Does Methadone inhibit your H buzz

[Raz]

Hola, for the chemists out there.Does the juice inhibit your gear buzz, make it less powerfull.And whats this term "agonist" and "Halflife" Fuck i'm just an uneducated booter, so would appreciate some answers. Thanks Raz

[Woowoo]

I hope these answers are helpful to you and others. I'm no great chemistry genius, but maybe that's why my description is easier to understand than some of the technical explanations you get from the chemistry geeks.

Does methadone block the heroin high? Most people say "yes". When I was on the methadone program I couldn't enjoy heroin at all, and that led me to an overdose one day when I decided that I would shoot up an enormous amount of smack to break through the barrier. (Yes, I'm stupid!) I suppose it's subjective, but that's the general consensus, and there are reasons why this should be true. I have run into a few people who say that they take methadone to potentiate/boost other opiates, but frankly I think they are nuts.

What is half life? That's the time it takes for a drug in your system to diminish by one half. For example suppose you inject 120mg of heroin. After about 3 hours, there will only be 60mg of heroin in your system. After 6 hours, there will be 30mg of heroin in your system. At the 9-hour mark, oly 15mg of heroin remains. And so forth, until it gradually leaves your system entirely. Even after a day or two there will still be tiny traces of the drug left in your system--not enough for you to feel it, but enough to detect with urinalysis. The importance of half-life is that if an opiate has a really long half life, like methadone does, then if you take the drug you stay fucked up for a looooong time.

How receptors work: To understand the terms "agonist" and "antagonist" you need to understand how these drugs work: they target receptors. Your brain has specialized neurons which are coated with protiens called "receptors"--when the right kind of molecule encounters the right receptor, it makes the neuron fire. You could think of it as your brain having tiny little locks, and the opiate molecules are like keys floating around in your bloodstream, and the keys just happen to encounter the right kind of lock, and that makes the neuron do its thing. The opiates stays attached to the receptor for a little while, then they detach, to go back into your bloodstream, and will reattach again to another receptor.

An important detail: The neural stimulation (i.e. "getting off") happens when the key (the opiate) detaches from the lock (the receptor). It doesn't happen when the opiate first encounters the nerve, and it doesn't happen while it is locked in place, it only happens when it breaks away. Threfore, a drug that perfectly locks into place and stays locked is not a fun drug--quite the opposite, a drug like that would produce instant WDs! The most fun drugs are ones that fit the receptor in a lazy half-assed sort of way, so they trigger the neuron then they let go, only to do it again later with another receptor. Heroin is like that.... so it hydromorphone.... yummmmmmy, fun stuff there!!!

What's an agonist? The term "agonist" is used to describe a drug which locks into place with a receptor for a short time, then breaks away from it. All of our favorite molecules are agonists... heroin, oxycodone, hydromorphone, these are all agonists.

What's an antagonist? The term "antagonist" is used to describe drugs which lock into place and then they STAY locked, for incredibly long periods of time. These molecules are not fun at all. Narcan (the stuff they shoot you up with when you overdose) is an antagonist. It should be easy to understand why it works: each Narcan molecule finds an opiate receptor, it locks into place, and greedily won't let go. Then the heroin in your system just keeps going around and around in your bloodstream with no receptors to click into. This has the side effect of inducing instant withdrawl, but it can also save your life. Paramedics give Narcan to people who are overdosed on opiates, and it works like a charm.

What's a partial agonist? Finally there are a few molecules called "partial agonists" which as I understand, sometimes acts as an agonist and other times acts as an antagonist. Imagine that the key can slip into the lock either right-side-up or upside-down, and depending on which orientation it takes determines how it behaves. (That's not really how it works chemically, but it's a good way to keep the lock-key metaphor intact.) An example is codeine... not an especially fun drug, but it does produce some effect.

Where can I score some dope? Ummmm sorry, no soliciting! ;-)

[OxyContinuously]

couldn't have said it better, WooWoo

[doctor diesel]

couldn't have said it better, WooWoo


Well, I agree Oxy, BUT I have to take exception to WooWoo saying that codeine is a partial agonist; it's not, it's a full agonist.



Doc

[OxyContinuously]

Well, I agree Oxy, BUT I have to take exception to WooWoo saying that codeine is a partial agonist; it's not, it's a full agonist.



Doc


u are quite right, Doc...i missed that in his post....sure, tho, morphine, codeine, etc. come str8 from the P.som plant and are full agonists,,,the partials are usually shit like tramadol, bupe, pentazocine and all that junk...

good to see u Doc, my computer has been a piece of "shyte" as u would say, so I've been on and off....maddening, bro, I fuckin hate technology!!


later

Oxy

[cjd83us]

if I wait 24hrs since my lats dose and boot an 80 I still get high as fuck then I go dose and am noddin the rest of the day

[Woowoo]

Well, I agree Oxy, BUT I have to take exception to WooWoo saying that codeine is a partial agonist; it's not, it's a full agonist.
Is that a fact?? Really? Well what then is a good example of a partial agonist? Bupe?

Sorry about the inaccuracy. I learn new things here all the time.

[Paregoric Kid]

I'd say at the right doses heroin potentiates my methadone buzz lol
you'd have to be taking a dose of methadone big enough to cause receptor saturation for it to block heroin

[nick]

Yeah,what PG says.

[cjd83us]

true but I know people that no matter what dose they are on they still do dope and get high. but i guess if one was at like 150mg of mdone then it would be kinda hard but im on 75 and I can still get high.