Home Fentanyl Synthesis

[Samcastic]

SWIM ran across this, searched the forums here for it, didn't see it, so he's posting it here for anyone who is savvy enough...


Drone's home-made fentanyl analog!

Yep, drone has doen what was thought impossible, and
will now divulge what is thought unmentionable,
because DRONE #342 is DRONE #342, and can do that!

Folks, have you ever had a hankering for a big, juicy
ounce or two of synthetic heroin, but just thought it
impossible to allocate the necessary chemicals? Well,
your friend drone has taken out the guesswork and
managed to develope a synthetic route to a chemical
1000 or so stronger than conventional smack.
Impossible, you say? NAY, my dear worker bees.

Here's the general overview of fentanyl synthesis.
4-piperidone is reacted with a trimethyliodo
(quaternary) salt of a phenethylamine (or any number
of aromatic ethylamines), to produce an
N-arylethylpiperidone (you can use the quaternary salt
of the piperidone with the primary substituted
arylethytlamine, if you like, too.) Anyways, this is
reacted with aniline, and reduced with NaBH4, and then
reacted with propionic anhydride to produce the
fentanyl freebase.

It turns out:

*adding an ethyl carbon bridge to the piperidine ring
will not reduce potency.

*adding an extra methyl to the phenethyl substituent
to make a phenylisopropyl makes for a strong,
long-lasting compound.

*adding a hydroxy to the alpha-carbon of the pehethyl
side chain -- as seen in ephedrine -- will also
increase potency.

*as I said in a previous post, propionic anhydride can
be made at home (this is the most closely watched
chemical on the DEA's list, but this watching was
rendered obsolete by YoursTruly not too long ago.)

The Fentanyl Suite, in d(l)-major; Movement 1

(the curtain rises, our anti-hero is found quietly
sauntering through the woods, foraging for
precursors.)

Taking this into account, Atropine is extracted from
nightshade. It is hydrolyzed to form tropine. Tropine
is oxidized to form tropinone. Tropinone is then
exhaustively methylated with iodomethane.

Second Movement

Dexatrim is bought in a fiendish quantity. The PPA is
extracted and isolated as its free base. This is
combined with tropinone, to form
N-(1-hydroxy-1-phenyl)isopropyl tropinone.

(intermezzeo)

Third Movement

Aniline is combined with the aforementioned
freshly-made tropinone, and reduced with NaBH4.

Fourth Movement
(Allegro)

Propionic anhydride is made from a propionate salt
like calcium propionate by adding bromine or even
chlorine. Alternatively, propionate esters are
hydrolyzed, the acid component isolated, and combined
with acetic anhydride and allowed to reflux, with the
product being fractionally distilled.

(crescendo)

The propionic anhydride is added to our soon-to-be
fentanyl analog compound, and allowed to react (I
think around 50 C). The product is flash
chromatographed, combined with citric acid (or any
acid of your choice), and allowed to dry.

The material is cut with hundreds of times its mass of
mannitol.

Viola! China white has just been made out of
Nightshade, diet tablets, aniline, and food
preservatives. It's all there in the literature. Ref's
available upon request.

Are we having fun yet?

-drone #342

[Mokelly]

someone do this now! (Bogumil?) and send product to me for quality assurance testing.....

[exitwound]

dang! Somehow I doubt that anyone with the resources and equipment would risk such a ghetto synth.....but hell, if it works, it works!

[caesee]

ok, guess I just flush the kilo of o I was going to use o make h, and go with this..lol:D

[exitwound]

LMAO! Yeah, who needs opium when you have ghetto fentanyl made from deadly nightshade! LOL :D

[tophatgr]

Hey Guys...I am new, and aced Chem 1 in college, IQ 191 and have a several engineering degrees.
Think I can systhesize some FA?
I want to develop a detailed procedure for this, step by freaking tiny step, listing every piece of equipment and labwear, how and where to get all the precusors (nightshade, dexatrim, sodium propionate).
All Who Participate Will Be Compensated! We will share the wealth.
This is a SERIOUS PROPOSAL....REMEMBER THAT THIS IS FOR THE DEVELOPMENT OF THE PROCEDURE ONLY AND IS NOT INTENDED TO BE ACTUALLY USED...:D

Let us start with complete, detailed lab procedure steps for the following modules:
1) PPA(Phenylpropanolamine) free base extraction from Dexatrim tablets. This procdeure needs detailing.
2) Extraction and purification of Atropine from Nightshade ==>hydrolyzation==>oxydation==>methylation (iodomethane)==>tropinone (or can atropine be bought? Sched IV drug - so I don't think so...) the plant is only found in a few areas of the USA, can it be bought at nurseries? This procdeure needs detailing.
3) Propionic anhydride synthesis: Calcium propionate + Br ==> Propionic anhydride This procdeure needs detailing.
4) Obtaining Aniline: Is it a monitored chemical? I don't think so as it is used in dye production.
What specific type of aniline is required for this process?
5) Aniline + tropinone, then reduced with NaBH4. This procdeure needs detailing.
6) Details of the flash chromatographing operation used to separate the product. What is the citric acid used for? Recomendations on the type and brand of unit are needed.

__________________________________________________ ______________

Taking this into account, Atropine is extracted from
nightshade. It is hydrolyzed to form tropine. Tropine
is oxidized to form tropinone. Tropinone is then
exhaustively methylated with iodomethane.


Drone's home-made fentanyl analog!

Yep, drone has doen what was thought impossible, and
will now divulge what is thought unmentionable,
because DRONE #342 is DRONE #342, and can do that!

Folks, have you ever had a hankering for a big, juicy
ounce or two of synthetic heroin, but just thought it
impossible to allocate the necessary chemicals? Well,
your friend drone has taken out the guesswork and
managed to develope a synthetic route to a chemical
1000 or so stronger than conventional smack.
Impossible, you say? NAY, my dear worker bees.

Here's the general overview of fentanyl synthesis.
4-piperidone is reacted with a trimethyliodo
(quaternary) salt of a phenethylamine (or any number
of aromatic ethylamines), to produce an
N-arylethylpiperidone (you can use the quaternary salt
of the piperidone with the primary substituted
arylethytlamine, if you like, too.) Anyways, this is
reacted with aniline, and reduced with NaBH4, and then
reacted with propionic anhydride to produce the
fentanyl freebase.

It turns out:

*adding an ethyl carbon bridge to the piperidine ring
will not reduce potency.

*adding an extra methyl to the phenethyl substituent
to make a phenylisopropyl makes for a strong,
long-lasting compound.

*adding a hydroxy to the alpha-carbon of the pehethyl
side chain -- as seen in ephedrine -- will also
increase potency.

*as I said in a previous post, propionic anhydride can
be made at home (this is the most closely watched
chemical on the DEA's list, but this watching was
rendered obsolete by YoursTruly not too long ago.)

The Fentanyl Suite, in d(l)-major; Movement 1

(the curtain rises, our anti-hero is found quietly
sauntering through the woods, foraging for
precursors.)

Taking this into account, Atropine is extracted from
nightshade. It is hydrolyzed to form tropine. Tropine
is oxidized to form tropinone. Tropinone is then
exhaustively methylated with iodomethane.

Second Movement

Dexatrim is bought in a fiendish quantity. The PPA is
extracted and isolated as its free base. This is
combined with tropinone, to form
N-(1-hydroxy-1-phenyl)isopropyl tropinone.

(intermezzeo)

Third Movement

Aniline is combined with the aforementioned
freshly-made tropinone, and reduced with NaBH4.

Fourth Movement
(Allegro)

Propionic anhydride is made from a propionate salt
like calcium propionate by adding bromine or even
chlorine. Alternatively, propionate esters are
hydrolyzed, the acid component isolated, and combined
with acetic anhydride and allowed to reflux, with the
product being fractionally distilled.

(crescendo)

The propionic anhydride is added to our soon-to-be
fentanyl analog compound, and allowed to react (I
think around 50 C). The product is flash
chromatographed, combined with citric acid (or any
acid of your choice), and allowed to dry.

The material is cut with hundreds of times its mass of
mannitol.

Viola! China white has just been made out of
Nightshade, diet tablets, aniline, and food
preservatives. It's all there in the literature. Ref's
available upon request.

Are we having fun yet?

-drone #342[/quote]

[trainwrecker]

Well, I know Bitter sweet night shade grows all over here (Pacific North West) I would be willing to collect a bunch and make it available to anyone who pays for shipping.

[EndRun]

(or can atropine be bought? Sched IV drug - so I don't think so...)

I thought atropine was in immodium? Or is that only in the prescription version (lomotil, me thinks?) If it's in immodium, I assume it'd be much easier to get from here than to pull from nighshade. But then, my chem degree came free with a bundle of smack, so what do I know?

[superman]

"All Who Participate Will Be Compensated! We will share the wealth.
This is a SERIOUS PROPOSAL...."

first of all, to propose something like this makes you sound like a cop. to say you're a chemist, and a genius, and looking for people to help you make fentanyl...... now that's just stupid.

besides these points, you're on the wrong forum for this kind of shit. it's not secure, it's not chemistry oriented, and it's not going to be much help (unless you're looking for some suckers to throw in jail)

[chemboy7]

Yeah, superman's right that kinda sounds like there would be an exchange of an illegal substance and this is strictly forbidden. There's alittle chemistry talk around here, not too much though; this is a forum that get's into sythesis alot more/indepth (although they seem to be down at the moment)

https://www.synthetikal.com/

I'm not too sure that Atropine is a controlled substance either, in the medication Lomotil it is schedualed but that is due to the Diphenoxylate not the Atropine. The Atropine is in there to prevent abuse and thus the low schedual (or high I guess); I bet that Diphenoxylate by itself would be a much lower schedual. I know of at least one chemical supply house that currently advertises Atropine HCL in it's cateloge... whether or not they have it in stock is another matter though, if you had your email addy up I could send it along but I won't post it publically and you don't have PM ability yet.

And this is the second time in a week that someone has dropped their IQ on us... that's just weird.

[devilsdrug]

yea 191 no less shit that is signifigant what % does that fall in yikes

[RobOC]

Oh yea! Well my IQ is so high all I have to do is think about fent and WHAMO, it exists. Who needs ghetto synthesis when your a super genius with psychokinetic powers?

[antony]

I wanna know when we had to start posting our IQs.

[nick]

Peeps have already started posting their IQ's.So when it feels right go for it Antony.

[antony]

thanks, nick. I'll retake the test when I'm finished writing up my American Scientific Journal article on how I recently discovered and produced dark matter.
http://www.futuramer.ru/pics/publications/characters_promo/Nibbler.jpg

[northernstar]

the atropine is easy to get.....the dexatrim now.....thats hard,
but ChRIST theres a million steps......i remeber some parkinsons breakthrough occured becuse some jackass was only 10 degrees off on a snthetic fentanyl recipie.. it made some brain-mushifying compound form in the batch, and then a bunch of junkies were zombies within a week. really helped scientists understand how parkinsons fucks the brain up tho...those 20 junkies are still getting poked and proded ......

This is really cool, and there must be a way to make homeade opiates...but this recipie lacks details, and way to many steps....without yeild...and from my experince atropine s a fragile chemical that breaks down easy. the final yeild must be like .02% lol

[chemboy7]

the atropine is easy to get.....the dexatrim now.....thats hard,
but ChRIST theres a million steps......i remeber some parkinsons breakthrough occured becuse some jackass was only 10 degrees off on a snthetic fentanyl recipie.. it made some brain-mushifying compound form in the batch, and then a bunch of junkies were zombies within a week. really helped scientists understand how parkinsons fucks the brain up tho...those 20 junkies are still getting poked and proded ......

This is really cool, and there must be a way to make homeade opiates...but this recipie lacks details, and way to many steps....without yeild...and from my experince atropine s a fragile chemical that breaks down easy. the final yeild must be like .02% lol

It was the Meperidine analoge MPPP that was the goal of the synthesis in question, it ended up being tainted with MPTP; which is the compound that caused the instant Parkinson's-like symptoms and subsequently all the ruckus.

[Hammilton]

Actually Diphenoxylate is C2. It's pretty enjoyable stuff. It's a cogener of meperidine I believe.

[northernstar]

[quote=chemboy7;43117]It was the Meperidine analoge MPPP that was the goal of the synthesis in question, it ended up being tainted with MPTP; which is the compound that caused the instant Parkinson's-like symptoms and subsequently all the ruckus.[/quote}


ahh, thanks chemboy!
the important thing i remembered was that it all happened becuse of a 10 degree screwup in the cooking....home ghetto synth can have tempatures all over the place from lack of real lab equipment. it seems dogey to me, yet doable too in a way becuse atropine is gettable..in almost any quantity one would want...

[john_doe]

In one of the recipes above it says to acquire DEXATRIM tablets. But they took those off the market so good luck finding that unless you live in Brazil or some crazy country like that. Nothing against brazil but you guys are crazy! Fentanyl synth is going to be more and more common in the future. People in America are going to start learning it and doing it. I think it's already begun. In mexico they could make this shit and pump it into the U.S and canada easily and it's very cheap to make and a good high very strong. but along with this comes unexperienced chemists and they will probably not dilute it right or cut it right and end up killing alot of people. people dont know how to handle fentanyl either they always asusme it's just good white heroin and shoot it up and they end up in a coma. I heard of a group of users in the U.S who were shooting up and they found them all dead in a circle. I think it was 8 people but i may be wrong. Apparently they all died from a fentanyl overdose. Not plain Fentanyl i think it was alpha methyl or methyl fentanyl i'm not sure of the name.

[bonkers]

Damn, why's chemistry gotta be so damn complicated? I just want some fent, I'm not trying to win a Nobel prize for science. Jeez...

[nick]

Wasn't that guy trying to make fent in Calafornia when he turned people into statues?

[jab]

Wasn't that guy trying to make fent in Calafornia when he turned people into statues?

No.. From Page 1, of this thread, entry #17

It was the Meperidine analoge MPPP that was the goal of the synthesis in question, it ended up being tainted with MPTP; which is the compound that caused the instant Parkinson's-like symptoms and subsequently all the ruckus.

[superman]

"In one of the recipes above it says to acquire DEXATRIM tablets. "
that's odd... isn't dexatrim just dextroamphetamine?the only usefull thing someone would make with this is methamphetamine but it's not even worth the effort.

[BorisB]

Yeah, Dexatrim is an odd thing to ask for as a precursor... also it's really an odd social habit to post your IQ and your college grades.

Maybe I'm odd too, but I'm taking Organic Chem right now for the fun of it. I'm interested in this idea, but it doesn't seem to be a "home" thing.

You're talking about fractional distillation. I think that's inherently not a "home" process. If we had fractional distillers everywhere, LSD would be just easy as pie too and I'd be stealing everyone's San Pedro's to get the mescaline out of em.

Also, we're talking about working with phenethylamines - which are basically semi-scheduled right now. It's retarted. But dexatrim isn't going to be got and any sort of ephedrine/pseudoephedrine is sold in small amounts; it's very regulated.

I wish it were possible, but it would probably be a much easier thing to become an amateur botanist rather than an amateur chemist - grow one's own poppies and harvest opium and then make heroin.

Like it was mentioned: the %yield will probably be tiny for us amateur chemists without access to professional lab equipment and pure precursors. Also, there is no detailed info on reactions (I doubt these all work out fine at Room Temp in unfettered aqueous sol'n) and no good info on extraction. In the end, you might end up with a mess of white gook of which 1% is some random-ass fentanyl analogue and the other 99% is SodiumBromatoic acid or whatever.

I just don't know about drone #342, but I wish it were good enough to be true. I think it's easier to be a social-engineer than a chemical-engineer and go doctor-shopping. However much I love chem, I'm still only going to stick to the easiest of reactions for now.

[northernstar]

Yeah, Dexatrim is an odd thing to ask for as a precursor... also it's really an odd social habit to post your IQ and your college grades.

Maybe I'm odd too, but I'm taking Organic Chem right now for the fun of it. I'm interested in this idea, but it doesn't seem to be a "home" thing.

You're talking about fractional distillation. I think that's inherently not a "home" process. If we had fractional distillers everywhere, LSD would be just easy as pie too and I'd be stealing everyone's San Pedro's to get the mescaline out of em.

Also, we're talking about working with phenethylamines - which are basically semi-scheduled right now. It's retarted. But dexatrim isn't going to be got and any sort of ephedrine/pseudoephedrine is sold in small amounts; it's very regulated.

I wish it were possible, but it would probably be a much easier thing to become an amateur botanist rather than an amateur chemist - grow one's own poppies and harvest opium and then make heroin.

Like it was mentioned: the %yield will probably be tiny for us amateur chemists without access to professional lab equipment and pure precursors. Also, there is no detailed info on reactions (I doubt these all work out fine at Room Temp in unfettered aqueous sol'n) and no good info on extraction. In the end, you might end up with a mess of white gook of which 1% is some random-ass fentanyl analogue and the other 99% is SodiumBromatoic acid or whatever.

I just don't know about drone #342, but I wish it were good enough to be true. I think it's easier to be a social-engineer than a chemical-engineer and go doctor-shopping. However much I love chem, I'm still only going to stick to the easiest of reactions for now.


I agree with you about this being a "dodgy" recipie, but about the fractional diastillation....its used in the refineing of oil, and in principle seems simple....altho prob misleading. What do they use in a O-chem lab to do this? Could someone build a fractional still at home.....diffrent chemicals sublimate at different tempatures, and are collected at different points in the colum, lowest to highest i belive.....

[superman]

fractional distillation at home is definately do-able, even more so if you're willing to using google to find out how to do it. the only roadblock is the effort required to know how to build the apparatus, which in some cases is very simple, and in other quite the opposite.

there are countless drugs that can be made at home, but i suggest anyone wanting to be a clandestine chemist learn to use search engines and find a strictly chem forum for support. if you want help with extractions and other basic things, you should be able to get the advice here (unless you didn't use the search engine first).

[surreal]

Hey all,

new here, just wanted to add my 2 cents to this as it's one of my favourit themes :)

Dexatrim is, as far as i know only required as a source for Phenylpropanolamin, which is, banned now almost everywhere in "the western world". Don't know about the rest.

Also i remember that drone's synth wasn't to be without controversy, regarding the details and the practical doability - at least it should be pretty impossible to perform without real good theoretical and practical chemical background.
But there should be other ways if one is stearleggy enough.

- none the less drone was a real genius - his name shall be praised in eternity :)

[chemchem]

my understanding is that tropine is taking place of the piperidone, and PPA replaces phenethyl-Br.

Now, my question is if anyone knows why it must be a quaternary salt?

I'm thinking of methylating piperidone and then reacting it with phenethylamine?

I'll have to look into it more but this could be a feasible idea to get NPP.

Edit: I'm having a real hard time seeing this reaction. He said either one can be the quaternary salt and react with the other, but how does this reaction occur and what is the side product?

[robojunkie]

As someone who actually knows what I am talking about, drone 342 is likely full of feces, and this would be best used to grow poppies, not synth fent. Very derivative procedure written by a creative guy with some knowledge of the structures, but one could only react the atropinonen with the exhaustively methylated (what he called the trimethy iodo salt of alpha whatever phenethylamine) quat amine salt of PEA/PPA/amp. And by the way, doing it a more creative way one can use amp to make AMF. This procedure may be actually doable in theory but not the way he says.

I call self serving trollish bullshit on drone 342. The queen (or king) bee probably sacrificed his ass after that post...

Oh yeah, a quarternary amine is positively charged so its a goood leaving group. The secondary amine of tropinone then attacks with its "lone pair" at the alpha methyl and kicks the trimethyamino group the fuck out. Since the once tropinone has a hydrogen that is easily lost, the reaction is irreversible, as alkly groups (from the trimethyl iodo salt) aren't easily exchanged the same way.

For all of you guys who really want to know this stuff the best place to look is the college bookstore and pick up Ege or McMurry or Streetweiser Organic chem texts, then maybe March or another Advanced Organic text. Then you can figure out all thewhys and hows as well as nail the bullshit as it steams.