Naloxone ==> Oxymorphone ???

[SpecialGuy69]

These two are so close chemically it seems like a done deal. I mean you break one fuckin single bond and you're IN!!! Naloxone is pretty easy to get your hands on, they hand it out in some cities at needle exchanges. So, heres what you gotta do:

Get from here (Naloxone).................To here (oxymorphone)
http://upload.wikimedia.org/wikipedia/commons/thumb/c/c5/Naloxone.png/220px-Naloxone.pnghttp://upload.wikimedia.org/wikipedia/en/thumb/6/62/Oxymorphone.png/220px-Oxymorphone.png
So, how do you knock off that allyl group, leaving the methyl?

This seems like it should be possible. Fuck, they are more similar than ephederine ==> methamphetamine

[betmylife]

if only Mr.Wizard was a junkie.....remember that guy?

[Nate]

Lets hear what our Opiophile chemist thinks, if the conversion is easy, I think we will be very happy :D

[Papa Verine]

Robojunkie!!! Are you out there buddy??? We need ya!

I have a big bottle of Naloxone (Narcan). I'm following this thread...

[Nate]

With our luck the instructions to convert it will be in a foreign language, hahaha.....hopefully not cause if it's easy I will cream my pants.

[SpecialGuy69]

With our luck the instructions to convert it will be in a foreign language, hahaha.....hopefully not cause if it's easy I will cream my pants.well if it's in Robojunkie, I'll do my best to translate. If only you could just shrink down and break those allyl groups into methyls.

See where I'm talking about? On the left side of the molecules, the only difference is what comes off of the N. The angles are carbon atoms. So all you would have to do (If the molecule were made of tinker-toys) is break the bond that holds the extra carbons (allyl group) off, leaving just one carbon after the N (methyl group).

PV- how many mg are in the naloxone bottle?

Its great that you have that. Everyone should. I was actually worried about posting this because if its really easy to do, it might lead to further restrictions in the distribution of naloxone. We need MORE naloxone out there on the streets. Naloxone saves lives, oxymorphone is just fun.

[Woody Bear]

You see how the Nitrogen has 3 lines coming out from it, each line ends in a carbon molecule. So you want to break just one of those lines, which if you could use something that would break the carbon nitrogen bond, it would break all 3.

The other reason why you can't do this is the same, you really want to break the carbon-carbon bond AFTER the the first carbon attached to that Nitrogen. Now if you have something that can break carbon-carbon bonds, then it would break up the whole molecule. That's why chemistry targets Functional Groups, which are the more reactive parts of the molecule, like Nitrogens, and OH groups, and things like that rather then carbon-carbon bonds.

So the short answer is No, it's not possible to convert Naloxone to Oxymorphone.

[aj11]

I can hear the hearts breaking from here

[stvip]

That's why chemistry targets Functional Groups, which are the more reactive parts of the molecule, like Nitrogens, and OH groups, and things like that rather then carbon-carbon bonds.

Or things like a double bond, as in, say, an allyl group.

[Papa Verine]

I feel like my parents just told me "We're not going to Disneyland anymore".

[SpecialGuy69]

You see how the Nitrogen has 3 lines coming out from it, each line ends in a carbon molecule. So you want to break just one of those lines, which if you could use something that would break the carbon nitrogen bond, it would break all 3.

The other reason why you can't do this is the same, you really want to break the carbon-carbon bond AFTER the the first carbon attached to that Nitrogen. Now if you have something that can break carbon-carbon bonds, then it would break up the whole molecule. That's why chemistry targets Functional Groups, which are the more reactive parts of the molecule, like Nitrogens, and OH groups, and things like that rather then carbon-carbon bonds.

So the short answer is No, it's not possible to convert Naloxone to Oxymorphone.It IS possible, in the sense that any organic synth is technically possible, given enough steps and unlimited reagents/reactants etc. It might be impractical/not cost effective/stupid to attempt, but I wouldn't say impossible. Goonies never say die.

Well, what about converting that allyl group to something else? Oxycodone and codiene have an amine group in place of the allyl group. What would that make? Or just change the allyl group into whatever is possible.
Then if you could change the -OH group to a -CH30 group and you'd have oxycodone.

It's insane how close all these compounds are chemically.
The whole idea I was working on here is to find some easily available opiate- naloxone, buprenorphine, codiene (i know i know), nalextrone, lope; and turn it into something worthwhile. Any suggestions?

BTW all the other C-C bonds in naloxone are all in ring structures- is there a way to selectively break only the C-C bonds that aren't in ring structures? If so, that would make oxymorphone.

OR

In nalextrone, its the allyl group is substituted with methylcyclopropane. Is that easier to knock off?