Oxy w/ naltrexone

[tptptp]

ok so this is from 2001 when they expected it to take 3 years what happened if anything?

http://tgorski.com/drug_updates/OxyContin%20-%20Manufactures%20Plan%20For%20A%20Safer%20Pain%20 Medication%20010808.htm

sounds not fun.

[Synack]

tsk, tsk - search - we've already made a thread on this :p
.
AFAIK, nothing is contining on that drug.. but I did read something recently, where a company that start's with an M was trying to create something similar to that..

[Curio]

Let's not remind them they are behind schedule, eh?!! :cool:

bad news, that would be....

[oc80tn]

I have a feeling that it is going to be close to impossible for Purdue to develop a tamper-resistant formulation of OxyContin. They have been working on this for close to seven years now. Of course I know it can often take years to develop a new drug, but Purdue should have a jump start on this one because it is not finding a new drug, simply trying to find a new delivery system for an existing drug.
I just don't see how they'll be able to put an opioid antagonist into the pill/capsule/tablet and guarantee there will be no problems with the drug accidentally delivering a dose of naloxone or naltrexone to a chronic pain patient. They can't. Nothing is 100% foolproof, and this is one place where close don't cut it, even if it works 99% of the time. I'd hate to be a person in the one percent who inadvertently gets thrown into withdrawal by their PAIN MEDICINE!
I can somewhat understand the DEA, FDA and Purdue Pharma want to protect people (or their own asses), but let's be honest here. Purdue Pharma didn't shove an 80 mg OxyContin down some fratboys throat when he had a point-22 blood alcohol content and maybe a couple of Xanax or Klonopins on top of that. There has to be some personal responsibility placed on the kid. This drug wasn't created to get people high. Granted, if you don't have chronic pain issues or a high tolerance to opioids, it's very likely you will get high, but that's secondary. Its main purpose was, and is, to improve the quality of life for someone suffering from an agonizing disease, like cancer or AIDS, or for those of us who have non-malignant skeletal, muscular or neurological pain. It does this amazingly well, with a lot less side-effects than morphine.
It irritates me to no end to hear people in power (politicians, media, etc) villify this drug and basically call it a scourge upon humanity. OxyContin has been around for quite a few centuries. It just came in other forms. It was the first person in the middle east eating poppies who found out about its "secret". It was the Chinese who found out smoking opium would ease pain and provide euphoria. It was the discovery of morphine in the 19th century and, a few decades later, the invention of the hypodermic needle that increased the potency of opiates and the high that accompanied it. It was in a European laboratory later that century that found a process of turning plain old morphine into diacetyl morphine in hopes of finding a less addictive painkiller, that led to millions over a century-and-a-half becoming addicted to "the cure" in the form of heroin.
And despite leaps in medicine in the 20th century finding better opiates and semi-synthetic opioids, addiction is still with us. As long as pain is present, so will the possibility of addiction. It is wrong for the powerful to use someone's suffering, either chronic pain or addiction, for personal gain. Unfortunately, this is exactly what is happening. The villification of drugs is a multi-billion dollar business for the government. It provides jobs in the federal, state and local bureaucracy. DEA, FDA, FBI, state law enforcement, local police/sheriffs offices and even jobs in corrections for prison guards and other. Which in turn provides a great deal of private sector jobs. Weapons manufacturers, body armour, automobile industry...you name it, the war on drugs has a trickle down effect on essentially every sector of our economy, either directly or indirectly. And that is why drugs will never be legalized and why prescription pharamceuticals will never be placed over-the-counter. It would have a devastating effect on our economy. One beneficial effect it would have would be in crippling a large part of organized crime. Drugs have been their number one source of income for decades. They would have to depend on other sources of income like prostitution, pornograph and gambling.
This will never happen. Too much to lose for far too many people.
Sorry I wandered so far off the subject and the beaten path. I have a tendency to do that.

[tptptp]

I have a feeling that it is going to be close to impossible for Purdue to develop a tamper-resistant formulation of OxyContin. They have been working on this for close to seven years now. Of course I know it can often take years to develop a new drug, but Purdue should have a jump start on this one because it is not finding a new drug, simply trying to find a new delivery system for an existing drug.
I just don't see how they'll be able to put an opioid antagonist into the pill/capsule/tablet and guarantee there will be no problems with the drug accidentally delivering a dose of naloxone or naltrexone to a chronic pain patient. They can't. Nothing is 100% foolproof, and this is one place where close don't cut it, even if it works 99% of the time. I'd hate to be a person in the one percent who inadvertently gets thrown into withdrawal by their PAIN MEDICINE!
I can somewhat understand the DEA, FDA and Purdue Pharma want to protect people (or their own asses), but let's be honest here. Purdue Pharma didn't shove an 80 mg OxyContin down some fratboys throat when he had a point-22 blood alcohol content and maybe a couple of Xanax or Klonopins on top of that. There has to be some personal responsibility placed on the kid. This drug wasn't created to get people high. Granted, if you don't have chronic pain issues or a high tolerance to opioids, it's very likely you will get high, but that's secondary. Its main purpose was, and is, to improve the quality of life for someone suffering from an agonizing disease, like cancer or AIDS, or for those of us who have non-malignant skeletal, muscular or neurological pain. It does this amazingly well, with a lot less side-effects than morphine.
It irritates me to no end to hear people in power (politicians, media, etc) villify this drug and basically call it a scourge upon humanity. OxyContin has been around for quite a few centuries. It just came in other forms. It was the first person in the middle east eating poppies who found out about its "secret". It was the Chinese who found out smoking opium would ease pain and provide euphoria. It was the discovery of morphine in the 19th century and, a few decades later, the invention of the hypodermic needle that increased the potency of opiates and the high that accompanied it. It was in a European laboratory later that century that found a process of turning plain old morphine into diacetyl morphine in hopes of finding a less addictive painkiller, that led to millions over a century-and-a-half becoming addicted to "the cure" in the form of heroin.
And despite leaps in medicine in the 20th century finding better opiates and semi-synthetic opioids, addiction is still with us. As long as pain is present, so will the possibility of addiction. It is wrong for the powerful to use someone's suffering, either chronic pain or addiction, for personal gain. Unfortunately, this is exactly what is happening. The villification of drugs is a multi-billion dollar business for the government. It provides jobs in the federal, state and local bureaucracy. DEA, FDA, FBI, state law enforcement, local police/sheriffs offices and even jobs in corrections for prison guards and other. Which in turn provides a great deal of private sector jobs. Weapons manufacturers, body armour, automobile industry...you name it, the war on drugs has a trickle down effect on essentially every sector of our economy, either directly or indirectly. And that is why drugs will never be legalized and why prescription pharamceuticals will never be placed over-the-counter. It would have a devastating effect on our economy. One beneficial effect it would have would be in crippling a large part of organized crime. Drugs have been their number one source of income for decades. They would have to depend on other sources of income like prostitution, pornograph and gambling.
This will never happen. Too much to lose for far too many people.
Sorry I wandered so far off the subject and the beaten path. I have a tendency to do that.

Yep, but though maybe not as many if drugs were legalized there would be tons of jobs in production and regulation and a million regulatory agencies that they can come up with and other stuff like rehabs and therapy program and new studies on different types of maintenance. Drug dealers and non-violent "criminals" now would also need jobs though. It won't be easy but at some point they may have to as this shit becomes more and more out of control. Heroin's been illegal aklmost a centure in the US. The "war on drugs" is about 40 years old and things have only become cheaper, purer and more avilable. Hopefully other countries continue to be truthful and more lenient in their lawmaking and ignore American pressure butting into their business. When enough people are addicted and enough crazy shit happens and the other countries start showing great stats with programs like heroin maintenance and refuse to shut them down they will have to acknowledge. First thing we need to drop is the mother whose kid was a drug addict and now villifies and stigmatizes drugs even more then they were to begin with instead of realizing once someones a user its the illegalization that makes their life miserable. No one shoved it down their throat and if it hadn't been "that" drug it would have likely been another. So they blame the drug instead of the laws or the lack of education surrounding them.

Slavery was a huge economic thing too, but it was overcome with a war, but in a time when people didnt sit on their asses eating fast food and watching TV. Fat, complacent America now.

There needs to be BETTER drug education in school. Not all drugs are "dope". The drug Czars can make the penalties tougher and tougher and the risk/reward will just go up more for them. More and more kids become pushers this way and end up getting shot and shit.

American government is guilty of the way drugs are to begin with. Instead of representing drugs accurately everything is "dope." Marijuana makes you hallucinate and murder people way back when.......the kids just don't believe that shit anymore so they don't believe or realize what other drugs are TRULY like. Keeping drugs illegal just makes them "cool" and more kids wanna try 'em.

[evilfix]

preach the word my brotha's!