Tylenol

[Hammilton]

Hah I wonder how many people will read this thread because they think tylenol isn't interesting?

Here's an interesting fact: acetaminophen is not biologically active (at least it's not believed to be)- it is a prodrug for AM404, a cannabinoid antagonist (or agonist? I might have this backwards, but I don't believe so) which is believed to be entirely responsible for its analgesic action.

So, OxyC- you think there's a remote chance tylenol can be used as a precurser for any interesting cannabinoids?

[moviebuff927]

FUCK TYLENOL!!!

Everytime I see those dumbass commercials..."I make Tylenol not just for your children, but for my children as well" and all those dumbass "I am making a product better than GOD" promotions I just want to shoot the TV and the people saying those things...

But then again, I have issues.

[Hammilton]

yeah... but that doesn't have much to do with this thread, no?

jeez we need a chem forum.

[GoddessofRATs]

I sooo hate those Tylenol commercials as well. They act all high and mighty. Tylenol is crap!

Goddessofrats

FUCK TYLENOL!!!

Everytime I see those dumbass commercials..."I make Tylenol not just for your children, but for my children as well" and all those dumbass "I am making a product better than GOD" promotions I just want to shoot the TV and the people saying those things...

But then again, I have issues.

[Paregoric Kid]

yeah I was just reading about this on bluelight and wikipedia and some studies. tylenol is a prodrug that produces the active metabolite AM404 also known as N-arachidonoylphenolamine that works on endocannibinoids like anandamide like an ssri works on serotonin or ritalin on dopamine. it would potentiate anandamide but not THC because THC is not metabolized through FAAH. tylenols analgesic effects were reveresed with a cannabinoid antagonist. it is not a direct agonist it just prevents the breakdown/metabolism of anandamide and other endocannabinoids.

[Black_Pony]

Intriguing. I wonder if cannabinoid antagonists reverse your body's natural analgesic mechanisms. I always seem to feel any ache or pain I have more acutely when I smoke bud. Granted I don't give a shit because I am content to zone out on the couch and watch TV until I doze off. In my experience (daily smoker) muscle soreness, joint aches, and the like seem to be amplified by cannabis use.

yeah I was just reading about this on bluelight and wikipedia and some studies. tylenol is a prodrug that produces the active metabolite AM404 also known as N-arachidonoylphenolamine that works on endocannibinoids like anandamide like an ssri works on serotonin or ritalin on dopamine. it would potentiate anandamide but not THC because THC is not metabolized through FAAH. tylenols analgesic effects were reveresed with a cannabinoid antagonist. it is not a direct agonist it just prevents the breakdown/metabolism of anandamide and other endocannabinoids.

[OxyContinuously]

Hah I wonder how many people will read this thread because they think tylenol isn't interesting?

Here's an interesting fact: acetaminophen is not biologically active (at least it's not believed to be)- it is a prodrug for AM404, a cannabinoid antagonist (or agonist? I might have this backwards, but I don't believe so) which is believed to be entirely responsible for its analgesic action.

So, OxyC- you think there's a remote chance tylenol can be used as a precurser for any interesting cannabinoids?


"No"

[Hammilton]

would you agree that the only potentially interesting cannabinoids are the AAIs? the synthesis of any of those long fatty acids can't be easy