for 100mg morphine (I shit you not, heard from the horse's mouth at the clinic the other day). There's oxy, but not through the public health system so it doesn't hit the streets. Imagine how much it would cost if it did! Only other pharms available is pethadine & shitty OTC codiene. For maintenence, only done & the waiting list is at least 2 months. I tried a 10 day taper on suboxone (the onyl way they'll prescribe it) & the clinic wouldn't prescribe benzos, only 5 fucking zopiclones! & I could go on. :mad:

[Saint]

^^ You think you have it hard in Europe, try living in NZ. NO H AT ALL, $120 for 100mg morphine (I shit you not, heard from the horse's mouth at the clinic the other day). There's oxy, but not through the public health system so it doesn't hit the streets. Imagine how much it would cost if it did! Only other pharms available is pethadine & shitty OTC codiene. For maintenence, only done & the waiting list is at least 2 months. I tried a 10 day taper on suboxone (the onyl way they'll prescribe it) & the clinic wouldn't prescribe benzos, only 5 fucking zopiclones! & I could go on. :mad:

Hell Seedy, I'll cut the piss and moan! NZ sounds like a very expensive nightmare compared to Europe. A 10 day subtaper only? Surely they must be crazy.. & zopiclones are as strong as smarties as far as I'm concerned.

[Seedy]

^^ yep, needless to say the 10 day taper (actually turned into 6 days cos they thought that would be enough) was a complete failiure. The zopiclones were gone after my second night off the subs. Had to keep working so I caved in. They're pretty fucking backwards here!

Edit: sorry to hijack the thread, this isn't the piss & moan. On the up side my tolerance is down a little bit so I've been pretty high the last couple of days.

[Boudica]

I would sell my body to Science - while still alive, if I could get a bit o' yay off of any opiate left on this planet. The only thingy megets each month that does do it for me, is Fentura. I go through a box of 28 in about a day and a half.

Somebody, PUH-LEEZE, start a thread on "Tolerence Reduction Methods".

I'd be quite grateful.

Thank yas.

[Seedy]

^^ I'm experimenting with naltrexone to lower tolerance at the moment, I'll be starting a thread if it seems to be working.

[Inspektahdek]

Same goes for the Netherlands (and most of Europe I guess). It's 'just' methadone and heroin. Even subs are hard to come by.
Way back in my early stages of junkhood I could still get morfine-amps or palfium - & opium was all over the place - but I haven't seen anyone selling or using those in ages.


there's morphine "morfine" and oxy but it's hard to come by

[Saint]

there's morphine "morfine" and oxy but it's hard to come by

You mean in Deutschland or Nederland Inspektah? (I know you've been to the Netherlands). I'd love to try oxy once... but have never seen it.
Even subs are not on the streets (yet).

[Inspektahdek]

I hope opana comes to the EU soon, havent heard of it being here as far as I know, would love to try it

[Inspektahdek]

You mean in Deutschland or Nederland Inspektah? (I know you've been to the Netherlands). I'd love to try oxy once... but have never seen it.
Even subs are not on the streets (yet).


DE, but theyve got scag in the netherlands

[Saint]

DE, but theyve got scag in the netherlands

Yeah, that's why I resemble a sprinkler now.. good ol days

[underide]

they've got skag everywhere! (pretty much)

I have tried oxycodone once too. have come across it only once over here. (red and white gel capsules 5mg each and i got 10 of them) I was already on the 'done though, so i didn't really think much of it.

[austinslacker]

Guys I take 40mg Opana Er a.m, 20mgOpana ER at noon , 40 Opana Er at bedtime and 5mg IR 4 times a day for breakthrough. I'd been on Oxy for about 6 years, changed Dr. and he suggested this change about a year ago. I can only say it is much better than Oxy. I can get 2 20mg Teva oxy from a dealer for $5,but pass that by. The gel effect is very slight on the ERs, and I prefer them to the Ir since I rail them. Problem is the withdrawals are intense just like H. Been taking them over a year and still can't find them in hospitals.

I underwent surgery and the hospital here in ATX did not stock them!!! They had to keep me on dilaudid and IMO Opana is tops.

[nick]

You mean in Deutschland or Nederland Inspektah? (I know you've been to the Netherlands). I'd love to try oxy once... but have never seen it.
Even subs are not on the streets (yet).

With Oxy you ain't missing much Saint.

[Saint]

With Oxy you ain't missing much Saint.

Well, on to opana then..

[nick]

Well, on to opana then..

Now your talking.I'd love to try opana.

[Thanat0s]

Well, on to opana then..
really, oxys do fuck all to me... theyll keep me well but ive never gotten a high that really compared to heroin from them...

opana though is a different manner. id sell my soul...

if i believed in such a thing, and it was still of any discernable value.

[cg5]

Same goes for the Netherlands (and most of Europe I guess). It's 'just' methadone and heroin. Even subs are hard to come by.
Way back in my early stages of junkhood I could still get morfine-amps or palfium - & opium was all over the place - but I haven't seen anyone selling or using those in ages.

does any country in europe use oxycodone? all that ive seen used there is codiene morph, fent, and methadone.. seems oxy is like mostly used in us and canada? whatsup with that?

[Nate]

Haven't seen any Opana yet in my area....would love the pleaure of slamming that shit...

Though I am very happy we have lots of 30mg Palladones for so cheap, just yummeh.

[SurfRat]

Hell Seedy, I'll cut the piss and moan! NZ sounds like a very expensive nightmare compared to Europe. A 10 day subtaper only? Surely they must be crazy.. & zopiclones are as strong as smarties as far as I'm concerned.

I like Smarties, they are hard to get around here but I come across them sometimes. :)

I'd like to try Opana too.


Sounds like good times fo sho.

[Boudica]

Haven't seen any Opana yet in my area....would love the pleaure of slamming that shit...

Though I am very happy we have lots of 30mg Palladones for so cheap, just yummeh.


You had best get your lil arse home, and I mean NOW, MISTER!!! And bring me a big, fat handfull of those fookin' Palladones and a Mexican Pizza and a bean and cheese burrito from Taco Bell. Oh, and stop at the headshop and get me some Whippets, too.

You are STILL my husband, you know, and your lil "vacation" from me don't mean squat. I STILL own your arse, AND I"m horney too, so you better just DO everything I just told you to do, and get home and DO ME, or I'll be throwin' a spell on you that'll have you talkin' like that lil midget lady in Poltergeist in two minutes flat!!!!

Remember what happened when I made the Southern Wench have the Curthe of the Everlathting Lithp?!! She was talkin' with a lisp for weekth on end!

DO NOT TOY WITH ME AGAIN!

I shall be waiting at "home" in the Flamer's Forum. You'd best get your lil butt over there.

*Chopstix, my apologies for this brief thread hijack. I am not in control of my emotions at this time.

[Armegeddon73]

How do Opanas compare to Roxis when taken as directed?
ARM

[austinslacker]

Compared to Roxis when taken accordingly for analgesia, depends on the strength, but eating a heavy meal before dropping Opana intensifies the analgesic and euphoric effects.I'll never go back to Oxys having Opana around.

I must say, it is a much stronger analgesic than ANY other pharmies I have taken IMO including Roxis.

[duper]

I would sell my body to Science - while still alive, if I could get a bit o' yay off of any opiate left on this planet. The only thingy megets each month that does do it for me, is Fentura. I go through a box of 28 in about a day and a half.


What's Fentura??

[Boudica]

Compared to Roxis when taken accordingly for analgesia, depends on the strength, but eating a heavy meal before dropping Opana intensifies the analgesic and euphoric effects.I'll never go back to Oxys having Opana around.

I must say, it is a much stronger analgesic than ANY other pharmies I have taken IMO including Roxis.


I get the 20 mg Opana ER, and 10 mg IR's. I have yet to get any euphoric response. From what I've read here, that tells me that my tolerence is even worse than I thought. Virtually every person I know that's had them, has gone completely over the bend. Me? Big, fat nada.

I could cry, seriously.

What's Fentura??

Fentura, is the newer fentanyl product that comes as a little pill that is effervescent. You put it between your cheek and upper molar, as it is absorbed by the buccal membranes. It hits you just about as fast as a shot, seriously. Mg for mg, ime, much, much better/stronger than Actiq. I think that it is because of the ingenious delivery system. You feel that lil pill fizzing, and in a couple of minutes you feel all that fent, boom. Of course, I can't leave them alone when I've got them, doing one after another, because it's the only thing left I can get meself happy with. And no, I can't spare even one, sorry.

[chopstix]

How do Opanas compare to Roxis when taken as directed?
ARM

About like Heroin compares to tylenol.

Oxy doesn't do shit for me, chewed, insufflated or injected; nada.. It'll get me well but aside from that, it's a tease. I've had Opana twice now, 2x10mg IR IV & 2x20 mg ER insufflated. IV is as good if not better than anything else I've ever had in a rig, the only thing that compares was one experience with some really pure thai #4 and that shot almost got me medical attention.

Insufflating the ERs works pretty well, they do have a time release matrix that gels like the Tevas but it doesn't seem to be as bad (I've never had a Teva) although it could be that I'm just dealing with less material. I considered running the "Ike extraction" on one of the ERs but fuckin Opi was down and I was impatient.. Maybe some other time..

Ya, to any junkies in Europe - if you've got a taste for skag, you'd be disappointed with oxy, it's not worth the price, not even close..

[Inspektahdek]

Yeah, that's why I resemble a sprinkler now.. good ol days


Agh Nederlander! Kom tie dan he, kom tie, kom tie dan he! <----- u know that saint?

[Inspektahdek]

Compared to Roxis when taken accordingly for analgesia, depends on the strength, but eating a heavy meal before dropping Opana intensifies the analgesic and euphoric effects.I'll never go back to Oxys having Opana around.

I must say, it is a much stronger analgesic than ANY other pharmies I have taken IMO including Roxis.


more than fent!?!? heh

[chopstix]

more than fent!?!? heh

Fent is great but it doesn't have any legs. It's a lot of work staying high on that stuff unless you're actually wearing a patch, in which case you have to be really careful because the line between high and OD'd is so close. I do like the stuff, but there doesn't seem to be much middle ground with it.. I can't say that I have that much experience with it though..

[lib.sOCialist]

I honestly thought i would never come across Oxymorphone, ive had pretty much every other opiate besides it (fentanyl, oxycodone, hydromorphone, pethidine, everything but big bro H) but NOTHING compares. in fact ive never gotten high off 5mg's of anything, but when i came across 100 of the E613 10mg om's half of one had me nodding for 2 hours or so! I also have a pretty hefty tolerance, 160mg oxy insuffulated for a good nod. If anyone has the option to get this precious opie please do so, it is so worth it! Nothing on the face of the planet compares to a couple fat lines of Opana and a burger and fries! (high fat meal boosts nasal bioavailability by like 30%!)

Nod

[SurfRat]

....Nothing on the face of the planet compares to a couple fat lines of Opana and a burger and fries! (high fat meal boosts nasal bioavailability by like 30%!)

Nod


What's the theory behind that?

[jdub]

What's the theory behind that?

Not sure, but I have heard the same. If I wasn't at work, I would do some google research for ya's. But instead I am gonna call Sunil and try and sell him some software...

[Saint]

Agh Nederlander! Kom tie dan he, kom tie, kom tie dan he! <----- u know that saint?

It sounds like a high coming on (daar komt ie dan!)... or maybe you're talking sex which is more like ik kom... ik kom! haha.. but I'm not entirely sure..
Still your Dutch is better than my German ;-)

[lib.sOCialist]

What's the theory behind that?

Behind what, its the best thing on the planet, or that a meal high in fat before administering oxymorphone boosts all relative bioavailabilities?

[Mallinckrodt]

Behind what, its the best thing on the planet, or that a meal high in fat before administering oxymorphone boosts all relative bioavailabilities?

I think the question was regarding the high fat theory. I am curious as well. I thought it was best on an empty stomach. I think eating some high fat things may even induce certain enzymes that could more quickly metabolize and therefore destroy more of some drugs before they have a chance to get into your system.

[underide]

I think the question was regarding the high fat theory. I am curious as well. I thought it was best on an empty stomach. I think eating some high fat things may even induce certain enzymes that could more quickly metabolize and therefore destroy more of some drugs before they have a chance to get into your system.

I have heard something like that too. In fact i think i either heard or read somewhere that if you want your high to last longer and stay stronger, that you should avoid fatty meals before you ingest your opiate.
I'm not 100% sure it's true though. I'll have a look for that info

Edit: here is a piece quoted from one source that supports this theory:
Résumé / Abstract

The effect of food intake on the pharmacokinetics of sustained-release (SR) morphine sulfate capsules was assessed in 24 healthy male volunteers. Subjects were randomized to receive a single, 20-mg SR morphine sulfate capsule while fasting and immediately after consumption of a standard high-fat meal. Plasma samples were masked for pharmacokinetic analysis. Although the extent of absorption of the SR preparation was comparable in subjects in the fed and fasted states, plasma morphine concentrations were significantly lower at most sampling times up to 10 hours when the drug was administered after a high-fat meal. The rate of absorption of morphine from the SR capsule was slower with food intake as evidenced by a 13% decrease in the maximum concentration (Cmax) a 28% increase in the half-life of absorption, and a 19% increase in the time to Cmax, Results of this study indicate that food intake had an effect on the overall plasma-concentration-versus-time profile of the SR morphine sulfate oral preparation, the extent of which was not revealed by a comparison of Cmaxand area under the plasma concentration-time curve values alone.

taken from: http://cat.inist.fr/?aModele=afficheN&cpsidt=2672137

It looks like (with morphine at least) all that eating food does is slow the absorption t=rate down

[samsong]

I am scripted 5mg Opana IR and it states on the bottle not to eat either one hour before a dose or two hours after taking a dose, so they clearly don't want you to conusme food with it. Also, if you look at the detailed prescribing info for Opana, they actually did studies on this before the drug hit the market about the incrased bioavailability of the drug when taken on a full stomach.

[underide]

I am scripted 5mg Opana IR and it states on the bottle not to eat either one hour before a dose or two hours after taking a dose, so they clearly don't want you to conusme food with it. Also, if you look at the detailed prescribing info for Opana, they actually did studies on this before the drug hit the market about the incrased bioavailability of the drug when taken on a full stomach.

Yes, but they might be warning you against eating because that would slow the absorption rate down, hence making your opana less effective in analgesic effect. Also, nausea - that could cause you to expel your medication along with your food. There may be a number of different reasons why they advise you to not take your meds with food, other than not wanting you to od or get high on your meds because of eatin. (or maybe not)
Again, i'm no doctor, and i'm not saying that i'm 100% right but i do remember a number of sources claiming the exact opposite to what some of you guys are stating. I will look for more info on that

Roxi Stardust will probably know something about this, so maybe she'll chip in

[reddragon3668]

I have to agree that Opana is the shit. I've been on it now for like 5 months. I've railed the fuck outta the 40mg ER pills. It doesn't seem to affect the duration of time that it last. It still last a hell of a lot longer than anything else. I can get 150 of the 10mg IR's a month, but since I don't shoot, all it does is increase my tolerance. So, I think I am going to keep getting the Roxi 30's instead.

Boudica, I've been experimenting with DXM to lower my tolerance. I must say, that its been rather successful. It usually kicks in the next day. I can take 75-90mg and the next day, I can get by on a whole lot less Opana. I can get by on a very small percentage of my usual dose. I'm talking, less than 10%. I know it sounds weird, and maybe I am just unique, but it works for me. Give it a try. I get the Robotussin cough suppressant gel tabls, 15mg each. Let me know if it works for you.

[PantyShot9]

Sadly I've only got one Opana 10 mg ER. With my high tolerance and the fact that snorting half of it gave me pain relief and euphoria was nuts. I would really love to get these again especially the IRs.

[starglazer33]

Ancient dreams! Would love to try some of these drugs.


Certainly would..

[lib.sOCialist]

I know ive found more sources stating that a high-fat meal boosts the BA but i could only find these 2 atm..

This is in the detailed prescribing information available at www.opana.com

"Food Effect"
"After oral dosing with 40mg of OPANA in healthy volunteers under fasting conditions or with a high-fat meal, the Cmax (peak plasma concentration) and AUC (extent of absorption) were increased by %38 in fed subjects relative to fasted subjects. As a result OPANA should be dosed at least one hours prior or two hours after eating."

and http://www.freepatentsonline.com/EP1404331.html

TABLE 6 Summary of the Pharmacokinetic Parameters of Plasma Oxymorphone for Treatments B and A
------ Plasma Oxymorphone ------


Treatment A Treatment B

Pharmacokinetic Parameters Arithmetic Mean SD Arithmetic Mean SD 90% Cl Mean Ratio Cmax(ng/ml) 1.7895 0.6531 1.1410 0.4537 125.4-191.0 158.2 Tmax(hr) 5.65 9.39 5.57 7.14

Auc(0-24)(ng*hr/ml) 14.27 4.976 11.64 3.869 110.7-134.0 122.3 AUC(O-t)(ng*hr/ml) 19.89 6.408 17.71 8.471 100.2-123.6 111.9 AUC(O-inf)(ng*hr/ml) 21.29 6.559 19.29 5.028 105.3-133.9 119.6 T1/2el(hr) 12.0 3.64 12.3 3.99 57.4-155.2 106.3 Treatment B = 1 x 20 mg oxymorphone sustained release Tablet, Fed: test
Treatment A = 1 x 20 mg oxymorphone sustained release Tablet, Fasted: reference

[Boudica]

IBoudica, I've been experimenting with DXM to lower my tolerance. I must say, that its been rather successful. It usually kicks in the next day. I can take 75-90mg and the next day, I can get by on a whole lot less Opana. I can get by on a very small percentage of my usual dose. I'm talking, less than 10%. I know it sounds weird, and maybe I am just unique, but it works for me. Give it a try. I get the Robotussin cough suppressant gel tabls, 15mg each. Let me know if it works for you.


Whoa!!! Now THIS, is info I can surely use!!! Damn, if I could get me tolerence down, I would be doin' me "happy dance", for sho! Now, I am a complete noob ta this drug, so don't know how to use it, like how much, what's the effects, etc. I need to UTFSE here. But, any further info is greatly appreciated. Can ya just get the DXM without the additives that come in the cough medicines?

Thank YOU, RD. Most sincerely.

*I think I'll go eat a whole pint o' Ben and Jerry right now, before I dose for the night *tee heee*

[Nate]

Whoa!!! Now THIS, is info I can surely use!!! Damn, if I could get me tolerence down, I would be doin' me "happy dance", for sho! Now, I am a complete noob ta this drug, so don't know how to use it, like how much, what's the effects, etc. I need to UTFSE here. But, any further info is greatly appreciated. Can ya just get the DXM without the additives that come in the cough medicines?

Thank YOU, RD. Most sincerely.

*I think I'll go eat a whole pint o' Ben and Jerry right now, before I dose for the night *tee heee*

Me is eating ice cream too ;) Nothing like ice cream after a dose :)

[Synack]

once I get into a pain clinic, I'm trying to get my 20mg ER's bumped, and more 10mg IR's.. cause I have a shitload of b/t pain as is..