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Mild_Man
02-11-2006, 03:33 PM
I might be on the receiving end of some hydro syrup soon but just wanted to ask a question. I coudln't really find an estimated human lethal dose and the ld50's from animal studies I've heard are near impossible to correlate with humans. Anyways, I was wondering if anybody would know or direct me to some information on how much (in mg) hydrocodone could possibly cause lethal/near-lethal effects in a basically non-tolerant, average person? I read somewhere that for codeine it's between 0.5-1.0g estimated lethal dose possibility for a regular, non-tolerant person and I've also heard that hydrocodone is 6x stronger than codeine but I'm not sure when they say that if they are just referring to the pain-kiling effects because I've heard hydrocodone is less harsh than codeine.

-Sorry for the long post but just wandered if anyone knew

satori
02-11-2006, 04:28 PM
Just try not to exceed 30mg unless necassary, over that makes me feel sick but im sure its.... semi safe.

hovadagod
02-11-2006, 09:53 PM
Under 30mg makes me feel shit!!! (But back in the day would have been too much)

JimmyJoe
02-12-2006, 09:06 PM
If you are new to hydro 30 mg is a good upper limit. The main problem with hydro is overdose on tylenol which is toxic to the liver at high doses. I think doctors recommend no more than 3000mg of tylenol per day so if your taking hydro 500mg tylenol-5mg hydro you've got to be careful. Either do cold water extraction or take less. If you're a newbie with hydro, I can assure you that 30mg would more than enough to feel the effects of it. If you are taking something like vicoprofin with ibuprofen in it, it is not so much of a problem but you can still overdo it. And, I don't think cold water extraction works as well with ibuprofen. I don't know what is in the syrup you refer to since there are different ones. I think there is one where the hydro is in suspension and it has an expectorant in it which can make you vomit if you take too much. Really, 20 mg. of hydro is a sufficient dose for newbies to have very positive effects in my opinion. Better safe than sorry.

hovadagod
02-12-2006, 09:57 PM
20mg for newbies is plenty. I started at 10mg. 20mg was soon my dose. Now....well thats another story. As for the acetamenophen, buy some NAC form GE or a vitamine shop and you could help protect your liver. Also milk thistle. With the NAC and milk thistle you can safely take a little more APAP or aceta. NAC produces the chemical that is depleted in the liver by the APAP. It can really help protect the liver but it's not a cure all.

Brony
02-14-2006, 03:54 PM
I've been into the opies for a fairly long time (most recently for chronic pain), and currently my pain specialist gives me 20mg hydrocodone sustained-release capsules (made at a compounding pharmacy, of course), and while I will say that for the most part, hydrocodone is a benign drug, you should be careful with any pure agonist opiate/opioid (at approx. 160mg [taken at once] I start to notice PROFOUND respiratory depression [it fucking scares me]). Anyway, time to get off my soapbox. The long and short of it is, pure agonists don't have a "ceiling effect", that's why you gotta be careful.

shaunclo
02-21-2006, 01:35 PM
When I 1st started taking hydro's, I would only take 1 5/500 vicodin and feel the affects greatly. I think I remember taking 3 on an empty stomach 1 night and threw up for like 2 hours straight. I think a good starting dose for a newbie would be 10 mg's of hydrocodone.

exitwound
02-21-2006, 05:52 PM
Just try not to exceed 30mg unless necassary, over that makes me feel sick but im sure its.... semi safe.

It's all about tolerance. I could easily take 50mg and not get nauseous or have any ill effects these days, whereas back when I had no tolerance, 20mg would make me feel like lying down so I wouldn't vomit....

PRIZEFIGHTERINFERNO
03-14-2006, 12:24 PM
i just want to report what i know my friend takes. Currently at least 100 mg's a day. But if my friend goes five days without, its back down to 30 mg's. It just depends on how you want to feel! If you want to catch a nod then take them carefully till you acheive that state. Thats the cool thing about pharmies, they are reliable (?) because there made in a lab and they have a set MG. Hydros are powerfull and as someone said they are converted to Hydromorphone?

PRIZEFIGHTERINFERNO
03-14-2006, 12:25 PM
Oh yeah, the hydros my friend takes are 10/325.

psilocybin
03-19-2006, 06:19 PM
I wish I could get some syrup.30mg should be a good starting dose

RThompson
03-24-2006, 08:58 PM
I wish I could get some syrup.30mg should be a good starting dose

Also--and many years ago I learned this the hard way...--make sure you gauge the amounts of other chemicals that might be in the syrup, i.e. pseudoephedrine, whatever. Syrup affects me differently than hydrocodone in pill form (with APAP, at that); it's much more of a depressant and seems to be less potent... but it's not, it's just different. If you're not used to liquid hydrocodone: 20-50mg, starters.

ontario_opiophile
03-25-2006, 03:10 AM
I've ingested 50 OTC codeine 8mg + acetaminophen 325 + caffeine 15mg which ends up being about 400mg of Codeine, 16 grams of Acetaminophen, and 500+mg of Caffeine, and lived to talk about it. Although I don't recommend doing what I did or ingesting anything with Tylenol in it in large amount like I did. You will die if you do what I did. You are not supposed to exceed 3000mg of Tylenol per day, so don't go and take a fuckload of hydrocodone if it's mixed with tylenol unless you can find some way to filter the tylenol out properly. Getting high isn't worth losing your liver or kidneys. I'm lucky I didn't die from that tylenol overdose. The bad thing is, if you poison yourself with tylenol, you feel fine for a couple days so you think you are in the clear and that you've cheated death, but as I said, you feel fine for a couple days and then, the damage sets in and it harms your liver sooooo much. Trust me, you don't want to fuck around with the tylenol. There is a specific antidote for tylenol that protects your organs from damage, but if you OD you need to get to the hospital to get it. If you wait for yourself to start feeling sick from the overdose it will be too late and you will end up needing a new liver, and you probably wont get one very fast so you could die. Anyways, just be careful. Thats all I can say. I want all my opiophile buddies to live long happy lives :)

If I was going to do Hydrocodone I would start with 30mg-60mg. If you have had hydrocodone before and know your not allergic or anything then you're fine. Unless you have tried opiates and needed tiny amount to get a buzz, if this is the case, I would take 20mg-30mg. The LD50 of hydro is pretty high I think. Somewhat similar to Oxycodone. A bit less than the codeine LD50 as well. Probably 30-50% less. I could be wrong it's just an estimated guess. I am not a doctor. I am not responsible for anything you do with this information. It is information not directions on how to use drugs. It's simply what I would do in the given situation(s). I know all of the "regular" Opiophiles, know not to just follow what somemone says but some kid might read it and blame me if they OD on 20mg. lol. So I must warn the masses. This is a public site ya know. Take care friends :)

antony
03-26-2006, 11:51 AM
I've never done CWE, but I wish I did. Use to tear through 10's with at least 500mgs of tylenol. At least 5 at a time, 3-4 times a day. Sometimes, I'd think Ive o'dd, start dry heaving, masssive amounts of saliva, thinking im gonna puke. most of the time i never happend unless I drank too much oj or GF juice, but I think that was due to too much acid in the stomach. Never got high when the last happend.
And I would get pains where my liver is. No fun, and a BIG waste of Hydro and cash.:mad:

HandMeSomeOpiates
04-02-2006, 01:54 PM
Wow..to me hydro is weak after 2 years of use. I now take 5 10mg at a time(50mg) and it rocks. Anything under 50mg just pisses me off now. I remember when I could take 10mg/20mg and be fine but boy has my tolerance sky rocketed... It depends on your body chemistry/tolerance to say what a lethal dose is. I never take more than 60mg at a time though.

ticken
04-11-2006, 01:02 AM
i once went into the ER cuz i worred about a cold-water extraction on 60 (10/325) tabs. found out that they don't even consider less than 8 grams of acute tylenol an emergency.

they made me wait some time, then took blood and did some test, it came back after a while as ok, so the CWE musta worked.

i regularly take 3 grams of tylenol PER DOSE, like 12-15 grams a day no problem. i have my liver tested regularly (LFT+lipid panel, every 3-6 months due to other medications i'm on) and it's always come back clean, no liver problems at all.

YMMV, and i've been ramping up VERY slowly over a number of years with my consumption -- now i'll take 40x 15/80's for a decent buzz. not a good place to be.

exitwound
04-11-2006, 11:17 AM
It's all about tolerance. I could easily take 50mg and not get nauseous or have any ill effects these days, whereas back when I had no tolerance, 20mg would make me feel like lying down so I wouldn't vomit....

Interesting now that I seem to be developing some of the same symptoms with constant moderate doses, as I used to get with high "recreational" doses before I developed chronic pain. I get nauseous and sometimes vomit in the mornings. So far I'm averaging about one vomiting incident and one nausea incident per month. But that's too many, and it indicates that my body is not handling the morphine as well as I had hoped. I don't know how much better a higher ratio of hydrocodone will make things, but that's what I'm trying now. Just slightly. It's mostly a matter of reducing my mscontin to 2-2.5 60mg tablets per day instead of the 3-4 I was taking before, and slightly increasing my lortab dosages.

paesan
04-11-2006, 12:12 PM
Hydro as well as oxy are both mild opiates, once you start fucking with the potent opioids like fentanyl or any of the morphine derived opies you'll realize the codones are weak as they completely lose their flavor.

As for your question Mild Man: first off I've been gone for like 4 months and when I come back your still asking questions about the dangers of hydrocodone and it's formulations..least it looks like you got over the acetominophen and liver damage thing. It's good that you're being caution bro but you do not need to worry that much. Unless your planning on funneling the bottle and chasing it with some tequilla I'd say you'll probably be ok. I'm assuming that you have an 8oz bottle and that the syrup is a cough formulation??? With the cough syrup the mg's are generally 5 per 5ml (tsp) which adds up to about 235mg's hydro per 8oz bottle, so even the whole bottle isn't that much hydro. Honestly I'm not even sure taking the entire bottle would be lethal...it'll definetely make you sick as hell but kill you, I'm not sure.

I'd say 20-30mg's for a non tolerant person is safe...30 may cause some nausea but it definetely will not kill you. When I first started on opies 4 regular vics or 2 of the 10/whatever formulations got me nice and warm whereas 6 or 3 (30mgs) got me fuuuuuuucked up. So stick with 20-30 to start and you'll be fine. As long as you don't take too much up front than you should be fine...with oral opies it's hard to OD as long as you pace yourself...you'd notice if you were getting too fucked up, that's when you cut yourself off.

shaunclo
04-11-2006, 12:19 PM
Hydro as well as oxy are both mild opiates, once you start fucking with the potent opioids like fentanyl or any of the morphine derived opies you'll realize the codones are weak as they completely lose their flavor.

As for your question Mild Man: first off I've been gone for like 4 months and when I come back your still asking questions about the dangers of hydrocodone and it's formulations..least it looks like you got over the acetominophen and liver damage thing. It's good that you're being caution bro but you do not need to worry that much. Unless your planning on funneling the bottle and chasing it with some tequilla I'd say you'll probably be ok. I'm assuming that you have an 8oz bottle and that the syrup is a cough formulation??? With the cough syrup the mg's are generally 5 per 5ml (tsp) which adds up to about 235mg's hydro per 8oz bottle, so even the whole bottle isn't that much hydro. Honestly I'm not even sure taking the entire bottle would be lethal...it'll definetely make you sick as hell but kill you, I'm not sure.

I'd say 20-30mg's for a non tolerant person is safe...30 may cause some nausea but it definetely will not kill you. When I first started on opies 4 regular vics or 2 of the 10/whatever formulations got me nice and warm whereas 6 or 3 (30mgs) got me fuuuuuuucked up. So stick with 20-30 to start and you'll be fine. As long as you don't take too much up front than you should be fine...with oral opies it's hard to OD as long as you pace yourself...you'd notice if you were getting too fucked up, that's when you cut yourself off.

PAESAN!!!! WTF???

Glad your back buddy, this beers for you!

exitwound
04-12-2006, 05:26 PM
i'll second that....welcome back, paesan :D

paesan
04-12-2006, 06:28 PM
thanks guys good to be back...

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04-12-2006, 08:22 PM
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