Morphine And Celexa

[Narkotikon]

I'm specifically wanting to know if Celexa will hinder the effects of oral morphine. I'm planning on getting a small order of pods soon, but I'm taking 40mg of Celexa a day. I've taken Prozac in the past, and I know that Prozac completely messes up the CYP enzyme required to metabolize codeine into morphine, therefore making the codeine completely useless. I also know that there are lots of different alkaloids in the pods, but morphine is the one I'm most concerned about. Will the Celexa prevent the morphine from working? Will I be able to get a nod?

[AWOL]

I'm specifically wanting to know if Celexa will hinder the effects of oral morphine. I'm planning on getting a small order of pods soon, but I'm taking 40mg of Celexa a day. I've taken Prozac in the past, and I know that Prozac completely messes up the CYP enzyme required to metabolize codeine into morphine, therefore making the codeine completely useless. I also know that there are lots of different alkaloids in the pods, but morphine is the one I'm most concerned about. Will the Celexa prevent the morphine from working? Will I be able to get a nod? I doubt it. I'm curious about the prozac problem that you mentioned, I tried prozac and didn't notice any difference in my buzz.

Didn't notice any difference period in anything to be honest. Other than being a sex god (to my girl, to me it was just annoying)

[Narkotikon]

That's good to know. I didn't think Celexa would, but I just wanted to make sure, because I have very limited funds right now and I don't want to waste pods if I'm not going to feel it from the Celexa.

But yeah, Prozac inhibits the CYP enzyme required to metabolize codeine (methylmorphine) into morphine, which is the main reason why it works. So if you can't metabolize it, codeine doesn't really work at all. Back in 2005 I sprained my ankle by falling in the shower (from nodding out in there actually) and I thought what the hell and went to the Urgent Care Center and was given 24 Tylenol-3's, which I know are shitty, but my tolerance wasnt' that bad back then, so I took them, but noticed I couldn't feel anything, and I realized I was also taking Prozac, and researched it and found that codeine and Prozac aren't compatible, so I just called to UTC back and they called in Vicodin for me.

I was just wondering if SSRI's would have a similar effect on morphine, but I doubt it, because you don't have to metabolize it into anything for it to work on it's own.

[AGV10]

Narkotikon raises an intresting point: tricyclic anti-depressents co-administered with certain narcotic analgesics can have "undesirable" side effects - one of the most common being in the the re-uptake of seratonin can be messed up.

This is a specifically documented side effect (in some patients) as far as MO and Prozac goes.

For those interested in this, I suggest you read up on

Serotonin-norepinephrine reuptake inhibitor

Now, with respect to Celexa - thats a good question. Specificaly I don't know, but in principal it makes sense as Celexa is a tricyclic just like Prozac, and hence the effect on seratonin re-uptake is likely to be similar in some patients.

What that leads to (as far as what the patient feels) is a feeling that the narcotic is not doing what it should do. the question is, is that really happening, or is it just a perception.

Good question - is there anyone else out there who has had the experiance of using both Morphine/Condiene at the same time as using Prozac?

Very interesting comment .....

[Narkotikon]

^^^^^^^ One minor correction. Prozac and Celexa are both SSRI's, not tri-cyclics. Some of the more popular tri-cyclics are Anafranil (commonly used for Obsessive Compulsive Disorder), Trazodone (commonly used for sleep) and Elavil / Amitryptaline (commonly used for sleep also). I can see tri-cyclics having a bad reaction with morphine because both are sedating, so that would probably potentiate each other.

Other than that, interesting info.

[AGV10]

Aaah, yes how the f did that happen - I first wrote out the reponse on MSWord, then pasted it to the forum, done a preview, thought it was to much waffle and too long so cut out a lot of stuff and land up with "tricyclic" - as opposed to "they are SSRI's not tricyclics"


Thanx for the correction - u r correct, they r indeed SSRI's - and thanx for correcting in a constructive way. Courtesy goes a long way on this site when noting others errors.

AGV10

[AWOL]

that's very interesting about the prozac and codiene deal, who would have thunk eh?