This is a first post, but..

[Tylercwxzy]

I'm just wondering if anyones ever tried melatonin pills to increase the fun with there opiates? I just took 2 3mg's with Vitamin B-mixed in and drank grapefruit juice to try and get all I can out of these 4 Hydro's.

(also this is my first post, sorry if something like this has been posted before, I looked around to check.)

[cg5]

melatonin makes me just passout... probably would make you nod harder and longer and faster:D

[Tylercwxzy]

Well I experienced a nice nod afterwards, I usually don't get much out of 40mgs anymore but it was fun while it lasted.
Smoked a few bowls and now I'm heading off to dream land, but I would recommend it for a try! :)

[RxQueen]

glad it worked for ya, and welcome to opiophile!

[EleusisII]

Listen kid (No offense I hope... I just like to sound like a wise and tired ol' doper), the only thing grapefruitjuice is going to do, is to give you some of those healthy vitamins we all need.

The whole potentiation/grapefruitjuice thing is kinda like Amway or other pyramid-schemes. There is a THEORETICAL possibility of it working, but I haven't met anyone it really worked for yet.

Thinking and discussing potentiating is a sure sign that your tolerance is too high though. Time to take a break?

[TappyTibbons]

Listen kid (No offense I hope... I just like to sound like a wise and tired ol' doper), the only thing grapefruitjuice is going to do, is to give you some of those healthy vitamins we all need.

The whole potentiation/grapefruitjuice thing is kinda like Amway or other pyramid-schemes. There is a THEORETICAL possibility of it working, but I haven't met anyone it really worked for yet.

Thinking and discussing potentiating is a sure sign that your tolerance is too high though. Time to take a break?

I was always under the impression that trying to potentiate was a sure sign of having to little opiates and/or money (for buying more opiates with) and wanting to get as high as one possibly could given the circumstances. I've always had good experiences with potentiation efforts.

[EleusisII]

Really? I tried the juice, the tagamet, standing on your head while dosing, none of that shit seems to work...

[Thanat0s]

Really? I tried the juice, the tagamet, standing on your head while dosing, none of that shit seems to work...

aye, most dont really seem to work for me either... diphenhydramine on the other hand...

[robojunkie]

I can't provide anecdotals for the grapefruit juice but I'll speak volumes for cimetidine, when I was on the clinic, I'd do the occasional three days on cimetidine and I definitely would notice the feeling that I had taken significantly more than usual, enough that there was no question that it wasn't placebo effect, and I'd compare it to taking an extra half dose while on totally tolerant maintenance.

And dissociatives (PCP, DXM from experience, ketamine from what I've heard) are absolutely both potentiators and tolerance inhibitors (they don't stop it, only slow its development rate). I can also vouch for 200 mg proglumide about 20-30 minutes before hit. I'd like to try all four, PCP, proglumide, grapefruit juice and cimetidine, see what that shit would do...



But, to be honest, I'd rather potentiate with more potent opiates, ya think? Can I get a second?

[Thanat0s]

amen brotha robojunkie

[ndoftaworld]

I've never experienced the 'power' of gfj, though I know A LOT of medications are affected by it. Could be a placebo in terms of opies, but ya never know...

Nd

[Mallinckrodt]

I can't provide anecdotals for the grapefruit juice but I'll speak volumes for cimetidine, when I was on the clinic, I'd do the occasional three days on cimetidine and I definitely would notice the feeling that I had taken significantly more than usual, enough that there was no question that it wasn't placebo effect, and I'd compare it to taking an extra half dose while on totally tolerant maintenance.


I have the same experience. I know it's not placebo, actually I wish I could stop taking them. I very seldom am running late to the clinic and forget to take a cimetidine or two about an hour before. I most definitely notice a difference about half way through those days.

I actually feel like I am even more fucked when it comes to ever getting off the clinic due to the potentiation effects of tagamet (and I have used WHITE gf juice with good results too, key is it has to be white to do much good). Lately I have been cutting the dose of tagamet little by little trying to break this habit. Once I accomplish that, I plan on trying to detox very slowly.

[wafflehead77]

The grapefruit juice is not going to do much if you are taking hydro's or oxy. It is possible that it would completely destroy any chance of a buzz from codeine (since it inhibits the CYP3A4 and i believe 2D6, which is the enzyme needed to metabolize codeine --> morphine.

I think morphine would be the only drug it would significantly potentiate, due to its low oral bioavailability. Cimetidine on the other hand, appears to be a more potent inhibitor, and I have noticed some potentiation of oxy with it, although the high didnt seem to last, probable because there was not as much conversion to o-morphone.

[chemiKalz]

I've been doing the white grape juice thing before dosing for about a year now, idk if it really helps, it seems like it may, but god damn buying a bottle of grapefruit juice for 4 dollars every few days adds up, I think today I'll drink a little nyquel for the dxm in it and take a few tylenol pm's before I dose.

[HowLongIsTooLong]

Welcome to the 'phile... sounds like you'll fit right in

D