Roxanol Liquid MS Concentrate (20mg/ml)

[D-Stabilized]

Another thread on liquid morphine (I've read all the others).
My pain doc just switched me from MS suppositories, 30 mg. to Roxanol MS oral liquid concentrate, 20 mg./ml.
I'm scripted 120 ml. at a time - a whopping 2,400 mg. - nice!.
It's Roxanol NDC #66479-560-12. A check for inactive ingredients turned up zilch but it must have at least some red dye since the solution is light red/dark pink. Don't think it has any sweeteners though since it's incredibly bitter to taste. I'm thinking that it may also have some sort of preservative since it's stored at room temperature. Still, the website for Xanodyne Pharmaceuticals, Inc. lists Morphine Sulfate as the only ingredient with no mention of inactives.

On to the questions:

1. How safe to IV? I'm quite used to shooting Dilaudid tablets and have had zero problems (so far) despite the fillers and other junk in them.

2. Can I just draw up the liquid and inject away? I'd hate to have to dilute/cut it with water or anything since my 1cc rigs will only hold 20 mgs. as it is.

Any personal experience or verifiable answers would be greatly appreciated.

D-Stabilized

[roxi*stardust]

Another thread on liquid morphine (I've read all the others).
My pain doc just switched me from MS suppositories, 30 mg. to Roxanol MS oral liquid concentrate, 20 mg./ml.
I'm scripted 120 ml. at a time - a whopping 2,400 mg. - nice!.
It's Roxanol NDC #66479-560-12. A check for inactive ingredients turned up zilch but it must have at least some red dye since the solution is light red/dark pink. Don't think it has any sweeteners though since it's incredibly bitter to taste. I'm thinking that it may also have some sort of preservative since it's stored at room temperature. Still, the website for Xanodyne Pharmaceuticals, Inc. lists Morphine Sulfate as the only ingredient with no mention of inactives.

On to the questions:

1. How safe to IV? I'm quite used to shooting Dilaudid tablets and have had zero problems (so far) despite the fillers and other junk in them.

2. Can I just draw up the liquid and inject away? I'd hate to have to dilute/cut it with water or anything since my 1cc rigs will only hold 20 mgs. as it is.

Any personal experience or verifiable answers would be greatly appreciated.

D-Stabilized
I could not find anything listed as far a Zanodyne's Roxanol solution and inactive ingredients. I did find this: Ethex makes a compareable product.



Inactive ingredients: ascorbic acid, citric acid, FD&C Blue

No. 1, FD&C Red No. 40, flavors, glycyrrhizin, propylene

glycol, purified water, saccharin sodium, sodium benzoate,

sodium gluconate, sodium phosphate dibasic, and sorbitol
solution.







Here's a link to the .pdf:
http://www.ethex.com/pages/pdf/58177088657_PIS.pdf
My best guess is they are very similar as far as inactives.

[roxi*stardust]

You know this thread shows up already in google search results for: inactives ingrediants roxanol solution

[Seedy]

Holy fuck, 2.4 grams of morphine in 120mls! 20 mgs a ml! If you can't inject it it would plug pretty well. ;)

[Nate]

Holy fuck, 2.4 grams of morphine in 120mls! 20 mgs a ml! If you can't inject it it would plug pretty well. ;)

True that!

[irish]

Mmmmmmmmmmmmm... Morphine juice.:D

[D-Stabilized]

Well, as usual I had all of my info screwed up. Now that I have the product in hand and can read the insert, I see that it IS Ethex NDC #58177-886-01 and the inactive ingredients include:
Ascorbic Acid
Citric Acid
FD&C Blue #1
FD&C Red #40
Flavors (pretty vague)
Glycyrrhizin
Propylene Glycol (antifreeze?)
Purified Water
Saccharin Sodium
Sodium Benzoate
Sodium Gluconate
Sodium Phosphate Dibasic
Sorbitol SolutionQuite a friggin laundry list! And it's thicker than I remembered too, barely drawing up through a 30ga. point.
Now I'm kinda worried about it but I don't want to have to use it any other way than IV. Any budding chemists/pharmacologists out there want to give me some words of encouragement (or not)?

And yeah, it is 20mg/ml x 120ml = 2,400mg - sweet. Call me crazy but if it's relatively safe to shoot, I'm thinking of using it instead of saline to liquify 8mg dilaudids. That ought to be a nice rush! :p

D-Stabilized

[insaneike]

I got friends who shoot oramorph, though it's not red nor thick at all... Totally diff liquid morph. Never seen the red/thick stuff... From what I've read, don't shoot that shit man... I can't think of any 'kitchen' methods of cleaning it either. You're going to have to go through a lengthy ass process if that morph is ever extracted. Without doing an A/B extract I just don't see how you can get the morph out and cleaned. Sorry man. I think you're going to be stuck with using orally here.. I'm not into plugging myself but if you are maybe..I personally wouldn't use that stuff rectally though seeing as all the inactives it has.

later

[20Dollarholla]

If your taking 2,400mg orally, shootin 1ml isnt going to do shit. Fuck even shooting 10ml isnt going to do shit. My advice is to take it how its perscribed or you will be the human pin cushion. You will have to do WAY too many shots for it to be worthwhile.

Plugging it may be an option, It think morphine has a bioavailability of around 80% when plugged, but you are still going to have to get a couple ounces of liquid up your ass, so the traditional syringe without a needle is out of the question because it wont hold enough.

If I were you, I would put 3oz (90ml) of your liquid in an enema bottle and use that to plug with. I wouldnt put much more until you experiment a little and know how much is going to be too much, because oral bioavailability is only 30% and rectally it is 80% so it is going to be quite stronger up your ass than down your throat. Rectally is your best option because 3-4oz of liquid squirted up your ass isnt going to cause any problems, but 3-4oz of liquid I.V.ed might cause a problem from all the other inactives in it not to mention thats like 100 shots!

I do have a question though, why in the fuck havent they switched you over to Duragesic, Fentora, or Actiq's. Around here when a person has a tolerence that high they are switched over to Fentanyl immediately, unless money is an issue because Fent is fuckin expensive, but I bet that liquid you have isnt cheap either.

[D-Stabilized]

20Dollarholla,

I think you misunderstood. I sure as heck don't take 2,400 mg. all at once, orally or otherwise. I have a wicked tolerance, but not THAT wicked! That's the amount of the entire script. And the reason that I haven't switched to Duragesic, etc. is because I don't require 24/7 pain relief. My pain is kinda chronically acute, if that makes any sense.

I guess I'm just gonna go ahead and plug it. I do have the perfect thing for it though. It's one of those large rubber bulb-type syringes like you would irrigate you ears with or like they use to clear a newborn's airway. I should be able to get away with 120 mg. (6 ml.) at a time since I used to use the 30 mg. MS suppositories 4 at a time. Still that's only 20 doses total for the bottle whereas I probably would've gotten about sixty 40 mg. IV doses. Ah, well...

Thanks for the other advice, though. I'm curious where you got the 80% rectal availability figure from. Sounds about right - I've just never been able to find any figures on that ROA before.

BTW: I have tried the Actiq suckers (1200 mcg.) and loved them. :drunk: Unfortunately the Doc was a little uneasy scripting those since my respiratory system ain't quite up to snuff. Can't say I blame him.

D-Stabilized

[Nate]

Plugged morphine is so nice :o

[irish]

Maybe try a potentiator to stretch that morphine a little bit.

[20Dollarholla]

Oh I see my bad, I thought that that was a huge dose of morphine lol, thats why I wanted to know why you didnt have something stronger. Thats still a pretty stong morphine soloution you got there, the only liquid morphine sulfate I have ever had was 10mg/5ml, blue, and tasted like oranges.

Yeah definetly plug it, that would be the way to go, but if your are used to the suppositories you really arent going to feel any higher if you plug the same amount of the liquid. You are already used to getting that extra 50% of the bioavailability because of the suppositories. S you might want to take more than your suppository dose unless 120mg of those got you where you wanted to be, if thats the case than like you said 6ml will be the same 120mg so it should feel exactly the same.

Did the doctor raise your dose when swithching your perscription, from a Morphine Sulfate that was administered rectaly to a Morphine Sulfate that is administerd orally? If not you could probaly get him to raise your daily dose since morphine is considerably stronger rectally, the only other method of administration for morphine thats stronger than rectally is the needle. Most doctors know that rectally administed morphine is twice as strong tham when it is adminisred orally. Tell them that it doesnt seem to work as good as the suppositories did and you researched on the internet and found a bioavailability chart for Morphine and it Methods of Aministration say the chart said:

-Intrnasal 20% (unless mixied with chitosan then it jumps to 60%)
-Orally 30% bioavailale
-Rectally 80% bioavaialbe
-IM injectin or a skin pop shot the bioavailability is 90%
-and of couse our good friend mainling the bioavailanility of that we all know is the full100%

Have fun with that shit, you may want to take a benrdryl before dosing HIGH because it will help eith the pins and needle feeligs when you dose, also it will hlp any type of allergy to morphine.

[edhorfin]

FWIW, My mother was on Roxane Labs roxanol(no generic) in the 80's when she was dying of cancer. It wasn't thick or pink, it was clear and watery. Long story short, her legacy to me was several bottles of the stuff after she passed. I shot it all, with no ill effect, other than a primate tumor, a big one, a couple of months down the road.

Of course, at my age then, I was bulletproof and didn't need to read no stinking ingredients. I knew it had at least one ACTIVE ingredient, and I wanted it in my veins ASAFP.

I'd probably look on the net some more, maybe porg, and if I couldnt find anything, I'd maybe thin it down with some sterile water and try a little...That's just me.

good luck

Ed

[D-Stabilized]

This is getting to be quite a thread. For what it's worth, I have now tried it every which-way and the jury's still out, so to speak. No immediate ill effects from IV'ing but since my rigs are only 1cc, the rush just isn't really there and it's just not the same thing doing multiple shots in succession as it is one large one. I'm hitting my dilaudids 16 mg. at a time (2 K8s in 1cc of saline) and there's just NO comparison. And boy howdy - you definitely don't want to get a single drop of the morph outside of the vein unless you enjoy skin-popping napalm. No way you're gonna IM or SC this stuff! Plugging is OK and oral/sublingual just plain sucks. No big surprises, really.

To clarify one thing - I never meant to suggest that this stuff is really thick. It's just somewhat noticeably thicker than water. I've found that warming it up just a bit in a spoon allows it to draw up and shoot just fine. Don't know if I wanna do the whole bottle that way but the other options are pretty limited.

Hey, it's a shitty job but someone's got to do it. :D

Time for another hit - see ya!

D-Stabilized

[toighttoiger]

you know, i'm sure there's a fairly easy way to just let the liquid evaporate and then shoot the leftover morphine powder kind of akin to the same procedure that people do with bottles of liquid ketamine? correct me if i'm wrong

[20Dollarholla]

you know, i'm sure there's a fairly easy way to just let the liquid evaporate and then shoot the leftover morphine powder kind of akin to the same procedure that people do with bottles of liquid ketamine? correct me if i'm wrong

I think you would end up with some sort of gummy shit instead of a powder, it would be the same as trying to evap the cherry methadone soloution. ketamine is the consistency of water, this stuff is a lil thicker.

[jersey_emt]

Hmm..I ended up getting this stuff because my pharmacy was out of stock of 30mg MSIR's. So they gave me the Ethex generic morphine sulfate liquid, 20mg/mL. Here's my thoughts on its use (oral):

Tastes pretty bitter. I definitely prefer just swallowing a tablet as compared to 1.5 dropperfuls of this liquid.
Comes on significantly quicker. MSIR's usually take at least 30 minutes to kick in for me. With the Roxanol, my breakthrough pain is gone in 15 minutes.

I may ask to be switched to this instead of MSIR for my breakthrough pain because it works so much faster.

[Inspektahdek]

-Intrnasal 20% (unless mixied with chitosan then it jumps to 60%)
-Orally 30% bioavailale
-Rectally 80% bioavaialbe
-IM injectin or a skin pop shot the bioavailability is 90%
-and of couse our good friend mainling the bioavailanility of that we all know is the full 100%




I have to completely agree with these outcomes, that's about as close as you can be, dead-on. Nice one, I either plug or use oral and found that IV becomes tenuous after having to do multiple shots not to mention the bumps and pricks of a missed shot, etc.

Anyone else think that plugging effects decrease after you've been backed up and haven't shit in a while? Kind of curious about this one...