I'm participating in a Clinical Trial...

[tyrant]

Hi there, long time listener, third time caller.
I've been accepted to participate in a clinical trial. Responded to a newspaper ad seeking recreational opiate users. Had an extensive physical and Q&A session. It's testing the effectiveness and potential for abuse of a new opiate-like painkiller. It's a double-blind study where they will be using this new drug(no name yet) and how the effects are compared with dilauded, xanax, dexadrine, caffein, and a sugar pill placebo. My 4 day qualifier is next week, then after that it's a series of seven 3 day/4night stays at their clinic. My girlfriend fucking HATES the idea, so i'm still debating on backiong out...but the compensation for about a month's worth of getting high on this company's dime is $6,000.00.
Just thought i'd post for anyone interested. If i actually do go through with it, i will post here and let you all know how it is as i go along.

[Opilover]

Hell I'd probably do it,,get high on their dime and get paid for it,,but then again,,could be something non-opiate and then you would be doing 7 days of WD'ing...hell I'd just sneak my DOC in and play thir game and collect the cash

[OhJoy]

Oh I would def do it. It would be really great if you report your progress.

I mean 6K! What do you have to loose? What is your girlfriend concerned about? I guess if you get stuck in the group with placebo, you could end up in w/d if you aren't taking any opiate.

[betmylife]

where is this? I wanna sign up...lol....

[GoddessofRATs]

for 6 grand I'd tell my girlfriend to just deal with it!!!! Heck yea I'd do it. But isn't there a change you'd get the sugar pill? They don't tell you if your getting the real stuff or a placebo, right? Than you'd be in there 7 days on a placebo. But, I think I'd still do it if i was in a position to do it.

Coolness!!!

GOR

[kyuss]

I'm interested.
What states?

[tui]

damn,,, sounds brilliant.

i've participated in clinical trials before... 2 stays of 2 nights. They only gave us $850 for that though. And it wasn't for opiates, it was trialling some new high blood pressure meds. no whoop-dee-doo there.

t

[Black_Pony]

Thats friggen awesome!

At the same time Opi is right, you'd have to sneak in your DOC because you'll just get sick and booted out of the program. 4 nights away from home sounds like hell to me unless you can bring in your own full antagonist

Hi there, long time listener, third time caller.
I've been accepted to participate in a clinical trial. Responded to a newspaper ad seeking recreational opiate users. Had an extensive physical and Q&A session. It's testing the effectiveness and potential for abuse of a new opiate-like painkiller. It's a double-blind study where they will be using this new drug(no name yet) and how the effects are compared with dilauded, xanax, dexadrine, caffein, and a sugar pill placebo. My 4 day qualifier is next week, then after that it's a series of seven 3 day/4night stays at their clinic. My girlfriend fucking HATES the idea, so i'm still debating on backiong out...but the compensation for about a month's worth of getting high on this company's dime is $6,000.00.
Just thought i'd post for anyone interested. If i actually do go through with it, i will post here and let you all know how it is as i go along.

[NastyZilla]

Hi there, long time listener, third time caller.
I've been accepted to participate in a clinical trial. Responded to a newspaper ad seeking recreational opiate users. Had an extensive physical and Q&A session. It's testing the effectiveness and potential for abuse of a new opiate-like painkiller. It's a double-blind study where they will be using this new drug(no name yet) and how the effects are compared with dilauded, xanax, dexadrine, caffein, and a sugar pill placebo. My 4 day qualifier is next week, then after that it's a series of seven 3 day/4night stays at their clinic. My girlfriend fucking HATES the idea, so i'm still debating on backiong out...but the compensation for about a month's worth of getting high on this company's dime is $6,000.00.
Just thought i'd post for anyone interested. If i actually do go through with it, i will post here and let you all know how it is as i go along.

No offense, but something here doesn't smell right. Pharmaceutical companies sponsor drug trials... and there is no pharma company on earth that is attempting to target the recreational opiate user market with a "painkiller" as you stated. The United State Food and Drug Administration (FDA) would never approve such a drug targeted at recreational users, rather than legit pain patients.

Or are you saying that the drug in question is something like suboxone, and is intended to remove the craving to use opiates recreationally or perhaps removes withdrawals symptoms, etc? That sounds more likely but it just wasn't clear from your post. Also sounds like way too much money - I've handled the documentation for a number of studies, and the money is always a fraction of what you have mentioned. Almost sounds like a sting operation where the cops are hoping some poor souls show up with enough stash on them to arrest them.

Why don't you tell us the name of the drug's sponsor (the manufacturer)? It will allow everyone to do a little research and look for a local physician participating in the trial as a PI (principal investigator). Thanks.

[Black_Pony]

Excuse me, 'agonist' not 'antagonist.' I just read my own post and it made no sense... :rolleyes: (it won't let me edit no more either)

Thats friggen awesome!

At the same time Opi is right, you'd have to sneak in your DOC because you'll just get sick and booted out of the program. 4 nights away from home sounds like hell to me unless you can bring in your own full antagonist

[tyrant]

No offense, but something here doesn't smell right. Pharmaceutical companies sponsor drug trials... and there is no pharma company on earth that is attempting to target the recreational opiate user market with a "painkiller" as you stated. The United State Food and Drug Administration (FDA) would never approve such a drug targeted at recreational users, rather than legit pain patients.

Or are you saying that the drug in question is something like suboxone, and is intended to remove the craving to use opiates recreationally or perhaps removes withdrawals symptoms, etc? That sounds more likely but it just wasn't clear from your post. Also sounds like way too much money - I've handled the documentation for a number of studies, and the money is always a fraction of what you have mentioned. Almost sounds like a sting operation where the cops are hoping some poor souls show up with enough stash on them to arrest them.

Why don't you tell us the name of the drug's sponsor (the manufacturer)? It will allow everyone to do a little research and look for a local physician participating in the trial as a PI (principal investigator). Thanks.


Well, you have to understand that pharm companies typically subcontract the testing of their product. I'm assuming the reason for this is that they are coming up with a wide variety of drugs all the time, and extensively testing each one in-house would be impossible. When i did my physical i spoke candidly with one of their rent-a-quacks, who when i asked what the ultimate goal of the study was, told me "we dont really know. they tell us what to do, we are on a need to know basis." He did tell me that the effects of a standard dose of this drug would be comparable to 8mg hydromorphone in terms of intoxicating effects.

Regarding the FDA, that point is moot as I'm in Canada.

Also, they way it works is that there are 7 4 night stays, each time you could be getting dosed with any of the drugs i mentioned, however on wednesday which is the qualifying session, they hit you with the opiates in order to see if you can handle using a computer to answer questions about the effects, if any, that yr feeling.


you can see the study here:

http://studies4u.com/viewAd.php?pID=52

[tyrant]

This study is sponsored by Grünenthal, the same german co that invented tramadol.

[CSiiSEQ]

I'm interested. What states?

Yes, could you state which state or if you don't want to say that, will you say which coast (or if it's a coast)? I know where I work, we have a few studies going on for recreational opiate users and 1 I think for coke - I haven't looked into them though, so am not sure what they're looking at.

If i actually do go through with it, i will post here and let you all know how it is as i go along.

Definitely do it (post about the experience if you do it). What is your GF's concern? Is she thinking it's dangerous or just pissed that you'd be using drugs?

and there is no pharma company on earth that is attempting to target the recreational opiate user market with a "painkiller" as you stated.

That's not what they're looking at (from the description). Pharm companies do give candidates to recreational users and have them subjectively rate the high or euphoric effects. If they find the druggies like it, they'll get scheduled higher and have a tougher time getting through the approval stages. It is a fairly common study type now and must be done inpatient if it involves scheduled meds or drugs (street).

Also sounds like way too much money - I've handled the documentation for a number of studies, and the money is always a fraction of what you have mentioned.That's not crazy out of range for 21 days inpatient.

Why don't you tell us the name of the drug's sponsor (the manufacturer)? It will allow everyone to do a little research and look for a local physician participating in the trial as a PI (principal investigator). Thanks.
That would be interesting to know if it is available to this person.

[CSiiSEQ]

tyr- we must have been typing at the same time- ignore my questions, you covered them in your last couple posts, thanks!

[tyrant]

Excuse me, 'agonist' not 'antagonist.' I just read my own post and it made no sense... :rolleyes: (it won't let me edit no more either)


regarding your statement, yeah it would suck being away 4 days...if i had a habit, which i havent for years. i dabble here and there, i have groovy doctor so oxycodone is fairly easily available. if anything i'll be higher in the inside than on the outside....kind of like jail.

[Black_Pony]

In that case, go pack your bags! What are you still doing here? :D

Honestly though, when does it start? Watch, this new drug causes hellish W/Ds worse than any other before and you come back from 4 days with a raging habit! That would be horrible, but doubtful. 8 mg IV of Hydromorphone is a decent shot for someone who isn't dependent. Sounds like you'll be having fun.

regarding your statement, yeah it would suck being away 4 days...if i had a habit, which i havent for years. i dabble here and there, i have groovy doctor so oxycodone is fairly easily available. if anything i'll be higher in the inside than on the outside....kind of like jail.

[freedomclub]

They were testing bupe patches a few years back in N.O.

[betmylife]

I wonder if you can do this if you are an american, thats alot of dough to try some drugs....especially if its Canadian dollars....

[EleusisII]

Could it be Tapentadol?
Sounds like Tramadols big brother ;)

https://secure.grunenthal.com/cw/en_EN/html/cw_en_en_press.jhtml?CatId=cw_en_en_press_a_01

[EleusisII]

Oh, and speaking of which, I just got offered 850$ for a two day study on Ritalin. I think I'll go for it!

[Hammilton]

Zilla-

Pharmaceutical companies often contract this sort of testing. I actually haven't seen a new drug being tested directly by the actual pharma co. but usually by small research deals.

And just because they're testing the potential for abuse doesn't mean they're targetting the recreational market. Actually they're doing just the opposite.

opioid drugs, at least in the US, are tested for abuse potential to aid in scheduling. Pharma's want them unscheduled or no higher than C3 (if avoidable) so they can have refills and docs that are willing to unload them on patients.

If this is a drug that's already undergoing this sort of human testing it's not the sort of thing that's gonna take long to get to the market.

[jacky]

It would make sense to post your experiences here at opiophile....a bit of a peek into the r and d phase of a synthetic compound.

of course knowing what compound it is that your going to take would be nice, and perhaps that is why they keep you in the dark for a period.

if you think you can handle the boredom of the clinical setting, hanging out with nurses and techs all day, then this sounds like a good deal for most people.

just hope your girlfreind doesnt get pissed further!!

I have talked to people that spent days on cocaine and opiates in clinical research trials, one minute they were high flying, the other slammed with withdrawl.

I read of one research project in which nicotine was shot up into seasoned IV drug users, who were "clean" for the testing.....most of them thought that pure nicotine was cocaine when it was shot IV...a very interesting notion...one that I hope the jungle dope factories dont take advantage of...there is not need for nicotine in dope when you got all that strychnine!

its definitely a heavy decision, but it sounds like an interesting thing to do, for the right person, at the right time.

keep us tuned in!

[NastyZilla]

Zilla-

Pharmaceutical companies often contract this sort of testing. I actually haven't seen a new drug being tested directly by the actual pharma co. but usually by small research deals.

And just because they're testing the potential for abuse doesn't mean they're targetting the recreational market. Actually they're doing just the opposite.

opioid drugs, at least in the US, are tested for abuse potential to aid in scheduling. Pharma's want them unscheduled or no higher than C3 (if avoidable) so they can have refills and docs that are willing to unload them on patients.

If this is a drug that's already undergoing this sort of human testing it's not the sort of thing that's gonna take long to get to the market.


Ummm... I will admit I did the math wrong on how many days he would be in the trial, and based upon my misunderstanding it sounded like he was being paid too much. Plus, you have to admit the original post did state that the sponsor was looking for recreational users... that doesn't make sense to me. Then again, I believe this is in Canada (which I didn't realize at the time) and appears to be an early phase trial with human subjects... and I am far more familiar with late phase trials.

A significant portion of what I do for a living relates to late phase human subject clinical research... I understand the relationships between sponsors (the manufacturer), contract or clinical research organizations (known in the industry as CROs, which may be contracted by the sponsors to handle finding patients for the trials and to work to enlist participating researchers such as physicians and hospitals). With late phase trials, almost all sponsors I have worked with have been the drug's or device's manufacturer.

This study sounds odd to me ... but then again, I usually deal with late phase human subject trials. Also, I am not a clinician or a chemist, so I have no doubt that there are trials and research issues out there I know little about.

[Hammilton]

abuse studies are still done with recreational users in the US. It doesn't make sense to give a drug to non-users and ask them which they enjoy more.

It's pretty commonly known that addicts have preferences about their favorite drugs, so it makes good sense to compare one of the most sought after (hydromorphone) with any potential new drug of abuse.

I think it'd make more sense to compare any new opioid with a few different opi-ates and -oids. Say, diamorphine, hydromorphone, hydrocodeinone, morphine, codeine and maybe Paralaudin. Maybe that's not enough in the low, low end of things

[lister40]

I know a good test to see if it is real. IV it and see if you get high, or die.

[tptptp]

It is a large amount maybe super high for 21 days OUTpatient but if this guys gotta go inpatient....yeah its still alot but I guess not impossible...I mean hes probably signing his right away, subjected to side effects, W/D, whatever with no recourse. I dunno though, could be good.

[tyrant]

jeez, i forgot i made this thread. Sadly, i dint make it through the qualifying portion of the trial. Aside from a few percs here and there and the rare bump of H, i had been clean prior to this trial. Not only that, I had gone cold turkey from 450mg wellbutrin and 50-60mg dexedrine due to the study's restriction. So when they did the qualifier, I was in the group that got hit with 4mg oral alprazolam. Needless to say, I was out for the fucking count in about 30 minutes, leading them to believe I wouldnt be suitable for the trial, since they need subjects to stay awake while on whatever drug they gave them. Just as well, spared me a month of grief from wifey.

[roxi*stardust]

jeez, i forgot i made this thread. Sadly, i dint make it through the qualifying portion of the trial. Aside from a few percs here and there and the rare bump of H, i had been clean prior to this trial. Not only that, I had gone cold turkey from 450mg wellbutrin and 50-60mg dexedrine due to the study's restriction. So when they did the qualifier, I was in the group that got hit with 4mg oral alprazolam. Needless to say, I was out for the fucking count in about 30 minutes, leading them to believe I wouldnt be suitable for the trial, since they need subjects to stay awake while on whatever drug they gave them. Just as well, spared me a month of grief from wifey.
How do they expect anyone to stay awake after a 4mg dose of alprazolam?

[reddragon3668]

Damn, that is a big dose of alprazolam. At least you tried. Hell, 1500 bucks a week to sit around and get high off of free drugs? And some people say there's no heaven on earth. Seems to prove that there is a god! :D

[Nate]

dont feel bad, 4mg would have me blacking out. What a wild dose to be given and expect to be awake LOL.

[Synack]

Could it be Tapentadol?
Sounds like Tramadols big brother ;)

https://secure.grunenthal.com/cw/en_EN/html/cw_en_en_press.jhtml?CatId=cw_en_en_press_a_01

I think so, I might sign up for that clinic trial as I qualify, what's the strength of it like?

Currently, I'm trying to sign up for Clinical Trial NCT00463047

[jackjohnson]

dont feel bad, 4mg would have me blacking out. What a wild dose to be given and expect to be awake LOL.

maybe im some freak of nature (i have some weird ass tolerance to benzos) but it takes me 10mg of alprazolam or 20mg of clonazepam to even feel anything, and i wont be passing our or blacking out. is there some genetic mutation or something i have? i took 22mg of clonazepam along with 6mg of alprazolam and a shot of heroin one night and was fine.....i know this should have killed me but i didnt even black out, i was nodding hard, but didnt pass out or black out

I think so, I might sign up for that clinic trial as I qualify, what's the strength of it like?

Currently, I'm trying to sign up for Clinical Trial NCT00463047

according to wikipedia its a norepinephrine reuptake inhibitor as well as an opioid agonist.....and it says its like a cross between tramadol and morphine. so i'd expect it might possibly give a feeling quite like a speedball, which would be quite nice :D

[StrungOutAgain]

Damn 4mg's they must be looking for some kind of super junkie or something.

[Chicago]

I have to take 6mg klonopin & 2mg xanax daily, just to stay calm never even close my eyes.
its called tolerance. Slow down on the benzos. They arent even that fun.

[Soda]

I have to take 6mg klonopin & 2mg xanax daily, just to stay calm never even close my eyes.



Do you still work out with the benzos? Do they help or hurt?