low dose partial agonists as potentiator

[Consumed.]

I can not find a definitive answer in any posts. Does anyone have real factual info on this? Is it ultra low doses of naltrexone that's the supposed to potentiate or ultra low does of buprenorphine? Im sorry I know theres is mixed info on this but whats the real deal? I have read some FDA trials about this for PM but they are murky also.

[pharmboy]

It's Naltrexone.

I have never tried it, but sounds like it might work.
Let us know.

Find more info at - www.lowdosenaltrexone.org (http://www.lowdosenaltrexone.org)

Good luck . .:xmas-smil

[mikells43]

alot of people use LDN along with an antidepressant for pain. i know people that have cut their pain meds (narcs) in half cause of the use of LDN and lets say cymbalta is a good one. also bupe is used in low dose too in aussie in a patch form for pain.

[Consumed.]

alot of people use LDN along with an antidepressant for pain. i know people that have cut their pain meds (narcs) in half cause of the use of LDN and lets say cymbalta is a good one. also bupe is used in low dose too in aussie in a patch form for pain.

thanks for the reply, I probably sound stupid but I still dont understand. What I am getting is; it's good for PAIN but as a potentiator for getting high off of other opiates is a gray area. I experimented and took .10 (roughly) of sub. before my normal dose and it did seem to work. I still dont know if it was placebo or maybe some other external environmental factor. I mean cymbalta doesnt work as an opiate and from what I understand it works on nerves and this is what the LDN research seems to say it works with, not narcotic pain relievers. Am on the right track here? You are saying that people have cut their narcotic pain meds in half though so Im assuming you mean oxycodone, morphine etc. (?) Anybody else have any knowledge or experience? I would think that if worked so great everybody would be taking miniscule amounts of sub. before their DOC. We opiophiles are always on the hunt for the holy grail of potentiators and with it seemingly so promising research wise there's not a lot of info. That always leads me to believe the opio heads give it the thumbs down. We always seem to be on the cutting edge more than legit science! I feel I have a very good gauge on my own placebo affect so Id have to say I lean toward the position of the LDN (sub) did work. So WTF, so I keep a super low dose constant? Is there anyone doing this? With my junk science theory, it would make sense that an ultra low dose of a partial agonist would work to. I would think with an ultra low amount of sub it would "ignite" the receptors to give a full agonist a synergistic effect. But its such a fine line. Im imagining like one or two molecules per receptor to let the light bulb know powers gonna be a comin'. As for the nalaxone well i dont want to sound any more crack potted than Im sounding now, so Ill wait for responses!

[mikells43]

i dont think it would be a good potentuator(sp). just stick with what u got.

[SpecialGuy69]

has anyone ever tried using like .1mg of bupe with their DOC? I dont think it would be enough to precipitate w/d's and even if it did make you feel shitty, your DOC would knock it right out anyways, right???

[tptptp]

has anyone ever tried using like .1mg of bupe with their DOC? I dont think it would be enough to precipitate w/d's and even if it did make you feel shitty, your DOC would knock it right out anyways, right???

.125mg's stabilized can leave someone with a bad wd so I'd say for bupe .1mg isn't even close to low enough.

[tch2296]

Buprenorphine, in low doses, has a much more full-agonist type of effect then when used in higher doses; it is unique for this reason. It has a ceiling effect, meaning the antagonistic effects of the bupe even out the agonist effects. This is why it is prescribed in .1 mg tabets (Temgesic I believe, may be wrong) for severe pain. Buprenorphine is a very strange drug in that it has both agonist and antagonist effects. That's why I can take 60 mg and feel nothing. I take 12 mg/day but used to be at 24 mg. I've been fucking around with it for a long time and can tell you that if you keep your doses small and spaced apart (a couple days), the agonist and euphoric effects are much more noticable.

[SpecialGuy69]

I'm just thinking that a lot more people have access to bupe than naloxone (how fucked is that???) so if there is a way to use it in the same manner as nalox (as a potentiation/tolerance lowerer) then it would help a lot of people.

Possible? Stupid? Weird? I don't know.

[Consumed.]

has anyone ever tried using like .1mg of bupe with their DOC? I dont think it would be enough to precipitate w/d's and even if it did make you feel shitty, your DOC would knock it right out anyways, right???

thats exactly what I said i did in my previous post, thanks for readin'

[mikells43]

no it wouldnt get knocked out, cause bupe has a higher binding affinity than any opiate there is out there. it takes alot of naloxone to knock it off of receptors.

[Consumed.]

fuck gettin technical here, ill stick with how fat my bags are, and what city the dope is good in. Or what hole is better to stick it in

[Indy]

Enough DOC will knock it out of the receptors. It'll take a lot, but just like people on methadone, you can still get high, you just need a lot more.

[Consumed.]

wow thats some new news!!!!

[mikells43]

LMFAO!!!!!!!!!!!!!!!!!!!!!!!!

[roxi*stardust]

I have taken low doses of bupe with my pain meds (roxicodone) and it does seem to increase the drugs effects and length of action. The doses I have tried are 0.5mg (1/16 of a tablet), 0.25mg (1/16 of a tablet), 0.125mg (1/32 of a tablet). I did not experience any forced w/d at these doses.

[EleusisII]

There's definetly something about naltrexone potentiating opiates, or preventing tolerance from happening.
A biotech company in the US is developing a version of oxycontin with naltrexone in it, to prevent tolerance from happening. It's kinda of the holy grail of painkillers, so if anybody has some money they're not going to use on dope, i suggest buying some stocks!

[roxi*stardust]

There's definetly something about naltrexone potentiating opiates, or preventing tolerance from happening.
A biotech company in the US is developing a version of oxycontin with naltrexone in it, to prevent tolerance from happening. It's kinda of the holy grail of painkillers, so if anybody has some money they're not going to use on dope, i suggest buying some stocks!


I read about the Naltrexone but Bupe is different. It is a partial agonist/antagnoist where Naltrexone is a full antagonist. In my experiments with low doses of Bupe, it seemed to potentiate the oxycodone. It especially increased the mu2 effects; constipation, dry mouth, etc. But I did notice an increase in the mu1 effects to, analgesia and euphoria. The Bupe seemed to extend the length of action of the oxy too, I went from dosing every 3 hours to about every 5-6 hours.

[OCfenatiq]

I read about the Naltrexone but Bupe is different. It is a partial agonist/antagnoist where Naltrexone is a full antagonist. In my experiments with low doses of Bupe, it seemed to potentiate the oxycodone. It especially increased the mu2 effects; constipation, dry mouth, etc. But I did notice an increase in the mu1 effects to, analgesia and euphoria. The Bupe seemed to extend the length of action of the oxy too, I went from dosing every 3 hours to about every 5-6 hours.
Yea I gotta agree here, its been a minute but when I was taking subs not long ago I would also take a bump or two in the evenings of doc and it seemed pretty good when I lowered my dose of subs. At first when sub dose was higher it seemed to be a waste to even take anything, but subs gave me a bad headache constantly so I continued lowering the dose daily and taking doc in the evening... I wasn't trying to potentiate, just trying to get rid of a bad headache but I remember a few times wondering if it didn't potentiate. I kind of pushed those thoughts to the side since I knew bupe had a blocking effect and figured it was all in my head... Take that for what it is but wouldn't be a bad idea to try some experiments with it, I wonder what all it might potentiate???

[roxi*stardust]

I hear you on the precip w/ds as I have done it to myself on a few occassions, but never when I tried this with ultra low dose bupe and my oxy.

I noticed the effect when I did what OCFent was describing above. I too had headaches from the Sub so I tried some OC one time to get rid of it. Now mind you I am not on Sub regulary, only when I run out of my DOC. So after I noticed the effect accidently I decided to experiement with it hoping to either reduce my tolerance or extend the "life" of my oxy.

I would take an 8mg Sub and crush it into a very fine powder, then divide it into 4 equal lines then divide each of the 4 lines into 4 more lines (getting 16 total). The next time I tried this I even went as far as dividing those lines in 1/2 for a total of 32 lines. I would snort one every morning and wait about 1 hour before dosing with my oxy.

What I experienced was a very noticeable increase in the mu2 effects; those being consitpation, dry mouth, etc. I also experienced an increase in the mu1 effects, those being the good things; increased analgesia and euphoria. I also noticed that it seemed to extend the length of action. My theory on the increase in the length of action is that the Bupe's affinty for the receptors in so great that it doesn't leave as fast as the oxy does (same reason it is used for opiate detox). So basically since the receptors are not left totally empty, you don't get the urge to do another pill as quickly. I think it tricks your mind into thinking it lasts longer just because the receptors aren't left totally empty like they would be if you took oxy alone and not in conjuction with Bupe.

If you are only taking these tiny doses of Bupe you aren't likely to experience forced w/d. But if you are worried about it and want to try this; follow these steps. Wait until you are in w/d and take a small dose of bupe (like the doses I described above). Wait about 1-2 hours for it to bind to the receptors. Dose with your DOC.