Turning oxycontin

[tui]

Hi all,

i've come across some oxycontin (!!!) for sale here in nz.

now, in nz we don't have h, so we "turn" morphine (MSTs and M Eschelon) using AA.

i was wondering if this same process can be done to oxycontin.

no one here has even heard of oxy, i only have through this forum...

so any help will be much appreciated...
t

[havok]

You can't turn oxy into anything with Acetic Anhydride, thats only for morphine. You can however turn oxycodone into oxymorphine with the right chemical reactions. It is pretty difficult if I remember correctly and probably not worth the effort. I would just take your oxys as is.

[Synack]

Hi Tui,

How ya been? - You should PM me.. I've got updates.

Anyways, oxycodone cannot be turned into morphine, or H. It CAN however be converted to oxymorphone (the thebaine version of H, IMO) - but due to the cost and the benefits gained. It's just not worth it.

Read here for more: http://forum.opiophile.org/showthread.php?t=8443

Also, I'm going to move this thread over to the chem section so that you'll get some more chem savvy replies..

-Syn

[robojunkie]

Oxycodone can be demethylated with BBr3 just like codeine although the reaction is longer, I believe in the article I've read it took several hours, compared to less than 30 minutes for codeine. Once it was demethylated you'd have oxymorphone as is which could easily be acylated at the phenolic OH, I'd have to check on how this would effect the potency/availability. Technically the ketone can be acylated and then you'd have the enol acetate and there are opiates with this structure, unlike thebaine which is a dienol methyl ether the body would easily hydrolize this back to the ketone. if thebaine was a dienol acetate the body could also easily lop off the acetyl group but then you'd just have codeinone, not dihydrocodeinone which would be more often known as hydrocodone.

Since you're on the "bottom" of the world where this pyridine/HCl thing is common that may also work, and believe it or not good old concentrated hydrobromic acid will demethylate oxy or morphine or hydro, this was the old method used prior to developmet of the BBr3 aryl ether cleavage which is easier and higher yielding (easier in a lab obviously, BBr3 is some nasty shit that releases plumes of hydrogen bromide gas on opening, when contacting water this is hydrobromic acic).

I'm sure someone down there has done this stuff with the pyridine/HCl with whatever results.

[southernbelle]

Girl, just take 'em and have some fun!

[aj11]

where the fuck do you come across some AA at?????????????
wish I had some

[roxi*stardust]

Girl, just take 'em and have some fun!
For real. They have a great bioavailablity when taken orally. The IR form is near 100%, the ER is about 85%

[robojunkie]

Yeah, aj, I've always wondered that too. Tui, where is it that all you opys in tomorrowland get the AA such that this "homebake" stuff seems to be so commonplace down there? It seems as though its like a regular part of the NZ junkie's works, codeine, spoon, pyridine, HCl, AA, water, rigs and dope, oh wait no dope. well not for a few hours right? Seriously though I get the impression that its commonplace down there. The average US junky will probably never see AA in his/her lifetime.

[EleusisII]

Yeah, that's some crafty junkies!

Could it be the sheep? AA is used for dying, right? NZ makes a lot of wool... Can that have something to do with it?

[Seedy]

^^ Sounds plausable.

Hey Tui, long time no see. U scored some oxy too, eh? I had my first go on it a couple of months back. Fun but you always need more.

[Mustelid]

where the fuck do you come across some AA at?????????????
wish I had some

I found a neat site with precursor recipes, including acetic aldehyde / acetylaldehyde.
http://www.roguesci.org/megalomania/synth/synthesis1.html

[robojunkie]

I visited an Vaxn8's lab at Johns Hopkins chemistry department (she was an old-school opiophile with a brain for chemistry, read her posts, good stuff) and she showed me a 1L bottle of AA just chillin on the counter. But when your in baltimore, you dont need AA that often.

They also had a digi scale that weighed to like the .00001g (or something like that) and ALL KINDS of other list 1 and 2 chems!!! I'm pretty sure I saw pyridine, p2p, phossy, thionyl chloride, hydriodic acid, methylamine, sodium and lithium metals, shit i dream of getting (no not that kind of dream, bees!)

A properly stocked and respectable synthetic lab would have all of those chems, often methylamine HCl, sodium is more common than lithium, one exception is the p2p, cause of the C-III scheduling, although lots of old school profs that have been in one lab for decades often have plenty of phenylacetone, current labs usually have phenylacetic acid or the ethyl ester, always pyridine, often RP and HI, always I2, always SOCl2 or POCl3/PCl5 also always acetic anhydride as well as acetyl chloride, propionyl chloride, boron tribromide and other lewis acids (ether cleavage), liquid ammonia (anhydrous), some have piperidones, quite often 3,4,5 trimethoxybenzaldehyde (mesc/TMA), less often but still frequently piperonal (MDA/MDMA) and so on. Most people I meet when they hear what is in a typical research lab practically shit themselves!

[underide]

The average US junky will probably never see AA in his/her lifetime.

the average US junky will have no need for it. with all that dope around

AA is easy enough to get in Russia but then almost anything is, as long as you have the money.
Poland too as far as i know.

[bronyraur]

You can't turn oxy into anything with Acetic Anhydride, thats only for morphine. You can however turn oxycodone into oxymorphine with the right chemical reactions. It is pretty difficult if I remember correctly and probably not worth the effort. I would just take your oxys as is.

Just like to make a correction: it is oxyMORPHONE.

[betmylife]

Just like to make a correction: it is oxyMORPHONE.

perfectionist.

[WarmCyanide]

perfectionist.

hey man, opiate nomenclature is a must on this site in particular:D

[robojunkie]

There is nothing worse than hearing auditorily some say "Oxycottin"! Yeah, but you want some oxycottin? Here ya go 400 for 40 good deal.

Gets home, onnly to open baggie finding what he asked for, 10 freshly used cottons from oxy slamming.

Fuking oxycottin. Christ!

Technically all the names are "wrong"...

hydrocodone, no...dihydrocodeinone, yes
oxycodone, no...dihydrohydroxycodeinone, yes
hydromorph/oxymorph, no...dihydromorphinone, dihydrohydroxymorphinone, yes, by all means!

and really fucking codeine doesn't deserve its own name, it should just be 3-methylmorphine or just methylmorphine.

dihydrocodeine, yes, they got that one right way back when! props!

etorphine, reasonable, but really endo-6-methyl-6,14-ethenyl-7-(sec-butanol-2-yl)-dihydromorphine, or "the stuff of dreams"...or the true final stop on the dope train...

I can see it on the horizon, hurry up!!!

Wannabe etorphine chemists, that name is misleading...think about it...

[SpecialGuy69]

hey robo, oxyc, I got a very similar question for you: What if you DID acetylate codiene?

Maybe not through the same reaction as morphine==>diacetylmorphine
BUT, would it be possible to make diaceylcodone? (or diacetylcodiene, whichever is right)

Or, diacetyloxycodone? You know what I'm getting at here- the diacetyl version of morphine is 3x stronger, has a better rush, and is just better than plain morphine. So, would it be possible to make a diacetyl version of codiene or (better yet) oxycodone? Has this product been made ever? Could you expect a similar product to h?

okay i just realized there is only one free -oh group to acetlyate, so the closest you could do would be monoacetylcodiene, but still the question stands.

[eerased]

I'm probably gonna make myself sound stupid here, I just read this thread twice and I feel like I might have been reading a chinese book...lol

Jeesh you guys are smart!! Kudos

ps.. I'm a lil high as well..

[robojunkie]

The name could be wrong here, but monoacylated codeine would be Pantopon, I believe. I'm not 100% on this name though, but you could only mono-acylate any of the codeine derivatives. Technically speaking, you could diacylate oxycodone, but not at the 3-methoxy poeisition, only at the ketone, producing an enol acetate ester, and possibly the 14 hydroxy, which is likely since it points "up" in relation to the piperidine/ketone ring system. (ie, there is no steric hindrance). I'm sure these have been done. You would not believe the number of semi-synthetic opiates produced from morphine, thebaine and codeine. There are literally thousands recorded with the morphinan skeleton (the 4-ring 3-D system) and most are active so long as they have a methyl, ethyl or phenethyl at the N-position, PhEt being strongest usually, Et being the weakest and Me in the middle.

However, this is a counterproductive idea. If one acylates codeine, producing 3-methyl-6-acetylmorphine, you now have something that crosses the bbb much more effectively as is relative to straight codeine (3-methylmorphine), which increases its relative presence in the brain as codeine, which is neurotoxic at high levels. However it causes there to be less present for the liver to O-demethylate, which is required to produce opiate effects, ie morphine. The likelihood, when taking into account the pharmacokinetics, of this being a good prodrug for 6-monoacetylmorphine is almost nil, as the transesterification/hydrolysis inducing enzymatic process are much more efficient and faster than the O-demethylation pathway.

The oxy idea seems to be more interesting, as you would have two acetylated alcoholic positions, though I'm not sure what the toxicity of larger amounts of the methylated oxycodone being present in the brain would be or if it even is. However, imagine this: Triacylated oxymorphone, 3,6-14-triacetyl- hydroxydihydromorphinone. A nice combination of the phenolic acetate (like heroin), an enol acetate (unlike most opioids, and w/o checking studies I would imagine a very effective modification, carrying it across the bbb then hydrolyzing to give back the active ketone) and the 14 hydroxy acetate, the effects of which are hard to speculate on, other than increased lipophilicity (higher octanol/water pc), although that hydroxy is what about doubles to triples its strength relative to hydrocodone. I'd be curious to see how acylating that 14-hydroxy effects activity though...

Here's what I'd love to see...etorphine, which is a free phenol but methylated at the 6 position, called the "oripavines" and it has an additional hydroxy at the 2'-position of the sec-butyl group attached at C-7. Imagine acylating all 3! You may have to leave the 6 methyl alone to avoid any retro-Diels Alder effects, but the others would be simple, simple of course if you had etorphine to begin with...

Eventually will find an opioid and receptor that is effective with one molecule, lasts 10 years and is resistant to tolerance. When I discover it they better name it after me or I'm gonna be pissed! haha, I wish!!!

[underide]

Admit it Robo, all the chemistry aside, you're just in love with that word - Etorphine.
Hey, i like it too... E-TOR-PHINE, beautiful! Just slides rumbling off the tongue.

Really though, that is some serious 'under lock and key' material.
That shit would make for some perfect poison - all you have to do is get a drop of it onto someone's skin, and that person is history.

Would there be an opiate rush before you died? I'd imagine only if you had an ENORMOUS opiate tolerance, otherwise it is probably just like poison.:confused: