IVing capadex?

[tui]

is it possible to IV capadex? is it worth it?

thanks guys...

t

[robojunkie]

Had to look that one up, guess its a NZ brand name for d-propoxyphene hcl/paracetamol. The dextroprophoxyphene HCl is water soluble, the paracetamol (tylenol) is very weakly soluble, something around a gram per 100 mls if I remember correctly. So in theory I imagine it is possible, but I wouldn't do it. First of all its only something like 32.5 mg of darvocet (american name for it) which wouldn't do shit for us H junkies and it is one of the weakest "narcotics" around. I think it'll just about beat tramadol and loperamide and that's about it. Another thing, is that in high doses, around 600 mg or more orally, can lead to convulsions and toxic psychoses. I don't recall ever hearing of anyone injecting propoxy, usually only hear of it as a desperation measure to make ends meet w/o too bad of WDs. You'd have to filter out all that paracetamol which will be a big mess since its in their in a 10 to 1 ratio by weight, then there's the fact that we both know 1 or 2 ain't gonna do shit for ya, and then there's the whole bizarro convulsions/toxic reactions that can come with high doses. If 600 mg is a borderline dangerous dose for this shit (in theory at least as I have eaten like 15 of the 65 mg darvons-no tylenol-and didn't sieze up or get psychosis although I did feel wierd and it was not a "clean" feel at all, more semi-opiody, jittery and kinda twitchy), I imagine the IV dose that would border on these effects would be reasonably lower. Not worth the bother to IV, even if sick. Like it's stronger cousin methadone, it has a very good oral bioavailability and since there's not likely to be any rush with this shit, ain't much point in using the point, other than maybe quicker effects.

I would think its only real use would be oral for getting through some shitty times w/o the real shit. I called methadone it's stronger cousing but really propoxyphene is methadone's bastard son and should be treated as such.

[tui]

thanks for the info rj. that's what i needed to know.

i'm staying with my 90 yr old granny... & unbelivably, though her cupboards are stuffed with meds, a script of capadex from the 80s is the only vaguely interesting thing i could find!! she's a tough nut ;)

thanks again

t

[jonny-5]

i scored some darvon from my grandma as well. it was back when i was addicted to vicodin and i used it to get off of the vikkies a few times. even with vicodin withdrawls it barely did shit i cant imagine it would do much to a junkie. but anyways i imagine it would be IVable. my friend opened up one of the darvon capsules and cut it into 2 lines. he snorted one line and was immediately on the flo0or in agonizing pain. he said it was the worst burning sensation he has ever felt up his nose, like snorting shards of glass. then he goes and puts the second line up the other nostril! hahahaha dumbass. i laughed for so long.

[Hammilton]

I don't think there'd be any unusual risks associated with it not associated with IVing other pills.

That said, d-propoxyphene is probably the worst opioid re: therapeutic index and respiratory depression.

propoxyphene has actually been shown to be LESS effective than aspirin at releiving pain. That's really something.

Because of the horrible therapeutic index, the difference between analgesia and death by respiratory depression is awfully slim. Using it to get high is way riskier. One of the few drugs I've ever taken as prescribed that caused me to worry about whether or not I've live through it's effects.

One interesting note: Death by overdose from propoxyphene happens incredibly fast. Something like 33% of propoxyphene deaths occur within 30 minutes of dosing.

That's hardly enough time to even realize there's a problem.

[Seedy]

Tui, I'm shocked! Going through your poor gran's meds. Tut tut ;)

[CSiiSEQ]

It's really not water soluble enough to make it worth it (1 mg per 10 ml HOT water - see below), and you have the added problem of all the acetaminophen. There are a few case reports of people doing it (one is included below). In two of the others, the patients had pulmonary edema and disseminated intravascular coagulation after intravenous abuse of d-propoxyphene (darvon only). So no, it is not just the same risk of shooting any other tablet, it is more dangerous than the average water soluble tablet. If you really want to take them, stick with the po route.





Clin Toxicol. (http://javascript%3Cb%3E%3C/b%3E:AL_get%28this,%20%27jour%27,%20%27Clin%20Toxi col.%27%29;) 1981 Sep;18(9):1099-104.
Intravenous self-administration of propoxyphene napsylate: case report and in-vitro studies.

Green HM (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=Search&Term=%22Green%20HM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstractPlus), Decker WJ (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=Search&Term=%22Decker%20WJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstractPlus).
A man who was prescribed propoxyphene napsylate (PN) for treatment of heroin addiction stated that he received no effect from the drug by the oral route. He then decided to administer the drug to himself intravenously in a manner identical to that used by most heroin addicts (heating the tablet with water in a spoon and drawing the liquid through a needle); this procedure brought him immediate subjective relief. Several reports have stated than PN is not efficacious via the intravenous route since it is relatively water insoluble and is therefore not likely to be abuse in this manner. However, in vitro experiments demonstrated that at least 1 mg of PN can be extracted by 10 mL of hot water from a tablet containing 100 mg of the drug. Assuming (as a conservative estimate) that the subject received a bolus injection of approximately 40 mg PN (he used four 100 mg tablets at once), his response may not have been entirely subjective. Moreover, severe cardiovascular and pulmonary complications may ensure as a result of the insoluble material injected.
PMID: 6119187 [PubMed - indexed for MEDLINE]

[tui]

^^interesting... thanks

t

[Hammilton]

Theres no increase in problems because the drug isn't very water soluble compared to any other drug that contains paracetamol.

the paracetamol is going to present far more problems than undissolved d-propoxyphene.

And actually, the undissolved propoxyphene might not present any problem, since it should dissolve fine in the blood (that's not something i can find data on).

I'm pretty sure the insoluble material they're talking about are the filters, not the drug material.