Im an annoying person but hear me out ibeoprofen

[satori]

I normaly dont ask so many questions, i have read so much about opiates and other substances that i never need to ask, BUT what i never did read about was tylenol or ibeoprofen (never entrested me) now i find myself needing help (HELP!). I really want to up my codeine dose to atleast 60mg. To do this i would have to take 1,000 mg (one gram) of ibeoprofen. Can i do this safely? I take 800mg 2-3 times a day normaly so i know i wont automaticly have a problem with it, but can this be done once in a while safely (every other week or so). Also going to drink grapefruit juice with it (befor it) about an hour correct? Much love to all!

[candy]

Satori,
Don't think you have too much to worry about. 800mg is the max dose if taken every 6-8 hours. You can take it closer together, but if your taking it daily, I would go every 6-8.
With Ibuprofen or any antiinflammatory, what you need to be concerned with is GI problems, especially an ulcers, which can cause bleeding.
If your taking Ibuprofen daily, I wouldn't advise taking 1000mg at a time, on a daily basis. But, if this is something your going to be doing once in a while, then I wouldn't worry.
Ibuprofen does thin the blood, so anyone who is on blood thinners should avoid it.
Generally the side-effects your going to get from Ibuprofen, I discussed above and that is GI problems.
So go enjoy and if you should notice your stools looking black or any rectal bleeding, I would stop and see a doc ASAP. Classic signs of bleeding in the stomach,(black stools).

[candy]

Just wanted to add this:
Max dose for Ibuprofen per day is 3.2 grams. For those with stomach problems 2.4 grams daily.
If taking it daily, it should not be for more than a few weeks, unless your seeing a doctor and then he should be giving you something for your stomach to avoid an ulcer or other stomach problems.

[JoyDivision]

There was a story on ibuprofen last night on ABC's (Australian Broadcasting Corporation) 7:30 Report. Talking about how 1 in 5 Australians? I think. Have severe side effects to ibuprofen. There were some real scary stories. I've been using Nurofen for really bad headaches since I was like 12 or perhaps younger and I've tolerated it ok.

If you're using Nurofen Plus tablets. Then split them. Do a google search to find out how. I've already posted a link in another one of these type threads today on here.

[katomic]

you cant split them no more at least in europe they have found a way to mix the two up, shame

[candy]

When I worked in the GI Lab, more than half of the patients we saw were those with GI Bleeds. Most caused by ulcers from taking Ibuprofen. These patients were using Ibuprofen daily for problems like chronic pain, Osteoarthritis, etc. Ibuprofen decreases the amount of prostaglandins in the stomach which protects the lining of the stomach. When there is a decrease in prostaglandins, the risk for ulcers increases. Docs can prescribe medications that will reduce the acid production in the stomach, but often times they don't due to lack of medical insurance, cash patients, or patients who are noncompliant with meds.
There are those patients who won't take meds unless they feel pain or experience a problem. They may take the Ibuprofen, but won't take their other meds. While this is a small percentage, they do make up a number of patients who come in with GI bleeds.

Taking Ibuprofen on a needed only basis most likely won't cause problems, but when taking it daily, talk to your doc about something to take with it to decrease acid production. OTC meds are now available, ZAntac, Pepcid, and Prevacid. Some of the newer drugs out there are costly and some insurance companies will not cover them and they are not available in generic brands.

Although combination drugs, like Tylenol #3 are great or the combinations with Ibuprofen, help to increase the effects of the narcotic, go for a prep without them. Tell your doc you have a history of ulcers. Being a Hep C patient, I just avoid Tylenol altogether. Especially for those looking for pain meds without the added analgesic, complain of stomach discomfort and ask for something without the analgesic. Tell them you have a history of ulcers in the family. There is a genetic predisposition .

[ginger]

I hate ibuprofen...I can take it once or maybe twice and after that I literally cannot stand up straight because of the pain in my stomach. It really wrecks havoc with my digestive system...shame too because it is good for minor bumps and bruises...of course one can take better meds to relieve pain!:D

[shaunclo]

Also going to drink grapefruit juice with it (befor it) about an hour correct? Much love to all!

Satori, drinking grapefruit juice with codiene doesnt work like it does with morphine. There are reasons for this, but I cannot remember. Im sure someone will chime in and let you know the details regarding this. There are so many other threads regarding this exact same question, Im just not sure where the hell they are.

[satori]

Satori, drinking grapefruit juice with codiene doesnt work like it does with morphine. There are reasons for this, but I cannot remember. Im sure someone will chime in and let you know the details regarding this. There are so many other threads regarding this exact same question, Im just not sure where the hell they are.


It might be because it raises the blood plasma levels, and codeine is converted to morphine in the brain (right?). So changing the blood plasma levels wouldnt increase the potency because by the time it gets to the point of being morphine it is no longer in your blood stream (or something like that lol).

[hovadagod]

There's gotta be supplements that increase prostoglandis. Do some research and find them.

Penks=Penkies=pain killers. Derivation-Tussionex Penkinetic suspension....hey this stuff is called has penk in its name...like pain killers....spreads like wild fire. Sounds childish but hey...I made it up as a HS student.

[JoyDivision]

you cant split them no more at least in europe they have found a way to mix the two up, shame

I've read that you just can't mix codeine + ibuprofen in the manufacturing process, the pills I used to get were stuck right together. Don't ask me why. Read the eating nurofen pluses thread in the Australian Drug Discussion section of bluelight.nu this issue has been covered over many, many, many pages.

It may seem like you can't split them because they crumble and don't split as cleanly with the convex shape as they used to. But trust me. They do split. I did the two glass cold water test to see which half dissolved first (codeine is very soluble in water) on two different batches of 48's and both times it was the N+ side. If all else fails. Do a CWE. To get rid of the goo. Perhaps suck off the outside coating or use cold or luke warm water to wipe it off (think OxyContin coating style, except do it quickly cause your pill will start to dissolve where as the OxyContin won't), dry with tissue paper or just leave out for a bit and then crush in mortar and pestle. Don't use boiling water either. Use inbetween hot and warm or warm. You want less heat but not so little heat that they don't dissolve properly. Unlike morphine. Codeine doesn't like heat as much I believe. I just don't seem to feel my CWE's if I use too hot of water. Then again. I've only done a few Nurofen Plus CWE's. I normally do the Codeine + Para/Ace ones. Because you can get more codeine per pack in those than in Nurofen Plus packs of 48 or 72. Nurofen Plus is just good because if you really want you can pop em without going through all the CWE bs. If you know how to split em properly. Even the crappy seemingly unsplittable new logo packs.

Remember people. These drugs are designed for temporary usage. Not everyday chronic usage.

I'm pretty sure I've read somewhere that you could take 3200mg of ibuprofen spread out in a 24 hour period. But this would only be for one day not every damn day. I could be wrong and I could be thinking of Aspirin instead. So could someone please verify this for me.

However. I've taken 12 x 12.8mg Codeine + 200mg Ibuprofen in a day without any problems. Sixthseal.com ate 8 his first try. I've heard of reports in the news over here of a woman who took a whole 48 pack in a day. When I used to split em. A 48 pack would last me 2 days.
I just wouldn't recommend you do this often. Or for people for which Ibuprofen is not a good idea to take with some medications. The max doses per packs of any NSAIDs are:
Paracetamol / Aceteminophen 8 x 500mg in a 24 hour period.
Aspirin 13 x 300mg in a 24 hour period.
Ibuprofen 6 x 200mg in a 24 hour period.
On the back of all products containing these it explains they are for temporary use and prolonged use can be harmful. If pain persists see your Doctor. Well if you have no pain and are just getting high. Obviously you don't have to persist. Unless you want the monkey on your back and want to fuck up your liver and kidneys and other organs.

As for Codeine. It's a pretty clean drug. Leaves your system pretty quick. Just like other opiates. LD50 is 800mg. I still haven't touched 400mg and I have a tolerance. I just think that does is stupid. I would only try it if I had pure codeine phosphate. Even then I'd be hesitant to touch that much. The most Codeine I'll use is 256mg max. I had a bad experience with 300mg once. Never touched that much again. Like hydrocodeine. Too much Codeine can make you really sick. And I just think 300mg or more is a damn waste. You're better off using less than 256mg and potentiators. I've always liked 120-150mg plus 5 to 10mg of valium :-).

So yeah. This OTC shit isn't good for chronic use. Trust me. I have chronic pain. I know :-). I know how bad all the shit I take is for me. But it sure beats being in pain. But it's also why I alternate between stuff I take. Anyway. Rant over. Can't help it. This codeine and valium mix makes me talk my arse off :-).

[JoyDivision]

Satori, drinking grapefruit juice with codiene doesnt work like it does with morphine. There are reasons for this, but I cannot remember. Im sure someone will chime in and let you know the details regarding this. There are so many other threads regarding this exact same question, Im just not sure where the hell they are.

See here: http://www.globalrph.com/gfruit.htm
"Drugs which may exhibit increased serum concentrations based on this interaction"
codeine, diazepam.
"Grapefruit juice is a potent inhibitor of the intestinal cytochrome P-450 3A4 system (specifically: CYP3A4 - mediated drug metabolism) which is responsible for the first-pass metabolism of many medications. This interaction can lead to increases in bioavailability and corresponding increases in serum drug levels. "

Is this your reasoning? "If Grapefruit juice (GFJ) is a CYP2D6 inhibitor, and Codeine is converted to Morphine via CYP2D6, why would you want to drink GFJ to increase Codeine's conversion rate?"

An SSRI (selective serotonin re-uptake inhibitor) is a serotonin inhibitor. So by this definition of inhibitor anti-depressants shoudn't work. Inhibitor has a different meaning in medicine I believe.

To inhibit something in medicine I believe is to basically make sure the chemical doesn't break down as fast as it normally would. Hence, SSRI's :-) as in people with depression serotonin breaks down way faster than normal.

Also look at what it says in the Codeine FAQ at Erowid.org
" Finally, codeine itself is a cyp2d6 inhibitor. This means that taking the whole dose as quickly as possible will probably give you the biggest high (ie. its a waste to redose in 30 mins)."
Therefore Codeine shouldn't convert to Morphine by the same definition of inhibitor people are using in this context.

Do you know this from experience? Because when I was on Paxil which interferes with Codeine to Morphine metabolism. I read on coldwaterworld that grapefruit juice would potentiate codeine. So I took just 2 Panadeine Fortes which equals a total of 60mg of Codeine + 1000mg Paracetamol and the effect was much stronger for the first time in ages! And I had a real tolerance to codeine and was taking 120mg of Codeine! or 4 PAnadeine Fortes twice a day because of the Paxil interaction.

If anyone has taken Codeine + Grapefruit jucie and had it not work better I'd surely like to know. Oh Carbonate is supposed to help it absorb slower aswell. So I'll drink a coke a bit afterwards too. Something like Eno, or other bi-carb containing stuff is good. Or magnesium free antacids. Naproxen Sodium is also a good codeine potentiator but harsh on the stomach. So you want to eat something first. Take the Naproxen Sodium and take the codeine or other narcotic 1 hour later.

I wish that damn coldwaterworld page didn't go down. Anyone know the site address for the ADH potentiators page?

[satori]

So grapefruit juice WOULD help make codeine stronger, right???? Or atleast have a stronger affect.

[ontario_opiophile]

I wouldn't drink the grapefruit juice if I was taking Acetaminophen or Ibuprofen in any amount. But that's just me. If it was codeine, morphine alone. Yes I would.