Opana IR--not too impressed

[samsong]

So my doc moves me from perc 5s to Opana IR 5mg x 4 per day for my BT and still on fent 50mcgs for round the clock (which I abuse with a passion and run out within the first 10 days of the month). Anyway, I have been eating, snorting, plugging these Opanas and getting really no euphoria at all, just a bit of sluggishness. I have tried taking them on a full stomach and all and really no difference in euphoria.

On Bluelight, there are stories of H addicts nodding out on 5-10mgs of Opana and just dozens of people raving about how the great euphoria and nod when snorting. I don't IV and I know the effects would most likley improve a lot if I did shoot them, but figured I would at least get something from the other ROAs mentioned.

I really think I was geting better effects from the perc 5s than from these, and without the sluggishness. I am getting better effects from pod tea than from the Opana as well, even small does of the pd tea like 3-4 larges. Is this weird or does Opana IR just suck unless IV'd.

Thanks for any inputs.

[Synack]

Yeah, it doesn't have much if any euphoria, but they work well for pain relief.. but IV'd ... "ton of bricks"

[9177]

IV'd, I put them up there with Dilaudid HP ampules.
Maybe even before them.;)

[Floating]

IV Oxymorph feels alot like IV Fent. Ton of bricks....truer words were never spoken.

[havok]

The reason you arent getting much out of them is because they are most effective IV'ed. Any drug ending in morphine like hydromorphine, oxymorphine, etc has a low bio-availability. That is why they work so much better IV'ed than anything else. Most people already know this about dilaudid. They are pretty much worthless unless IV'ed. Well the same thing is true of oxymophine. The difference between eating oxymorphine and injecting it is huge.

[Synack]

continuing from the above, I believe the bio-availability with oxymorphone is around 10% when taken orally.

Assuming oxycodone's bio-av orally is 100%, and oxymorphone PO at 10% is considering 2x as strong. there for, 5mg of oxymorphone is equal to 10mg oxycodone orally. BUT 5mg of oxymorphone IV'd is equal to 50mg oxymorphone orally, or 100mg oxycodone orally.

I doubt that makes sense.

[RxQueen]

The reason you arent getting much out of them is because they are most effective IV'ed. Any drug ending in morphine like hydromorphine, oxymorphine, etc has a low bio-availability. That is why they work so much better IV'ed than anything else. Most people already know this about dilaudid. They are pretty much worthless unless IV'ed. Well the same thing is true of oxymophine. The difference between eating oxymorphine and injecting it is huge.

just for info's sake, and cuz i'm feeling like being correct tonight.... those drugs are "hydromorphone" and "oxymorphone."

[I-Nod]

Got to try a 5mg Opana (orally) last month, and it didn't get rid of my WD's.

A family member got switched from 40mg OC/ day to 5mg Opana/ day (he's got a very bad back, disabled). He can see I'm not feeling well, so he brings out his bottle... "here, try one of these, tell me what you think." An hour later I take some of the OC's he gave me shortly after my "testing"...

It made me yawn a 100 times, but I was still sweatin' and sneezing. What's weird is they work ok for his back pain. Not quite well enough so the Dr upped him to 10mg/ day... but still... these are replacing 40mg's of OC/ day. I wouldn't mind foregoing the euphoria (although it would def be really nice!) if it wiped out the pain. I can scrounge up my own buzz... but these Tramadols the doc throws at me are no better than Smarties.

Wonder if Dr's know these suck recreationally (if taken as prescribed) so they're more liberal w/ the pad? Might ask my doc to try those, hmm... worth a shot (no pun intended.)

[havok]

continuing from the above, I believe the bio-availability with oxymorphone is around 10% when taken orally.
Wow the bio-availability is really that low?



just for info's sake, and cuz i'm feeling like being correct tonight.... those drugs are "hydromorphone" and "oxymorphone."

Ya you are right. It is morphone not morphine. I am just so used to typing morphine with an "i".

You know what I was wondering though? Why are hydromorphone and oxymorphone spelled with an "o" but diacetylmorphine (heroin), nicomorphine and morphine are spelled with an "i". Is there a reason for this? It is kinda like the difference between codeine and codone.

[RxQueen]

a chemistry person would probably be able to answer this better (robojunkie? OxyC?) but i think that the name of hydromorphone (for example) is actually something like "hydromorphinone" or something quite similar. it's not even morphine chemically speaking, but a whole different compound. maybe we'll get lucky and one of our resident chem-experts will come along and educate both of us!

[Inspektahdek]

I thought it was all a bout ROA with IV and then plugging being the only useful routes. Was your bowels empty when you plugged or did u plug correctly? snorting or oral isn't going to do much but relieve pain. I wish I could try opana I don't even think it's made here

[Inspektahdek]

Got to try a 5mg Opana (orally) last month, and it didn't get rid of my WD's.

A family member got switched from 40mg OC/ day to 5mg Opana/ day (he's got a very bad back, disabled). He can see I'm not feeling well, so he brings out his bottle... "here, try one of these, tell me what you think." An hour later I take some of the OC's he gave me shortly after my "testing"...

It made me yawn a 100 times, but I was still sweatin' and sneezing. What's weird is they work ok for his back pain. Not quite well enough so the Dr upped him to 10mg/ day... but still... these are replacing 40mg's of OC/ day. I wouldn't mind foregoing the euphoria (although it would def be really nice!) if it wiped out the pain. I can scrounge up my own buzz... but these Tramadols the doc throws at me are no better than Smarties.

Wonder if Dr's know these suck recreationally (if taken as prescribed) so they're more liberal w/ the pad? Might ask my doc to try those, hmm... worth a shot (no pun intended.)



Think of it this way, oxymorphone is only approximately 2X times stronger than oxycodone when taking orally PO. Now compare and contrast this and other meds and ROAs, O_morphone is really not too potent yet I'd love to toy with it.

[havok]

Oxymorphone (Opana, Numorphan) or 14-Hydroxydihydromorphinone (http://en.wikipedia.org/wiki/Morphinone) is a powerful semi-synthetic opioid (http://en.wikipedia.org/wiki/Opioid) analgesic (http://en.wikipedia.org/wiki/Analgesic) that is derived from thebaine (http://en.wikipedia.org/wiki/Thebaine), and is approximately 6–8 times more potent than morphine (http://en.wikipedia.org/wiki/Morphine). [wikipedia]



RESULTS: The most precise estimates of relative potency showed that controlled-release oxycodone was 1.8 times more potent than controlled-release morphine for total effect
CONCLUSION: Oral controlled-release oxycodone was twice as potent as oral controlled-release morphine in this single-dose, relative potency assay.
[http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=10492054] (http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=10492054])


According to these statistics, oxymorphone is 3.5 times more potent than oxycodone.

[samsong]

Well this morning I railed about 10mgs ( alot of fucking powder due to about 200mgs of filler for each pill) and then chugged the grit of one jumbo pod and I am feeling a lot better, both pain wise and have a good buzz going as well, not too euphoric or nodding or anything like that, but it feels like I railed about 30mgs of OC (I don't have a huge tolerance)--nice speedy oxy type of buzz going. Will rail another 10mgs in an hour or so and see if I can get a nod going.

I will try plugging 10mgs tonight without any pods and see if it feels any better. I won't even bother with these things orally anymore, they are worthless. Not going to go the IV route either though it is very tempting. But if I c0ntinue to get the same effects as I did this morning by intransal, then there may be hope yet for these little guys. However, unless you plan on IV'ing them, I wouldn't suggest anyone asking doctors to switch them from oxycodone to these.

[bronyraur]

just for info's sake, and cuz i'm feeling like being correct tonight.... those drugs are "hydromorphone" and "oxymorphone."

You beat me to it.

That's a pet peeve of mine, spelling drug names incorrectly. When I see Suboxone spelled Subuxon it drives me nuts.

[OxyContinuously]

a chemistry person would probably be able to answer this better (robojunkie? OxyC?) but i think that the name of hydromorphone (for example) is actually something like "hydromorphinone" or something quite similar. it's not even morphine chemically speaking, but a whole different compound. maybe we'll get lucky and one of our resident chem-experts will come along and educate both of us!


basically, Dilaudid is the "hydrogenated" ketone of morphine. that's why it ends in [-morphone[ not -phine. it is def. not morphine, however is derived from morphine in many cases, although one CAN get it from hydrocodone...but commercially, Dilaudid is made by hydrogenating morphine.

think of acetone, a ketone as well. although two totally diff. animals, in chem. the naming for classes of compounds is universal regardless what the properties are. for example, all ketones end in -one (for the most part)

yep and it's full name is" 4, 5-alpha-epoxy-3-hydroxy-17-methyl-morphinan-6-one"

[jackjohnson]

i think most of the really hard opiates are like this...

snorting hydromorphone/oxymorphone/diacetylmorphine/morphine/fentanyl/etc, etc or plugging/swallowing them (and if you dont know chem names, that is dilaudid/opana/heroin) people say there not much stronger than oxycodone/hydrocodone (percs/oxycontin - vics/lortabs) - and from my experience, that is very true. the only real strong opioids ive ever had the luxury of enjoying have been heroin and morphine, but i can easily attest that snorting morphine/heroin doesn't even begin to compare or do ANY justice for the substances when IV'd. and from my experience, what i hear, and what i know, its the same for the other strong opiates as well. (besides maybe fent, which i hear is pretty goddamn potent if you heat the pad or smoke it)

but you IV them, and BAM. 10x as potent. i hate hearing of anyone wasting away good hard opiates by any ROA besides injection. but if IV is out of question for you, just ask to be switched back to the percocet.