How's that possible

[Canis aureus]

Howdy,

I'm newbie here...

But anyways: I'm on 24mg's maintenance (it's our uppest limit dosage) and I could get high from other opioids yet in the evening?

So bupe won't block other opiate's power to get me feel them (and well, in fact, I feel them like real). How's that possible?

[Zoop]

That's very unusual. Unheard of, really. Either you have some kind of opiate receptor mutation, or you metabolize the buprenorphine very quickly.

You are one in a million, either way. How long have you been on bupe? If it's only been like a couple of days, then it might start blocking other opiates after a little while longer.

Or, I just thought of this - maybe the buprenorphine you are getting is really not buprenorphine, but some other type of opiate. Is the product from a reputable pharmaceutical manufacturer, like Reckitt Benckiser, who makes suboxone and subutex ( they are British, I think) or is it from some small company in Romania or Albania or something?

[Canis aureus]

I'm on Suboxone; those orage fuckers; I know that they are bupe, plus 1/4 naloxone ... But, in blood tests, there were no norbubrenorphine in my blood in the moning after (24 hours after the intake), but trace amounts of buprenorphine only. The doctor said thart it's very unusual... Indeed she thought that I had used extra subutex, or illegal bupe. I hadn't.

I know, that now, even codeine (300-400 mg's) would work... I must test :D


And another strange thing is that I smoked weed, good weed at last saturday and I was tested (piss test) at wednesday, and I did't got caught... there wasn't thc in my piss, though I was sure that ther would be.

I must have some strange betabolism... And all that wehat i told is true, and the weed was bud and a good bud it was.

[doctor diesel]

I'd always heard that if your take buprenorphine and wait a bit, ingesting any other opiate won't work. So I put it to the test, and the other opiate (codeine) worked.
Isn't this the difference between suboxone, which also containe naloxone or naltrexone, and pure buprenorphine hydrochloride. The latter type are what I tried (brand name Temgesic) and they had not blocking effect whatsover.

Your Doc.

[Zoop]

Hey, Canis, maybe you're not absorbing any through your mouth. when you first start, the technique takes a little while to master, holding the pill under your tongue. I mean, what if you just weren't getting any of the buprenorphine in your system? Or only a tiny bit?

I tried taking a big dose of kratom back several months ago, right after I got on the buprenorphine maintenance, and it was totally blocked by the buprenorphine.

It's the buprenorphine itself that blocks other opiates. the naloxone in suboxone is only there to discourage people from injecting them. Naloxone doesn't get absorbed sublingually or orally, but will if you shoot it.

[mmnyc9]

Many of these Labs don't test for weed anymore. The first test is a screen if there's a problem or they want to be more accurate they do a second test which is very accurate.

[Canis aureus]

And naloxone hasn't anything to do.. as it doesn't absobt, and it lasts about an hour, if injacted. I've been addict since -88, and know how to dissolve bupe. And anything doesn't work right after, but ten hours or so....

Look what Dr Diesel said also

[blahblahblah]

Naloxone doesn't get absorbed sublingually or orally, but will if you shoot it.


Not entierly true its oral bioavailabilty is 3% in large doses it could be active orally, technically. It doesnt get absorbed when isufflated either, even in high doses [minus the few ppl that are super reactive to Naloxone]. It doesnt really get absorbed when injected either [suboxone] as bupe itself has such a high affinty for the opiate receptor sites that it has a hard time knocking them out of there barbed position in the receptor. Ove course there is a limit to when the Naloxone might effect you when injecting bupe but if you are on no other opiates and just a bupe regamine the Naloxone will have no effect. I usually wont go past the 4mg mark of IV Suboxone which contains roughly 1mg of Naloxone as Subs have a 4:1 ratio of bupe:Naloxone. Its alot more dangerous if you are binging on other opiates heroin, morphine and than taking bupe. Inject only when your stable on bupe. Even some Buprenorphine OD Naloxone can not reverse the high affinity of bupe. THink of the bupe molecule like a little BB that is barbed with little hooks it does not comeout of the receptor easily. If your brain is already sturated with bupe injecting bupe/naloxone ontop of that isnt going to effect you much because Naloxone is not powerfull enough to kick the bupe out of there receptors.

Im tired this new sleeping pills is kicking my ass, I forget the name but it works similar to meletonin but MUCH stronger. I dont feel like looking at my bottle for the name starts with an R ahh fuck it good nite.

[hovadagod]

If "you've been an addict since '88" and know how to dissolve bupe, what's the question? It's obvious that the reason the bupe is not blocking has something to do with the fact that you don't have any in your blood; or trace levels I should say. You had it tested. So then you try and figure out why you have no bupe in you're blood stream...only thing I can think of is that it's not being absorbed under your tongue; now wait...I'm not saying that you don't know how to dissolve bupe or that you're not a "hard core" addict; Only that your tongue may be a little thick on the bottom...less permiable than the ordinary bupe user. I bet if you snorted enough you wouldn't feel another opi. Sorry for the tone; I just don't really know how to talk to someone who is so hard core. Bupe is new after all, so even the most experienced addicts need help every now and again.

[Canis aureus]

I think thare is just something strange with it... I had bupe in my blood after 24 hours, but no norbupe... and if I take some opiate in the eve, it works, though it shouldn't; but I'm not sick (only those lgs are aching).

Didn't Dr. Diesel said something like same, or was he just joking.

Doesn't bupe in your bloodstream should break down in norbuprenorphin...? (and it is, if I remamber it right delta agonist, which bupe blocks...)

[Canis aureus]

Make the test yourself, if you want (but don't waste anything before a good deal of time has passsed; of course, I don' recommed anyone to do anything, though)... I just don't believe in blocking mechanism after good ten hours. And I must talk to my doctor about those anomalies in bloodtests... But he thinks I have taken bupe with my own 8besides the program)...

[doctor diesel]

I think thare is just something strange with it... I had bupe in my blood after 24 hours, but no norbupe... and if I take some opiate in the eve, it works, though it shouldn't; but I'm not sick (only those lgs are aching).

Didn't Dr. Diesel said something like same, or was he just joking.

Doesn't bupe in your bloodstream should break down in norbuprenorphin...? (and it is, if I remamber it right delta agonist, which bupe blocks...)

No I wasn't joking, Canis. I don't understand the chemistry for one minute, bit what I DO know is that having read here that Bupe prevents other opies from working, I put it to the test. 3 sub-lingual 0.2mcg pills, and 45 minutes later, about 120mg codeine. I didn't expect the codeine to do anything, but it did - the usual rather poor semi-high that it tries to give despite my five years of pounding the stuff.

Just to reiterate these are pure bupe hydrochloride - nothing else mixed in.

Explain that if you can. :(

Doc.

[jacky]

hey, listen, I have taken even naltrexone for MONTHS in 50 milligram a day doses, and STILL GOTTEN HIGH from heroin.

a person I know died from doing this, so dont rush out and score some dope thinking that there are no drawbacks to doing dope while on opiate blockers or buprenorphine, but mark my words, the scientists dont have a clue about the human variable and euphoria casued by opiates. in my opinion.

I have taken bup for a few months to weeks at a time, and I never mixed other opiates with it because I figured it was a waste, so I dont really have any experiences to back up a claim that buprenorphine doesnt block all the actions of other opiates.

BUT, I figure if an antagonist like naltrexone isnt capable of inhibiting an opiate high, then an opiate like buprenorphine might not block all the effects as well.

Ever used methadone and heroin together for awhile? some people claim that the methadone blocks all the other opiates from working, but try dropping that heroin from you regimine and you might find yourself not feeling so well. I think the main reason people claim methadone doesnt allow for other opiates to work is that methadone is so long lasting, you lose the peaks and valleys of the opiates "signature" in a way, the methadone provides a long lasting slow excreting drugged state. just like its supposed to. so a person might not feel the dope as a "spike" or a "charge", but take that daily supplementation of the added opioid and most people will figure it out a day or two later.

the only way to "somewhat" clear this confusion up is to radiate certian opioids and do imaging work on the actions of the drug in the body, of course you have a slightly modified compound, and it may not perform in the same way as the original compound anyway.

I think the best way for a person to find out is to take an opiate and find out. personally I have had some BAD experiences with buprenorphine while coming off my drug of choice and switching to bup, I was ignorant of the knowledge that taking an opiate while on buprenorphine may not do anything, or may cause some added analgesia/euphoria.

so many people claim buprenorphine does nothing for them, but for me in the first few days I am extremely opiated, sometimes to the point of dysphoria.

friggin variables.

[Pointy]

The bupe blocks pretty darn good. At least with me it does. That kind of sucks since I came accross 60 40mg tabs of oxy yesterday. I might have well run into a 100 tab bottle of asprin. I get the same high.

[shaunclo]

Like I have said a hundred million times, Buprenorphine is a weird ass drug. It has the most different affects on so many people, you would think we are all getting different shit. Thats just the way the stuff works, it has so many variabels to it.

I do little binges here and there when I have the resources for it, with H, I have no problem switching back to my subs, but with methadone, it was a nightmare. I have IV'd 2 mg's of bup on day, and the next day gotten a good strong high from H, Oxy, Fentanyl, Methadone, codeine, hydro and more. If you are on a small amount, like 2-4 mg's a day, then you can easily achieve a good nod from some opies, but I have not been able to feel anything the next day when I was on 24 mg's a day. This just goes to prove how much we dont know about bup.

[psychotiKK]

Not entierly true its oral bioavailabilty is 3% in large doses it could be active orally, technically. It doesnt get absorbed when isufflated either, even in high doses [minus the few ppl that are super reactive to Naloxone]. It doesnt really get absorbed when injected either [suboxone] as bupe itself has such a high affinty for the opiate receptor sites that it has a hard time knocking them out of there barbed position in the receptor. Ove course there is a limit to when the Naloxone might effect you when injecting bupe but if you are on no other opiates and just a bupe regamine the Naloxone will have no effect. I usually wont go past the 4mg mark of IV Suboxone which contains roughly 1mg of Naloxone as Subs have a 4:1 ratio of bupe:Naloxone. Its alot more dangerous if you are binging on other opiates heroin, morphine and than taking bupe. Inject only when your stable on bupe. Even some Buprenorphine OD Naloxone can not reverse the high affinity of bupe. THink of the bupe molecule like a little BB that is barbed with little hooks it does not comeout of the receptor easily. If your brain is already sturated with bupe injecting bupe/naloxone ontop of that isnt going to effect you much because Naloxone is not powerfull enough to kick the bupe out of there receptors.

Im tired this new sleeping pills is kicking my ass, I forget the name but it works similar to meletonin but MUCH stronger. I dont feel like looking at my bottle for the name starts with an R ahh fuck it good nite.

Please tell me how you can shoot up suboxone.. how does it work? Can you actually feel euphoric and nod offa it?

[Coddfish]

Please tell me how you can shoot up suboxone.. how does it work? Can you actually feel euphoric and nod offa it?
Yeah, yeah, yeah. I wanna know that too.

[shaunclo]

Please tell me how you can shoot up suboxone.. how does it work? Can you actually feel euphoric and nod offa it?

you do it just like you would any other pill. Like Blah said though, you dont want to shoot more than 4 mg's of suboxone. But if you have subutex (like I do) it is very very easy to shoot. Subutex dissolves so good with a small amount of water.

I have actually been a bad little boy over the past couple of months, I have been IV'ing my subutex (about 1-2mg's a day) for the past couple of months. At first, its not that euphoric, but after a couple of days, it almost starts getting more and more euphoric. Very non-euphoric compared to H, oxy or morphine, but atleast its something. It almost seems to build up in your body over a couple of days. I have actually caught myself nodding after shooting about 1 mg.

[Canis aureus]

But could you shoot 8mg's of suboxone (with that naloxone in), if you're addict?

[HistoryofMadness]

But could you shoot 8mg's of suboxone (with that naloxone in), if you're addict?

I wouldn't this is exactly why the craps in there... to try to stop diversion of suboxone. If you're not addicted it won't make you sick if you eat it, but anyone can get sick if they shoot it.

The bupe in is for treatment, the antagonist is there to stop diversion and IV'ing.

That's my understanding, anyway.

-H

[Canis aureus]

Yes,

that's my undestanding also... the naloxone prevents shooting! But there are stories and posts about shooting. And I'm spending my time with three 8mg's suboxone right now (thinking shooting, snorting or taking them sublingually tomorrow). :cool:

[blahblahblah]

Its kinda of hard to explain but I'll give it a shot...

You shoot up 3 bags of heroin you fall-out and wake-up in the hospital feeling very sick and w/d's cursing thru your cells. The reason why is because a doctor knew you were OD'ing on an opiate, heroin in this example. He injected you with Naloxone [an opiate antagonist], some doctors will use a large amount and multiple injections so that when you come to you are thrown into w/d and aching for some more dope like a bitch, than you get the doctors that are a little bit hmmm how can I say it compasionate or understanding and just inject you with enough Naloxone to bring you out of an O/D but not enough to throw you into w/d hell. I have seen some doctors that must have got off on the fact or figured they were teaching you a lesson when they would judge the amount of Naloxone to use. I swear there are some doctors out there that even after the have enough Naloxone in you to prevent the OD from being fatal and they know you are going to be ok they will slam another 1mg or so into your veins so that it will kick out any opiates left and throw you into w/d. I am sure there are insurance/saftey/ethic issues involved also, but I am getting off track.

But could you shoot 8mg's of suboxone (with that naloxone in), if you're addict?

What would be an addict, thats the question. If I was habituated on daily heroin use or daily use of a mix a pure opiate agonists would you catch me shooting up 8mg of Suboxone? Fuck No. Thats 2mg of Naloxone, which can be more than enough Naloxone to bring a habituated heavily addicted heroin addict out of a OD. If I was chipping around and using heroin for a few days a week, than Suboxone for a couple days, and shooting morphine on other days, no I still wouldnt shoot it.

Keep in mind this is just one persons [B]opinion and know that bupe reacts with so many people in so many different ways, as whats good for me might be bad for you. Now if I was habituated on Suboxone I would let my guard down alot more on the amount of Naloxone I would allow into my body, knowing that it has a hard time kicking bupe out of the receptor sites. Naloxone can clean out and spit shine your opiate receptors when the opiate the person is habituated on is a pure agonist, i.e. heroin, methadone, morphine, oxycodone, fentanyl, etc. with much more easy than it can with a person habituated on a partial agonist [mixed agonist-antagonist] especially conrening buprenorphine in this case. As bupe has a very high affinty for its receptor sites, think of the bupe molecule in your brain as a little ball with a bunch of barbed hooks all over it. Once that gets seated in the receptor it is hard to get it out of there basically only sure-fire method on removing it is time. You can talk about using drugs that help to speed up the enzymes that metabolize bupe but thats not really relavent in this discussion. Now even a pure opiate antagonist such as Naloxone has been documented in having a hard time reversing buprenorphine OD's and in general kicking it out of its seat. Remember that bupe has a VERY wide range of reaction per the individual and this aspect would be no different.

So now if I am habituated on buprenorphine and all [or well some Mu and Kappa, Bupe is a partial agonist at the Mu receptors sites and an antagonist at the Kappa receptor sites] of some of my opiate receptor sites have been saturated with bupe for awhile I wouldnt be so worried about 1mg of Naloxone ripping the bupe out of its seat in its comfy long lasting seat and throwing me into w/d's because once again bupe high affinty for its receptors. Now if I am pretty much clean and my body is free of any opiates I might hesitate a bit more on injecting Suboxone because there is no bupe in my receptors and it might? be a fight on what would happen first. Would the bupe seat itself and the Naloxone just glide over it or would the Naloxone possible jump the gun and protect the receptor site from allowing bupe to enter. I dont know the answers to these questions, and the rest of the above is just my opinion after trail and error and being on buprenorphine for 4 years, sometimes heavily abusing other opiates during that time also. I have limited experience on injecting Suboxone [few dozen times or so] and that is not a whole lot but its enough for me to form some what of a theory on what works for me or what I am willing to try.

8mg Suboxone pills come in a 4:1 ratio [buprenorphine:naloxone] so a full 8mg tablet contains 2mg of Naloxone. Now how much of that Naloxone gets into solution I cant tell you. Naloxone is readily soluble in water, and [B]slightly soluble in alcohol, while buprenorphine has limited solubility in water 17mg/mL and a significantly higher solubility in alcohol 42mg/mL. Now you can draw your own conclusions from that or do some more research.

IMO and IME Suboxone is best taken as directed sublingual and when you get to smaller doses its best taken insufflated as the bioavaiblility increases semi significantly over sublingual rates. Also for me it gives me more of an instant effect, although never get high or buzzed or any euphoria from it, the adminstration by snorting just gives me a feeling of immediate 'at ease' while sublingual does not. IMO/IME it is not worth it to shoot Suboxone as bupe in itself is not really much better when injected and with all the bulk in those pills: [lactose, mannitol, cornstarch, povidone K-30, FD&C Yellow No. 6 color, magnesium stearate, Acesulfame K sweetener] they are not the safest pills to inject even if one goes about it properly using a .8 filter wheel. Its just one of those things you get bored and try type of things. Granted other people get vastly different effects from Sub, bupe than I do and injecting it might be something that might be up your alley. I dont recommend it though, its not worth it for me. Not enough benefits and to much risk. I have never gone past the 1mg mark of Naloxone and the 4mg mark of bupe. If you really want to inject bupe at least try to get some Subutex and eliminate the tricky component of Naloxone and the adverse effects it can have.

Interesting link, make your own transdermal buprenorphine patches at home: http://www.freepatentsonline.com/5008110.html

[Coddfish]

That was very helpful. Thank you, blahblah. I wondered how mush better injecting would be. Still, as a junky, can't say I won't try it. :o

[psychotiKK]

Yeah, I was thinking about shooting 1mg to 2mg of subs IV. Now, you say it's best to snort lower doses.. why not higher? Snorting bupe makes me feel worse I think. I would snort 4mg or 8mg though..

Has anyone tried both Suboxone and Subutex in high doses? I'm wondering if there would be any difference, even though it says the nalaxone won't do anything unless IVed.. but it's STILL in your bloodstream and maybe some people feel it stronger then others? That's what I thoguht my problem was with suboxone.. idk?

[blahblahblah]

Now, you say it's best to snort lower doses.. why not higher?

Too much powder, a rail of a 8mg tablet is a huge amount of powder. You might feel worse when you snort bupe [Suboxone] because the bioavailability of the drug increases and that means also more Naloxone can be aborbed. It seems some people are more sensitive to Naloxone and it can cause headaches. Personally I have never experienced the 'Naloxone Headache Phenomena' [I dont care if I spelled it wrong I am tired and need to dose] from snorting, only a few times when IV'd or rectal dosing as the bio-avail. goes up in those modes of dosing.

I feel achey thinking about this I have only dosed about 1mg today, I guess its time for a bit more, some benzos, ambien, HBO, Rozerem, and the leather Lazyboy.

Happy Easter :)

[hovadagod]

maybe you're body doesn't convert the bupe to norbupe? Enzymes missing from the liver? Maybe you have some wached out liver that makes different enzymes.

[Canis aureus]

Yeah,

maybe there is something strange in my liver -- while I'm probably the only one here (in the place where I live) who don't have hepatite C (or any of those). I didn't share or won't share those needles or syringes...

[shaunclo]

Yeah,

maybe there is something strange in my liver -- while I'm probably the only one here (in the place where I live) who don't have hepatite C (or any of those). I didn't share or won't share those needles or syringes...

You dont have to share needles to get Hep C.

[Tea Time]

Im tired this new sleeping pills is kicking my ass, I forget the name but it works similar to meletonin but MUCH stronger. I dont feel like looking at my bottle for the name starts with an R ahh fuck it good nite.

It's Rezorem. I have been on that too. Only problem is how fucking expensive it is. It works like a charm and you can take it every night if you want to my doc said. He said no tolerance, no dependence, no addiction. It was developed in Japan. It worked even when the non-benzo ones didn't work.

edit: My bad, I didn't see that you listed the name of the med later another post. It is working very well for me.

[blahblahblah]

Yeah its working well for me also, it gives me a bit a relief that I dont have to rely on anti-psychotics for sleep or worthless sleeping meds like the 'z-drugs' ambien sonata, imovane, lunesta, etc. Although I think those hold a very high potential for helping out with anxiety issues and mark my words ambein'ish like drugs will start to replace the oh so addictive benzos to help relieve anxiety. Still there is nothing like a injection of Ativan or Valium to calm a panic attack down or even a couple crushed bars under the tongue. Or if your in a pinch and dont have a quick acting benzo. Rectal administration of a long lasting but takes awhile to start to work benzo [i.e. klonopin] dissolved in water half and half or high fat milk and 6mg of Klonopin administered in that fashion can have my panic attack killed almost instantly instead of waiting 1-2 hrs for klonopin to start to reach high enough plasma levels for any relief to occur.

Back to Rozerem [ramelteon], it is a great drug. Kinda reminds me of Trazadone in the fact that tolerence doesnt build and that addiction does not apply also [physical that is mental addiction to non-physical addicting benzos is another story and really a joke because the mental addiction can manifest itself into actual physical w/d symptoms. So when they say a med is not physicallly addicting I try not to laugh, tell that someone who was taking Prozac and told it was non addicting and once she stopped she was so sick it was insane. Now they just go with a play on words non-habit forming? Whats that to mean? Whats to say it I wont form a habit to it compared to my next-door neighbor? Its all a joke, almost all meds that are psycho-active tend to be physically addicting ala non habit forming.]

Anyways Rozeram is a bit expensive but its worth it for me, no more cloudy head for a couple hours after waking, no more sleeping thru my alarm[s], whats brings me some relief about the drug is its action. It is chemically related to the natural hormone melatonin, which helps regulate the body's sleep-wake cycle, and is thought to work by stimulating melatonin receptors in the brain. Much as the same way that the 'z-drugs' [i.e. Ambien] manipulate the GABA receptors but dont actually lock into the receptor sites. GABA receptor sites being the sites where benzodiazapines take root and seat themselves. Thats why I think with a little more playing around with the chemical blueprints of some of the ambien'sih drugs where they can do more than manipulate the GABA receptor zone there can be a great big new door open for anti anxiety medications. The same could apply for Rozerem as it stimulates/manipulates the melatonin receptors in the brain rather than actually latching itself into a receptor site.

I know that plain old OTC Melatonin does nothing for me sleepwise it wouldnt work, at all. Other than increasing dream landscapes. Now with Rozerem manipulating the melatonin receptor sites or rather stimulating them I wonder what would happen if I took actual Melatonin? Would the stimulation of the sites from Rozerem have a change in the function of OTC not naturally ocurring melatonin? Would I be able to take say 1 mg or Rozerem and than be able to take 3-10 mg of Melatonin and still have the sleeping potential of a 8mg dosage of Rozerem?

I know I play around with the 'z-drugs' ambein, lunesta, imovane, etc. while taking benzo's. As ambein itself will not put me to sleep even in high doses 50mg+, but when I include ambien [which manipulates the GABA receptor sites, I am not sure the exact form of manipulation, anyone?] in the mix of my daily benzo regimine I seem to get a better response from the benzos and there action in helping me relief my anxiety or muscle spasms [i.e shakes]. Now these days I almost always include some ambien when taking my benzos as it seems to increase there function. I think I might go out and buy a bottle of Melatonin and do a few little experiments concerning its actions when combined with Rozerem. Possibly I might be able to get the relief and extra benefit of increased dream activity melatonin provides by simpley taking a small dose of Rozerem and than taking actual Melatonin. Things that make you go hmm...

I pay around I think about 3 per 8mg pill and I have found that 4mg's often does the trick just as good as 8mg does. What are you paying? A monthly script for 30 isnt too bad 80-90'ish$ but it would be nice to cut that price in half. And that $3 is from Cost Co. I dont even want to imagine the price from a big chain pharmacy like CVS or Walgreens [fuck walgreens they dont even price match other pharmacies, btw]. Jewel~Osco pharmacies will price match but they sure as fuck wont tell you that and when you really look into it the price variations on the generics are pretty massive. For example I get 50 or so 30mg IR generic Adderalls a month. If I go to Cost. Co. pharmacy to fill it I usually have to choices for the generic form Barr and Ipzone [or something like that, to lazy to go check an old bottle] and the price for the generic Barr pharmaceutical amphetamine salts is about 17-20$ the other form of generic is around 35-43$, if I would pick up that same prescription from Osco I would be paying at least 75$ and thats for the cheap generic. The funny thing is the Barr brand blows the other generic outtta the water in terms of effecency and strength. Yeah, yeah all generics are the same, bull motherfucking shit is what I have to say to that. Oxycontin is a prime example of that. I cant praise Cost Co. enough when I go pick up my Klonapin script at Jewel Osco and pay st8 across with no price matching [klonopin 2mg x3 a day] I pay roughly a dollar a pill when I get it from Cost Co. or Sams Club I pay 20-30 cents a pill. Saving me almost 75%!!! You cant beat that.

Well Ill end this post as it is all over the board and hardly even has any thing to do with the main topic at hand, but I did include alot of worthwhile info in the thread and if your smart you might be able to pick up on some of it and save some cash buy using drugs that stimulate receptor sites before taking an actual drug that uses the receptor site, or at least save your self some money and use Cost Co. to fill your prescriptions or have Jewel Osco price match. Also as you can see the wide range of different prices on the generics, if you do a little research before you pick up your script and find out which generics work best for you you might save yourself a bundle of money. Dont get me wrong I am not a penny scrounger in the least but pharmaceutical companies takes a huge chunk outta of my pocket each month. Roughly $500 on medications alone not to mention Dr. visits. If I didnt use Cost. Co and check the prices on the genreics and request the generic that works best for me I would be paying over 7-800$ a month on just fucking medicine, granted I have a shitload of meds and the majority of that price comes from Suboxone which come Tues I think I am goin g to raise my dose anyways as I am getting off home monitoring and dont need the added temptation. ramble, ramble.

Ok I am thru.

Curious as if anybody knows any medicines that stimulate Mu Delta or Kappa receptor sites, other than your typical meds to boost potency, what is it Tagament that increases methadone plasma levels greatly? I forget and my minds jumbled with pharmaceutical jargon at the moment and am not going to bother to look up to see what boosts hydrocodone potency. In the same vein as pure grapefruit juice increases the effect of benzos [never really works for me but it seems to work for others]. Does grapefruit juice manipulate the GABA receptor area in any matter or does it just help increase apsorbtion by playing with enzyme levels and I forget how it works my brain is pulling one of those forgetfull moments.

I'd love to hear some comments back regarding using meds that manipulate receptor sites that in turn help to increase the effectiveness of a said drug that will be sinking its body into those receptors.

http://en.wikipedia.org/wiki/Melatonin
http://www.medscape.com/viewarticle/509498
http://www.rozerem.com/

Seedless...