Antihistamine comparison

[Tortoise]

Howdy kids

I was interested to know if there was any benefit to taking one kind of antihistamine over another to potentiate opes. I use dramamine because it doesn't seem to leave me too groggy for too long whereas something like doxylamine succinate knock me out for about 10 hours. Never tried promethazine.

So, in your opinion, what is the best antihistamine to take with your opes?

peace & love
T

[HistoryofMadness]

Howdy kids

I was interested to know if there was any benefit to taking one kind of antihistamine over another to potentiate opes. I use dramamine because it doesn't seem to leave me too groggy for too long whereas something like doxylamine succinate knock me out for about 10 hours. Never tried promethazine.

So, in your opinion, what is the best antihistamine to take with your opes?

peace & love
T

methinks dyphenhydramine and maybe a little dextromethorphan might be a a nice combo... but if you're on wellbutrin run like hell from dxm

[Thebane]

methinks dyphenhydramine and maybe a little dextromethorphan might be a a nice combo... but if you're on wellbutrin run like hell from dxm

What's wrong with Wellbutrin and DXM? Do you mean tripping amounts? I was on 300mg Wellbutrin daily and stabilized at that level probably since I'd been on it for 4 weeks, 300mg the last 3 weeks. And I took 30-40mg DXM daily with my opiates.

Everywhere I've seen says benadryl is the best anti-histamine. I'm assuming the anti-histamine action is what potentiates? And it's also second in sedation behind doxylamine succinate I believe. So I stick to benadryl. If you mean the sedating effect when you say grogginess, that usually goes away pretty quickly. I've been taking benadryl daily for a few months with opiates and it has absolutely no sedating effect anymore. Doctors recommend it for a sleep-aid but they even say it will only work for a short time before you become tolerant to that effect. So I'd go with benadryl and if it makes you sleepy just take a small enough dose you can handle it and slowly increase until you get to wherever you want to be for opiate potentiation. While using small amounts you can always use dramamine also, just don't take too much of them by adding the benadryl and taking the same amount of dramamine. I hear large amounts of anticholinergics are no fun.

[HistoryofMadness]

What's wrong with Wellbutrin and DXM? Do you mean tripping amounts? I was on 300mg Wellbutrin daily and stabilized at that level probably since I'd been on it for 4 weeks, 300mg the last 3 weeks. And I took 30-40mg DXM daily with my opiates.

wellbutrin takes a lot of time to metabolize, and has several metabolites, one of which apparently slows the process of metabolizing dxm (at least this has been suggested)... for me it increased the dysphoric side effects of dxm (not the 'good' ones) and kept me up for a long time.

just an fyi to some, it made my last dxm experience quite the nightmare. and i normally am just fine with the stuff.

[Thebane]

Ahh ok, I guess I was lucky enough to only be using low doses, even on the therapeutic end, so I didn't have any problems.

[Tea Time]

In my opinion, promethazine is the best antihistamine for potentiating opiates. It is related to phenothiazine tranquilizers so it can really be quite sedating, and luckily it doesn't have the nasty side effects that others in that class of meds have. Hydroxyzine is also a good prescription antihistamine for potentiating opiates. But like I said - both of these are by prescription only in the US, so that might prevent some opiophiles from using these two pharms. As for OTC antihistamines, I would personally say that diphenhydramine is the best. Dimendydrinate is also good (being closely related to diphenhydramine) and it is not as sedating as diphenhydramine so some might prefer dramamine over benadryl. That has been my experience. Take care,

TT

[resorcinol]

AVOID DXM while on WELLBUTRIN like the plague!!!

I made the horrible mistake of taking 100 mg dxm once while on 300 mg wellbutrin once daily. I was in a very unpleasant dreamlike anxious state of depersonalization for 24 fucking hours... I felt spread out all over the place in a most unpleasant way. Other CYP2D6 inhibitors don't have QUITE such a pronounced dysphoric effect so I think it's something happening neurochemically with the combination too. AVOID.

[clinton]

can someone please explain how the antihistamines potentiate...thanks.

[resorcinol]

can someone please explain how the antihistamines potentiate...thanks.

I don't think anyone knows the exact mechanism. Some (like diphenhydramine) seem to just add to the sedation and 'nodding' feeling, while a few gems like cyclizine seem to actually significantly increase the euphoria.

As OTC antihistamines go I like doxylamine (Unisom sleep TABS)

[Thebane]

I don't think anyone knows the exact mechanism. Some (like diphenhydramine) seem to just add to the sedation and 'nodding' feeling, while a few gems like cyclizine seem to actually significantly increase the euphoria.

As OTC antihistamines go I like doxylamine (Unisom sleep TABS)

I'm sure I've posted this somewhere recently but it doesn't seem to be in this thread. But, doxylamine is supposedly the strongest OTC sedative, more so than benadryl. I liked it much more than benadryl for potentiation, until I didn't get any sedation from any anti-histamine from using them daily. Now I can't really tell the difference between them.

[modega]

I'm not sure if one type of anti-histamine over the other will work any better, but I've always liked the diphenhydramine in Tyenoi PM. It seems to work really well, and it stops the itchies better than some of the alternatives.

[resorcinol]

I'm not sure if one type of anti-histamine over the other will work any better, but I've always liked the diphenhydramine in Tyenoi PM. It seems to work really well, and it stops the itchies better than some of the alternatives.

Why take diphenhydramine in tylenol PM? Unnecessary APAP. The less APAP the better, imho.

Buy generic diphenhydramine tabs or capsules. Cheaper and no APAP.


On another note about diph...

I've heard the benadryl CAPSULES (not the tabs) break down well for IV administration. I've also heard that IVing your usual opiate WITH a small dose of diph like 25-50 mg increases the rush rather substantially. I'm in NO WAY advocating injecting pills, just sharing some anecdotal information i've heard. If you do this, be careful... diphenhydramine potentiates opiates, and nobody wants to have an OD on their hands... remember, sedating antihistamines ARE true CNS depressants, just less euphoric than benzos/barbs/booze (GABA agonist drugs). BE CAREFUL!!!

[Thanat0s]

res is right, iv diphenhydramine even by itself provides a substantial rush and really is nice mixed with opies... 25-50mg is sufficient though i have ived upwards of 200mg(8caps) at a time before. DO NOT do this, i am posting this for info purposes only to verify that it is indeed possible. i actually got kinda stuck on those shots for about a year, nearly daily with no real adverse effects other than some hardened veins that eventually returned to normal. they cook up very clean actually, be aware of the brands you buy as some do have different fillers in them that dont cook up... i think the brand name benadryl was the cleanest, the equate brand if i recall had a thick goop form rendering them less than ideal. all this was roughly 10 years ago though i do enjoy the occasional shot when insomnia or a fit of hives has taken hold.

heh, cheese anyone?:rolleyes:

[lunchbox]

promethazine is they way i'd go because it's a great sedative and of course a main ingredient in dj screw shit will get ya leanin!

[brimanic]

wellbutrin takes a lot of time to metabolize, and has several metabolites, one of which apparently slows the process of metabolizing dxm (at least this has been suggested)... for me it increased the dysphoric side effects of dxm (not the 'good' ones) and kept me up for a long time.

just an fyi to some, it made my last dxm experience quite the nightmare. and i normally am just fine with the stuff.

First time I tried DXM I was taking Wellbutrin. I swore I would never do it again. It was a rather unpleasant experience to say the least. I've been off that stuff (Wellbutrin) for a year and a half now and DXM trips are much less unpleasant. Though, I don't make a habit of it. Maybe once every other month or so.

[Narkotikon]

Vistaril / Atarax (Rx only), brand names for hydroxyzine. Good at potentiating the sedative effects of opiates (the nod).

Phenergan (Rx only), brand name of promethazine. Good at potentiating the sedative effects, and also good at helping with the nausea associated with opiate use, especally for people who are opiate naive. Although, people who are opiate naive really shouldn't need potentiators to increase the sedative effects of opiates. Be careful.

Benadryl (OTC), brand name of diphenhydramine. Good at potentiating the sedative effects, as above. Also good for the itchieness associated with opiates. Although, personally, I like being itchy. It's pleasureable to scratch while you're nodding off to la la land.

[Seedy]

I been loving cyclizine recently!!!!!

[SynthMorph]

I heard some crazy shit about that cyclizine. Apparently the best rush out there when mixed with methadone related opiates.

[Seedy]

^^ Yeah, in trainspotting they were booting it while on done to get that rush back. I just been using it with my PST and it's very smooth. Boosts the euphoria without the usual antihistamine side effects. I'm looking forward to trying it out with subs when I get on them in a week or 2. Just for the sake of experimentation.