Just got some Methadose 40's!

[exitwound]

A new contact closer to "civilization" recently sent me a sample package of three 40mg Methadose wafers.

Considering that I take approximately 200mg of morphine and anywhere from 50-100mg of hydrocodone per day, what would be a good way to dose this stuff, and how (or even *if*) should I mix them with my other meds?

Should I take the rest of the day off from my regular meds and take 10mg (one quarter piece) at a time? Or what?

I'm looking not only to keep my pain under control, but also to experience a recreational type level of effects. Not a total nod, because I'm supposed to be cleaning house with my wife and some friends today to prepare for a visit from our landlord tomorrow.....but something enjoyable, at the very least.

Please, post your thoughts and tips/tricks ASAP.....it's a matter of minutes before I will probably try my first 10mg dose!

[mkchll]

Hello Exitwound, If you take 200mg of morphine a day plus the hydro I'm sure you would have no problem taking 120mg's of methadone. mg for mg methadone and morphine are the same when injected but methadone is going to be way more bioavailible when taken oraly. Also the half life of Methadone is 24 hours so it will last much longer then morphine. I'm prescribed 80mg per day of Methadose. I get a nice High that last very long if i take 150-200mg's but in order to really feel it good I cut my dose down to 20-40mg's per day for about a week. You build a tollerance to Methadone very quickly. Very low doses 20mg is all I need to keep wd's away but in order to keep a nice glow going the mg's can get up there very quickly. Methadone has actually become my drug of choice. I love the feeling it gives and how long it lasts. Good luck I'm sure you'll enjoy. Let me know if you have any questions.

[JunkYardSaint]

A new contact closer to "civilization" recently sent me a sample package of three 40mg Methadose wafers.

Considering that I take approximately 200mg of morphine and anywhere from 50-100mg of hydrocodone per day, what would be a good way to dose this stuff, and how (or even *if*) should I mix them with my other meds?

Should I take the rest of the day off from my regular meds and take 10mg (one quarter piece) at a time? Or what?

I'm looking not only to keep my pain under control, but also to experience a recreational type level of effects. Not a total nod, because I'm supposed to be cleaning house with my wife and some friends today to prepare for a visit from our landlord tomorrow.....but something enjoyable, at the very least.

Please, post your thoughts and tips/tricks ASAP.....it's a matter of minutes before I will probably try my first 10mg dose!


There is an abundance of info online concerning methadone, but personally, based on my experience, I'd say that you can rely on methadone as your only opiate, it's got a longer half life, you won't feel a 'rush', however after about an hour or so you should be free of any cravings for anything else. I also know that in cases of severe pain that they will prescribe both methadone AND a short acting opoid such as morphine, though I've also heard it said that as methadone patients we require higher doses. At the risk of stating the obvious, I think Google will provide the specifics to any question you may have... A two second Google search just now produced the following:

SECTION 5: CONVERTING FROM SHORT-ACTING OPIOIDS TO METHADONE ... (http://www.ohsu.edu/ahec/pain/part2sect5.pdf)
http://www.ohsu.edu/ahec/pain/part2sect5.pdf



http://www.mywhatever.com/cifwriter/library/70/4932.html

[poppy]

I'm ashamed to expose my lack of knowledge but I've never heard of 'methadose' and I wondered what (if any) difference there is between it and methadone? Also as my 'methadone' (both amps and mixture) are labelled as being physeptone I'm assuming they're one and the same thing. Am I right?

PS Sorry Junkyard Saint I can't help you in your quest for methadone but I can and do wish you luck.

[JunkYardSaint]

METHADOSE® ORAL TABLETS CII (methadone hydrochloride tablets, USP) is simply a brand name of methadone as manufactured by the Mallinckrodt pharmaceutical company. That's all it is, a brand name for the same drug known generically as methadone hydrochloride first manufactured in the USA by Mallinckrodt pharmaceuticals under the brand name DOLOPHINE®.

PHYSEPTONE® (methadone HCl) is also a brand name for methadone as marketed by the GlaxoSmithKline company of Australia ... I've never seen it here in the United States of Amerikkka, but it's all the same drug, in the category of opioid analgesics and available by prescription only for pain or for addiction.

[exitwound]

Even though I only took one 10mg quarter-wafer piece yesterday, I battled nausea and numerous hints of imminent vomiting (although it never quite happened) all day long and well into the night.

Granted, I did take higher than normal doses of some of my other meds too in an attempt to enjoy a rare "high day" now that last year's MJ crop is gone (except for a few hash capsules). Maybe if I'd had some MJ left, the nausea wouldn't have been as big of a deal. Not sure.....

I took a lot of Phenergan which is probably the only reason I never vomited. I have to wonder, was the nausea and near-vomiting a direct effect of the Methadone, or should I be taking it alone with nothing else in my system (opiate wise) to avoid this effect?

I'd love to be able to make good use of the other 110mg methadone I have, but not if it's going to make me that sick!

[exitwound]

I think there's a slight chance that my reaction was due in part to the fact that I'm tapering off of an SNRI that I was trying for nerve pain but which didn't do much for me....it's very possible that this left me more open than normal to the nauseating effects of Methadone.

Hopefully, once I'm completely off the Cymbalta and re-adjusted to my "normal" brain chemistry, I'll tolerate the methadone better.

[poppy]

Hi exitwound, I take methadone (65ml mixture[mine!],and usually a 35ml amp depending on the generosity of my boyfriend,ie.current argument status). I swapped my own amp script a while back for mixture in an attempt to show that I am serious about cutting my injecting down after a series of consistently dirty (for heroin) swab tests. Unfortunately my drugworker is less tolerant of dirty tests than my boyfriend's, and the thought of losing my meth script terrifys me. No way do I want to go back to those dark days of not knowing where the next hit is coming from, waking up ill everyday etc etc!!!! So I'm happy (ish) to comply with the meth clinics rules even if I don't like them very much. The alternative's far worse!!
Anyway (lost the plot a bit there!!)generally I don't experience any nausea from my meth on a daily basis. However on occasion, usually when I have my first 50ml blast of amps after a few days abstinence from the gear and amps (injectable meth), I have suffered a brief but intense wave of nausea directly after injection. But it quickly passes.
When I first took opiates I often suffered from nausea and vomiting which I can't really describe other than to say that it was totally different to any other sort of vomiting in that whilst it was very intense it wasn't as unpleasant as other times I've vomited eg through a stomach upset, too much alcohol or whatever. Also as long as I didn't eat or drink anything I was OK. Really though I don't think 10mg should have caused the intense symptoms you describe. Was there any nice sensations from it? I remember injecting 10ml amps before I had an opiate habit, I used to use them as a come down after weekends abusing speed and they never caused me any nausea. So perhaps it was down to the mixture of the meth with the combination of your other meds. I'm sure one of the guys who know loads about pills and potions and their effects will let you know. I hope you sort it out and are able to enjoy a nice buzz off your meth.Laters Poppyx

[candy]

Opiates do cause nausea and vomiting, especially if taken in high doses. Morphine has one of the most intense effects when it comes to nausea. Opiates trigger activity in the cells found in the vomiting center of the brain, the brainstem. Seeing as how you are taking a large dose of Morphine along with other opiates, I would imagine that it is going to cause nausea. Be careful with the amount of Phenergan your taking. Phenergan can cause respiratory depression when taken in large doses as it acts on the Central Nervous System as do opiates.

Something else to note: Phernergan taken in large doses can cause Extrapyramidal symptoms. These are dystonic type movements and can be quite unpleasant. This is commonly seen with the use of antiemetics; Reglan and Phernergan.

Try taking the prescribed dose. If it is taken every 4 hours, you can take it every 3 and still be in a safe range. The usual dose is 25mg every 4 hours or as needed. You may want to take it about an hour before. It can take up to 60 mins to get an effect. I would not go any higher than 50mg per dose.

[JunkYardSaint]

I know this may seem gross, but I couldn't help but be reminded of my early days of opiate addiction, living bi-coastally between San Francisco's Mission District and New York's Lower East Side - it was not at all uncommon for me to just blow "The Excoricist" - like streams of grape soda, root beer or whatever and it was not at ALL unpleasant, just maybe a little akward at times LOL. I actually used to almost like it. It didn't usually last too long, and it always meant the dope was good.

[ontario_opiophile]

Don't take alot of Methadone unless you want to blow chunks. It's a really unpredictable drug. And once you take a large amount you can't take it back and you'll feel it for 24+ hours. It's an unforgiving drug and you can probably get by without withdrawing on like 10mg or 20mg per day. For some people they need 100mg+ to keep off withdrawals but usually it's about 30mg-60mg, you sound like you don't tolerate it very well so don't take a whole shitload of it. You might just not react to it well. Good luck! I wouldn't go and take 120mg of Methadone even if you take 200+mg of Morphine everyday. In my experience Methadone is much more potent than morphine and 120mg of it is equal to about 350-400mg of morphine to me. I am very sensitive to methadone and you sound like you might be too.

[exitwound]

I know this may seem gross, but I couldn't help but be reminded of my early days of opiate addiction, living bi-coastally between San Francisco's Mission District and New York's Lower East Side - it was not at all uncommon for me to just blow "The Excoricist" - like streams of grape soda, root beer or whatever and it was not at ALL unpleasant, just maybe a little akward at times LOL. I actually used to almost like it. It didn't usually last too long, and it always meant the dope was good.

Yeah, 'cept I'd much rather keep my food and drink down, my pain under control, and my buzz to a dull hum if that's how it has to be.

Man, I need to have a big huge custom user title in my name (i guess i'll get it when i donate!) that lets everyone know I'm a chronic pain opiophile, not (mostly) a recreational one :rolleyes: :cool:

Anyhow, I've heard many a similar story, I just don't want to live it out. I've already had those times, in my early poppy tea-making days before I had chronic pain.....I've earned my stripes and don't feel the need to repeat those self-hazings :speechles :krank: :jumping-s :vomit: :bricks: :magicshit :violent4:

[exitwound]

Don't take alot of Methadone unless you want to blow chunks. It's a really unpredictable drug. And once you take a large amount you can't take it back and you'll feel it for 24+ hours. It's an unforgiving drug and you can probably get by without withdrawing on like 10mg or 20mg per day. For some people they need 100mg+ to keep off withdrawals but usually it's about 30mg-60mg, you sound like you don't tolerate it very well so don't take a whole shitload of it. You might just not react to it well. Good luck! I wouldn't go and take 120mg of Methadone even if you take 200+mg of Morphine everyday. In my experience Methadone is much more potent than morphine and 120mg of it is equal to about 350-400mg of morphine to me. I am very sensitive to methadone and you sound like you might be too.

Good advice, brother -- always appreciated, esp. by a Canuckistani :-) We Mainahs feel a special kinship with you Great White North'ahs :D

Sounds like the Methadose goes into my withdraw/emergency/backup toolbox, and to the source who provided them, goes a request to try to get me other meds instead in the future. He says he has someone who will give him generic OC40's and Percs (presumably Ethex or Endo's) for the methadone, and that's much more useful to me; for some reason, I find that oxy is much more useful for groin/pelvic pain than any other opiate I've tried except maybe hydromorphone. So hopefully that will come together before too terribly long. I've got a bunch of stuff I'm sending him in trade so hopefully I'll get my trades' worth since I'm sending him a bunch of stuff that isn't very useful to me, but which brings in a pretty solid price on the black market....

Well, I guess that's another opioid scratched off the list of front-line weapons in my war against chronic pain. =/

Out of the major options that I'm likely to ever get my hands on, the obvious choice would have to be diacetylmorphine. Not totally sure where it'll come from, but I do want to give it a try (no needles, probably just chase the dragon and plug/snort/swallow) and see if it has a viable place in my armory. Barring that, I'm in the market for oxy and dilaudid primarily. I already get a fair amount of hydro and some morphine, plus of course my steady supply of PT.....

Anyhow, thanks for the info man. It's a big help. I owe ya one.

[ontario_opiophile]

Methadone can make you sick for the first while you take it. It takes a while to get adjusted. It's not something you can take a few times to get high. You can use it recreationally but it has a dirty feel to it after a while. It took me about 2 weeks of using it everyday to get used to it. It's a weird one. It's good for pain for alot of people. It doesnt work particularly well for me but it's better than Oxycodone or Codeine or oral Hydromorphone or Morphine. It's a good drug, I like it and prefer it to almost everything except Fentanyl. If it were shorter acting and had a faster onset it would be alot more popular as a drug of abuse and would be tolerated better by people. I think the long action of it puts alot of people off. It's true long acting medication. Long acting Oxycodone lasts maybe 6 hours or something, way less than what they say it lasts. I find those long acting morphine and hydromorphone and oxy's to be shitty and they dont last as long as they say they do. Oxycodone is really good as an add on to Methadone for pain relief. The two together are really good. If you take Methadone as a long acting med and oxycodone every once in a while for extra pain it's pretty good. I have fibromyalgia and a whole bunch of auto-immune disease and disorders, i'm quite sick and one medication alone doesnt touch my pain. You should try maybe taking like 2 or 5 mg of Methadone sometimeand see what happens. I know it sounds like nothing but it may help. Other than that I wouldnt suggest taking bigger doses than you took the last time since you got sick.What type of pain do you have? if you dont mind me asking?

[shaunclo]

Ontario, GREAT PIC!!! you know what I mean Vern? what the hell ever happened to that guy anyways??

On the methadone subject, methadone is one of my favorite opiates. I am one of the few people that actually get crazy high off that shit. It is such a full body high and so euphoric to me. The first time I took it I only took 10mg's and was fuckered up ALL DAY LONG!!! Its great stuff, but sometimes it takes a really long time to kick in fully. Maybe you took too much to begin with, I would start at 10-20 mg's and wait atleast 2-3 hours before re-dosing. I swear, methadone is such a strong high!! I havnt done H in quite a while, but from what I remember, H is more like, "DAMNNNNNN" but methadone is more like "AHHHHHHHH" Just a little bit of some good ol' memories.

[exitwound]

Thanks for the insightful post, O_O :-)

Well, I have numerous pain sources that come and go during flare-ups/remissions, but the primary problem is something we sufferers call Chronic Pelvic Pain Syndrome. Basically I had a series of infections several years ago in my legs and pelvis, and those left nasty scars and cysts along the left side of my reproductive tract, my lymph system, etc.....pretty nasty when I saw it all on an ultrasound image. Basically it's as if somebody shot me in the groin with a 9mm pistol from below, and the bullet struck me in the left thigh above the knee, traveled up and exited near the top of my left hip.

The pain often spreads to the back of my pelvis, into my sacrum and up my spine. After two years of CPPS, my body got even more pissed off and entered a sort of "stage three" -- similar to Reiter Syndrome which is a type of reactive full-body arthritis that can go from no symptoms to complete agony in every bone and joint in your whole body overnight. Fun stuff :(

So, basically, most of the time I have severe groin pain as if you kicked me in the nuts and hit me in the ass with a baseball bat....and sometimes, the pain spreads to my whole body for weeks at at time. Unfortunately, although I have started seeing a doctor again and do get modest pain medication, the groin pain has the ability to punch right through them (time-release morphine and hydrocodone for "breakthrough") even when I take doses high enough to make me unpleasantly nauseous.

Oxy and hydromorphone are a bit better at capping off the groin pain but I am rarely able to get my hands on them. I was hoping methadone would be as good an option for the pain as some other people with CPPS and/or Reiter's have reported, but it seems whatever enzymes/genes make me sensitive to most other types of opiate nausea, also make me touchy with methadone. =/

I'll keep it in my toolbox for withdrawal/taper times, emergencies etc....rather than risk days or weeks of "adjustment" nausea. Plus the source I got this from can probably get oxy instead, so I'll probably just go that route. Hopefully he'll prove reliable, because he lives a long way away from me and we have to do trades via the mail.

[furber]

[quote= In my experience Methadone is much more potent than morphine and 120mg of it is equal to about 350-400mg of morphine to me. I am very sensitive to methadone and you sound like you might be too.[/quote]

it all comes down to how used you are to methadone we take 250 ml in one day(script day)then 50 ml for 3 days then 250 ml in one day then50 ml for 2 days

[JunkYardSaint]

Oddly enough, after years of taking every opiate known, I also have come to prefer Methadone. For me, it's superior. The longer half-life, pain relief, everything about it even how it's taken has become my preference; weird too cuz I was a die-hard junky, used to just love the needle. Now I don't even miss it.

[Inspektahdek]

Oddly enough, after years of taking every opiate known, I also have come to prefer Methadone. For me, it's superior. The longer half-life, pain relief, everything about it even how it's taken has become my preference; weird too cuz I was a die-hard junky, used to just love the needle. Now I don't even miss it.



wow that explains my views on methadone too! I absolutely love it, no real ceiling, all day effect and not "too" overpowering and subtle enough for me to really enjoy it! If I had an endless supply to methadone for pain, I'd be all over that. actually I'm thinking of getting on it soon for pain, we'll see. hate to give up my fent though :/


you've come a long way from when you first started posting here, I remember u were trying to fix bupe right? good job mann