Anti Potentiates

[kingzilla]

All this talk of Cimitadene and GFJ has me thinking of what kills the effect of Opi's. I take Prevacid for heartburn and it reduces stomach acid. Does this effect the absorption of narcotics ? Specifically Oxycodone ?

[upstate_007]

All this talk of Cimitadene and GFJ has me thinking of what kills the effect of Opi's. I take Prevacid for heartburn and it reduces stomach acid. Does this effect the absorption of narcotics ? Specifically Oxycodone ?

I have been taking Prevacid for a few years also and I have not noticed any good or bad effects from it.

[Balousch]

Opiate antagonists and other such drugs that can precipitate withdrawal by blocking the opiate receptors are the only anti-potentiators that I can think of off hand.

Prevacid to my knowledge does not effect the effects of opiates to any great extent for good or ill. But thinking about it, depending on the drug and since it does lower the acidity of the stomach, it should increase the amount of drug the body absorbs even if it is by an unmeasurable degree.
^
(I'm not 100% certain about this, just submitting it to the discussion and believe that most drugs do break down to a small degree when subjected to the stomach, thus lowering the acid can increase the amount that makes it though. I've noticed this with other drugs first hand.)

[upstate_007]

Another precsription I am on, Carbatrol (a nerve pain med), has been shown to precipitate withdrawal. It sucks because I need both the nerve pain med and the opiates. I just try to time them so they don't counteract as much. On the positive side, I think I got my tolerance down to nothing by going through a few days of hell.

[oldscratch]

Provigil (Modafinil) in doses that exeed 1000 mg can precipitate withdrawel in methadone users. ( see reports in www.erowid.org (http://www.erowid.org) provigil vaults). Though i do not know if this is the case with organic or semi-synthetic opiates.

[reddragon3668]

Damn! I sure didn't know that when I was taking Provigil. I don't think I ever come close to 1000mg at one time, but I'd crapped a bricked if the stuff would have thrown me into withdrawals.


Provigil (Modafinil) in doses that exeed 1000 mg can precipitate withdrawel in methadone users. ( see reports in www.erowid.org (http://www.erowid.org) provigil vaults). Though i do not know if this is the case with organic or semi-synthetic opiates.

[I-Nod]

Not sure if this was what you were looking for, but here's a thread from last year: http://forum.opiophile.org/showthread.php?t=8718&highlight=potentiat%2A

I've found "situations" to be the biggest buzz kill... for instance, your mom dropping in, ect. Also, alcohol... it can potentiate for some, but for me I get really sick fast. Can't do it, and I'm an alcoholic.

[oldscratch]

"Methadone is metabolized by several liver enzymes in the CYP2* cluster, with CYP3A4 being an important metabolizer. Because modafinil up-regulates CYP1A2, CYP2B6, and CYP3A4/5, the action of methadone may be substantially shortened. Erowid also received one experience report from a reported methadone user who found that they had to redose with methadone every few hours to avoid opiate-withdrawal after taking large doses (> 1000mg) of modafinil. " :(

....thought i'd post the reference data for reddragon3668's benefit and to present a caveate to all my good budds on dolophine (methadone)...While researching modafinil as a mood enhancer I stumbled across this opio-tid-bit and thought it might benefit those who check the board for drug interactions...If anyone has personal experience with this matter...please post!!! "oldscratch"

[resorcinol]

Gluthethimide (sp) is an old sleep aid depressand that induces CYP2D6, the opposite of cimetadine. That would weaken the effects of most opiates. Except codeine, it would potentiate codeine, because that enzyme turns codeine into morphine.