Hydrocodone/APAP

[GetinLow]

Id first like to thank Billi and Jacky for this forum and all others who helped get the forum back up and going :) !

.......... My concern is the APAP in the 10/325 Norcos I am Plugging every morning.........I am plugging 4 pills in the morning only . So its relatively low amount but I want to be safe as possible ! Question 1- So , Does plugging APAP have the exact same effect as taking orally concerning Liver damage ? 2- If I was taking 600mg N-Acetyl-L-Cysteine every day would this counter any negative effects the APAP would have on my liver ? I know about Cold Water Extraction but it seems to not work as well IME . Thanks in advance and Yes I am Plugging the Norcs with Water ;) Glad to be back Yee Haww !!!!!!!!!! GetinLow

[RxQueen]

do you take any more of them through the day, or are you done with them after those 4 in the morning? cuz they only have 1300mg of APAP, which is pretty low... that's only 300mg more than you'd get from 2 tabs of straight-up extra-strength tylenol. still, i understand your concern about that vile poison, and i'm currently dealing with it myself due to an elbow/wrist issue.

to answer the first question, i would think that once the APAP gets to your bloodstream, it won't matter how it was ingested. so the effects on your liver would be the same.

about the NAC... i recently did a little research on it for myself. when used to counter APAP overdose, it's given in HUGE doses. they like to start using it within 8 hours of ingestion of the APAP, and they start with a big loading dose with more big doses every 4 hours afterwards until 72 hours are up. they prefer to give it IV, but there is also a regimen for using it orally. here's what i figured out would be the dosages for me, to use as an example to show how huge the doses are:

the doses are based on body weight in kg's... i'm close to 130lbs, which is about 59kg. so my oral initial dose would be 8260mg (yes, that's NOT a typo.... that's between 13-14 of the 600mg caps). then i would need to take an additional 4130mg (about 6-7 caps) every 4 hours, for 17 more doses.

it's crazy, right? but since i'm taking some of these stupid 7.5/750 vikes they gave me without the CWE (i do it for the vast majority of them, but it's just not practical, or even possible, to CWE the ones i need when i'm at work), i've started to take NAC. i have the 600mg caps too, and i'm taking 3-4 of them here and there throughout the day. i figure that i don't need to take the large amounts i would need for an actual OD of APAP, but taking larger than average doses may hopefully avoid some of the strain on my liver caused by the fucking 750mg of APAP per pill.

so i think that you could actually be safely taking much higher doses of NAC to protect your liver. of course, the 1300mg of APAP you're taking probably isn't enough to do significant liver damage anyway, but it never hurts to be extra safe, right? also, i read on one site that some believe in also increasing your vitamin C intake when using NAC.... i can't remember exactly why.... something like it can somehow deplete your own reserve of it maybe? but i've started taking some vitamin C as well, cuz it can't hurt and besides, these chewable ones taste good!

i hope this helps, and good job for doing what you can to protect your liver! (now if we could just get you to perfect your CWE technique so you'd find it usable! ;))

[GetinLow]

Thanks Rx Queen ! I figured somebody was doing something similar . And yes those 4 in the morning are it, mostly,............. sometimes maybe 2 in the evening or some Black Tar :) ...... Quite a jump aye ! I probably have more cocern with whatever is bungled in my Effin roofing tar :mad: But, I figure if I take all kinds of antioxidants it might help with that also . Thanks for reminding me about the Vitamin C ..... I think I heard about that also ........but forgot . Hope you find some Hydro W/ less ASHAT in them or maybe some Oxy:p. Do you ever fill sick from that much APAP or NAC ? take Care and glad you are back ! ................... GetinLow