Huge jug of acetic anhydride

[resorcinol]

I had a wild dream last night!

I was in lab in a room I hadn't been in before, and it had a huge cabinet of chemicals. I had to take a peek (actually for non drug reasons, I would love to procure a wide variety of reagents). I've already done tons of chemistry for the sheer fun of it with the chems I have been able to procure. I've got my own set of glassware and labware at home.

So I take a peek, and down on the bottom shelf was a huge jug of AA, and the cabinet wasn't locked. Too many other students and the TA were around though, so I couldn't take any. I wouldn't even consider taking the whole jug if this was a real life discovery, I'd put some in a smaller container that was thoroughly dry, and I'd have to tread lightly... don't wanna get caught by a uni employee and get kicked out.

I could kick pod extract up another notch with some of that :)

How about valeric anhydride, propanoic anhydride, and other short chain acid anhydrides? Would those "H" analogs be more potent that morphine too? anyone know?

[Papa Verine]

Robojunkie????

I'm no chemist but I do know how to turn morphine into heroin. Good find man... be careful and I hope you get to have some fun with it.

[SpecialGuy69]

I was in lab the other day in a room I hadn't been in before, and it had a huge cabinet of chemicals. I had to take a peek (actually for non drug reasons, I would love to procure a wide variety of reagents). I've already done tons of chemistry for the sheer fun of it with the chems I have been able to procure. I've got my own set of glassware and labware at home.

So I take a peek, and down on the bottom shelf was a huge jug of AA, and the cabinet wasn't locked. Too many other students and the TA were around though, so I couldn't take any. I wouldn't even consider taking the whole jug, I'd put some in a smaller container that was thoroughly dry, and I'd have to tread lightly... don't wanna get caught by a uni employee and get kicked out.

I could kick pod extract up another notch with some of that

How about valeric anhydride, propanoic anhydride, and other short chain acid anhydrides? Would those "H" analogs be more potent that morphine too? anyone know?propionic anhydrate works. Its not so much the short chain acid anhydrates- its accessable acetyl- groups you need.

there are many other things you can do to M.

Keep an eye out for HBr (pretty easy to get) and BBr3 (very hard to get). That opens the door to hydromorphone/oxymorphone.

[GOLD N DIEMONDS]

I am no chemist so can't help there. But this would be a good post to make into a more of a hypothetical question and answer thing. Be careful

[resorcinol]

I am no chemist so can't help there. But this would be a good post to make into a more of a hypothetical question and answer thing. Be careful

eh, yeah, you're right. none of us are as anon as we think we are most likely.

[GOLD N DIEMONDS]

Unfortunately not (even w/ our cute screen names) - I tend to think more that way when the words AA pops up. - for obvious reasons. Just watching out for you there, buddy. You're smart , thanks for not taking offense. Good Luck (good find, dream on!)

[stvip]

First, you should know that according to several papers, the much easier to acquire GAA can be used to acetylate at the 6-O position, theoretical chemistry objections nonwithstanding.
6-monoacetylmorphine is at least as potent as 3,6-diacetylmorphine.

For a novel approach, try my "Hmongous Success" (sic) thread.

Now, a few other novelties which I find extremely intriguing are various alternative acylations. The synthesis should be very straightforward, and apparently, some of these acylated morphine compounds have good oral bioavailability and are longer-acting than the acetylated ones.

Have a look at these:
http://www.ncbi.nlm.nih.gov/pubmed/6733591?dopt=abstractplus
http://www.ncbi.nlm.nih.gov/pubmed/6733592?dopt=abstractplus
http://www.ncbi.nlm.nih.gov/pubmed/402470?dopt=AbstractPlus
http://www.ncbi.nlm.nih.gov/pubmed/6727542?dopt=abstractplus


By the way, Resorcinol - could you divulge what's your field of study/research? Always happy to meet new scientifically literate opiophiles.

[SpecialGuy69]

also if you can get your hands on:

lithium or sodium metal (easy)
iodine crystals (easy)
ether (easy)
elemental phosphorus
phosphoric or hypophosphoric acid
hydriodic acid
ammonia gas (not hydroxide)
phenylacetone (p2p)
methylamine

you can make quick big $$$ selling to meth cooks.

also might want to stock up on:

p-benzoquinone
LAH
THF
palladium chloride
mercuric chloride
methylene chloride

Just in case you ever happen to bump into any indoles that need to be oxidized and then reduced to their secondary amine...

[SpecialGuy69]

First, you should know that according to several papers, the much easier to acquire GAA can be used to acetylate at the 6-O position, theoretical chemistry objections nonwithstanding.
6-monoacetylmorphine is at least as potent as 3,6-diacetylmorphine.

For a novel approach, try my "Hmongous Success" (sic) thread.

Now, a few other novelties which I find extremely intriguing are various alternative acylations. The synthesis should be very straightforward, and apparently, some of these acylated morphine compounds have good oral bioavailability and are longer-acting than the acetylated ones.

Have a look at these:
http://www.ncbi.nlm.nih.gov/pubmed/6733591?dopt=abstractplus
http://www.ncbi.nlm.nih.gov/pubmed/6733592?dopt=abstractplus
http://www.ncbi.nlm.nih.gov/pubmed/402470?dopt=AbstractPlus
http://www.ncbi.nlm.nih.gov/pubmed/6727542?dopt=abstractplus


By the way, Resorcinol - could you divulge what's your field of study/research? Always happy to meet new scientifically literate opiophiles.If you have access to AA, why bother with GAA? I'm sure you both know this, but just to the new guys- Acetic acid and acetic anhydrate are totally different chemicals, and separating the water from GAA won't make AA. AA is made through a dehydration reaction, hence the Anhydrous name.

The GAA theory has been kicked around quite a bit, and has generally been disreguarded by RJ and other chemists who I trust around here.

[stvip]

The GAA theory has been kicked around quite a bit, and has generally been disreguarded by RJ and other chemists who I trust around here.

If true, I would be very interested in Robojunkie's take on this. He's an honorable man and knows his stuff, and is an actual chemist (more importantly - an academical researcher of Chemistry) while I am not. As far as I recall, he didn't doubt the papers describing the viability of the reaction, only pointed out that mucking around with GAA is dangerous too, and would require a fume hood and other safety measures, as with AA.
I can dig up the research papers describing the successful synthesis (the research described in the paper itself was merely to confirm a result published in a paper from over a hundred years ago).

[SpecialGuy69]

If true, I would be very interested in Robojunkie's take on this. He's an honorable man and knows his stuff, and is an actual chemist (more importantly - an academical researcher of Chemistry) while I am not. As far as I recall, he didn't doubt the papers describing the viability of the reaction, only pointed out that mucking around with GAA is dangerous too, and would require a fume hood and other safety measures, as with AA.
I can dig up the research papers describing the successful synthesis (the research described in the paper itself was merely to confirm a result published in a paper from over a hundred years ago).you need more than just GAA + M. You need a catalyst for the reaction to occour.

6-monoacetylmorphine already has a free 3-hydroxy group and shares the high lipophilicity of heroin, so it penetrates the brain just as quickly and does not need to be deacetylated at the 3-position in order to be bioactivated; this makes 6-monoacetylmorphine somewhat more potent than heroin,but it is rarely encountered as an illicit drug due to the difficulty in selectively acetylating morphine at the 6-position without also acetylating the 3-position. This can however be accomplished by using acetic acid with an appropriate catalyst to carry out the acetylation, rather than acetic anhydride, as acetic acid is not a strong enough acetylating agent to acetylate the phenolic 3-hydroxy group but is able to acetylate the 6-hydroxy group, thus selectively producing 6-MAM rather than heroin.

If GAA worked by itself, then you could theoretically just use pickling vinegar (20% acetic acid) and M.

[stvip]

AO:

Who or what are you quoting there (second paragraph)?

As for

you need more than just GAA + M. You need a catalyst for the reaction to occour.

On what basis do you claim this?

If GAA worked by itself, then you could theoretically just use pickling vinegar (20% acetic acid) and M.

The conclusion does not follow from the premise.

The papers:

http://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1963-01-01_1_page008.html

"The method of preparation of pure 6-monoacetylmorphine hydrochloride has long been known (6). C. I. Wright [ (7) (http://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1963-01-01_1_page008.html#f007)] improved on earlier procedures by adding a concentrated aqueous solution of hydroxylamine hydrochloride to an alcoholic solution of heroin base. In this laboratory we have found that Wright's procedure can be made quantitative by eliminating all water and adding an alcoholic solution of hydroxylamine hydrochloride to an alcoholic solution of heroin base. We have also followed C. R. A. Wright's [ (4) (http://www.unodc.org/unodc/bulletin/bulletin_1963-01-01_1_page008.html#f004) ] procedure for producing alpha-monoacetylmorphine by reacting morphine alkaloid with glacial acetic acid; the alphamonoacetylmorphine so prepared had an infra-red spectrum identical to the spectrum of the 6-monoacetylmorphine prepared by the reaction of heroin and hydroxylamine hydrochloride."

What is C.R.A. Wright's procedure?

" § 3. Action of Acetic Acid on Morphine
When morphine is boiled for several hours with twice its weight of glacial acetic acid, and inverted condenser being attached, a large amount is converted into a substance related to morphine in the same manner as diacetyl-codeine is to codeine; by dissolving the product in water, adding ammonia, and shaking up with ether, an ethereal solution is obtained which yields a copious crystalline hydrochloride on shaking with hydrochloric acid; this hydrochloride is but sparingly soluble in cold water, but can be recrystallised from that menstruum when hot without change. The crystals contain C34H36(C2H3O)2N2O6.2HCl.6H2O. [...]
When pure, neither the free base nor its salts give any coloration with ferric chloride; simultaneously with this base, however, there is formed a small quantity of a substance that does colour ferric chloride blue like morphine, but differs therefrom in being soluble in ether and in being precipitated by carbonate of soda in white amorphous flakes, soluble in excess of the precipitant; this substance does not seem to give a crystalline hydrochloride, and is apparently identical with the ß-diacetyl-morphine (2) described in § 5, i.e, is isomeric with the above base, yielding a sparingly soluble crystalline hydrochloride, which is accordingly designated [alpha]-diacetyl-morphine (2)."

What you should note is that the original paper if from 1874, and assumes a wrong structure for morphine (basically, they believed the structure was doubled), hence they mean alpha-monoacetylmorphine, not alpha-diacetylmorphine (and likewise, acetylcodeine, not diacetylcodeine). The paper citing that article is from 1963, corrects the structural naming error, reproduces the result with the same technique (heating morphine with GAA, yielding 6-MAM) and uses modern techniques (sepctral analysis) to confirm this result.

[clinton]

isnt this what the poles use to up the dosage power oF their tea?

[SpecialGuy69]

Okay remember the abortion that was Wood's "h without acetic anhydrate" thread? I'm NOT going down that road. You can be right.

I went to the quickest source I know- wiki. Now that I look at the article, this section is uncited.

I didn't realize that the exclusion of water was so important to the reaction.

Anyways, back to the original topic, take a couple hundred mL's of AA. One day you will thank yourself.