plugged oxy is better according to FDA

[Inspektahdek]

Table 2
Mean [% coefficient variation]
Regimen Dosage Form
AUC∞
(ng•hr/mL)†
Cmax
(ng/mL)
Tmax
(hrs)
Trough
Conc.
(ng/mL)
Single Dose 4 x 40 mg OxyContin* 1935.3 [34.7] 152.0 [28.9] 2.56 [42.3] n.a.
2 x 80 mg OxyContin* 1859.3 [30.1] 153.4 [25.1] 2.78 [69.3] n.a.
1 x 160 mg OxyContin* 1856.4 [30.5] 156.4 [24.8] 2.54 [36.4] n.a.
† for single-dose AUC = AUC0-inf; for multiple-dose AUC = AUC0-T
* data obtained while volunteers received naltrexone which can enhance absorption.


OxyContin® IS NOT INDICATED FOR RECTAL ADMINISTRATION. Data from a
study involving 21 normal volunteers show that OxyContin® tablets administered per
rectum resulted in an AUC 39% greater and a Cmax 9% higher than tablets
administered by mouth.





the AUC and cmax stand for concentration absorbed and peak plasma levels so im assuming its stronger


this is straight from the FDA's OC .pdf official file so im assuming its pretty damn legit

[doctor diesel]

Yes, as I've always said... "One up the bum, no harm done".


Laters peeps.

[I-Nod]

Single Dose 4 x 40 mg OxyContin* 1935.3 [34.7] 152.0 [28.9] 2.56 [42.3] n.a.
2 x 80 mg OxyContin* 1859.3 [30.1] 153.4 [25.1] 2.78 [69.3] n.a.
1 x 160 mg OxyContin* 1856.4 [30.5] 156.4 [24.8] 2.54 [36.4] n.a.
† for single-dose AUC = AUC0-inf; for multiple-dose AUC = AUC0-T
* data obtained while volunteers received naltrexone which can enhance absorption.

Enhance absorption in the bum? Wonder if the increase in AUC is due to naltrexone or plugging...

"one up the bum, no harm done" :hangloose:cheeky2: Nice!!!!!!!!!111oneone

[Inspektahdek]

naltrexone?

[evilfix]

hmm damn. there a guide somewhere that shows how to plug? can it even be done with Teva's? (heh, cant imagine the gelling in the fucking ass!)

[jonny-5]

hmm damn. there a guide somewhere that shows how to plug? can it even be done with Teva's? (heh, cant imagine the gelling in the fucking ass!)

you dont need a guide. obtain one of those syringes for squirting water like you get when you get your wisdom teeth pulled, or a normal syringe that has the needle that screws on and off. crush DOC and mix with water. put up bum and squirt. enjoy!

[evilfix]

how far in? Teva OCs gel like a bitch. is that something to worry about? i assume it is. gel in the ass is only for, special occasions (JOKE!)

[opiATEmALL]

Table 2
Mean [% coefficient variation]
Regimen Dosage Form
AUC∞
(ng•hr/mL)†
Cmax
(ng/mL)
Tmax
(hrs)
Trough
Conc.
(ng/mL)
Single Dose 4 x 40 mg OxyContin* 1935.3 [34.7] 152.0 [28.9] 2.56 [42.3] n.a.
2 x 80 mg OxyContin* 1859.3 [30.1] 153.4 [25.1] 2.78 [69.3] n.a.
1 x 160 mg OxyContin* 1856.4 [30.5] 156.4 [24.8] 2.54 [36.4] n.a.
† for single-dose AUC = AUC0-inf; for multiple-dose AUC = AUC0-T
* data obtained while volunteers received naltrexone which can enhance absorption.


OxyContin® IS NOT INDICATED FOR RECTAL ADMINISTRATION. Data from a
study involving 21 normal volunteers show that OxyContin® tablets administered per
rectum resulted in an AUC 39% greater and a Cmax 9% higher than tablets
administered by mouth.





the AUC and cmax stand for concentration absorbed and peak plasma levels so im assuming its stronger


this is straight from the FDA's OC .pdf official file so im assuming its pretty damn legit



As in sticking the whole pill up there or browning as per the "guide to rectal admin..."

[pdxninja]

browning oxy is yum (browning oxy+dillys is double yum as i ahve recently found out)

i know theres an extensive browning guide but...
the process of how i do it. is i take a shotglass or a short wine glass that has a dent in the middle and try to powder up whatever i get as much as possible.
i use the 1ml syringes, because i have them prescribed and they are small and easy to fit up in there
then i draw out however many syringes full of water ill use/ ive found that a small conic shaped dent makes it easier to get every little bit and chunk drawn up.

20-40 mg of oc i use 2 ml of water

with :(tevas:(. ive had to use a lot more water and let it sit longer on account of the gelling. you really have to make sure those things are crushed SUPER FINE

the nice thing about tevas is their gellyness provides a bit of lubrication, but then i know i have some drugs jjust sitting on the outside of my anus :(